期刊
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
卷 28, 期 2, 页码 122-127出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WAD.0b013e318299d096
关键词
Alzheimer disease (AD); functional magnetic resonance imaging (fMRI); cholinesterase inhibitor; apolipoprotein E (APOE); resting state functional connectivity
资金
- National Institute of Mental Health (NIMH) [K23MH081786]
- National Institute of Nursing Research (NINR) [R01NR012907, R01NR012657]
- Alzheimer's Association
- St Louis College of Pharmacy through the Office for Research on Aging (ORA) [20-122-3000-1336, P01AG03991, P50 AG05681]
- American Roentgen Ray Society Foundation
- Avid Radiopharmaceuticals
- Janssen Alzheimer Immunotherapy
- Eli Lilly
- Pfizer
This work is to determine whether apolipoprotein E (APOE) genotype modulates the effect of cholinesterase inhibitor (ChEI) treatment on resting state functional connectivity magnetic resonance imaging (rs-fcMRI) in patients with Alzheimer disease (AD). We retrospectively studied very mild and mild AD participants who were treated (N = 25) or untreated (N = 19) with ChEIs with respect to rs-fcMRI measure of 5 resting state networks (RSNs): default mode, dorsal attention (DAN), control (CON), salience (SAL), and sensory motor. For each network, a composite score was computed as the mean of Pearson correlations between pairwise time courses extracted from areas comprising this network. The composite scores were analyzed as a function of ChEI treatment and APOE epsilon 4 allele. Across all participants, significant interactions between ChEI treatment and APOE epsilon 4 allele were observed for all 5 RSNs. Within APOE epsilon 4 carriers, significantly greater composite scores were observed in the DAN, CON, and SAL for treated compared with untreated participants. Within APOE epsilon 4 noncarriers, treated and untreated participants did not have significantly different composite scores for all RSNs. These data suggest that APOE genotype affects the response to ChEI using rs-fcMRI. Rs-fcMRI may be useful for assessing the therapeutic effect of medications in AD clinical trials.
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