Article
Neurosciences
Marieclaire Overton, Benjamin Sjogren, Solve Elmstahl, Aldana Rosso
Summary: This study compared the diagnostic stability and prediction of dementia using the Petersen criteria and the Neuropsychological criteria in patients with mild cognitive impairment (MCI), and found that the reversion rates were similar for both criteria. Moreover, factors such as multiple domain MCI, cohabitation, and alcohol consumption played important roles in predicting the trajectory of MCI patients.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Andrea M. Weinstein, Swathi Gujral, Meryl A. Butters, Christopher R. Bowie, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, James L. Kennedy, Linda Mah, Shima Ovaysikia, Bruce G. Pollock, Tarek K. Rajji, Benoit H. Mulsant
Summary: This study compared diagnostic rates and clinical predictors between NIA-AA criteria and DSM-5 criteria, finding that discrepancies were more likely in individuals with a history of MDD or carrying at least one ApoE4 allele. Detailed neuropsychological testing and NIA-AA criteria identified a greater prevalence of cognitive impairment compared to DSM-5 criteria and the Montreal Cognitive Assessment.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Review
Clinical Neurology
Paul C. Donaghy, Claudia Carrarini, Daniel Ferreira, Annegret Habich, Dag Aarsland, Claudio Babiloni, Ece Bayram, Joseph P. M. Kane, Simon J. G. Lewis, Andrea Pilotto, Alan J. Thomas, Laura Bonanni
Summary: This study conducted a systematic review and meta-analysis of the diagnostic clinical features and biomarkers in MCI-LB, supporting the inclusion of current clinical features in the diagnostic criteria and finding promise in FDG-PET and quantitative EEG as diagnostic biomarkers.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemical Research Methods
Yi-Hua Huang, Wei-Yu Chen, Yao-Hong Liu, Ting-Ying Li, Ching-Po Lin, Pou-Leng Cheong, Yi-Min Wang, Jiann-Shing Jeng, Chia-Wei Sun, Chau-Chung Wu
Summary: This study explores the potential of using fNIRS and the WCST to detect MCI patients. The results show that individuals with lower cognitive scores have greater changes in blood oxygenation during the WCST. This noninvasive approach combined with cognitive assessments may effectively detect MCI, offering hope for proactive dementia prevention.
JOURNAL OF BIOPHOTONICS
(2023)
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Zuliani, Alessandro Trentini, Gloria Brombo, Valentina Rosta, Patrizia Guasti, Tommaso Romagnoli, Michele Polastri, Lisa Marabini, Dario Pedrini, Chiara Pistolesi, Salvatore Pacifico, Remo Guerrini, Davide Seripa, Carlo Cervellati
Summary: Serum BACE1 activity significantly increased in MCI patients, particularly in aMCI patients with better cognitive performance. The association between serum BACE1 activity and progression from MCI to dementia suggests that dysregulation of this enzyme may be an early event primarily related to neurodegeneration.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Geriatrics & Gerontology
Kym McNicholas, Maxime Francois, Jian-Wei Liu, James D. Doecke, Jane Hecker, Jeff Faunt, John Maddison, Sally Johns, Tara L. Pukala, Robert A. Rush, Wayne R. Leifert
Summary: This study identified biomarkers in saliva that can be used for early detection of cognitive impairment and Alzheimer's disease. The findings suggest that combinations of specific proteins can effectively distinguish patients with cognitive impairment and Alzheimer's disease from cognitively normal individuals.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Manuela Tondelli, Simone Salemme, Giulia Vinceti, Roberta Bedin, Tommaso Trenti, Maria Angela Molinari, Annalisa Chiari, Giovanna Zamboni
Summary: By analyzing the clinical features and patterns of brain atrophy in patients with Mild Cognitive Impairment, this study found that the CSF p/t-tau ratio may be useful in identifying those at higher risk of subsequent conversion to dementia, especially in patients with negative CSF amyloid biomarkers.
NEUROSCIENCE LETTERS
(2022)
Review
Clinical Neurology
Lei Zhuang, Yan Yang, Jianqun Gao
Summary: Mild cognitive impairment (MCI) is a clinical condition with a high risk of progressing to dementia. Early diagnosis and intervention at the MCI stage are considered critical strategies in disease management. Lack of consensus on guidelines for routine screening of MCI leads to a considerable number of undiagnosed patients in the community.
JOURNAL OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Kang Min Park, Chang Min Heo, Dong Ah Lee, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Bong Soo Park
Summary: This study aimed to investigate the effect of hemodialysis on functional brain connectivity in patients with end-stage renal disease (ESRD) using functional near-infrared spectroscopy (fNIRS). The study found significant changes in functional brain connectivity measures between the pre- and post-hemodialysis periods, but no changes between the pre- and mid-hemodialysis periods or between the mid- and post-hemodialysis periods. These findings suggest that hemodialysis has a significant effect on functional brain connectivity in patients with ESRD.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Camilla Elefante, Giulio Emilio Brancati, Zahinoor Ismail, Sara Ricciardulli, Maria Francesca Beatino, Vittoria Lepri, Antonella Fama, Elisabetta Ferrari, Linda Giampietri, Filippo Baldacci, Roberto Ceravolo, Icro Maremmani, Lorenzo Lattanzi, Giulio Perugi
Summary: This study aimed to investigate the prevalence and differentiating features of Mild Behavioral Impairment (MBI) with respect to major neurocognitive disorders (MNDs) and primary psychiatric disorders (PPDs). The results showed that patients with MBI had higher scores of psychopathology, specifically in terms of negative symptoms, compared to patients with PPDs. Additionally, MBI patients frequently reported higher severity of apathy and motor retardation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Public, Environmental & Occupational Health
Jui-Hung Hsu, Chien-Cheng Liu, I-Wen Chen, Jheng-Yan Wu, Po-Yu Huang, Ting-Hui Liu, Kuo-Chuan Hung
Summary: The visual cognitive assessment test (VCAT) is a language-neutral screening tool for detecting MCI/mild dementia. This meta-analysis showed that VCAT demonstrated acceptable diagnostic accuracy in distinguishing MCI/mild dementia in cognitively normal older adults.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Health Care Sciences & Services
Lindsay White, Bailey Ingraham, Eric Larson, Paul Fishman, Sungchul Park, Norma B. Coe
Summary: Timely diagnosis of cognitive impairment is a key goal of the National Plan to Address Alzheimer's Disease, but studies on factors contributing to timely diagnosis are limited. This retrospective observational study found that only 26% of respondents with incident dementia and 11.4% with incident MCI received a timely diagnosis. Non-Hispanic Black and individuals with lower educational attainment were less likely to receive timely diagnosis of dementia or MCI compared to Non-Hispanic White respondents or those with a college degree.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Randall L. Kuffel, Amy L. Byers, Brie Williams, Richard Fortinsky, Yixia Li, Michael A. Ruderman, Lisa C. Barry
Summary: This study examines the prevalence of dementia and mild cognitive impairment (MCI) among incarcerated individuals in the United States. The findings highlight the importance of understanding the link between cognitive impairment and incarceration in order to inform healthcare optimization and prevention strategies for this vulnerable population.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Psychology, Clinical
Dae Jong Oh, Hee Won Yang, Seung Wan Suh, Seonjeong Byun, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Jong Bin Bae, Ji Won Han, Ki Woong Kim
Summary: The study found that the COVID-19 pandemic has a significant impact on the risk of depression in older adults. The pandemic is associated with increased depressive symptoms in older adults, and even euthymic older adults without a history of depression have a doubled risk of developing depressive disorder during the pandemic. Less social activities are not associated with the risk of depressive disorder during the pandemic, but less family gatherings are associated with an increased risk of depressive disorder.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Hyun-Ju Yang, Young-Eun Jung, Joon Hyuk Park, Moon-Doo Kim
Summary: The study aims to explore the accuracy of expectation of medical lethality and identify characteristics related to high medical lethality in suicide attempters. The results reveal that suicide attempters with accurate expectations of medical lethality demonstrate higher suicide intent and older age compared to those with lower expectations.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2022)
Review
Psychiatry
Areum Han, Tae Hui Kim
Summary: This systematic review and meta-analysis examined the effects of internet-delivered behavioral activation (iBA) on individuals with depressive symptoms. The findings suggest that iBA has small to medium effects on depressive symptoms, anxiety, quality of life, functioning, perceived social support, and behavioral activation. However, more high-quality studies are needed to confirm these effects and explore other health outcomes and process measures.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Dae Jong Oh, Jun Sung Kim, Subin Lee, Hee Won Yang, Jong Bin Bae, Ji Won Han, Ki Woong Kim
Summary: This study examines the association between serum free hemoglobin (sfHb) level and white matter hyperintensity (WMH) volume, considering nonlinearity, sex dimorphism, and WMH type. The findings indicate a linear association between sfHb level and periventricular WMH in men, a U-shaped association in women, and no association with deep WMH in both sexes.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Hyeong Min Kim, Ji Won Han, Young Joo Park, Jong Bin Bae, Se Joon Woo, Ki Woong Kim
Summary: This study investigates the relationship between retinal layer thickness and cognitive impairment and decline in a community-based population. The findings suggest that macular RNFL thickness may serve as a prognostic biomarker for long-term cognitive decline in older adults.
JAMA OPHTHALMOLOGY
(2022)
Article
Rheumatology
Ji Sup Hwang, Sanghoon Lee, Jung Wook Shin, Ki Woong Kim, Hyun Sik Gong
Summary: The study aimed to evaluate the association between index-to-ring finger ratio (IRFR) and trapeziometacarpal joint (TMCJ)OA in an elderly Korean population. The results showed that radiographic IRFR, specifically metacarpal IRFR, was associated with the presence of TMCJ OA, and visual IRFR with severe TMCJ OA in both elderly Korean men and women.
JOURNAL OF RHEUMATOLOGY
(2022)
Review
Substance Abuse
Louise Mewton, Rachel Visontay, Nicholas Hoy, Darren M. Lipnicki, Matthew Sunderland, Richard B. Lipton, Maelenn Guerchet, Karen Ritchie, Jenna Najar, Nikolaos Scarmeas, Ki-Woong Kim, Steffi Riedel Heller, Martin van Boxtel, Erin Jacobsen, Henry Brodaty, Kaarin J. Anstey, Mary Haan, Marcia Scazufca, Elena Lobo, Perminder S. Sachdev
Summary: This study synthesizes international findings on the alcohol-dementia relationship, indicating that abstinence from alcohol is associated with an increased risk for all-cause dementia, while there is no consistent evidence to suggest that the amount of alcohol consumed in later life is associated with dementia risk among current drinkers.
Article
Geriatrics & Gerontology
Gihwan Byeon, Sung Ok Kwon, Jin Hyeong Jhoo, Jae-Won Jang, Jong Bin Bae, Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Dong Young Lee, Ki Woong Kim
Summary: This study aimed to determine the differences in risk factors for dangerous driving between older adults with normal cognition and those with cognitive impairment. The driving risk questionnaire (DRQ) and accident/violation records were analyzed. Significant associations were found between risky driving and crash history, safety concern, reduced mileage, and aggressive driving in the normal cognition group. In the cognitive impairment group, only crash history was significantly associated. These findings contribute to evaluating and predicting risky driving and providing advice on whether to continue driving in clinics.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Neuroimaging
Jun Sung Kim, Jong Bin Baeb, Ji Won Han, Dae Jong Oh, Seung Wan Suh, Jae Hyoung Kim, Ki Woong Kim
Summary: This study investigated the effects of controlled hypertension (cHT) and white matter hyperintensity (WMH) on cognitive function, as well as the mediating role of WMH in the relationship between cHT and cognitive impairment. The results showed that older WMH age was associated with a faster decline in cognitive function, and WMH age mediated the effects of cHT on cognitive function. Therefore, older individuals with cHT and older WMH age may be at a higher risk of cognitive decline.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Hyang Jun Lee, Ji Sun Park, Hee Won Yang, Jeong Wook Shin, Ji Won Han, Ki Woong Kim
Summary: This study aimed to construct age-stratified normative data of non-dimensionally normalized temporal and spatial gait features in healthy older adults. The results showed that age and sex had significant effects on gait features, but after dimensional normalization, only age remained as a significant factor. These normative data can be useful in comparative studies of gait function between sexes or ethnicities with different body shapes.
Review
Psychology, Clinical
Areum Han, Tae Hui Kim
Summary: A growing body of evidence suggests that self-compassion can help alleviate depressive symptoms, anxiety, and stress in various populations. This meta-analysis aimed to identify studies on the effects of self-compassion interventions in reducing these symptoms.
Article
Neurosciences
Sang-a Park, Gihwan Byeon, Jin Hyeong Jhoo, Hyung-Chun Kim, Myoung-Nam Lim, Jae-Won Jang, Jong Bin Bae, Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Dong Young Lee, Ki Woong Kim
Summary: This study investigated the relationship between reduced glutathione (GSH) and glutathione reductase (GR) and the prevalence of Alzheimer's dementia and cognitive decline. The results showed that higher levels of GR were associated with a lower likelihood of developing Alzheimer's dementia and higher neurocognitive test scores. However, there was no significant association between GSH and cognitive status.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Su Jeong Seong, Bin Na Kim, Ki Woong Kim
Summary: This study compared the implementation basis and specific action plans of National Dementia Plans (NDPs) between G7 countries and South Korea. It found that some NDPs lacked support for caregivers, safe environments, healthcare services, and end-of-life care. Some countries strengthened the policy priority of their NDPs through timely updates, evaluation, legislations, or leadership, but only three countries had a legislative basis and three countries included outcome measures in their latest NDP.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Min Jeong Kwon, Subin Lee, Jieun Park, Sungman Jo, Ji Won Han, Dae Jong Oh, Jun-Young Lee, Joon Hyuk Park, Jae Hyoung Kim, Ki Woong Kim
Summary: Texture analysis may be an important neuroimaging marker for early detection of svPPA and differentiation from AD.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
