Article
Medicine, Research & Experimental
Bao-Shu Xie, Xin Wang, Yao-Hua Pan, Gan Jiang, Jun-Feng Feng, Yong Lin
Summary: Our study revealed that intravenous injection of AAV-PHP.eB led to more efficient transduction to the CNS in C57BL/6 mice compared to BALB/c mice, and transduction was significantly reduced in Apoe or Ldlr knockout C57BL/6 mice. Furthermore, poor CNS transduction in BALB/c mice was dramatically increased by B-cell or natural killer-cell depletion.
Article
Ophthalmology
Hideki Hayashi, Misuzu Mori, Mina Harashima, Tatsuya Hashizume, Miho Furiya, Chihaya Mukaigaito, Emi Takemura, Mariko Yamada, Kanako Mise, Bo Yuan, Norio Takagi
Summary: The study found that E-LPs can protect the optic nerve from degeneration and reduce the increase of alpha-2-macroglobulin in the aqueous humor and retina of rats. E-LPs directly decreased the expression and secretion of alpha-2-macroglobulin in primary cultures of Muller glia, which was blocked by knockdown of LRP1. E-LPs promoted the phosphorylation of STAT3 and inhibited the expression of alpha-2-macroglobulin, suggesting a potential protective mechanism against excitotoxicity in the retina.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Chih-Kuo Lee, Che-Wei Liao, Shih-Wei Meng, Wei-Kai Wu, Jiun-Yang Chiang, Ming-Shiang Wu
Summary: Despite advancements in pharmacotherapy and intervention devices, residual cardiovascular risks remain a significant burden on public health. Molecular modifications of lipid and lipoprotein components play a critical role in atherogenicity, with levels of certain lipids and proteins closely associated with atherosclerotic cardiovascular disease. Therapies targeting these modifications are showing promising results in trials for reducing risks and enhancing cardiovascular health.
Article
Neurosciences
Lenique K. L. Huggins, Se Hee Min, Samantha Kaplan, Jingkai Wei, Kathleen Welsh-Bohmer, Hanzhang Xu
Summary: There are racial and ethnic variations in the association between the APOE epsilon 4 allele and the risk of developing Alzheimer's disease and related dementias (ADRD). This study examined this association among global Hispanic populations and found that APOE epsilon 4 was significantly associated with increased risk of ADRD for the South American subgroup, while the association was not significant for other Hispanic subgroups.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Victoria Marco-Benedi, Ana Cenarro, Martin Laclaustra, Asier Larrea-Sebal, Estibaliz Jarauta, Itziar Lamiquiz-Moneo, Pilar Calmarza, Ana M. Bea, Nuria Plana, Xavier Pinto, Cesar Martin, Fernando Civeira
Summary: This study aimed to compare Lp(a) concentration in controls, genetically diagnosed heFH, and mutation-negative hypercholesterolemia subjects, as well as to assess the influence of the genetic defect responsible for heFH on Lp(a) concentration. The results showed that Lp(a) concentration was elevated in mutation-negative subjects and heFH patients. Among heFH patients, APOB-dependent FH had the highest Lp(a) concentration, followed by LDLR-dependent FH.
Article
Endocrinology & Metabolism
W. Hudson Robb, Omair A. Khan, Humza A. Ahmed, Judy Li, Elizabeth E. Moore, Francis E. Cambronero, Kimberly R. Pechman, Dandan Liu, Katherine A. Gifford, Bennett A. Landman, Manus J. Donahue, Timothy J. Hohman, Angela L. Jefferson
Summary: The study found interactions between CMRO2 and APOE-ε4 status in cognitive performance and neuroimaging variables among older adults, suggesting that low oxygen metabolism is associated with certain cognitive impairments, particularly in APOE-ε4 carriers.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Multidisciplinary Sciences
Zhanzhang Wang, Xiuqing Zhu, Yuguan Wen, Dewei Shang
Summary: Alzheimer's disease (AD) has seen significant growth in research in the past decade, with a focus on the role of apolipoprotein E. This study conducted a bibliometric analysis to identify trends in global research, finding that the USA and the University of California were prominent in this field. The most productive author was Zetterberg H, and Petersen RC was the most cited author. The analysis also revealed shifts in research focus towards tau mechanisms and genetic risk factors.
Article
Biochemistry & Molecular Biology
Ewa Wieczorek, Agnieszka Cwiklinska, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwinska, Maciej Jankowski
Summary: The study focused on evaluating the impact of HDL-2 and HDL-3 on VLDL degradation related to hypertriglyceridemia. The findings showed that HDL-3 had a significant effect on the composition and electrophoretic mobility of VLDL, compared to HDL-2.
Article
Public, Environmental & Occupational Health
Klodian Dhana, Neelum T. Aggarwal, Kumar B. Rajan, Lisa L. Barnes, Denis A. Evans, Martha C. Morris
Summary: Adherence to a healthy lifestyle is associated with slower cognitive decline in older adults, particularly among those with a genetic predisposition, highlighting the importance of healthy habits in maintaining cognitive function as individuals age.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Klodian Dhana, Neelum T. Aggarwal, Kumar B. Rajan, Lisa L. Barnes, Denis A. Evans, Martha C. Morris
Summary: Adherence to a healthy lifestyle is associated with slower cognitive decline in older adults, even for those with a genetic predisposition such as carriers of the APOE*E4 allele. On the other hand, individuals carrying the APOE*E4 gene experience faster cognitive decline. However, following a healthy lifestyle can help to mitigate this decline.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Endocrinology & Metabolism
Q. Zhang, Y-D. Wu
Summary: The study found that the ApoE gene polymorphism is correlated with the lipid-lowering effects of rosuvastatin and atorvastatin, with better effects in patients with E2/E3 and E3/E3 genotypes.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Biochemistry & Molecular Biology
Weibin Shi, Jing Li, Kelly Bao, Mei-Hua Chen, Zhenqi Liu
Summary: Comparing C3H-Ldlr(-/-) mice with C3H-Apoe(-/-) mice, we found that a Western diet and hyperlipidemia lead to the development of type 2 diabetes, regardless of genetic causes.
Article
Gastroenterology & Hepatology
Satoru Joshita, Yuki Yamashita, Toru Okamoto, Yoko Usami, Ayumi Sugiura, Tomoo Yamazaki, Akemi Kakino, Masao Ota, Tatsuya Sawamura, Takeji Umemura
Summary: Direct-acting antivirals have significantly increased lipid levels and led to PCSK9 recovery in patients with chronic HCV infection who achieved sustained virological response. Additionally, qualitative lipid improvements may confer additional benefits, potentially reducing cardiovascular disease events.
HEPATOLOGY RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew S. Bell, Daniel B. Rosoff, Lucas A. Mavromatis, Jeesun Jung, Josephin Wagner, Falk W. Lohoff
Summary: The study investigated the potential neuropsychiatric consequences of genetically proxied PCSK9 inhibition in men and women. The results showed no major differences between men and women in terms of neuropsychiatric effects.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Hae Won Jung, Moni Ra, Han Joon Bae, Seung-Pyo Hong
Summary: The association between Apo B, Apo B/A1 ratio, lipoprotein (a), and LDL-C/Apo B ratio with coronary artery disease (CAD) in non-diabetic patients without high LDL-C levels was unclear. A study was conducted on 487 non-diabetic patients with LDL-C < 130.0 mg/dL to evaluate the most strongly associated parameter with CAD. The LDL-C/Apo B ratio was found to be the most predictive parameter for coronary atherosclerosis in non-diabetic patients without high LDL-C levels.
Article
Clinical Neurology
Larissa Salvador, Luana Giatti, Maria Carmen Viana, Claudia Kimie Suemoto, Bruce B. Duncan, Maria del Carmen Bisi Molina, Maria de Jesus Mendes da Fonseca, Andre R. Brunoni, Sandhi Maria Barreto, Paulo Caramelli
Summary: This study aimed to investigate the impact of alcohol intake on cognition in middle-aged participants and found that heavy alcohol consumption can affect executive functions in men and memory in women, while moderate alcohol intake may have a protective effect on gender-specific cognitive functions.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Roseli da S. Soares, Talita de S. Laurentino, Camila T. da Silva, Jessica D. Goncalves, Antonio M. Lerario, Suely K. N. Marie, Sueli M. Oba-Shinjo, Miriam G. Jasiulionis
Summary: This study establishes a model of malignant astrocyte transformation by subjecting primary astrocytes from healthy adults to successive cycles of anchorage impediment. The transformed cells exhibit malignant characteristics and molecular analysis reveals the involvement of multiple signaling pathways and genes related to cell dedifferentiation. This model is significant for understanding glioblastoma treatment strategies and the underlying transformation mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Maira Garcia Martins, Pedro Augusto Magliarelli Filho, Suely Kazue Nagahashi Marie, Luiz Ubirajara Sennes
Summary: This study aimed to investigate the distribution of leptin receptors in the brain stem and hypoglossal nucleus, and their association with sleep apnea. Immunohistochemical staining analysis was conducted on five cadavers, revealing the immunopositivity of leptin receptors in the motor neurons of the hypoglossal nucleus. These findings contribute to a better understanding of the neuromuscular control of airway collapse during sleep and the potential development of new drugs for improving upper airway tone in individuals with sleep apnea.
Article
Psychiatry
Izabela Guimaraes Barbosa, Flavia da Mata Chiacchio Leite, Maxime Bertoux, Henrique Cerqueira Guimaraes, Luciano Inacio Mariano, Leandro Boson Gambogi, Antonio Lucio Teixeira, Paulo Caramelli, Leonardo Cruz de Souza
Summary: This study found that bipolar disorder type 1 (BD1) and behavioral-variant frontotemporal dementia (bvFTD) have similar deficits in social cognition functions. The results of the Facial Emotion Recognition (FER) and Modified Faux-Pas (mFP) tests can be used to differentiate between the two disorders.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Virology
Janaina Macedo-da-Silva, Livia Rosa-Fernandes, Vinicius de Morais Gomes, Veronica Feijoli Santiago, Deivid Martins Santos, Catarina Maria Stanischesk Molnar, Bruno Rafael Barboza, Edmarcia Elisa de Souza, Rodolfo Ferreira Marques, Silvia Beatriz Boscardin, Edison Luiz Durigon, Claudio Romero Farias Marinho, Carsten Wrenger, Suely Kazue Nagahashi Marie, Giuseppe Palmisano
Summary: We found that SARS-CoV-2 infection leads to increased protein arginylation, and inhibition of this process has potential therapeutic value.
Article
Oncology
Isabele Fattori Moretti, Antonio Marcondes Lerario, Paula Rodrigues Sola, Janaina Macedo-da-Silva, Mauricio da Silva Baptista, Giuseppe Palmisano, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie
Summary: This study analyzed the effects of MET combined with TMZ treatment in two GBM cell lines, U87MG and A172, stimulated with LPS. MET treatment led to mitochondrial respiration blunting and oxidative stress in both cell lines, with U87MG cells exhibiting increased apoptosis after MET + LPS + TMZ treatment and A172 cells showing cell cycle arrest after MET + TMZ treatment. The observed differential response was associated with the metabolic status of the cells. This study highlights the potential of MET as a treatment option for GPM-GBM cases with an activated TLR4 pathway and suggests the use of combination therapies, such as an IL8 inhibitor for cases with upregulated CXCL8 and an antioxidant inhibitor for MTC-GBM cases.
Article
Surgery
Benedito Jamilson Araujo Pereira, Sueli M. Oba-Shinjo, Paulo Henrique Pires de Aguiar, Antonio Nogueira de Almeida, Wellingson da Silva Paiva, Suely Kazue Nagahashi Marie
Summary: This study analyzed the expression of AQP4 in meningiomas using immunohistochemistry and qPCR, and found that AQP4 expression was not associated with the malignant progression of meningiomas.
BRAZILIAN NEUROSURGERY-ARQUIVOS BRASILEIROS DE NEUROCIRURGIA
(2023)
Article
Clinical Neurology
L. L. de Godoy, A. Studart-Neto, D. R. de Paula, N. Green, A. Halder, P. Arantes, K. T. Chaim, N. C. Moraes, M. S. Yassuda, R. Nitrini, M. Dresler, C. da Costa Leite, J. Panovska-Griffiths, A. Soddu, S. Bisdas
Summary: This study aimed to investigate the key differences in discriminative networks and their main nodes between superagers and cognitively average elderly controls. The key networks that differentiated superagers and elderly controls were the default mode, salience, and language networks. Potential imaging biomarkers for predicting superagers can be provided by the functional connectivity in these networks. The 7T field holds promise for accurately detecting the functional connectivity patterns in superagers.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Neurosciences
Karoline Carvalho Carmona, Elisa de Paula Franca Resende, Henrique Cerqueira Guimaraes, Thais Helena Machado, Viviane Amaral-Carvalho, Etelvina Lucas dos Santos, Maira Tonidandel Barbosa, Paulo Caramelli
Summary: This study investigated the presence of high-performance older adults (HPOA) in an oldest-old population with low education and explored associations with sociodemographic, clinical, and lifestyle variables. Results showed that 18 individuals fulfilled HPOA criteria, with an average age of 77.4 years and education level of 4.6 years. Younger age and lower scores on the Geriatric Depression Scale were associated with HPOA.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Article
Cell Biology
Caio Yogi Yonamine, Marisa Passarelli, Claudia Kimie Suemoto, Carlos Augusto Pasqualucci, Wilson Jacob-Filho, Venancio Avancini Ferreira Alves, Suely Kazue Nagahashi Marie, Maria Lucia Correa-Giannella, Luiz Roberto Britto, Ubiratan Fabres Machado
Summary: Diabetes mellitus is a risk factor for dementia and can induce neuronal dysfunctions through inflammation and other processes. This study found that obese individuals with diabetes had reduced GLUT4 expression and neuronal soma area in the hippocampus. Inflammatory activation decreased GLUT4 expression and negatively affected genes related to neuronal function. Inhibiting HDAC3 could potentially improve GLUT4 expression and counteract the negative effects of inflammation.
Article
Neurosciences
Karina Braga Gomes, Ramon Goncalves Pereira, Alexandre Alberto Braga, Henrique Cerqueira Guimaraes, Elisa de Paula Franca Resende, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Wagner Meira Junior, Maria das Gracas Carvalho, Paulo Caramelli
Summary: This study used machine learning algorithms to assess the ability of routine laboratory variables in predicting cognitive and functional decline in older adults. The random forest model was found to be the most accurate in predicting cognitive decline, including variables such as triglycerides, glucose, and hemoglobin. For functional decline, platelet count, hemoglobin, and cortisol were identified as important features. The findings suggest that routine laboratory variables can be used to predict cognitive and functional decline in older populations using machine learning algorithms.
Editorial Material
Neurosciences
Paulo Caramelli
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Article
Neurosciences
Leonardo Cruz de Souza, Sonia Maria Dozzi Brucki, Lucas Porcello Schilling, Leticia Costa da Silva, Leonel Tadao Takada, Valeria Santoro Bahia, Breno Jose Alencar Pires Barbosa, Marcio Luiz Figueredo Balthazar, Norberto Anizio Ferreira Frota, Ricardo Nitrini, Paulo Caramelli, Jerusa Smid
Summary: The aim of this study was to investigate the difficulties and limitations faced by Brazil in the diagnosis and management of frontotemporal dementia (FTD). A total of 256 Brazilian physicians participated in an online survey, and the results showed that the main difficulty in the diagnosis of FTD was the performance of genetic testing. Social cognition assessment and AD CSF biomarkers were considered useful for the diagnosis of FTD by 93% and 63% of participants, respectively.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Article
Clinical Neurology
Viviane Amaral-Carvalho, Thais Bento Lima-Silva, Luciano Inacio Mariano, Leonardo Cruz de Souza, Henrique Cerqueira Guimaraes, Valeria Santoro Bahia, Ricardo Nitrini, Maira Tonidandel Barbosa, Monica Sanches Yassuda, Paulo Caramelli
Summary: The study investigates the value of using ACE-R combined with sociodemographic factors in the differential diagnosis between AD and bvFTD. The results show that combining ACE-R scores with age, sex, and education level can effectively differentiate AD from bvFTD.
CURRENT ALZHEIMER RESEARCH
(2023)