Review
Biochemistry & Molecular Biology
Akane Wada, Yu Sawada, Hitomi Sugino, Motonobu Nakamura
Summary: Fatty acids, as essential mediators in physiological and pathological processes, play a potential role in the development of angioedema, involving vascular permeability and vasodilation in addition to bradykinin and histamine-mediated reactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Karen Lindsay, Ignatius Chua, Anthony Jordan, Simone Stephens
Summary: This study presents a national audit on Hereditary Angioedema (HAE) and Acquired Angioedema (AAE) in 2019, revealing the usage of related treatments and identifying issues such as infrequent liver ultrasound screening. Based on the findings, corrective actions are proposed to enhance long-term care for HAE patients and their families.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Immunology
Roberta Parente, Silvio Sartorio, Luisa Brussino, Tiziana De Pasquale, Alessandra Zoli, Stefano Agolini, Ester Di Agosta, Paolina Quattrocchi, Paolo Borrelli, Donatella Bignardi, Angelica Petraroli, Riccardo Senter, Valentina Popescu Janu, Chiara Cogliati, Maria Domenica Guarino, Oliviero Rossi, Davide Firinu, Stefano Pucci, Giuseppe Spadaro, Massimo Triggiani, Mauro Cancian, Andrea Zanichelli
Summary: This study aimed to collect data on the safety and tolerability of COVID-19 vaccines in patients with angioedema due to C1 inhibitor deficiency. The results showed no increase in the frequency of acute attacks within 72 hours following COVID-19 vaccinations compared to the rate before vaccination. This suggests that adult patients with angioedema due to C1 inhibitor deficiency can safely receive SARS-CoV-2 vaccination in a controlled medical setting and should have access to on-demand therapy.
Article
Allergy
Zsuzsanna Balla, Zsuzsanna Zsilinszky, Zsofia Polai, Noemi Andrasi, Kinga Viktoria Kohalmi, Dorottya Csuka, Lilian Varga, Henriette Farkas
Summary: This study evaluated the results of complement testing in patients experiencing angioedema while taking angiotensin-converting enzyme inhibitors. The findings revealed that most initial angioedema episodes in the 149 patients occurred in the face, lips, and tongue. The diagnosis of acquired angioedema related to angiotensin-converting enzyme inhibitors is closely linked to the use of these medications.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Patrick F. K. Yong, Tanya Coulter, Tariq El-Shanawany, Tomaz Garcez, Scott Hackett, Rashmi Jain, Sorena Kiani-Alikhan, Ania Manson, Sadia Noorani, Catherine Stroud, Christine Symons, Ravishankar Sargur, Cathal Steele, Hana Alachkar, Ariharan Anantharachagan, Peter D. Arkwright, Jolanta Bernatoniene, Malini Bhole, Lindsay Brown, Elizabeth Drewe, Jillian Edmonds, Anjali Ekbote, Shuayb Elkhalifa, Sarah Goddard, Dorothea Grosse-Kreul, Padmalal Gurugama, Rosie Hague, Richard Herriot, Archana Herwadkar, Stephen M. Hughes, Laura Jones, Sara Lear, Elizabeth Mcdermott, Sai Hurng Kham Murng, Arthur Price, Vyanka Redenbaugh, Alex Richter, Andrew Riordan, Fiona Shackley, Julia Stichbury, Debbie Springett, Michael D. Tarzi, Moira Thomas, Pavaladurai Vijayadurai, Austen Worth
Summary: This study provides valuable demographic data and treatment modalities used in HAE and acquired C1 inhibitor deficiency in the United Kingdom, which are helpful for improving services and focusing on areas of improvement.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Review
Allergy
Stephen D. Betschel, Aleena Banerji, Paula J. Busse, Danny M. Cohn, Markus Magerl
Summary: Hereditary angioedema (HAE) is a rare disease characterized by sudden and unprovoked swelling, which can be life-threatening. Previous treatment options were limited and had considerable side effects. However, with the understanding of HAE pathophysiology, newer targeted therapies have been developed for both acute treatment and long-term prophylaxis. This review article outlines current and potential future treatments for HAE, emphasizing considerations for special patient populations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Allergy
Gesa Bindke, Manuela Gehring, Dorothea Wieczorek, Alexander Kapp, Timo Buhl, Bettina Wedi
Summary: This study compared HAE, ACE-AE, and CSU-AE for the first time, identifying Tie-2 as a promising biomarker candidate for HAE. FAP-alpha and tPA may serve as markers for AE in general, while sE-selectin and Ang-2 were increased in BK-AE only. The study adds information to the role of endothelial dysfunction and serine proteases in different AE subtypes.
Article
Allergy
Zsuzsanna Balla, Noemi Andrasi, Zsofia Polai, Beata Visy, Ibolya Czaller, Gyorgy Temesszentandrasi, Dorottya Csuka, Lilian Varga, Henriette Farkas
Summary: Early diagnosis is crucial in preventing lethal upper airway edemas in patients with bradykinin-mediated angioedemas, as shown by our retrospective survey.
CLINICAL AND TRANSLATIONAL ALLERGY
(2021)
Article
Pediatrics
Mauro Cancian, Paola Triggianese, Stella Modica, Francesco Arcoleo, Donatella Bignardi, Luisa Brussino, Caterina Colangelo, Ester Di Agosta, Davide Firinu, Maria Domenica Guarino, Francesco Giardino, Marica Giliberti, Vincenzo Montinaro, Riccardo Senter
Summary: This study aims to investigate the impact of puberty on the onset, frequency, location, and severity of attacks in hereditary angioedema patients. The results show that the proportion of symptomatic patients and the monthly mean of acute attacks significantly increase after puberty, especially in females.
FRONTIERS IN PEDIATRICS
(2023)
Article
Allergy
Grzegorz Porebski, Mateusz Kwitniewski, Avner Reshef
Summary: Biomarkers are defined characteristics used to measure normal, biological, pathogenic processes, or biological responses. Different types of biomarkers can be used for diagnosing diseases, monitoring medical conditions, checking biological responses, predicting patient responses, and assessing future clinical event likelihood. While HAE involves various molecules, there are currently limited biomarkers for its diagnosis, disease activity evaluation, and treatment.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Raffi Tachdjian, Douglas T. Johnston
Summary: Acute angioedema is a serious condition that requires prompt intervention, as patients may be at risk of airway obstruction at any time. The disease is caused by three mediators, each requiring different management strategies based on individual circumstances.
POSTGRADUATE MEDICINE
(2021)
Article
Allergy
Susamita Kesh, Umesh Singh, Jonathan A. Bernstein
Summary: This study retrospectively analyzed the clinical characteristics and treatment responses of 13 patients with AAE. The results showed that using TXA as prophylaxis significantly reduced AE attacks. However, it is worth noting that potential adverse effects of TXA should be taken into consideration.
ALLERGY AND ASTHMA PROCEEDINGS
(2022)
Article
Medicine, General & Internal
Katarzyna Piotrowicz-Wojcik, Malgorzata Bulanda, Aldona Juchacz, Joanna Jamroz-Brzeska, Jacek Gocki, Krzysztof Kuziemski, Robert Pawlowicz, Grzegorz Porebski
Summary: This study investigated the clinical characteristics and treatment practices of 138 adult HAE patients in Poland, finding that plasma-derived C1-INH, icatibant, and recombinant C1-INH were the main treatments used for attacks. Symptomatic women had a higher frequency of attacks and were more likely to treat themselves compared to men, while older patients experienced longer delays in diagnosis and self-administered rescue medication less frequently.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Allergy
Constance H. Katelaris, Anete S. Grumach, Konrad Bork
Summary: Angioedema is a localized nonpitting edema characterized by increased vascular permeability and extravasation of intravascular fluid. It can occur through various mechanisms, and differentiating it from similar conditions is important. The classification of angioedema is based on the presence or absence of concurrent urticaria. Understanding the underlying pathogenesis is essential for effective management.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Medicine, General & Internal
Paola Triggianese, Matteo Di Marino, Carolina Nesi, Elisabetta Greco, Stella Modica, Maria Sole Chimenti, Paola Conigliaro, Raffaele Mancino, Carlo Nucci, Massimo Cesareo
Summary: This study utilized SD-OCT and OCT-A to explore retinal abnormalities in a specific group of type I HAE patients, revealing thicker retinal nerve fiber layer and optic nerve head thickness, as well as decreased capillary density in both superficial and deep regions compared to healthy controls. These findings suggest the potential utility of SD-OCT/OCT-A for comprehensive care of individuals with HAE.
JOURNAL OF CLINICAL MEDICINE
(2021)
