Article
Allergy
Marlon Munera, Dalgys Martinez, Judith Wortmann, Josefina Zakzuk, Walter Keller, Luis Caraballo, Leonardo Puerta
Summary: The study identified LvFABP as a shrimp allergen that cross-reacts with the house dust mite allergen Blo t 13, and has allergenic activity in shrimp allergic patients. The structure of LvFABP was characterized, showing a beta-barrel fold with two alpha-helices and ten beta-strands. Epitope mapping revealed two IgE-binding antigenic regions and inhibition assays demonstrated high cross-reactivity between LvFABP and Blo t 13.
Article
Immunology
Yasmeen S. El Ansari, Cynthia Kanagaratham, Oliver T. Burton, Jenna V. Santos, Brianna-Marie A. Hollister, Owen L. Lewis, Harald Renz, Hans C. Oettgen
Summary: Mast cells and basophils play important roles in IgE-mediated hypersensitivity reactions. IgG and IgA antibodies can regulate the activation of these cells by activating or inhibiting receptors. This study found that IgA antibodies can bind to mast cells and basophils, and inhibit their activation to maintain immune homeostasis at mucosal sites.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Jun-ichi Kashiwakura, Mari Yoshihara, Kodai Saitoh, Kota Kagohashi, Yuto Sasaki, Fuki Kobayashi, Iori Inagaki, Yuichi Kitai, Ryuta Muromoto, Tadashi Matsuda
Summary: Propolis can inhibit IgE-dependent basophil activation and basophil-mediated allergic inflammation, potentially offering protection against food allergic reactions in sensitive individuals.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Francesco Savino, Francesca Giuliani, Stefano Giraudi, Ilaria Galliano, Paola Montanari, Valentina Dapra, Massimiliano Bergallo
Summary: The aim of this study was to assess the serum values of IL-4, IL-5, IL-10, and IL-13 in infants with non-IgE mediated food allergies treated with a hydrolyzed formula. The study found that the levels of IL-4 and IL-13 were significantly higher in the non-IgE food allergy group compared to the control group, while IL-5 and IL-10 levels were significantly lower.
Article
Immunology
Remo Poto, Isabella Quinti, Gianni Marone, Maurizio Taglialatela, Amato de Paulis, Vincenzo Casolaro, Gilda Varricchi
Summary: Release of proinflammatory mediators and cytokines from basophils and mast cells mediated by IgE is a key event in allergic disorders. The presence and functional activity of anti-IgE autoantibodies in atopic dermatitis (AD) are largely unknown. This study evaluated the ability of IgG anti-IgE from patients with AD to induce in vitro IgE-dependent activation of basophils and mast cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Songwen Ren, You Gao, Luanjin Wang, Ce Qiu, Lingtao Yang, Li Li, Yueyue Xiao, Nengming Xiao, Lixin Liao, Zhenghong Zuo, Chunyan Yang, Chengyong He
Summary: The study demonstrated that Sacran could alleviate symptoms in AD mice, reduce skin inflammation induced by DNCB, potentially through inhibiting Th2 cell activation and decreasing IgE release.
Article
Immunology
Daiki Matsubara, Yuhki Yanase, Kaori Ishii, Shunsuke Takahagi, Akio Tanaka, Koichiro Ozawa, Michihiro Hide
Summary: This article discusses the role of basophils in the pathogenesis of chronic spontaneous urticaria (CSU), as well as the critical role of the complement system in its activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Jeffrey M. Wilson, Behnam Keshavarz, Hayley R. James, Maya K. C. Retterer, Alexander J. Schuyler, Alice Knoedler, Lisa J. Workman, Lucy Ng'ang'a, Martha E. Chico, Eva Ronmark, Peter W. Heymann, Matthew S. Perzanowski, Thomas A. E. Platts-Mills, Philip J. Cooper
Summary: The study found that alpha-Gal sensitization is common in children from Ecuador and Kenya, associated with Ascaris exposure, and characterized by a low percentage of specific/total IgE compared to children with meat allergy in the United States.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Veterinary Sciences
Antonia Fettelschoss-Gabriel, Katharina Birkmann, Stanislav Pantelyushin, Thomas M. Kundig
Summary: This review focuses on the immunopathology and molecular mechanisms of equine Culicoides hypersensitivity, discussing the role of eosinophils and the impact of allergen exposure on T helper cells. The key aspects of CH diagnosis and treatment, including allergen-specific immunotherapy and targeting hypereosinophilia, are also addressed.
VETERINARY JOURNAL
(2021)
Article
Allergy
Dubravka Smiljkovic, Harald Herrmann, Irina Sadovnik, Susanne Gamperl, Daniela Berger, Gabriele Stefanzl, Gregor Eisenwort, Gregor Hoermann, Sonja Kopanja, Yulia Dorofeeva, Margarete Focke-Tejkl, Peter Jaksch, Konrad Hoetzenecker, Zsolt Szepfalusi, Rudolf Valenta, Michel Arock, Peter Valent
Summary: Siglec-6 is identified as a surface antigen specifically expressed on human MC and basophils. Its expression is dynamically regulated and varies depending on cell types and activation factors. Understanding the expression changes of Siglec-6 provides insights into the function of MC and basophils in allergic reactions.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Sisi Lin, Florian Kuehn, Tobias S. Schiergens, Andrey A. Zamyatnin Jr, Eldar Gasimov, Orkhan Isayev, Jens Werner, Yongyu Li, Alexandr V. Bazhin
Summary: The study found that postoperative ileus (POI) is not only associated with Th1 cells, but also involves an increase in Th2 cells and Th2 cytokines, as well as activation of mast cells. In addition, POI can induce activation of the NF-kappa B and p38 MAPK signaling pathways mediated by ROS.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Lei Fang, Ying Yan, Zhengxin Xu, Zhenpeng He, Shuting Zhou, Xin Jiang, Fan Wu, Xiaoling Yuan, Tong Zhang, Duonan Yu
Summary: Tectochrysin demonstrates efficacy in treating mouse asthma by reducing airway inflammation, inhibiting Th2 cytokine production, and enhancing antioxidant defenses.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Anette T. Hansen Selno, Vadim V. V. Sumbayev, Bernhard F. F. Gibbs
Summary: Basophils play a crucial role in allergies and Th2-driven diseases by releasing inflammatory and immunomodulatory mediators. The responsiveness of basophils to IgE-mediated activation may be regulated by the expression of SERCA2, a calcium-regulating protein. This study found an inverse correlation between SERCA2 expression and basophil responsiveness, suggesting that SERCA2 may be an additional regulator of basophil reactivity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Ankit Sharma, Matija Rijavec, Sunil Tomar, Amnah Yamani, Varsha Ganesan, James Krempski, Charles F. Schuler, Supinda Bunyavanich, Peter Korosec, Simon P. Hogan
Summary: This study aimed to identify dysregulated immunological processes associated with severe food allergic reactions by integrating bulk RNA-sequencing data from human and mouse samples. The results showed that genes related to innate and inflammatory immune responses, MAPK and NFkB signaling, as well as 429 genes correlated with reaction severity in mice. By comparing the mouse transcriptome with two independent human cohorts, 11 significantly dysregulated genes correlated with severity were identified. Additionally, during IgE-mediated reactions, rapid changes in blood leukocytes, particularly inflammatory monocytes and neutrophils, were observed along with changes in surface expression of CLEC4E, CD218A, and GPR27.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Review
Allergy
David I. Pritchard, Franco H. Falcone, Piers D. Mitchell
Summary: This article discusses the evolutionary origin and immunological role of the allergic phenotype, suggesting that allergies may have evolved for a purpose and emphasizing the positive impact of allergies on mammals.
Article
Allergy
Yoshinori Yamanishi, Kotone Mogi, Kazufusa Takahashi, Kensuke Miyake, Soichiro Yoshikawa, Hajime Karasuyama
Review
Immunology
Hajime Karasuyama, Kensuke Miyake, Soichiro Yoshikawa
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Allergy
Kensuke Miyake, Sho Shibata, Soichiro Yoshikawa, Hajime Karasuyama
Summary: Basophils are rare granulocytes that play crucial roles in allergic inflammation by releasing effector molecules to regulate immune responses and allergic disorders. They are recruited to inflamed tissues and activated in various ways, highlighting their versatile functions in the immune system.
Article
Immunology
Anais Wanet, Mahmoud A. Bassal, Sweta B. Patel, Francisco Marchi, Samanta A. Mariani, Nouraiz Ahmed, Haoran Zhang, Marta Borchiellini, Sisi Chen, Junyan Zhang, Annalisa Di Ruscio, Kensuke Miyake, Mindy Tsai, Anuya Paranjape, Shin-Young Park, Hajime Karasuyama, Timm Schroeder, Elaine Dzierzak, Stephen J. Galli, Daniel G. Tenen, Robert S. Welner
Summary: E-cadherin expression in the hematopoietic system was studied using single-cell RNA-sequencing analyses and immunophenotyping. High levels of E-cadherin were found in progenitors within the granulocyte-monocyte progenitors (GMPs) fraction, with an enriched capacity to differentiate into basophils and mast cells. The transcriptional priming of these progenitors to the basophil and mast cell lineages was observed, with GATA-2 directly regulating E-cadherin expression in these lineages.
SCIENCE IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Takashi Nagaishi, Taro Watabe, Kunihiko Kotake, Toshihiko Kumazawa, Tomomi Aida, Kohichi Tanaka, Ryuichi Ono, Fumitoshi Ishino, Takako Usami, Takamasa Miura, Satomi Hirakata, Hiroko Kawasaki, Naoya Tsugawa, Daiki Yamada, Kazuhiro Hirayama, Soichiro Yoshikawa, Hajime Karasuyama, Ryuichi Okamoto, Mamoru Watanabe, Richard S. Blumberg, Takahiro Adachi
Summary: The study revealed that IgA plays a crucial role in mucosal homeostasis by regulating intestinal microbiota and protecting against mucosal inflammation, especially in the ileum. Mice lacking IgA showed spontaneous inflammation in the ileum and imbalanced intestinal microflora, while mice with IgA tail mutations appeared normal, suggesting the dispensability of the IgA cytoplasmic tail for preventing intestinal disorders.
Review
Cell Biology
Kensuke Miyake, Hajime Karasuyama
Summary: Trogocytosis is an active process where one cell extracts cell fragments from another, transferring cell surface molecules and membrane fragments. It can modulate various biological responses, including immune responses, and is evolutionarily conserved from protozoan parasites to eukaryotic cells. This process can result in cell death or grant recipient cells new functions.
Article
Neurosciences
Michiel van der Vlist, Ramin Raoof, Hanneke L. D. M. Willemen, Judith Prado, Sabine Versteeg, Christian Martin Gil, Martijn Vos, Roeland E. Lokhorst, R. Jeroen Pasterkamp, Toshiyuki Kojima, Hajime Karasuyama, William Khoury-Hanold, Linde Meyaard, Niels Eijkelkamp
Summary: The resolution of inflammatory pain is actively controlled by macrophages through the transfer of mitochondria to sensory neurons. This process requires the expression of CD200R on macrophages and the non-canonical CD200R ligand iSec1 on sensory neurons.
Article
Medicine, Research & Experimental
Juan-Manuel Leyva-Castillo, Mrinmoy Das, Jennifer Kane, Maria Strakosha, Sonal Singh, Daniel Sen Hoi Wong, Alexander R. Horswill, Hajime Karasuyama, Frank Brombacher, Lloyd S. Miller, Raif S. Geha
Summary: Research has shown that mechanical injury to mouse skin through tape stripping predisposes the skin to superficial infection with S. aureus. This infection is promoted by basophil-derived IL-4, which inhibits the production of IL-17A and facilitates S. aureus infection. IL-4 acts on multiple checkpoints to suppress the cutaneous IL-17A response, but blocking the IL-4 receptor can enhance Il17a expression and bacterial clearance.
Review
Immunology
Kensuke Miyake, Junya Ito, Hajime Karasuyama
Summary: Basophils are a rare type of granulocyte that have been overlooked in immunological research. Recent studies have revealed their non-redundant functions in immune responses and their involvement in various diseases. Basophils can either ameliorate or exacerbate inflammation, depending on the disease model. Further research on basophil biology could lead to the identification of novel biomarkers or therapeutic targets for a wide range of diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kenichi Inaba, Masaaki Higashiyama, Chikako Watanabe, Akira Tomioka, Suguru Ito, Rina Tanemoto, Akinori Mizoguchi, Shin Nishii, Akinori Wada, Nao Sugihara, Yoshinori Hanawa, Kazuki Horiuchi, Yoshihiro Akita, Yoshikiyo Okada, Chie Kurihara, Kazuyuki Narimatsu, Shunsuke Komoto, Kengo Tomita, Hajime Karasuyama, Takahiro Satoh, Ryota Hokari
Summary: This study investigates the roles of basophils in human ulcerative colitis (UC) and oxazolone (OXA) colitis using genetically engineered mice. The results show that basophil infiltration is significantly increased in patients with UC and correlates with disease severity. Depletion of basophils improves inflammation in mouse models of colitis. These findings suggest that basophils play a proinflammatory role in chronic intestinal inflammation such as UC.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
John Tchen, Quentin Simon, Lea Chapart, Christophe Pellefigues, Hajime Karasuyama, Kensuke Miyake, Ulrich Blank, Marc Benhamou, Eric Daugas, Nicolas Charles
Summary: Tissue-specific mouse models are important tools for studying the role of different cell compartments and genes in diseases. A new knock-in mouse model is described here, allowing selective expression of fluorescent protein tdTomato and CRE recombinase in the basophil compartment. This model enabled the identification and study of basophils, and breeding with another mouse model resulted in basophil-deficient mice with no abnormalities in other cell compartments. The study showed that basophils play a nonredundant role in pristane-induced lupus-like disease, both in its induction and amplification.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Hajime Karasuyama, Sho Shibata, Soichiro Yoshikawa, Kensuke Miyake
Summary: Basophils, previously neglected in immunological studies, have been shown to play important roles in immune responses, allergies, autoimmunity, and protective immunity against parasitic infections through recent research using new tools. Recently developed tools have helped researchers define the roles of basophils, enhancing our understanding of their functions.
INTERNATIONAL IMMUNOLOGY
(2021)
Review
Immunology
Soichiro Yoshikawa, Kensuke Miyake, Atsunori Kamiya, Hajime Karasuyama
Summary: Ticks are blood-feeding ectoparasites that can transmit pathogens, causing infectious diseases, but acquired immunity in hosts can reduce their ability to feed on blood and transmit pathogens. Basophils play a key role in this process and are essential for acquired tick resistance.
PARASITE IMMUNOLOGY
(2021)
Article
Immunology
Yue Yang, Shigenori Nagai, Siwen Kang, Yulong Xia, Yohei Kawano, Kensuke Miyake, Hajime Karasuyama, Miyuki Azuma
INTERNATIONAL IMMUNOLOGY
(2020)
Article
Microbiology
Yoshiko Aihara, Yota Fukuda, Akiyoshi Takizawa, Naomi Osakabe, Tomomi Aida, Kohichi Tanaka, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi
BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH
(2020)