Review
Immunology
Ying Wang, Ningning Xue, Ziyuan Wang, Xin Zeng, Ning Ji, Qianming Chen
Summary: With improving quality of life, the pressure on oral health is increasing. Common oral mucosal diseases, such as oral lichen planus and gingivitis, are related to the destruction of the oral immune barrier. T-helper 17 (Th17) cells and their cytokines play vital roles in maintaining oral immune homeostasis. An excessive Th17/IL-17 response can lead to autoimmune damage, highlighting the importance of understanding the role of Th17 cells in oral mucosa and their potential as therapeutic targets for oral mucosal diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Tomohiro Fukaya, Tomofumi Uto, Shuya Mitoma, Hideaki Takagi, Yotaro Nishikawa, Moe Tominaga, Narantsog Choijookhuu, Yoshitaka Hishikawa, Katsuaki Sato
Summary: Dysbiosis in the gut impairs the induction of oral tolerance generated in MesLNs. Antibiotic-driven gut dysbiosis causes dysfunction of CD11c+CD103+ conventional dendritic cells (cDCs) in MesLNs, leading to the failure of establishing oral tolerance. This breakdown is caused by the impaired crosstalk between CD11c+CD103+ cDCs and ILC3s due to antibiotic-induced dysbiosis.
Article
Biochemistry & Molecular Biology
Lara Marie DeAngelis, Nicola Cirillo, Alexis Perez-Gonzalez, Michael McCullough
Summary: This study used multiplex immunohistochemistry (mIHC) to investigate the presence and abundance of mucosal-associated invariant T (MAIT) cells in oral lichen planus (OLP) tissue samples, as well as their relationship with Candida infection and symptoms. The results showed the presence of MAIT cell phenotypes in OLP tissue, with significant differences in the percentage of positive cells between different OLP groups. The relative abundance of triple-stained cells also varied significantly. Reduced percentage of certain cells was observed in symptomatic OLP with and without Candida, suggesting a potential role of these cells in OLP pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Kuan-Hua Chu, Szu-Yu Lin, Bor-Luen Chiang
Summary: STAT6 plays a critical role in the generation of Treg-of-B cells, while Peyer's patch B cells are essential in regulatory T cell generation. IL-4 acts downstream of phosphorylated STAT6, maintaining the survival of Treg-of-B cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Richard A. Strugnell
Summary: IgA deficiency is a common immunodeficiency disease that affects a significant number of individuals. Recent studies have shown that the removal of secretory IgA can have subtle inflammatory consequences, suggesting a potential role for the excretory immune system in immune regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yi Zhang, Lei Li, Genevieve Genest, Wei Zhao, Dan Ke, Sabrina Bartolucci, Nils Pavey, Tho-Alfakar Al-Aubodah, Duncan Lejtenyi, Bahar Torabi, Moshe Ben-Shoshan, Bruce Mazer, Ciriaco A. Piccirillo
Summary: In this study, the induction of specific T-REG cells during oral immunotherapy (OIT) in children with cow's milk protein (CMP) allergy was found to be effective in promoting tolerance and reducing Th2 responses. The expansion of these T-REG cells correlated with successful desensitization to CMP and may be a potential marker for predicting the time to reach maintenance phase in OIT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Miri Stolovich-Rain, Sujata Kumari, Ahuva Friedman, Saveliy Kirillov, Yakov Socol, Maria Billan, Ritesh Ranjan Pal, Kathakali Das, Peretz Golding, Esther Oiknine-Djian, Salim Sirhan, Michal Bejerano Sagie, Einav Cohen-Kfir, Naama Gold, Jamal Fahoum, Manoj Kumar, Maya Elgrably-Weiss, Bing Zhou, Miriam Ravins, Yair E. Gatt, Saurabh Bhattacharya, Orly Zelig, Reuven Wiener, Dana G. Wolf, Hila Elinav, Jacob Strahilevitz, Dan Padawer, Leah Baraz, Alexander Rouvinski
Summary: Intramuscularly administered mRNA vaccines generate a strong temporary mucosal immunity component, indicated by the presence of RBD-targeting IgA in the saliva of BNT162b2 vaccinees, which mediate neutralization. The mechanistic understanding of the high neutralizing activity provided by mucosal IgA will advance vaccination design and surveillance principles and may lead to novel treatment approaches and new routes of vaccine administration and boosting.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Dong-il Kwon, Eun Seo Park, Mingyu Kim, Yoon Ha Choi, Myeong-seok Lee, Si-hyung Joo, Yeon-Woo Kang, Minji Lee, Saet-byeol Jo, Seung-Woo Lee, Jong Kyoung Kim, You Jeong Lee
Summary: This study demonstrates that plasma cells in the thymus secrete IgE and other immunoglobulins, and their development is induced by IL-4 and related to mast cell survival. Thymic B cells go through transitional, mature, memory, and plasma cell stages. Thymic plasma cells produce polyclonal antibodies without somatic hypermutation and regulate mast cell homeostasis in the gut and skin, which is linked to the severity of anaphylaxis.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Natasa Kustrimovic, Daniela Gallo, Eliana Piantanida, Luigi Bartalena, Adriana Lai, Nicola Zerbinati, Maria Laura Tanda, Lorenzo Mortara
Summary: Maintaining the delicate balance between immune response and tolerance is crucial for health. T regulatory cells play a pivotal role in preserving self-tolerance and suppressing inflammation. In Graves' disease, these cells are likely impaired or reduced in frequency. Understanding the role of Tregs in Graves' disease is important for developing new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Khalid W. Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Phuong Nguyen, Yuan Li, Ting Wen, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Anil G. Jegga, Yi Zheng, Fukun Guo
Summary: Targeting Cdc42 in Treg cells has shown promising therapeutic potential in cancer immunotherapy, by enhancing antitumor T-cell immunity without triggering autoimmune reactions. This approach involves inducing Treg cell instability through Cdc42 targeting, leading to improved immune responses against tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Payal Grover, Peeyush N. Goel, Mark I. Greene
Summary: T regulatory cells employ various immunosuppressive mechanisms to limit immune responses, including secretion of cytokines, cell cytolysis, metabolic perturbation, guiding antigen-presenting cell function, etc.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Modupe O. Coker, Cristiana Cairo, Alfredo Garzino-Demo
Summary: HIV-infected individuals on ART are at a higher risk for oral pathologies due to changes in oral microbial communities, which may lead to increased susceptibility to inflammation. Further research is needed to understand how interventions targeting inflammation and microbial diversity can mitigate these comorbidities.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Yejin Cao, Yueru Hou, Longhao Zhao, Yijin Huang, Guangwei Liu
Summary: Tfr cells are a unique subset of Treg cells located in germinal centers, expressing transcription profiles of both Tfh and Treg cells and negatively regulating GC reactions. They have specific characteristics in different local immune microenvironments.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)