Article
Immunology
Rui Tang, Shubin Lei, Liping Zhu, Yuzhen Lv, Hong Li
Summary: This study aimed to evaluate the preventative efficacy of omalizumab for seasonal allergic rhinoconjunctivitis (SARC) and explore its influencing factors. The retrospective analysis of patients' medical records found that pre-seasonal omalizumab treatment could significantly alleviate SARC-related symptoms and reduce medication use. The dosage and number of injections of omalizumab did not affect the preventative efficacy, with a single dose of 150mg achieving satisfactory outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Behavioral Sciences
Jiehong Huang, Ruoyu Li, Lixi Li, Yunping Song, Lingjing Jin
Summary: This systematic review explores the association between tic disorders (TD) and allergic diseases (AD) through literature compilation and evidence analysis. It identifies a positive correlation between TD and asthma, allergic rhinitis, and allergic conjunctivitis. Provisional tic disorder (PTD) patients are more likely to suffer from these three AD. Shared genetic and etiological factors are suggested as responsible for this AD-TD association.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Camilla Stefani, Luca Pecoraro, Carl-Erik Flodmark, Marco Zaffanello, Giorgio Piacentini, Angelo Pietrobelli
Summary: Several epidemiological studies have found childhood obesity to be a risk factor for asthma, while the association with allergic rhinitis, atopic dermatitis, and chronic urticaria is more conflicting. This article suggests a relationship between childhood obesity and allergic diseases, as obesity can contribute to the development of asthma through mechanical and inflammatory effects. Excess adiposity also leads to systemic inflammation, increasing the risk of asthma exacerbations. Allergic rhinitis, atopic dermatitis, food allergies, and chronic urticaria are also associated with chronic low-grade systemic inflammation seen in obese children. Further research is needed to confirm the role of fat tissue in the development of allergic diseases and explore potential therapeutic strategies.
Article
Health Care Sciences & Services
Huijun Qiu, Rui Zheng, Xinyue Wang, Zhuanggui Chen, Peiying Feng, Xuekun Huang, Yuqi Zhou, Jin Tao, Min Dai, Lianxiong Yuan, Xiangdong Wang, Luo Zhang, Qintai Yang
Summary: Based on big data analysis, it was found that allergic rhinitis and allergic conjunctivitis in Beijing and Guangzhou have significant seasonal variations, and are positively correlated with hospital outpatient visits and pollen concentration. During the COVID-19 pandemic, although most people wore masks without eye protection, the outpatient visits for allergic conjunctivitis remained at a high level.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Allergy
David P. Strachan, Charlotte E. Rutter, Monica Innes Asher, Karen Bissell, Chen-Yuan Chiang, Asma El Sony, Eamon Ellwood, Philippa Ellwood, Luis Garcia-Marcos, Guy B. Marks, Eva Morales, Kevin Mortimer, Neil Pearce, Virginia Perez-Fernandez, Steven Robertson, Richard J. Silverwood
Summary: Globally, symptoms of non-infective rhinoconjunctivitis among schoolchildren may no longer be increasing, although trends vary substantially within and between countries.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Otorhinolaryngology
Jiayi Yang, Weidong Wang, Zhen Shen, Wei Kang, Pengfei Zhang, Xin Chen, Huajing Li, Yuan Shao, Lifeng Liu, Shaoqiang Zhang, Fang Quan
Summary: This study investigates the efficacy and safety of sublingual immunotherapy (SLIT) with A. annua allergens in patients with seasonal allergic rhinoconjunctivitis over two pollen seasons. The results show that the symptoms and medication scores of the SLIT group decreased in 2021 and remained lower than the baseline in 2022. Compared with the SLIT group, the control group showed significant improvement in efficacy indexes in 2022. Therefore, A. annua-SLIT can safely and effectively treat patients with moderate-severe seasonal allergic rhinoconjunctivitis over two pollen seasons.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Review
Medicine, General & Internal
Siti Muhamad Nur Husna, Hern-Tze Tina Tan, Norasnieda Md Shukri, Noor Suryani Mohd Ashari, Kah Keng Wong
Summary: Allergic rhinitis is a global health concern, affecting approximately 400 million people worldwide. The prevalence of AR has increased due to urbanization and environmental pollutants. Understanding the pathophysiology of AR is crucial for developing novel therapies.
FRONTIERS IN MEDICINE
(2022)
Review
Allergy
Amelia Licari, Paola Magri, Annalisa De Silvestri, Arianna Giannetti, Cristiana Indolfi, Francesca Mori, Gian Luigi Marseglia, Diego Peroni
Summary: This article systematically reviewed the epidemiology of allergic rhinitis in the pediatric population over the past 10 years, revealing a significant increasing trend in the overall prevalence of diagnosed allergic rhinitis. Further investigations are needed to explore the incidence, comorbidities, diagnosis, and treatment, in order to provide a comprehensive understanding of the disease and its burden and management.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Allergy
Klementina S. Avdeeva, Wytske J. Fokkens, Christine L. Segboer, Sietze Reitsma
Summary: This study is the first to describe the prevalences of non-allergic rhinitis (NAR) phenotypes in the general population. NAR and allergic rhinitis (AR) have distinct seasonal patterns, with NAR being more prevalent in autumn/winter and AR in spring/summer. The data on the prevalence of phenotypes can help clinicians anticipate patient types and guide tailored treatment approaches.
Article
Immunology
Yanlu Che, Nan Wang, Qianzi Ma, Junjie Liu, Zhaonan Xu, Qiuying Li, Jingting Wang, Yanan Sun
Summary: This study investigated the differences in nasal flora composition between patients with allergic rhinitis (AR) and non-allergic rhinitis (nAR) and their role in pathogenesis. The results showed that AR patients had a significantly higher abundance of Vibrio vulnificus and Acinetobacter baumanni in the nasal cavity compared to nAR patients, while the abundance of Lactobacillus murinus, Lactobacillus iners, Proteobacteria, Pseudomonadales, and Escherichia coli was lower. The study also identified specific bacterial models associated with AR and nAR, providing new insights for their treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pediatrics
Nannan Zhang, Yunwen Wu, Zequn Wei, Jinen Li, Jiao Shi, Rong Cai, Hailing Huang, Siyuan Ouyang, Qingfeng Zhang
Summary: This study investigated the major allergens that trigger allergic rhinitis (AR) in children in Guangdong, China. The most common inhalant allergens were dust mites, while milk was the most common ingestive allergen. The study also found that the severity of AR was higher in patients with dust mite allergies compared to milk allergies. This research provides important reference information for the prevention and treatment of AR in the future.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Hyo Geun Choi, Joo-Hee Kim, Yong-Hwi An, Min Woo Park, Jee Hye Wee
Summary: The COVID-19 pandemic has led to a significant decrease in medical visits for allergic diseases, particularly allergic rhinitis and asthma, while there has been little change in the number of visits for atopic dermatitis and allergic conjunctivitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Alan D. Workman, Lillian Dattilo, Vinay K. Rathi, Neil Bhattacharyya
Summary: Over the past decade, the number of patients receiving medical care for allergic rhinitis has significantly decreased, as well as the per-person healthcare expenditure associated with an AR diagnosis. The transition of nasal corticosteroids to over-the-counter may have been a key driver behind these changes.
Article
Environmental Sciences
Chuanteng Feng, Ying Shao, Tingting Ye, Changwei Cai, Chun Yin, Xiaobo Li, Hongyun Liu, Hua Ma, Bin Yu, Mingfang Qin, Yang Chen, Yongfang Yang, Wen Xu, Qiuyan Zhu, Peng Jia, Shujuan Yang
Summary: Long-term exposure to PM2.5 chemical constituents is associated with increased risks of allergic diseases, with NO3- and NH4+ being the most important contributors.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Medicine, General & Internal
Marcel Mazur, Maria Czarnobilska, Wojciech Dyga, Ewa Czarnobilska
Summary: The prevalence of asthma and allergies among children and adolescents has been increasing in the past few decades. A study analyzing data from 2014 to 2018 found that over 40% of respondents reported allergic symptoms, with nearly 50% of them not diagnosed or treated. However, there has been a reduction in the frequency of asthma and allergic rhinitis cases, indicating a positive effect on preventive measures taken in Krakow since 2010.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
Hajar Ali, Collin Brooks, Yu-Chieh Tzeng, Julian Crane, Richard Beasley, Peter Gibson, Philip Pattemore, Thorsten Stanley, Neil Pearce, Jeroen Douwes
Summary: This study found that autonomic nervous system activity is not associated with pathophysiology or inflammatory phenotype in young asthmatics with generally well-controlled asthma. However, enhanced sympathetic nervous system activity can be detected in asthmatics with airway hyperreactivity or who use beta-agonist medication.
Article
Public, Environmental & Occupational Health
William Mueller, Miranda Loh, Tony Fletcher, Sarah Rhodes, Lucy Pembrey, Neil Pearce, Martie van Tongeren
Summary: This study investigated the burden of COVID-19 in the UK food and drink processing industry. The results showed that infection rates were associated with deprivation, proportions of remote workers and workers in close proximity, and the number of workers.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Dermatology
Stephanie J. Lax, Amanda Roberts, Eleanor Cliffe, Grishma Ramesh, Dija Ayodele, Hywel C. Williams, Sharon Belmo, Paul Leighton
Summary: Our study found that the Fitzpatrick Scale fails to accurately reflect how individuals perceive their own skin tone. Respondents provided diverse descriptions of their skin tone, with some acknowledging the impact of social inequalities on their language choices. In order to create comprehensive and inclusive tools, it is crucial to incorporate the perspectives of patients.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Carolyn Charman, Hannah Wainman, Aswatha Rabindranathnambi, Chin Whybrew, Hywel C. Williams
Summary: The COVID-19 pandemic has accelerated the rapid expansion of digital Advice and Guidance (A&G) in medical and surgical specialties in the UK, particularly in dermatology. Limited guidance exists on what constitutes a high-quality A&G request and response. This educational article discusses good clinical practice based on extensive experience from primary and secondary care doctors.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Review
Dermatology
Sophie Leducq, Natalie Bonsu, Kate Clement, Richard Barlow, Hywel C. Williams
Summary: This educational review defines predatory journals and conferences, highlights their distinguishing features, and summarizes the consequences of publishing in or attending them. It also outlines tools available to recognize and avoid predation.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Editorial Material
Public, Environmental & Occupational Health
Neil Pearce, Jan P. Vandenbroucke
Editorial Material
Respiratory System
Richard Beasley, Pepa Bruce, Lee Hatter
Article
Immunology
Marjan Doppen, Cilein Kearns, Mark Weatherall, Nethmi Kearns, Peter McIntyre, Thomas Hills, Richard Beasley
Summary: This study aimed to determine the thresholds for Body Mass Index (BMI) and arm circumference above which a longer needle is needed for intramuscular (IM) delivery of a vaccine in the deltoid muscle at the recommended site in New Zealand. The analysis of two studies involving 442 adults showed that higher arm circumference and BMI values were associated with the need for a longer needle. Based on the findings, men with an arm circumference of 35 cm and women with an arm circumference of 30 cm should use a longer needle to ensure successful intramuscular injection.
Article
Medicine, General & Internal
Tae Yoon Lee, Mohsen Sadatsafavi, Chandra Prakash Yadav, David B. Price, Richard Beasley, Christer Janson, Mariko Siyue Koh, Rupsa Roy, Wenjia Chen
Summary: This study aims to develop and validate a novel risk prediction model for severe exacerbations in patients with severe asthma, and to examine the potential clinical utility of this tool.
Article
Public, Environmental & Occupational Health
Pilar Tavares Veras Florentino, Thiago Cerqueira-Silva, Luciana Freire De Carvalho, Flavia Jose Oliveira Alves, Vinicius De Araujo Oliveira, Gislani Mateus Oliveira Aguilar, Rodrigo De Sousa Prado, Daniel Soranz, Neil Pearce, Viviane Boaventura, Guilherme Loreiro Werneck, Gerson Oliveira Penna, Mauricio Lima Barreto, Marcio Henrique De Oliveira Garcia, Manoel Barral-Netto, Enny Santos da Paixao
Summary: This study provides evidence that COVID-19 vaccination during pregnancy, regardless of the vaccine type (CoronaVac or BNT162b2), is safe and does not increase the risk of adverse birth outcomes or neonatal deaths.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Nethmi Kearns, Neakiry Kivi, Emily Dickinson, Emma Mayo, Allie Eathorne, Augustus Anderson, Richard Beasley, Craig Thornley, Annette Nesdale
Summary: This study investigated the prevalence of ongoing symptoms and laboratory abnormalities in confirmed COVID-19 cases from the first wave in the Greater Wellington Region, New Zealand, at least 12 months post infection. The results showed a high prevalence of ongoing symptoms, with many participants reporting worse overall health compared to before contracting COVID-19. Additionally, 90% of participants reported having at least two ongoing symptoms. However, there were minimal laboratory abnormalities detected. It should be noted that this was an observational, cross-sectional study, so a causal relationship between symptoms and COVID-19 infection could not be firmly established.
NEW ZEALAND MEDICAL JOURNAL
(2023)
Correction
Respiratory System
Paola Rogliani, Rossella Laitano, Josuel Ora, Richard Beasley, Luigino Calzetta
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Pediatrics
Marilyn Urrutia-Pereira, Lucas Pitrez Mocelin, Philippa Ellwood, Luis Garcia-Marcos, Laura Simon, Pietro Rinelli, Herberto Jose Chong-Neto, Dirceu Sole
Summary: The study aimed to determine the prevalence of allergic rhinitis and factors associated with it in adolescents and their parents/guardians. A cross-sectional study was conducted involving 1,058 adolescents and 896 parents/guardians in Uruguaiana, Brazil. The results showed that the prevalence of allergic rhinitis was 28.0% in adolescents and 31.7% in adults. Factors such as low physical exercise, having only one older sibling, and daily meat consumption were associated with allergic rhinitis in adolescents, while exposure to fungi at home and weekly meat consumption were associated with allergic rhinitis in adults.
REVISTA PAULISTA DE PEDIATRIA
(2023)
Article
Medicine, General & Internal
Marjan Doppen, Melissa Black, Irene Braithwaite, Jonathan Bong, Allie Eathorne, Louis Kirton, Stacey Kung, Michaela Walton, Thomas Hills, Mark Weatherall, Richard Beasley, Cilein Kearns
Summary: Worldwide, immunisation guidelines have different recommendations for the deltoid injection site, which may impact the needle length required for intramuscular injection. This study aimed to estimate the differences in skin-to-deltoid-muscle distance between different vaccine injection sites recommended by the national guidelines of the USA, Australia, and New Zealand, in obese adults. The study found significant variations in skin-to-deltoid-muscle distance between the recommended injection sites, and emphasized the importance of considering factors such as sex, BMI, and arm circumference when choosing the appropriate needle length for intramuscular vaccination in obese individuals.
NEW ZEALAND MEDICAL JOURNAL
(2023)
Review
Allergy
Yuhan Xing, Agnes Sze-Yin Leung, Gary Wing-Kin Wong
Summary: Wheezing is common among preschool children, and environmental factors play a key role in the development from preschool wheezing to childhood asthma. Risk factors include severe respiratory infections, allergic sensitization, and exposure to tobacco smoke. On the contrary, a farming/rural environment is associated with asthma protection.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)