Review
Pharmacology & Pharmacy
Hae Jin Kee, Inkyeom Kim, Myung Ho Jeong
Summary: This article provides an overview of the pathogenesis of hypertension, current anti-hypertensive drugs, and the need for novel drugs. It focuses on the role and regulatory mechanisms of HDACs in hypertension and discusses the progress in developing HDAC inhibitors as potential therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yaoyao Du, Jie Chen, Lan Shen, Bing Wang
Summary: This article reviews the potential roles of transient receptor potential (TRP) channels in inflammatory bowel disease (IBD). TRP channels are widely distributed in the gastrointestinal tract and visceral sensory nervous systems and play various roles in physiological and pathological processes. Studies have shown that TRP channels could be novel drug targets for treating IBD.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jianglei Li, Meihong Yu, Shifeng Fu, Deliang Liu, Yuyong Tan
Summary: This review summarizes the research progress and underlying mechanism of ACY-1215 in cancer and other human diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Saikat Dewanjee, Jayalakshmi Vallamkondu, Rajkumar Singh Kalra, Pratik Chakraborty, Moumita Gangopadhyay, Ranabir Sahu, Vijaykrishna Medala, Albin John, P. Hemachandra Reddy, Vincenzo De Feo, Ramesh Kandimalla
Summary: Diabetes mellitus is a major manifestation of metabolic syndrome with increasing prevalence. Chronic hyperglycemia can lead to various vascular complications, being the major cause of morbidity and mortality in diabetic patients. Histone deacetylase (HDAC) plays a crucial role in regulating molecular activities in diabetes and could serve as a potential therapeutic target for developing novel intervention strategies.
Review
Biochemistry & Molecular Biology
Khuloud Bajbouj, Abeer Al-Ali, Rakhee K. Ramakrishnan, Maha Saber-Ayad, Qutayba Hamid
Summary: Lung cancer, especially non-small cell lung cancer, is a major cause of cancer mortality in both genders. Identifying new therapeutic targets, enhancing the efficacy of immunotherapy, and studying the epigenetics of lung cancer are crucial for improving treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Marzena Mazur, Anna Zielinska, Marcin M. Grzybowski, Jacek Olczak, Jakub Fichna
Summary: Chitinases belong to the GH18 family and can degrade chitin. Although mammals do not synthesize chitin, they still have chitinases and chitinase-like proteins. Chitinases play a role in human fibrotic and inflammatory disorders, serving as prognostic biomarkers of disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Kairui Yue, Simin Sun, Geng Jia, Mengting Qin, Xiaohan Hou, C. James Chou, Chao Huang, Xiaoyang Li
Summary: This study reports the development of a highly selective HDAC6 inhibitor with hydrazide as the zinc-binding group (ZBG), which exhibits superior pharmacokinetic properties compared to current hydroxamic acid inhibitors. Structure-activity relationship analysis reveals that the presence of an ethyl group substituent in the hydrazide-based ZBG and a cap group with increased rigidity and volume enhance the HDAC6 selectivity of the designed compounds. The representative inhibitor 35m demonstrates potent HDAC6 inhibitory activity and improved pharmacokinetic properties compared to hydroxamic acid-based HDAC6 inhibitors Tubastatin A and ACY1215. Furthermore, low-dose 35m effectively decreases LPS-induced IL-1 beta release by blocking the activation of NLRP3, indicating its potential as an orally active therapeutic agent for NLRP3-related diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Oncology
Amandine Badie, Christian Gaiddon, Georg Mellitzer
Summary: Our understanding of the identity of many cancers has greatly increased in recent years, leading to progress in early detection and treatment options. However, gastric cancer remains poorly treated with low survival rates. The lack of possibilities for early detection and the variations between tumors of gastric cancer patients are major challenges. Histone Deacetylases (HDACs) have been identified to be potentially related to gastric cancer. In this review, we summarize the current knowledge on the role of HDACs in gastric cancer development and their potential as early detection markers and targets for new treatment options.
Review
Biochemistry & Molecular Biology
Anna Fontana, Ilaria Cursaro, Gabriele Carullo, Sandra Gemma, Stefania Butini, Giuseppe Campiani
Summary: HDAC8, an important enzyme, plays a role in various diseases and selective HDAC8 inhibitors are being developed. Polypharmacological approaches have also been explored.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Patricia Teixeira Santana, Siane Lopes Bittencourt Rosas, Beatriz Elias Ribeiro, Ygor Marinho, Heitor S. P. de Souza
Summary: Microbe-host communication is crucial for maintaining vital functions of a healthy host. Disruption of this communication is associated with various diseases, including Crohn's disease and ulcerative colitis. Identifying microorganisms that affect disease susceptibility and phenotypes in humans is still challenging. Recent insights into the role of diet and environmental factors on the gut microbiome have direct implications for the immune response and the development of IBD. The complexity of IBD pathogenesis suggests the need for an integrative approach to identify specific therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Afrin Bahauddin, Maxim Ivannikov, Zhongying Wang, Mohammad Jamaluddin, Kyra Curtis, Naazneen Ibtehaj, Linsey Yeager, Lynn Soong, Xiang Fang, Ruksana Huda
Summary: This study investigated the role of histone deacetylases (HDACs) in myasthenia gravis (MG) and found that HDAC inhibition can reduce the production of the inflammatory cytokine IL-6 and lower autoantibody levels in MG, leading to milder disease and preservation of muscle function. The study suggests that HDACs or their gene targets could be potential adjunct treatments for MG.
FRONTIERS IN NEUROLOGY
(2022)
Review
Oncology
Bayley G. Matthews, Nikola A. Bowden, Michelle W. Wong-Brown
Summary: High-grade serous ovarian cancer (HGSOC) is the most common subtype of ovarian cancer, with a stagnant overall survival rate over the past three decades. Chemoresistance remains a major challenge in treating HGSOC, and may be driven by epigenetic modifications. Identifying epigenetic changes in chemoresistant HGSOC allows for the development of targeted therapies to improve outcomes.
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Article
Medicine, General & Internal
Jie Chen, Fengzhe Xu, Xixian Ruan, Jing Sun, Yao Zhang, Han Zhang, Jianhui Zhao, Jie Zheng, Susanna C. Larsson, Xiaoyan Wang, Xue Li, Shuai Yuan
Summary: A proteome-wide investigation using Mendelian randomization and colocalization analysis identified several proteins associated with the risk of inflammatory bowel disease. MST1, HGFAC, STAT3, ITPKA, and CXCL5 may serve as potential therapeutic targets for the disease.
Review
Pharmacology & Pharmacy
Sonali Kumar, Diksha Attrish, Arpna Srivastava, Jyotirmoy Banerjee, Manjari Tripathi, P. Sarat Chandra, Aparna Banerjee Dixit
Summary: The review explores the role of HDACs in epilepsy, focusing on their action on non-histone substrates and the potential of HDACi as anti-epileptic drugs. It also discusses the importance of identifying novel targets of HDACs for more effective anti-epileptogenic therapy.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2021)
Article
Gastroenterology & Hepatology
Antonio Tursi, Giammarco Mocci, Leonardo Allegretta, Giovanni Aragona, Maria Antonia Bianco, Raffaele Colucci, Antonio Cuomo, Nicola Della Valle, Antonio Ferronato, Giacomo Forti, Federica Gaiani, GianMarco Giorgetti, Maria Giovanna Graziani, Katia Lofano, Roberto Lorenzetti, Tiziana Larussa, Antonio Penna, Roberta Pica, Giuseppe Pranzo, Stefano Rodino', Antonella Scarcelli, Costantino Zampaletta, Gabrio Bassotti, Alessia Immacolata Cazzato, Stefania Chiri, Valeria Clemente, Andrea Cocco, Gianluigi de' Angelis, Laura Donnarumma, Roberto Faggiani, Camilla Graziosi, Marco Le Grazie, Francesco Luzza, Costantino Meucci, Rita Monterubbianesi, Cristiano Pagnini, Patrizia Perazzo, Marcello Picchio, Rodolfo Sacco, Ladislava Sebkova, Mariaelena Serio, Daniele Napolitano, Daniela Pugliese, Franco Scaldaferri, Elisa Schiavoni, Laura Turchini, Alessandro Armuzzi, Walter Elisei, Giovanni Maconi, Alfredo Papa
Summary: There is no significant difference in the efficacy and safety of different ADA biosimilars in the treatment of inflammatory bowel disease.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Edward V. Loftus, Daniel C. Baumgart, Krisztina Gecse, Jami A. Kinnucan, Susan B. Connelly, Leonardo Salese, Chinyu Su, Kenneth K. Kwok, John C. Woolcott, Alessandro Armuzzi
Summary: CDIs in patients with UC receiving tofacitinib were infrequent, with mild-moderate severity, and most cases resolved with treatment.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Cristina Bezzio, Gionata Fiorino, Davide G. Ribaldone, Alessandro Armuzzi, Simone Saibeni
Summary: This study investigated the impact of severe acute respiratory syndrome coronavirus 2 infection on inflammatory bowel disease course and found that therapy discontinuation is a risk factor for disease flare.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Gastroenterology & Hepatology
Konstantinos H. Katsanos, Fotios S. Fousekis, Alessandro Armuzzi
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Roberta Vitali, Francesca Palone, Alessandro Armuzzi, Valerio Fulci, Anna Negroni, Claudia Carissimi, Salvatore Cucchiara, Laura Stronati
Summary: This study identified three novel faecal biomarkers of gut inflammation using proteomic analysis in patients with inflammatory bowel disease. These biomarkers have good specificity and sensitivity for identifying the disease and significantly correlate with disease severity.
JOURNAL OF CROHNS & COLITIS
(2023)
Correction
Gastroenterology & Hepatology
A. Caputo, P. Parente, M. Cadei, M. Fassan, A. Rispo, G. Leoncini, G. Bassotti, R. Del Sordo, C. Metelli, M. Daperno, A. Armuzzi, V. Villanacci
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Olga Maria Nardone, Alessandro Armuzzi
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Gastroenterology & Hepatology
Giuseppe Privitera, Nitish Rana, Alessandro Armuzzi, Theresa T. Pizarro
Summary: This review provides a comprehensive summary of gasdermins (GSDMs) biology, with a focus on the gastrointestinal tract, addressing their clinical implications and future research.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Giulia Rizzo, Samuel Elias Pineda Chavez, Elisa Vandenkoornhuyse, Cindy Lorena Cardenas Rincon, Valeria Cento, Valentina Garlatti, Marek Wozny, Giusy Sammarco, Alessia Di Claudio, Lisa Meanti, Sudharshan Elangovan, Andrea Romano, Giulia Roda, Laura Loy, Arianna Dal Buono, Roberto Gabbiadini, Sara Lovisa, Roberto Rusconi, Alessandro Repici, Alessandro Armuzzi, Stefania Vetrano
Summary: This study found that pomegranate extract has beneficial effects in promoting the recovery phase of colitis and the complete restoration of the intestinal barrier. It also affects pathogen biofilm formation and promotes mucosal regeneration through the regulation of the crosstalk between epithelial and stromal cells.
Review
Medicine, General & Internal
Virginia Solitano, Arianna Dal Buono, Roberto Gabbiadini, Marek Wozny, Alessandro Repici, Antonino Spinelli, Stefania Vetrano, Alessandro Armuzzi
Summary: Fibro-stenosing Crohn's disease (CD) is a common disease presentation that leads to impaired quality of life and often requires endoscopic treatments or surgery. Currently, there are no existing imaging techniques that can accurately quantify the amount of fibrosis within a stricture, and managing patients is challenging, requiring a multidisciplinary team.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ahmad Albshesh, Lian Bannon, Tali Sharar Fischler, Marie Truyens, Stephan R. R. Vavricka, Katja Tepes, Daniela Pugliese, Edoardo V. V. Savarino, Eran Zittan, David Drobne, Xavier Roblin, Ariella Bar-Gil Shitrit, Alessandro Armuzzi, Triana Lobaton, Nitsan Maharshak, Henit Yanai, Shomron Ben-Horin, Uri Kopylov
Summary: The effectiveness of anti-TNF or ustekinumab as a second-line biologic after vedolizumab failure in patients with Crohn's disease was investigated. The results showed that there was no significant difference in the clinical response, remission rate, and discontinuation rate between the use of anti-TNF and ustekinumab as a second-line therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Gastroenterology & Hepatology
Arianna Dal Buono, Alessandro Armuzzi
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Tamas Resal, Peter Bacsur, Csilla Keresztes, Anita Balint, Renata Bor, Anna Fabian, Bernadett Farkas, Kostas Katsanos, George Michalopoylos, Davide Giuseppe Ribaldone, Mohamed Attauabi, Mirabella Zhao, Hadar Amir Barak, Henit Yanai, Cristina Bezzio, Antonio Rispo, Fabiana Castiglione, Ariella Bar-Gil Shitrit, Daniela Pugliese, Alessandro Armuzzi, Edoardo Vincenzo Savarino, Martin Kolar, Milan Lukas, Elena Chashkova, Rafal Filip, Aurore Rozieres, Stephane Nancey, Zeljko Krznaric, Eszter Schafer, Patricia Szamosi, Patricia Sarlos, Matej Franko, David Drobne, Oleg Knyazev, Anna Kagramanova, Jimmy Limdi, Panu Wetwittayakhlang, Peter L. Lakatos, Nitsan Maharshak, Lian Bannon, Tibor Nyari, Zoltan Szepes, Klaudia Farkas, TFB Study Grp, Tamas Molnar
Summary: Background and Aims: This retrospective, international cohort study aimed to evaluate the efficacy and safety of tofacitinib (TFB) in the treatment of moderate-to-severe colitis and acute severe ulcerative colitis (ASUC). The study found that TFB was effective in both indications and resulted in high rates of steroid-free remission in the short and long terms.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Medicine, General & Internal
Carolina Aliai Micol Cavalli, Roberto Gabbiadini, Arianna Dal Buono, Alessandro Quadarella, Alessandro De Marco, Alessandro Repici, Cristina Bezzio, Edoardo Simonetta, Stefano Aliberti, Alessandro Armuzzi
Summary: Inflammatory bowel diseases (IBDs) are associated with respiratory diseases, even in the absence of symptoms. The same embryological origin and exposure to common antigens and cytokine networks may play a role in respiratory involvement. Early identification and treatment of respiratory manifestations are crucial to prevent lung damage.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Bianca Bartocci, Arianna Dal Buono, Roberto Gabbiadini, Anita Busacca, Alessandro Quadarella, Alessandro Repici, Emanuela Mencaglia, Linda Gasparini, Alessandro Armuzzi
Summary: Inflammatory bowel diseases (IBD) have been shown to be associated with a high prevalence of psychiatric comorbidities, particularly anxiety and depression. Studies have suggested that the prevalence of mental disorders is higher in IBD patients with active intestinal disease. However, these comorbidities are often under-diagnosed and require more attention in the management of IBD patients.
MEDICINA-LITHUANIA
(2023)