Article
Oncology
Zheng Wang, Huimin Zhang, Hong Yang, Mengmeng Zhang, Jiaming Qian
Summary: Elderly-onset IBD patients have a significantly increased risk of malignancy, especially colorectal cancer and some extraintestinal malignancies. Their risk of cancer is higher compared to adult-onset IBD patients, and cancer progression is usually faster.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Gian Paolo Caviglia, Giorgio Martini, Angelo Armandi, Chiara Rosso, Marta Vernero, Elisabetta Bugianesi, Marco Astegiano, Giorgio Maria Saracco, Davide Giuseppe Ribaldone
Summary: The study found that patients with IBD have a similar risk of developing urothelial cancer compared to the general population, but males with a history of smoking are at increased risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Noreen Singh, Charles N. Bernstein
Summary: This article reviews the impact of environmental risk factors, such as early life exposures, lifestyle and hygiene, vaccinations, surgeries, exposure to drugs and gastrointestinal pathogens, on the risk of developing IBD.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Nabeel Khan, Dhruvan Patel, Dawei Xie, Tyler Pernes, James Lewis, Yu-Xiao Yang
Summary: A nationwide retrospective cohort study in the US Veterans' Affairs healthcare system found that patients with inflammatory bowel disease (IBD) did not have a significantly increased risk of developing SARS-CoV-2 infection compared to patients without IBD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Joana Torres, Catarina Gomes, Camilla Jensen, Manasi Agrawal, Francisco Morao, Tine Jess, Jean-Frederic Colombel, Kristine H. Allin, Johan Burisch
Summary: In this study, risk factors for unaffected first-degree relatives (FDRs) of inflammatory bowel disease (IBD) patients to develop the disease were identified. These findings provide an opportunity for counseling IBD relatives.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Rachel Cooney, Daniel Tang, Kevin Barrett, Richard K. Russell
Summary: This study assessed mental health burden in children and young adults with inflammatory bowel disease using a primary care database in the UK. The results showed that these patients were more likely to develop new mental health conditions, especially posttraumatic stress disorder, eating disorders, self-harm, sleep disturbance, depression, and anxiety. Male patients aged 12-17 and patients with Crohn's disease had the highest risk of developing new mental health conditions.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Manasi Agrawal, Kristine H. Allin, Francesca Petralia, Jean-Frederic Colombel, Tine Jess
Summary: This article discusses the current knowledge and applications of omics platforms in the diagnosis of inflammatory bowel disease and identification of risk factors, emphasizing the granular high-throughput data provided by multiomics platforms for characterizing molecular pathways and risk factors in chronic diseases like IBD. It also highlights the knowledge gaps in IBD risk factors and pathways, and stresses the importance of birth, at-risk, and pre-diagnostic cohorts, as well as neonatal blood spots in omics analyses. Moreover, the article touches upon the use of network analysis as a powerful bioinformatics tool to extract clinical relevance from high-throughput data.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Oncology
Joana Lemos Garcia, Isadora Rosa, Joao Pereira da Silva, Joana Moleiro, Isabel Claro
Summary: Inflammatory bowel disease (IBD) patients have a higher incidence of malignant neoplasia, especially in the skin and digestive system. Tobacco exposure is a risk factor for the development of neoplasia, as seen in the general population.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Psychiatry
Simeng Ma, Wei Wang, Qian Gong, Dan Xiang, Lihua Yao, Shuxian Xu, Xinhui Xie, Huiling Wang, Gaohua Wang, Jun Yang, Zhongchun Liu
Summary: Depression is more common in patients with chronic inflammatory diseases, including inflammatory bowel disease (IBD). This study found that IBD patients had a significantly higher risk of depression compared to individuals without IBD. The findings suggest the importance of screening for depression in middle-aged adults with IBD.
GENERAL HOSPITAL PSYCHIATRY
(2023)
Article
Gastroenterology & Hepatology
Sonia Friedman, Olav Sivertsen Garvik, Jan Nielsen, Bente Mertz Norgard
Summary: The use of anti-inflammatory/immunosuppressive medications by fathers before conception is not significantly associated with childhood infections, according to this study. These results address an important research gap regarding paternal medication safety.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Annie Guo, Malin Ostensson, Ketil Stordal, Johnny Ludvigsson, Karl Marild
Summary: This study investigated the influence of early-life hygiene-related factors on the risk of inflammatory bowel disease (IBD) in a Scandinavian population and found that daycare attendance reduced the risk of Crohn's disease while having siblings slightly increased the risk of IBD. Other hygiene factors were not significantly associated with IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Emily W. Lopes, Paul Lochhead, Kristin E. Burke, James M. Richter, Ashwin N. Ananthakrishnan, Andrew T. Chan, Hamed Khalili
Summary: In this prospective study, it was found that dietary and lifestyle risk factors for inflammatory bowel disease may differ according to disease phenotype.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Medicine, General & Internal
M. P. Eugenicos, N. B. Ferreira
Summary: This review examined recent evidence on the impact of depression and anxiety on disease activity, relapse, and healthcare utilization in inflammatory bowel disease (IBD), highlighting the importance of assessing depression and anxiety in routine management of IBD patients. Developing more longitudinal research and randomized controlled trials will provide further insights into the role of mental health in IBD outcomes.
BRITISH MEDICAL BULLETIN
(2021)
Article
Gastroenterology & Hepatology
Devin Abrahami, Richeek Pradhan, Hui Yin, Russell Yanofsky, Emily Gibson McDonald, Alain Bitton, Laurent Azoulay
Summary: This study aimed to determine whether the use of proton pump inhibitors (PPIs) is associated with an increased risk of inflammatory bowel disease (IBD) compared to histamine-2 receptor antagonists (H2RAs). It was a population-based cohort study that considered the impact of protopathic bias and conducted sensitivity analyses to ensure the accuracy of the results. The conclusion was that there is no association between the use of PPIs and an increased risk of IBD when accounting for protopathic bias, in contrast to H2RAs.
Article
Clinical Neurology
Alexander Maier, Cornelius Durrant-Finn, Alexander Pabst, Margrit Loebner, Marion Eisele, Christian Brettschneider, Kathrin Heser, Luca Kleineidam, Siegfried Weyerer, Jochen Werle, Michael Pentzek, Angela Fuchs, Dagmar Weeg, Edelgard Moesch, Birgitt Wiese, Anke Oey, Hendrik van den Bussche, Hans-Helmut Koenig, Michael Wagner, Wolfgang Maier, Steffi G. Riedel-Heller, Martin Scherer, Melanie Luppa
Summary: This study investigates the incidence rates and risk factors of depressive symptoms in the elderly, finding that female sex, unmarried family status, subjective cognitive decline, as well as vision and mobility impairment are significant risk factors for incident depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Gastroenterology & Hepatology
Shiran Gerassy-Vainberg, Alexandra Blatt, Yael Danin-Poleg, Katya Gershovich, Edmond Sabo, Alex Nevelsky, Shahar Daniel, Aviva Dahan, Oren Ziv, Rishu Dheer, Maria T. Abreu, Omry Koren, Yechezkel Kashi, Yehuda Chowers
Article
Gastroenterology & Hepatology
Oriana M. Damas, Derek Estes, Danny Avalos, Maria A. Quintero, Diana Morillo, Francia Caraballo, Johanna Lopez, Amar R. Deshpande, David Kerman, Jacob L. McCauley, Ana Palacio, Maria T. Abreu, Seth J. Schwartz
DIGESTIVE DISEASES AND SCIENCES
(2018)
Article
Gastroenterology & Hepatology
Andres J. Yarur, Anjali Jain, Maria A. Quintero, Frank Czul, Amar R. Deshpande, David H. Kerman, Maria T. Abreu
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2019)
Article
Immunology
Jason Miska, Jen Bon Lui, Kevin H. Toomer, Priyadharshini Devarajan, Xiaodong Cai, JeanMarie Houghton, Diana M. Lopez, Maria T. Abreu, Gaofeng Wang, Zhibin Chen
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Multidisciplinary Sciences
Juan F. Burgueno, Jessica K. Lang, Ana M. Santander, Irina Fernandez, Ester Fernandez, Julia Zaias, Maria T. Abreu
Article
Multidisciplinary Sciences
Li Zhang, Jingjing Meng, Yuguang Ban, Richa Jalodia, Irina Chupikova, Irina Fernandez, Nivis Brito, Umakant Sharma, Maria T. Abreu, Sundaram Ramakrishnan, Sabita Roy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Medicine, General & Internal
B. E. Sands, W. J. Sandborn, R. Panaccione, C. D. O'Brien, H. Zhang, J. Johanns, O. J. Adedokun, K. Li, L. Peyrin-Biroulet, G. Van Assche, S. Danese, S. Targan, M. T. Abreu, T. Hisamatsu, P. Szapary, C. Marano
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Editorial Material
Gastroenterology & Hepatology
Maria T. Abreu
DIGESTIVE DISEASES AND SCIENCES
(2019)
Editorial Material
Gastroenterology & Hepatology
Maria T. Abreu
DIGESTIVE DISEASES AND SCIENCES
(2019)
Editorial Material
Gastroenterology & Hepatology
Julia Fritsch, Maria T. Abreu
Review
Gastroenterology & Hepatology
Juan F. Burgueno, Maria T. Abreu
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2020)
Editorial Material
Gastroenterology & Hepatology
Maria T. Abreu, William J. Sandborn
Editorial Material
Gastroenterology & Hepatology
Marla C. Dubinsky, Rory Collins, Maria T. Abreu
Article
Gastroenterology & Hepatology
Maria T. Abreu, Julie M. Davies, Maria A. Quintero, Amber Delmas, Sophia Diaz, Catherine D. Martinez, Thomas Venables, Adrian Reich, Gogce Crynen, Amar R. Deshpande, David H. Kerman, Oriana M. Damas, Irina Fernandez, Ana M. Santander, Judith Pignac-Kobinger, Juan F. Burgueno, Mark S. Sundrud
Summary: Vedolizumab (VDZ) is effective in the treatment of inflammatory bowel disease (IBD) by inhibiting lymphocyte extravasation into intestinal mucosae. Changes in T regulatory cells in the periphery and mucosa have the greatest relationship to VDZ response.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Mona Rezapour, Maria Alejandra Quintero, Nidah S. Khakoo, Daniel A. Sussman, Jodie A. Barkin, Jennifer Clarke, Tanya Varma, Amar R. Deshpande, David H. Kerman, Oriana Damas, Maria T. Abreu
CROHNS & COLITIS 360
(2019)