Review
Nutrition & Dietetics
Claudia Infantino, Roberta Francavilla, Adriana Vella, Sabrina Cenni, Nicola Principi, Caterina Strisciuglio, Susanna Esposito
Summary: Vitamin D plays a crucial role in calcium homeostasis and bone health, and it may also modulate the immune system to affect the development of autoimmune diseases such as celiac disease and inflammatory bowel diseases. Research suggests that vitamin D could be involved in the pathogenesis and treatment of these conditions.
Review
Nutrition & Dietetics
Dominika Glabska, Aleksandra Kolota, Katarzyna Lachowicz, Dominika Skolmowska, Malgorzata Stachon, Dominika Guzek
Summary: Inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS) are associated with decreased quality of life and mental health problems. Vitamin D supplementation is considered to be effective in improving mental health in affected individuals. Studies have shown a positive effect of vitamin D supplementation on the mental health of IBD and IBS patients, but further research is needed for confirmation.
Review
Pharmacology & Pharmacy
Cristiano Pagnini, Maria Carla Di Paolo, Maria Giovanna Graziani, Gianfranco Delle Fave
Summary: Inflammatory bowel diseases (IBD) are chronic conditions with unknown etiology and immunomediated pathogenesis. Research on the intestinal microbiome and the vitamin D/VDR pathway have shown promising potential for novel approaches to diagnosis and treatment of IBD. Probiotic bacteria have shown more exciting results in experimental models than in clinical practice, and understanding their properties and mechanisms of action may lead to new therapeutic applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Filippo Vernia, Giorgia Burrelli Scotti, Noemi Sara Bertetti, Giuseppe Donato, Stefano Necozione, Piero Vernia, Nadia Pallotta
Summary: The inadequate intake of Vitamin D and Vitamin K in the diet is a reversible factor for IBD-associated bone loss, but there is a lack of data on Vitamin K. A study found that both IBD patients and control patients had inadequate intake of Vitamin D, while the intake of Vitamin K was inadequate in IBD patients and high in controls. The study suggests that proactive nutritional intervention is needed to address Vitamin K shortages in IBD patients.
Review
Medicine, General & Internal
Aleksandra Szymczak-Tomczak, Alicja Ewa Ratajczak, Marta Kaczmarek-Rys, Szymon Hryhorowicz, Anna Maria Rychter, Agnieszka Zawada, Ryszard Slomski, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Vitamin D plays various roles in patients with inflammatory bowel disease (IBD), including regulating bone mineral metabolism, modulating the immune system, and contributing to the pathogenesis of IBD. Vitamin D affects Th1 and Th2 lymphocytes, cytokine release, and the wnt/beta-catenin pathway. IBD is associated with dysbiosis of microbiota, abnormal inflammatory response, and vitamin D deficiency. Therefore, understanding the metabolic pathways, genetic determinants, and environmental factors of vitamin D is crucial for studying vitamin D supplementation in IBD patients, not only for osteoporosis prevention and therapy, but also for modulating the course and pharmacotherapy of IBD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Martyna Jasielska, Urszula Grzybowska-Chlebowczyk
Summary: The study found that the incidence of hypocalcemia and vitamin D deficiency is higher in children with inflammatory bowel diseases and lactose intolerance. However, the use of a low-lactose diet did not have a significant impact on these conditions.
Article
Nutrition & Dietetics
Karolina Sledzinska, Piotr Landowski, Michal A. Zmijewski, Barbara Kaminska, Konrad Kowalski, Anna Liberek
Summary: The study showed that IBD children have higher levels of vitamin D compared to controls, but a significant portion still lack optimal vitamin D levels. Despite the higher level of vitamin D, IBD children had lower calcium levels compared to healthy controls, with no correlation to disease activity or location of lesions in the gastrointestinal tract.
Review
Pediatrics
Mohammad Hassan Sohouli, Fatemeh Farahmand, Hosein Alimadadi, Parisa Rahmani, Farzaneh Motamed, Elma Izze da Silva Magalhaes, Pejman Rohani
Summary: This study demonstrated that vitamin D therapy has a significant and beneficial effect on 25(OH) D3, calcium, and inflammatory factors in children and adolescents with IBD.
WORLD JOURNAL OF PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Carolina Battistini, Rafael Ballan, Marcos Edgar Herkenhoff, Susana Marta Isay Saad, Jun Sun
Summary: Inflammatory bowel disease is a chronic inflammation of the GI tract, including Crohn's disease and ulcerative colitis, associated with microbiota dysbiosis and vitamin D deficiency. Further studies are needed to explore the mechanisms and therapeutic potential related to vitamin D/VDR in gut microbiota modulation for IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pediatrics
Yan-hong Sun, Dan-dan Tian, Jian-ming Zhou, Qing Ye
Summary: This study aims to calculate the relationship between pediatric inflammatory bowel disease (IBD) and vitamin D. Results from comprehensive literature search and data extraction indicate that there is no obvious relationship between pediatric IBD and vitamin D, while vitamin D supplementation can improve disease activity. Therefore, further prospective studies are needed to confirm the relationship between pediatric IBD and vitamin D.
FRONTIERS IN PEDIATRICS
(2023)
Review
Immunology
Susanna Esposito, Giulia Antoniol, Marialuisa Labate, Lucrezia Passadore, Patrizia Alvisi, Valeria Dacco, Chiara Ghizzi, Carla Colombo, Nicola Principi
Summary: The incidence of inflammatory bowel diseases (IBDs) is rising globally, leading to a higher risk of infections in children with dysfunctional immune systems. Vaccines are essential for preventing these infections, and should be administered according to specific immunization guidelines for IBD patients. Compliance with vaccination recommendations is generally low, highlighting the need for multidisciplinary educational programs to improve vaccination coverage and protect children with IBD from vaccine-preventable diseases.
Review
Nutrition & Dietetics
Somaye Fatahi, Naseem Alyahyawi, Naryman Albadawi, Farzaneh Mardali, Naghi Dara, Mohammad Hassan Sohouli, Kousalya Prabahar, Pejman Rohani, Nazanin Koushki, Aliakbar Sayyari, Amir Hossein Hosseini, Ahmed Abu-Zaid
Summary: This systematic review confirmed the association between vitamin D deficiency and IBD. Although there are conflicting results, the study found that vitamin D deficiency is very common among children with IBD.
FRONTIERS IN NUTRITION
(2023)
Article
Immunology
Christos Triantos, Ioanna Aggeletopoulou, Gerassimos J. Mantzaris, Athanasia Mouzaki
Summary: There is growing evidence of the involvement of vitamin D in immune regulation and gut barrier function, suggesting its critical role in the development of inflammatory bowel disease (IBD). Vitamin D acts as an immunomodulator, alleviating inflammation, and contributing to intestinal homeostasis in IBD, highlighting its potential therapeutic value.
AUTOIMMUNITY REVIEWS
(2022)
Article
Medicine, General & Internal
Antonia Topalova-Dimitrova, Ivan Valentinov Dimitrov, Rosen Nikolov
Summary: Patients with IBD have lower levels of vitamin D, which are associated with inflammation.
Review
Immunology
Zengrong Wu, Deliang Liu, Feihong Deng
Summary: This article provides a broad overview of the role of vitamin D in the immune system, specifically its role in the pathogenesis and treatment of inflammatory bowel disease (IBD), and its potential role in predicting relapse.
JOURNAL OF INFLAMMATION RESEARCH
(2022)