Article
Parasitology
Tokio Hoshina, Tatsuya Sakurai, Hidetoshi Ichimura, Kenji Ishiwata, Shitan En, Takahiro Yamada, Lee Kwangyole, Akihiro Shimizu, Koji Hase, Hirotaka Kanuka
Summary: The study demonstrated that healthy Japanese individuals tolerated all doses of TSO without any severe adverse events. However, mild to moderate abdominal symptoms were observed in some participants, and higher doses of TSO led to elevated eosinophil count. Close follow-up is recommended for sustainable medicinal use of TSO in Japan.
PARASITOLOGY INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Inyoung Hwang, Sang Chun Ji, Jaeseong Oh, Hyojin Kim, Hyunju Cha, John Kim, Chang-Seok Lee, Kyung-Sang Yu, SeungHwan Lee
Summary: This study investigated the safety, tolerability, pharmacodynamics, pharmacokinetics, and pharmacogenomics of zastaprazan. The results showed that zastaprazan effectively suppressed gastric acid secretion and exhibited favorable pharmacokinetic properties. The evaluation indicated that zastaprazan is safe and suitable for the treatment of acid-related diseases.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biology
Ivet A. Yordanova, Friederike Ebner, Axel Ronald Schulz, Svenja Steinfelder, Berit Rosche, Anna Bolze, Friedemann Paul, Henrik E. Mei, Susanne Hartmann
Summary: Studies have shown that multiple sclerosis patients receiving Trichuris suis ova treatment establish a specific T- and B-cell response, but there are variations in T cell responses and cellular functionality across individuals, potentially accounting for the diverse clinical efficacy observed in the studied patients.
Article
Ophthalmology
Vincenzo Papa, Ivanka van der Meulen, Sylvie Rottey, Guy Sallet, Jolanda Overweel, Nino Asero, Darwin C. Minassian, John K. G. Dart
Summary: This study evaluated the safety and tolerability of Polyhexamethyl biguanide (PHMB) in the treatment of Acanthamoeba keratitis (AK). The results showed that DLAE occurred in the treatment process of 0.06% and 0.08% concentrations of PHMB, but these adverse events were resolved within a short period of time. There was no significant trend in the incidence of other adverse events associated with increasing concentrations of PHMB. These findings are reassuring for patients using 0.02% PHMB.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Critical Care Medicine
Tracy J. Ruckwardt, Kaitlyn M. Morabito, Emily Phung, Michelle C. Crank, Pamela J. Costner, LaSonji A. Holman, Lauren A. Chang, Somia P. Hickman, Nina M. Berkowitz, Ingelise J. Gordon, Galina Yamshchikov, Martin R. Gaudinski, Bob Lin, Robert Bailer, Man Chen, Ana M. Ortega-Villa, Thuy Nguyen, Azad Kumar, Richard M. Schwartz, Lisa A. Kueltzo, Judith A. Stein, Kevin Carlton, Jason G. Gall, Martha C. Nason, John R. Mascola, Grace Chen, Barney S. Graham
Summary: The study evaluated the safety and immunogenicity of the DS-Cav1 prefusion F subunit vaccine in healthy adults aged 18-50 years. Results showed that DS-Cav1 vaccination was safe, well tolerated, and induced robust and sustained neutralising activity and binding antibodies. Higher vaccine doses or a second immunisation provided a transient advantage, but did not significantly impact long-term neutralisation, indicating that a single low-dose of pre-F immunisation may confer protection throughout an entire RSV season.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Kang Chao, Yibiao Huang, Xia Zhu, Jian Tang, Xueding Wang, Lang Lin, Huili Guo, Caibin Zhang, Miao Li, Qingfan Yang, Jie Huang, Lingna Ye, Pinjin Hu, Min Huang, Qian Cao, Xiang Gao
Summary: The study aimed to investigate whether an optimized strategy based on NUDT15 C415T genotypes affects thiopurine-induced leucopenia and efficacy in Chinese patients with Crohn's disease. The results showed that dose optimization by NUDT15 C415T reduced the rate of thiopurine-induced leucopenia, without significant influence on efficacy. Using 50% dose reduction for heterozygotes, and alternative drugs for homozygotes, are practicable strategies.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Parasitology
M. V. Prosberg, H. Kringel, J. S. Kapel, B. S. Kapel, B. L. Fredensborg, A. M. Petersen, L. H. Hansen, D. S. Nielsen, H. S. Kapel, K. R. Jacobsen, L. F. Mikkelsen, C. M. O. Kapel
Summary: In an ongoing clinical trial on ulcerative colitis patients, the probiotic medicinal product TSO is being administered with steroids and antibiotics. A pre-clinical study on Gottingen Minipigs evaluated the effects of these medications on the biological activity of TSO, showing that oral steroids did not affect TSO but oral antibiotics did. Fecal calprotectin levels, a marker of intestinal inflammation, did not show significant differences among groups.
PARASITOLOGY RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Timna Naftali, Lihi Bar-Lev Schleider, Shlomo Almog, David Meiri, Fred M. Konikoff
Summary: This study evaluated the effects of CBD-rich cannabis oil on inducing remission in patients with Crohn's disease. Results showed significant clinical improvement and quality of life enhancement without notable changes in inflammatory markers or endoscopic scores in the CBD group compared to the placebo group.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Ahmed Almradi, Rocio Sedano, Malcolm Hogan, G. Y. Zou, John K. MacDonald, Claire E. Parker, Jurij Hanzel, Eileen Crowley, Siddharth Singh, Geert D'Haens, William J. Sandborn, Brian G. Feagan, Christopher Ma, Vipul Jairath
Summary: This study quantifies the placebo rates in Crohn's disease trials and identifies factors influencing these rates. The findings suggest that placebo remission and response rates vary based on the trial phase, endpoint assessed, and induction or maintenance design.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Severine Vermeire, Geert D'Haens, Filip Baert, Silvio Danese, Taku Kobayashi, Edward Loftus, Siddharth Bhatia, Christian Agboton, Maria Rosario, Chunlin Chen, Wenwen Zhang, Krisztina Kisfalvi, William J. Sandborn
Summary: This study evaluated a new subcutaneous vedolizumab formulation as maintenance treatment for patients with moderately to severely active Crohn's disease. The results showed that the treatment was effective and safe in maintaining remission and enhancing clinical response in these patients.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Shirley Regev, Doron Schwartz, Orly Sarid, Ganit Goren, Vered Slonim-Nevo, Michael Friger, Ruslan Sergienko, Dan Greenberg, Alon Monsonego, Anna Nemirovsky, Shmuel Odes
Summary: This study aimed to investigate the effectiveness of a CD-tailored cognitive-behavioral and mindfulness intervention (COBMINDEX) in reducing abdominal pain and fatigue in patients with CD, as well as the mediating role of changes in abdominal pain and fatigue on improvements in work productivity and daily activities. The results showed that the intervention group receiving COBMINDEX had significantly lower levels of abdominal pain, fatigue, and impairments in work and daily activities compared to the control group. Furthermore, changes in abdominal pain and fatigue mediated the beneficial effects of COBMINDEX on work productivity and daily activities.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Roland Tschismarov, Pierre Van Damme, Clara Germain, Ilse De Coster, Mathieu Mateo, Stephanie Reynard, Alexandra Journeaux, Yvonne Tomberger, Kanchanamala Withanage, Denise Haslwanter, Katherine Terler, Sabrina Schrauf, Matthias Muellner, Erich Tauber, Katrin Ramsauer, Sylvain Baize
Summary: This phase 1 trial evaluated the safety, tolerability, and immunogenicity of a recombinant, live-attenuated, measles-vectored Lassa fever vaccine candidate (MV-LASV). The results showed that MV-LASV had an acceptable safety profile, was well tolerated, and induced a substantial immune response. It is a promising candidate for further development.
Article
Medicine, General & Internal
Johannes Levin, Nand Sing, Sue Melbourne, Amber Morgan, Carla Mariner, Maria Grazia Spillantini, Michal Wegrzynowicz, Jeffrey W. Dalley, Simon Langer, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Felix Schmidt, Daniel Weckbecker, Kai Prager, Torsten Matthias, Armin Giese
Summary: This study evaluated the safety and pharmacokinetics of an orally bioavailable compound anle138b in healthy subjects through a single ascending dose (SAD) and multiple ascending dose (MAD) study. The results showed that anle138b did not cause major adverse events at doses that achieved therapeutic exposure levels in a mouse Parkinson model. These findings suggest the need for further clinical trials of anle138b in patients with synucleinopathies.
Article
Critical Care Medicine
Jan Hedner, Kaj Stenlof, Ding Zou, Erik Hoff, Corinna Hansen, Katrin Kuhn, Peter Lennartz, Ludger Grote
Summary: This study explored the safety and tolerability of the carbonic anhydrase inhibitor sulthiame (STM) in patients with obstructive sleep apnea (OSA). The results showed that STM had a satisfactory safety profile in patients with moderate and/or severe OSA, and it significantly reduced the frequency of OSA events. Therefore, larger clinical studies of STM in OSA are justified.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Infectious Diseases
Heather Platt, Tosin Omole, Jose Cardona, Neil J. Fraser, Richard A. Mularski, Charles Andrews, Nizar Daboul, Nancy Gallagher, Aditi Sapre, Jianing Li, Adam Polis, Doreen Fernsler, Gretchen Tamms, Weifeng Xu, Rocio Murphy, Julie Skinner, Joseph Joyce, Luwy Musey
Summary: This study evaluated an investigational 21-valent pneumococcal conjugate vaccine (V116) specifically targeting serotypes associated with residual disease burden in adults. The results showed that V116 had a similar safety and immunogenicity profile compared to PPSV23, and was superior to PPSV23 for nine unique serotypes. These findings support the use of V116 for prevention of pneumococcal disease in adults.
LANCET INFECTIOUS DISEASES
(2023)
Review
Immunology
D. E. Elliott, J. V. Weinstock
PARASITE IMMUNOLOGY
(2017)
Article
Gastroenterology & Hepatology
Ahmed Metwali, Peter S. Thorne, M. Nedim Ince, Nervana Metwali, Sarah Winckler, Xiaoqun Guan, Sonay Beyatli, Jamie Truscott, Joseph F. Urban, David E. Elliott
DIGESTIVE DISEASES AND SCIENCES
(2018)
Article
Immunology
David E. Elliott, Joel V. Weinstock
YEAR IN IMMUNOLOGY
(2012)
Article
Immunology
Michael A. Kron, Ahmed Metwali, Sanja Vodanovic-Jankovic, David Elliott
CLINICAL AND VACCINE IMMUNOLOGY
(2013)
Article
Gastroenterology & Hepatology
David E. Elliott, Sana S. Siddique, Joel V. Weinstock
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2014)
Review
Gastroenterology & Hepatology
David E. Elliott, Joel V. Weinstock
CURRENT OPINION IN GASTROENTEROLOGY
(2012)
Review
Gastroenterology & Hepatology
Joel V. Weinstock, David E. Elliott
INFLAMMATORY BOWEL DISEASES
(2009)
Review
Parasitology
Joel V. Weinstock, David E. Elliott
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2013)
Letter
Allergy
Robert W. Summers, David E. Elliott, Joel V. Weinstock
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2010)
Article
Immunology
Yue Li, Hung-Lin Chen, Nadine Bannick, Michael Henry, Adrian N. Holm, Ahmed Metwali, Joseph F. Urban, Paul B. Rothman, George J. Weiner, Bruce R. Blazar, David E. Elliott, M. Nedim Ince
JOURNAL OF IMMUNOLOGY
(2015)
Review
Immunology
Joel V. Weinstock, David E. Elliott
JOURNAL OF IMMUNOLOGY
(2014)
Article
Immunology
Yue Li, Weiren Liu, Xiaqun Guan, Jamie Truscott, John W. Creemers, Hung-Lin Chen, Marko Pesu, Rami G. El Abiad, Bahri Karacay, Joseph F. Urban Jr, David E. Elliott, Mark H. Kaplan, Bruce R. Blazar, M. Nedim Ince
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Yue Li, Xiaoqun Guan, Weiren Liu, Hung-Lin Chen, Jamie Truscott, Sonay Beyatli, Ahmed Metwali, George J. Weiner, Nicholas Zavazava, Richard S. Blumberg, Joseph F. Urban, Bruce R. Blazar, David E. Elliott, M. Nedim Ince
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Ahmed Metwali, Sarah Winckler, Joseph F. Urban, Mark H. Kaplan, M. Nedim Ince, David E. Elliott
Summary: Intact but regulated T cell expression of Stat6 signaling is crucial for the regulation of pathogenic intestinal inflammation associated with helminth infection. Loss of Stat6 signaling may result in colitis that is not attenuated by helminth exposure.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)