Review
Gastroenterology & Hepatology
Yamile Zabana, Gian Tontini, Elisabeth Hultgren-Hornquist, Karolina Skonieczna-Zydecka, Giovanni Latella, Ann Elisabeth Ostvik, Wojciech Marlicz, Mauro D'Amato, Angel Arias, Stephan Mielhke, Andreas Munch, Fernando Fernandez-Banares, Alfredo J. Lucendo
Summary: This study is the first systematic review on the etiology of microscopic colitis (MC) supporting the notion that MC is a multifactorial disease. However, high-profile studies are lacking, and most evidence derives from small heterogeneous studies.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Pathology
Lin Yuan, Tsung-Teh Wu, Lizhi Zhang
Summary: Microscopic colitis (MC) is a chronic inflammatory disease of the colon characterized by chronic, watery, nonbloody diarrhea and normal or almost normal endoscopic findings. Two main subtypes of MC, lymphocytic colitis (LC) and collagenous colitis (CC), are identified through microscopic examination on colon biopsy. The pathogenesis of MC is still unclear, but it has been associated with various risk factors and other diseases such as celiac disease, inflammatory bowel disease, and medication use. This paper aims to provide a systematic introduction to the clinicopathologic features of MC, focusing on unusual features and associations with other conditions.
Review
Biochemistry & Molecular Biology
Aleksandra Garczyk, Marcin Mardas, Marta Stelmach-Mardas
Summary: Microscopic colitis is a rare cause of chronic diarrhoea and its incidence is increasing. Studies have found a decrease in the Akkermansia genus in the faecal samples of patients. However, the results regarding other taxa were inconsistent, indicating the need for further research on the impact of microbiota composition on this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Emese Mihaly, Arpad Patai, Zsolt Tulassay
Summary: Microscopic colitis (MC) is increasingly recognized, but there are still many unanswered questions regarding its pathogenesis, diagnosis, and therapy. The relationship between microbiome changes, different subtypes of the disease, and the effectiveness of treatments like budesonide and biologics remain unclear, highlighting the need for further research in the future.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Hamed Khalili, Jordan E. Axelrad, Bjorn Roelstraete, Ola Olen, Mauro D'Amato, Jonas F. Ludvigsson
Summary: The study reveals that gastrointestinal infections are associated with an increased risk of microscopic colitis, especially Clostridioides difficile. The association between gastrointestinal infections and risk of MC is stronger for the collagenous subtype.
Article
Gastroenterology & Hepatology
Tenghao Zheng, Giulia Roda, Yamile Zabana, Celia Escudero-Hernandez, Xingrong Liu, Ye Chen, Leticia Camargo Tavares, Ferdinando Bonfiglio, Marie-Rose Mellander, Izabella Janczewska, Lina Vigren, Klas Sjoberg, Bodil Ohlsson, Sven Almer, Jonas Halfvarson, Stephan Miehlke, Ahmed Madisch, Wolfgang Lieb, Juozas Kupcinskas, Rinse K. Weersma, Luis Bujanda, Antonio Julia, Sara Marsal, Maria Esteve, Danila Guagnozzi, Fernando Fernandez-Banares, Carmen Ferrer, Inga Peter, Jonas F. Ludvigsson, Darrell Pardi, Bas Verhaegh, Daisy Jonkers, Marieke Pierik, Andreas Munch, Andre Franke, Francesca Bresso, Hamed Khalili, Jean-Frederic Colombel, Mauro D'Amato
Summary: The study suggests that collagenous colitis and lymphocytic colitis have distinct pathophysiological foundations, with only collagenous colitis being associated with human leukocyte antigen (HLA). This challenges existing classifications and calls for a re-evaluation of the utility of the umbrella definition for microscopic colitis.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Gastroenterology & Hepatology
June Tome, Raseen Tariq, Leslie C. Hassett, Sahil Khanna, Darrell S. Pardi
Summary: Budesonide is an effective maintenance treatment for microscopic colitis. There is a high risk of recurrence after discontinuation, but long-term use at the lowest effective dose appears to be relatively safe with limited adverse effects.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
June Tome, Kanika Sehgal, Amrit K. Kamboj, Bryce Comstock, W Scott Harmsen, Sahil Khanna, Darrell S. Pardi
Summary: The long-term use of budesonide in microscopic colitis appears to be effective and generally well tolerated with limited adverse effects.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Kanika Sehgal, June Tome, Amrit K. Kamboj, Ross A. Dierkhising, Darrell S. Pardi, Sahil Khanna
Summary: This retrospective study investigated histological changes in microscopic colitis and found that patients with lymphocytic colitis (LC) may have more histological changes compared to collagenous colitis (CC) patients. Additionally, the study suggests that the use of proton-pump inhibitors (PPIs), aspirin, and budesonide treatment may be associated with histological resolution.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Yi-Hui Liu, Zhen Wu, Ji-Yuan Ding, Yu-Dan Shi
Summary: The study found that patients with microscopic colitis (MC) have a lower risk of colorectal adenoma or cancer compared to those without MC, supporting the recommendation that surveillance colonoscopy program is not necessary for MC patients.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Pathology
Peter Johan Heiberg Engel, Anne-Marie Kanstrup Fiehn, Danny Goudkade, Jeppe Thagaard, Henrik Holten-Rossing, Stefania Landolfi, Vincenzo Villanacci, Lars Kristian Munck
Summary: Microscopic colitis (MC) encompasses lymphocytic colitis (LC) and collagenous colitis (CC). LC often presents with thickening of the subepithelial collagen band, while CC is characterized by an increased number of intraepithelial T-lymphocytes (IELs). The essential histopathological feature of MC is considered to be the lymphocytic inflammatory infiltration of the mucosa, although there is a non-linear correlation between the number of IELs and thickness of the collagenous band, indicating differences in their pathogenesis.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2021)
Review
Pharmacology & Pharmacy
Amalie Rehde, Sebastian Kjaergaard Hendel, Carsten Bogh Juhl, John Gubatan, Ole Haagen Nielsen
Summary: This article systematically reviewed and meta-analyzed the effectiveness of non-budesonide therapies for microscopic colitis (MC) and compared them with other treatment options recommended by international guidelines. The results showed that bismuth subsalicylate (BSS) had the best treatment effect, followed by tumor necrosis factor inhibitors and bile acid sequestrants. These findings may help guide clinicians in selecting the most appropriate non-budesonide therapies for patients with MC.
Article
Medicine, General & Internal
Murtaza Shabbir Hussain, Harika Balagoni, Sankalp Dwivedi, Marc Piper
Summary: The association between microscopic colitis (MC) and inflammatory bowel disease (IBD) is uncertain and infrequently reported in the literature. A unique case is presented here, where a patient initially diagnosed with IBD was later found to have MC on histology after reappearance of diarrhea months later. Common pathophysiologic mechanisms, such as tumor necrosis factor a and T helper type 1 cells, may explain the relationship between MC and IBD. A prompt biopsy should be taken during endoscopy if suspicious for MC, in order to decrease the duration of patient's symptoms and save healthcare costs.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Emanuele Sinagra, Francesco Vito Mandarino, Marcello Maida, Daniela Cabibi, Francesca Rossi, Dario Raimondo, Guido Manfredi
Summary: Focal active colitis (FAC) refers to the isolated finding of neutrophil infiltration in the colonic crypts, causing debates about its clinical significance. This narrative review aims to provide an overview of the available evidence regarding the clinical implications of FAC in both adults and pediatric populations.
Review
Computer Science, Information Systems
Tanzilal Mustaqim, Chastine Fatichah, Nanik Suciati
Summary: Computer vision research in detecting and classifying the subtype Acute Lymphoblastic Leukemia (ALL) has contributed to computer-aided diagnosis with improved accuracy. Another contribution is to serve as an assistant and second opinion for doctors and hematologists in diagnosing the ALL subtype. Early detection can also rely on computer-aided diagnosis to determine initial treatment.
Article
Gastroenterology & Hepatology
Nynne Nyboe Andersen, Lars Kristian Munck, Susanne Hansen, Tine Jess, Signe Wildt
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Gastroenterology & Hepatology
Christian Borup, Signe Wildt, Juri Rumessen, Jesper Graff, Pierre Nordine Bouchelouche, Trine Borup Andersen, Lars Vinter-Jensen, Anna Zaremba, Soren Peter German Jorgensen, Tine Gregersen, Camilla Nojgaard, Hans Bording Timm, Dominique Rainteau, Emilie Gauliard, Lars Kristian Munck
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Pathology
Danny Goudkade, Anne-Marie Kanstrup Fiehn, Stefania Landolfi, Vincenzo Villanacci, Lars Kristian Munck, Peter Johan Heiberg Engel
ANNALS OF DIAGNOSTIC PATHOLOGY
(2020)
Letter
Gastroenterology & Hepatology
Christian Borup, Lars K. Munck
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Pathology
Anne-Marie Kanstrup Fiehn, Peter Johan Heiberg Engel, Francesco Lanzarotto, Danny Goudkade, Stefania Landolfi, Lars Kristian Munck, Vincenzo Villanacci
Article
Gastroenterology & Hepatology
Anne-Marie Kanstrup Fiehn, Stephan Miehlke, Daniela Aust, Michael Vieth, Ole Bonderup, Fernando Fernandez-Banares, Emese Mihaly, Juozas Kupcinskas, Ahmed Madisch, Lars Kristian Munck, Tanju Nacak, Ralf Mohrbacher, Ralph Mueller, Roland Greinwald, Andreas Munch
Summary: The study evaluated the distribution of histopathological features of microscopic colitis throughout the colon. Both collagenous colitis and lymphocytic colitis patients exhibited more pronounced inflammation in the proximal colon compared to the distal colon. The minimum criteria required for diagnosis were present in the majority of segments, suggesting microscopic colitis as a pancolitis with the rectum excluded.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Editorial Material
Gastroenterology & Hepatology
Laerke Muller Olsen, Peter Johan Heiberg Engel, Danny Goudkade, Vincenzo Villanacci, Jeppe Thagaard, Julie Sparholt Walbech, Johan Bohr, Juozas Kupcinskas, Bas Verhaegh, Andreas Munch, Danila Guagnozzi, Fernando Fernandez-Banares, Lars Kristian Munck, Anne-Marie Kanstrup Fiehn
Summary: This article is linked to Olsen et al and Lucendo papers, readers can visit the provided link to view these articles.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Laerke Mueller Olsen, Peter Johan Heiberg Engel, Danny Goudkade, Vincenzo Villanacci, Jeppe Thagaard, Julie Sparholt Walbech, Johan Bohr, Juozas Kupcinskas, Bas Verhaegh, Andreas Munch, Danila Guagnozzi, Fernando Fernandez-Banares, Lars Kristian Munck, Anne-Marie Kanstrup Fiehn
Summary: The study found that histological parameters were not significantly correlated with disease activity or disease course in patients with microscopic colitis, indicating that these parameters are currently not predictive factors for the progression of the disease.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pathology
Peter Johan Heiberg Engel, Anne-Marie Kanstrup Fiehn, Danny Goudkade, Jeppe Thagaard, Henrik Holten-Rossing, Stefania Landolfi, Vincenzo Villanacci, Lars Kristian Munck
Summary: Microscopic colitis (MC) encompasses lymphocytic colitis (LC) and collagenous colitis (CC). LC often presents with thickening of the subepithelial collagen band, while CC is characterized by an increased number of intraepithelial T-lymphocytes (IELs). The essential histopathological feature of MC is considered to be the lymphocytic inflammatory infiltration of the mucosa, although there is a non-linear correlation between the number of IELs and thickness of the collagenous band, indicating differences in their pathogenesis.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Andreas Munch, Emese Mihaly, Ferenc Nagy, Ahmed Madisch, Juozas Kupcinskas, Stephan Miehlke, Johan Bohr, Gerd Bouma, Jordi Guardiola, Blanca Belloc, Chunliang Shi, Daniela Aust, Ralf Mohrbacher, Roland Greinwald, Lars Kristian Munck
Summary: This study aimed to evaluate the efficacy of budesonide as induction therapy for MCi, but was prematurely discontinued due to insufficient patient recruitment. Although the primary endpoint of clinical remission was not statistically significant, budesonide showed advantages in improving quality of life and reducing the frequency of soft stools in patients with MCi.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Signe Wildt, Lars Kristian Munck, Matilde Winther-Jensen, Tine Jess, Nynne Nyboe Andersen
Summary: Using a matched case-control design based on nationwide registry data, it was found that there is a strong association between microscopic colitis and a wide range of autoimmune diseases, particularly those of gastrointestinal origin. The results suggest an autoimmune predisposition to microscopic colitis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Correction
Gastroenterology & Hepatology
Christian Borup, Svend Hoime Hansen, Lars Kristian Munck
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Christian Borup, Lars Vinter-Jensen, Soren Peter German Jorgensen, Signe Wildt, Jesper Graff, Tine Gregersen, Anna Zaremba, Trine Borup Andersen, Camilla Nojgaard, Hans Bording Timm, Dominique Rainteau, Svend Hoime Hansen, Juri Johannes Rumessen, Lars Kristian Munck
Summary: This study investigated the efficacy and safety of colesevelam in the treatment of bile acid diarrhoea. The results showed that colesevelam was superior to placebo in inducing remission of bile acid diarrhoea, and it was well-tolerated with no serious adverse events.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Lars Kristian Munck
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Bas P. M. Verhaegh, Andreas Muench, Danila Guagnozzi, Signe Wildt, Wojciech Cebula, Andreea R. Diac, Fernando Fernandez-Banares, Magid A. R. Al-Khalaf, Natalia Pedersen, Juozas Kupcinskas, Johan Bohr, Gilles Macaigne, Alfredo J. Lucendo, Ivan Lyutakov, Gian-Eugenio Tontini, Flavia Pigo, Evangelos Russo, Henrik Hjortswang, Stephan Miehlke, Lars K. Munck
Summary: Microscopic colitis is considered a chronic but benign disease, with most patients experiencing a chronic active or relapsing disease course during the first year after diagnosis. Symptoms and quality of life tend to improve after follow-up, but a relapsing or chronic active disease course is associated with significantly more symptoms and impaired quality of life.
JOURNAL OF CROHNS & COLITIS
(2021)