Article
Gastroenterology & Hepatology
Teruyuki Takeda, Masahiro Kishi, Noritaka Takatsu, Yasumichi Takada, Tsuyoshi Beppu, Masaki Miyaoka, Takashi Hisabe, Toshiharu Ueki, Hisatomi Arima, Fumihito Hirai, Kenshi Yao
Summary: The study investigated the long-term efficacy and safety of endoscopic balloon dilation (EBD) for intestinal strictures in patients with Crohn's disease (CD) receiving anti-tumor necrosis factor alpha antibodies (anti-TNF) as maintenance therapy. The results showed that EBD was an effective and safe treatment for CD patients with intestinal strictures, with 3- and 5-year cumulative surgery-free rates of 81.1% and 73.5%, respectively.
DIGESTIVE ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Kate E. Lee, Francesca Lim, Adam S. Faye, Bo Shen, Chin Hur
Summary: This study analyzed the cost-effectiveness of endoscopic balloon dilation (EBD) compared to resection surgery for managing Crohn's disease strictures. The results showed that EBD is a cost-effective strategy, considering patient risks and quality of life after intervention.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Hironori Yamamoto, Tomonori Yano, Akihiro Araki, Motohiro Esaki, Kazuo Ohtsuka, Naoki Ohmiya, Shiro Oka, Hiroshi Nakase, Shigeki Bamba, Fumihito Hirai, Naoki Hosoe, Tomoki Matsuda, Keigo Mitsui, Kenji Watanabe, Haruhiko Ogata, Shinichi Katsuki, Takayuki Matsumoto, Mitsuhiro Fujishiro, Kazuma Fujimoto, Haruhiro Inoue
Summary: This guideline provides a summary of new scientific techniques and evidence regarding endoscopic balloon dilation for the treatment of Crohn's disease-associated small intestinal strictures.
DIGESTIVE ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Hyun Seok Lee, Michael V. Chiorean, Elisa Boden, James Lord, Shayan Irani, Richard Kozarek, Michael Larsen, Andrew Ross
Summary: This study found that endoscopic balloon dilation for CD-related strictures can be safely and effectively performed without fluoroscopic guidance. Factors such as balloon size, patient age, stricture location, and multiplicity have been associated with clinical success and the need to avoid surgery.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Juanjuan Zhang, Yi Li, Yanqing Diao, Binlin Da, Zhiming Wang
Summary: Duodenal Crohn's disease-associated strictures can be effectively and safely treated with endoscopic balloon dilation (EBD). Serial dilations may delay recurrence and the need for surgery, but do not change long-term outcomes or prevent surgery.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Julien D. Schulberg, Emily K. Wright, Bronte A. Holt, Helen E. Wilding, Amy L. Hamilton, Alyson L. Ross, Michael A. Kamm
Summary: This study provides a summary of the latest advances in the treatment of stricturing Crohn's disease patients, indicating that anti-TNF drug therapy and endoscopic balloon dilation are effective strategies for avoiding surgery, while other drug therapies do not show significant benefits. Further evaluation is needed to assess the potential greater benefits of combining therapies.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Surgery
Jiankun Wang, Lili Zhao, Rui Wu, Min Wang, Li Liu, Xiang Wang, Wenjie Liu, Kexin He, Lin Miao, Zhining Fan
Summary: Benign esophageal strictures are common complications after esophageal surgery or extensive endoscopic submucosal dissection. This study retrospectively analyzed patients with such strictures and found that a 3-minute duration for endoscopic dilation was considered safe and effective for treatment.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Gastroenterology & Hepatology
Xiaoxuan Lin, Yu Wang, Zishan Liu, Sinan Lin, Jinyu Tan, Jinshen He, Fan Hu, Xiaomin Wu, Subrata Ghosh, Minhu Chen, Fen Liu, Ren Mao
Summary: Intestinal strictures, a common complication of Crohn's disease, remain difficult to treat. Current therapies, such as endoscopic balloon dilation and surgery, have high recurrence rates. The mechanisms of intestinal fibrosis are poorly understood, and there is a lack of reliable methods for evaluating it. However, new techniques like single-cell sequencing, multi-omics, and artificial intelligence are driving progress in this field.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Chengcheng Christine Zhang, Christian Rupp, Xenophon Exarchos, Arianeb Mehrabi, Ronald Koschny, Anja Schaible, Peter Sauer
Summary: This retrospective study evaluated the impact of scheduled endoscopic dilatation on the treatment of biliary strictures after liver transplantation. The results showed that the implementation of this strategy effectively controlled symptoms and significantly improved survival.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Surgery
Nan Lan, Jin-Jie Wu, Xian-Rui Wu, Tracy L. Hull, Bo Shen
Summary: This study compared the efficacy and safety of endoscopic stricturotomy and endoscopic balloon dilation in treating pouch inlet strictures. The results showed that both methods were effective with similar surgery-free survival rates, but EBD had a higher risk of perforation while stricturotomy had a higher risk of bleeding.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Partha Pal, Jaini Gala, Pradeep Rebala, Rupa Banerjee, Mohan Ramchandani, Zaheer Nabi, Swathi Kanaganti, Mahesh G. Shetty, Rajesh Gupta, Sundeep Lakhtakia, Guduru Venkat Rao, Manu Tandan, D. Nageshwar Reddy
Summary: Endotherapy for CD strictures requires more re-interventions compared with resection, although re-operation could be avoided in the majority with similar symptom-free survival at 1 year.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Amy L. Lightner, Hassan Buhulaigah, Karen Zaghiyan, Stefan D. Holubar, Scott R. Steele, Xue Jia, John McMichael, Prashansha Vaidya, Phillip R. Fleshner
Summary: Fecal diversion with an ileostomy is not very effective in achieving clinical response in patients with Crohn's disease. Some patients show improvement and undergo ileostomy reversal, but the majority do not improve and require total proctocolectomy.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
F. de Voogd, S. Bots, K. Gecse, O. H. Gilja, G. D'Haens, K. Nylund
Summary: This study investigated the use of intestinal ultrasound and contrast-enhanced ultrasound to predict endoscopic treatment response in Crohn's disease. The reduction in bowel wall thickness was found to be predictive of endoscopic response and remission, while the value of CEUS parameters was limited.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Eyal Klang, Ana Grinman, Shelly Soffer, Reuma Margalit Yehuda, Oranit Barzilay, Michal Marianne Amitai, Eli Konen, Shomron Ben-Horin, Rami Eliakim, Yiftach Barash, Uri Kopylov
Summary: The study tested a deep learning network for detecting intestinal strictures in Crohn's disease patients' capsule endoscopy images. The network exhibited excellent accuracy in distinguishing strictures from normal mucosa as well as different degrees of ulcers, suggesting potential for automated detection and grading of Crohn's disease-related findings.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Qingqing Liu, Xiaofei Zhang, Huaibin Mabel Ko, Daniel Stocker, Jordan Ellman, Joyce Chen, Yansheng Hao, Swati Bhardwaj, Yuanxin Liang, Judy Cho, Jean Frederic Colombel, Bachir Taouli, Noam Harpaz
Summary: This study identified and characterized ileal strictures in Crohn's disease, showing that it is primarily caused by mural constriction rather than fibromuscular hypertrophy. The study also found that mesenteric fat wrapping and myenteric plexitis may contribute to the pathogenesis of the strictures.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Anders Forss, Mark Clements, Par Myrelid, Hans Strid, Charlotte Soderman, Agnieszka Wagner, David Andersson, Fredrik Hjelm, Ola Olen, Jonas Halfvarson, Jonas F. Ludvigsson
Summary: This study demonstrates the long-term clinical effectiveness of ustekinumab in patients with active Crohn's disease, as well as its improvement in Health-related Quality of Life (HRQoL) measures.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Johanna Holmgren, Anna Froborg, Isabella Visuri, Jonas Halfvarson, Henrik Hjortswang, Pontus Karling, Par Myrelid, Ola Olen, Jonas F. Ludvigsson, Olof Grip
Summary: In patients with inflammatory bowel disease, the incidence rate of serious infection did not increase with the use of anti-TNF therapy and actually decreased more than 1 year after treatment initiation.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Jie Chen, Yajing Zhou, Yuhao Sun, Shuai Yuan, Rahul Kalla, Jing Sun, Jianhui Zhao, Lijuan Wang, Xuejie Chen, Xuan Zhou, Siqi Dai, Yu Zhang, Gwo-tzer Ho, Dajing Xia, Qian Cao, Zhanju Liu, Susanna C. Larsson, Xiaoyan Wang, Kefeng Ding, Jonas Halfvarson, Xue Li, Evropi Theodoratou, Jack Satsangi
Summary: This study identified 14 proteins associated with the risk of ulcerative colitis (UC) through the analysis of serum proteomic profiling data. Further analysis using Mendelian randomisation confirmed the causal relationship between two chemokines and the increased risk of UC. Additionally, a new protein associated with UC risk was identified. Reverse Mendelian randomisation analysis did not find any influence of genetic predisposition to UC on these three inflammation proteins.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Obstetrics & Gynecology
K. Hilden, A. Magnuson, S. Montgomery, E. Schwarcz, U. Hanson, D. Simmons, H. Backman
Summary: This study investigates the associations between pre-eclampsia, gestational diabetes mellitus (GDM), and cardiovascular disease (CVD). The results show that both pre-eclampsia and GDM are independent risk factors for later CVD. The association between pre-eclampsia and CVD is not modified by body mass index (BMI). Effective CVD preventive programs for high-risk women are urgently needed.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Genetics & Heredity
Zhanju Liu, Ruize Liu, Han Gao, Seulgi Jung, Xiang Gao, Ruicong Sun, Xiaoming Liu, Yongjae Kim, Ho-Su Lee, Yosuke Kawai, Masao Nagasaki, Junji Umeno, Katsushi Tokunaga, Yoshitaka Kinouchi, Atsushi Masamune, Wenzhao Shi, Chengguo Shen, Zhenglin Guo, Kai Yuan, Shu Zhu, Dalin Li, Jianjun Liu, Tian Ge, Judy Cho, Mark J. Daly, Dermot P. B. McGovern, Byong Duk Ye, Kyuyoung Song, Yoichi Kakuta, Mingsong Li, Hailiang Huang, Maria Abreu, Jean-Paul Achkar, Vibeke Andersen, Charles Bernstein, Steven R. Brant, Luis Bujanda, Siew Chien Ng, Judy Cho, Mark J. Daly, Lee A. Denson, Richard H. Duerr, Lynnette R. Ferguson, Denis Franchimont, Andre Franke, Richard Gearry, Hakon Hakonarson, Jonas Halfvarson, Caren Heller, Hailiang Huang, Antonio Julia, Judith Kelsen, Hamed Khalili, Subramaniam Kugathasan, Juozas Kupcinskas, Anna Latiano, Edouard Louis, Reza Malekzadeh, Jacob L. McCauley, Dermot P. B. McGovern, Christopher Moran, David Okou, Tim Orchard, Aarno Palotie, Miles Parkes, Joel Pekow, Uros Potocnik, Graham Radford-Smith, John D. Rioux, Gerhard Rogler, Bruce Sands, Mark Silverberg, Harry Sokol, Severine Vermeire, Rinse K. Weersma, Ramnik J. Xavier, Naizhong Hu, Qian Cao, Yufang Wang, Yinglei Miao, Hongjie Zhang, Xiaoping Lv, Xiang Gao, Hu Zhang, Jingling Su, Baisui Feng, Ye Zhao, Liangru Zhu, Yan Chen, Lanxiang Zhu, Chunxiao Chen, Yali Wang, Yingde Wang, Zhi Pang, Yingxuan Chen, Xiaolan Zhang, Hui Li, Qin Yu, Mei Ye, Sumin Zhang, Wen Tang, Mei Wang, Xiaocang Cao, Ruixin Zhu, Guangxi Zhou, Zhaolian Bian, Xiaofeng Guo, Xiaoli Wu, Jinchun Liu, Wei Xu, Yuqin Li, Qin Guo, Zhiguo Guo, Mingsong Li, Zhanju Liu
Summary: This study provides the largest investigation of inflammatory bowel diseases (IBDs) in individuals of East Asian ancestries, identifying 80 IBD loci, including 81 new loci. The study also discovers new IBD genes, such as ADAP1 and GIT2, and improves the accuracy of predicting IBD risk by incorporating data from both East Asian and European ancestries.
Article
Medicine, General & Internal
Jiangwei Sun, Fang Fang, Ola Olen, Mingyang F. Song, Jonas Halfvarson, Bjorn Roelstraete, Hamed Khalili, Jonas Ludvigsson
Summary: In this study, individuals who underwent endoscopic biopsy with normal mucosa were followed up for a median of 10 years. The study found that these individuals had an elevated risk of inflammatory bowel disease (IBD) for at least 30 years. These findings imply the presence of a substantial symptomatic period before the diagnosis of IBD and emphasize the importance of considering the long-term risk of IBD in patients with symptoms but normal mucosa on gastrointestinal investigation.
Article
Gastroenterology & Hepatology
Aiva Lundberg Bave, Ola Olen, Jonas Soederling, Jonas F. Ludvigsson, Annika Bergquist, Caroline Nordenvall
Summary: Colectomy in UC patients was not associated with a decreased risk of subsequent PSC. The observed differences in the risk of PSC development over calendar periods are likely due to changes in PSC-diagnosis and UC-treatment.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Jamie M. Horrigan, Edouard Louis, Antonino Spinelli, Simon Travis, Bjorn Moum, Jessica Salwen-Deremer, Jonas Halfvarson, Remo Panaccione, Marla C. Dubinsky, Pia Munkholm, Corey A. Siegel
Summary: This study investigated the global use and barriers to using patient-reported outcomes (PROs) in clinical practice for inflammatory bowel disease (IBD). The majority of healthcare providers use PROs in clinical practice, but there are variations in which PROs are used and how they influence management. Barriers to using PROs include lack of familiarity, integration issues, and time constraints. Education about PROs and the use of an accepted set of PROs can help overcome these barriers and achieve global harmonization.
CROHNS & COLITIS 360
(2023)
Article
Gastroenterology & Hepatology
Joel Thunberg, Olle Granno, Daniel Bergemalm, Carl Eriksson, Isabella Visuri, Michael Eberhardson, Jonas Halfvarson
Summary: This study examined the agreement between a point-of-care test (POCT) by ProciseDx and the in-house enzyme-linked immunosorbent assay (ELISA) for infliximab (IFX) quantification. The results showed good agreement between the two methods, supporting the use of ProciseDx's POCT for rapid IFX quantification.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Bjorn Roelstraete, Emma Svennberg, Jonas Halfvarson, Johan Sundstrom, Anders Forss, Ola Olen, Jonas F. Ludvigsson
Summary: This study found that patients with inflammatory bowel disease (IBD) have an increased risk of developing arrhythmias. This increased risk persists even 25 years after the diagnosis of IBD.
Article
Medicine, General & Internal
Ferdinando D'Amico, Virginia Solitano, Fernando Magro, Pablo A. Olivera, Jonas Halfvarson, David Rubin, Axel Dignass, Sameer Al Awadhi, Taku Kobayashi, Natalia Sousa Freitas Queiroz, Marta Calvo, Paulo Gustavo Kotze, Subrata Ghosh, Laurent Peyrin-Biroulet, Silvio Danese
Summary: As the patents for biologic originator drugs expire, biosimilars are emerging as cost-effective alternatives within healthcare systems. A global survey was conducted to shed light on physicians' knowledge, beliefs, practical approaches, and concerns related to biosimilar adoption. Based on the survey results, a consensus was reached on key statements covering biosimilar effectiveness, safety, indications, rationale, multiple switches, therapeutic drug monitoring, non-medical switching, and future perspectives. The consensus affirmed that biosimilars are equally effective and safe compared to originator drugs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Isabella Visuri, Carl Eriksson, Sara Karlqvist, Byron Lykiardopoulos, Per Karlen, Olof Grip, Charlotte Soderman, Sven Almer, Erik Hertervig, Jan Marsal, Carolina Malmgren, Jenny Delin, Hans Strid, Mats Sjoberg, Daniel Bergemalm, Henrik Hjortswang, Jonas Halfvarson
Summary: This study assessed the long-term outcomes of vedolizumab in treating inflammatory bowel disease. The results showed that vedolizumab had high continuation rates and was associated with improvements in clinical outcomes, health-related quality of life measures, and inflammatory markers at 2 and 3 years after treatment initiation.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Archana Shubhakar, Bas C. Jansen, Alex T. Adams, Karli R. Reiding, Nicholas T. Ventham, Rahul Kalla, Daniel Bergemalm, Paulina A. Urbanowicz, Richard A. Gardner, Manfred IBD BIOM Consortium, Manfred Wuhrer, Jonas Halfvarson, Jack Satsangi, Daryl L. Fernandes, Daniel I. R. Spencer
Summary: This study investigated a composite serum N-glycomic biomarker to predict future disease course in newly diagnosed IBD patients. The biomarker showed a predictive capacity for treatment escalation in both the discovery and replication cohorts of patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Public, Environmental & Occupational Health
Sall Olof, Eriksson Lorraine, A. Idosa Berhane, Persson Alexander, Magnuson Anders, Thulin Hedberg Sara, Sundqvist Martin, Olcen Per, Fredlund Hans, Stenmark Bianca, Sarndahl Eva, Molling Paula, Jacobsson Susanne
Summary: The aim of this study was to examine the prevalence, risk factors, distribution of meningococcal lineages, and persistence of N. meningitidis carriage among university students in Sweden. The carriage rate was 9.1%, with factors such as younger age, previous tonsillectomy, smoking, alcohol consumption, and attending parties, pubs, and clubs associated with higher carriage. Female gender and sharing a household with young children were associated with lower carriage. Further studies with longer follow-up times are recommended to investigate long-term carriage of N. meningitidis.
EPIDEMIOLOGY AND INFECTION
(2023)
Article
Gastroenterology & Hepatology
Amiko M. Uchida, John J. Garber, Ashley Pyne, Kathryn Peterson, Bjorn Roelstraete, Ola Olen, Jonas Halfvarson, Jonas F. Ludvigsson
Summary: In this nationwide cohort study, EoE was found to be associated with a 3.5-fold increased risk of later IBD diagnosis, possibly due to genetic or early environmental risk factors.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)