Article
Gastroenterology & Hepatology
Sawangpong Jandee, Panu Wetwittayakhlang, Pattira Boonsri
Summary: This study evaluated the efficacy of prucalopride on paralytic ileus in critically ill patients through a five-day treatment trial. Results indicate that prucalopride has a significant impact on large intestine but limited effect on small intestine. Further research is needed to assess the drug’s impact on upper gut motility.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Rheumatology
Pascal Richette, Augustin Latourte, Jeremie Sellam, Daniel Wendling, Muriel Piperno, Philippe Goupille, Yves-Marie Pers, Florent Eymard, Sebastien Ottaviani, Paul Ornetti, Rene-Marc Flipo, Bruno Fautrel, Olivier Peyr, Jean Pierre Bertola, Eric Vicaut, Xavier Chevalier
Summary: The study found that tocilizumab was not more effective than placebo in relieving pain in patients with hand osteoarthritis. Apart from the primary endpoint, there were no significant differences in secondary outcomes between the tocilizumab group and the placebo group.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Brad H. Rovin, Y. K. Onno Teng, Ellen M. Ginzler, Cristina Arriens, Dawn J. Caster, Juanita Romero-Diaz, Keisha Gibson, Joshua Kaplan, Laura Lisk, Sandra Navarra, Samir V. Parikh, Simrat Randhawa, Neil Solomons, Robert B. Huizinga
Summary: This study evaluated the efficacy and safety of voclosporin for the treatment of lupus nephritis, showing a superior complete renal response rate with voclosporin in combination with MMF and low-dose steroids compared to MMF and low-dose steroids alone. The safety profile was comparable between the two groups. This finding represents an important advancement in the treatment of patients with active lupus nephritis.
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Medicine, General & Internal
Athimalaipet Ramanan, Pierre Quartier, Nami Okamoto, Ivan Foeldvari, Alberto Spindler, Sarka Fingerhutova, Jordi Anton, Zhongkai Wang, Gabriella Meszaros, Joana Araujo, Ran Liao, Stuart Keller
Summary: Baricitinib demonstrated good efficacy and acceptable safety in the treatment of polyarticular juvenile idiopathic arthritis, extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, and juvenile psoriatic arthritis.
Article
Medicine, General & Internal
Zhuang Tian, Fang Wang, Wei Jin, Qing Zhang, Jingmin Zhou, Ping Yang, Geng Wang, Peiwen Hsu, Jing Sun, Shuyang Zhang, Yaling Han
Summary: This study aims to evaluate the efficacy and safety of mavacamten in Chinese adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). Approximately 81 participants with symptomatic oHCM will be enrolled and randomized to receive mavacamten or placebo for 30 weeks. The primary efficacy endpoint is the change in Valsalva left ventricular outflow tract peak gradient determined by Doppler echocardiography.
Article
Clinical Neurology
Pedro M. Machado, Michael P. McDermott, Thomas Blaettler, Claus Sundgreen, Anthony A. Amato, Emma Ciafaloni, Miriam Freimer, Summer B. Gibson, Sarah M. Jones, Todd D. Levine, Thomas E. Lloyd, Tahseen Mozaffar, Aziz Shaibani, Matthew Wicklund, Anders Rosholm, Tim Dehli Carstensen, Karen Bonefeld, Anders Norkaer Jorgensen, Karina Phonekeo, Andrew J. Heim, Laura Herbelin, Richard J. Barohn, Michael G. Hanna, Mazen M. Dimachkie
Summary: Arimoclomol did not show efficacy in individuals with inclusion body myositis compared to placebo, but it had an acceptable safety profile. This study provides valuable data on disease progression for future clinical trial designs in inclusion body myositis.
Article
Medicine, General & Internal
Raymond Hang Wun Li, Sue Seen Tsing Lo, Kristina Gemzell-Danielsson, Carol Ho Yi Fong, Pak Chung Ho, Ernest Hung Yu Ng
Summary: This study found that co-administration of oral piroxicam 40 mg with levonorgestrel improved the efficacy of emergency contraception. The use of piroxicam could be considered in clinical settings where levonorgestrel emergency contraception is the chosen option.
Article
Rheumatology
Maria C. Cid, Sebastian H. Unizony, Daniel Blockmans, Elisabeth Brouwer, Lorenzo Dagna, Bhaskar Dasgupta, Bernhard Hellmich, Eamonn Molloy, Carlo Salvarani, Bruce C. Trapnell, Kenneth J. Warrington, Ian Wicks, Manoj Samant, Teresa Zhou, Lara Pupim, John F. Paolini
Summary: This study evaluated the efficacy of the GM-CSF receptor antagonist mavrilimumab in maintaining disease remission in patients with giant cell arteritis. The results showed that mavrilimumab plus prednisone was superior to placebo plus prednisone in terms of time to flare and sustained remission.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Nicolino Ruperto, Hermine Brunner, Olga Synoverska, Tracy Ting, Carlos Abud Mendoza, Alberto Spindler, Yulia Vyzhga, Katherine Marzan, Lyudmila Grebenkina, Irit Tirosh, Lisa Imundo, Rita Jerath, Daniel J. Kingsbury, Betul Sozeri, Sheetal S. Vora, Sampath Prahalad, Elena Zholobova, Yonatan Butbul Aviel, Vyacheslav Chasnyk, Melissa Lerman, Kabita Nanda, Heinrike Schmeling, Heather Tory, Yosef Uziel, Diego O. Viola, Holly B. Posner, Keith S. Kanik, Ann Wouters, Cheng Chang, Richard Zhang, Irina Lazariciu, Ming-Ann Hsu, Ricardo M. Suehiro, Alberto Martini, Daniel J. Lovell
Summary: The trial showed that tofacitinib is an effective treatment for patients with polyarticular course JIA. New oral therapies are particularly relevant for children and adolescents, who might prefer to avoid injections.
Article
Infectious Diseases
James Welker, Juan D. Pulido, Andrew T. Ca Tarizaro, Carlos D. Malvestutto, Zihai Li, Jona Than B. Cohen, Eric D. Whitman, Dana Byrne, Olivia K. Giddings, Jordan E. Lake, Joel Chua, Ella Li, Flan Chen, Xiang Zhou, Kun He, Davis Gates, Amarjot Kaur, Jamie Chen, Hung-Yen Chou, Martin Devenport, Raymond Tommy, Shyamasundaran Kottilil, Yang Liu, Pan Zheng
Summary: CD24Fc is well-tolerated and accelerates clinical improvement in hospitalised adults with COVID-19 receiving oxygen support.
LANCET INFECTIOUS DISEASES
(2022)
Article
Nutrition & Dietetics
M. A. Wyon, R. Wolman, C. Martin, S. Galloway
Summary: The study tested the efficacy of different delivery methods of vitamin D on serum 25(OH)D levels and found that oral vitamin D pills and skin oil application of vitamin D with essential oil enhancer were the most effective in increasing serum 25(OH)D levels.
CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Kenneth B. Gordon, Peter Foley, James G. Krueger, Andreas Pinter, Kristian Reich, Ronald Vender, Veerle Vanvoorden, Cynthia Madden, Katy White, Christopher Cioffi, Andrew Blauvelt
Summary: The study demonstrated that Bimekizumab showed high levels of response in patients with moderate to severe plaque psoriasis, with durable effects over 56 weeks under both maintenance dosing schedules (every 4 weeks and every 8 weeks). Additionally, Bimekizumab was well tolerated with no unexpected safety issues, further supporting its therapeutic value for this patient population.
Article
Medicine, General & Internal
Lulu Bravo, Igor Smolenov, Htay Htay Han, Ping Li, Ramona Hosain, Frank Rockhold, Sue Ann Costa Clemens, Camilo Roa, Charissa Borja-Tabora, Antoinette Quinsaat, Pio Lopez, Eduardo Lopez-Medina, Leonardo Brochado, Eder A. Hernandez, Humberto Reynales, Tatiana Medina, Hector Velasquez, Leonardo Bautista Toloza, Edith Johana Rodriguez, Dora Ines Molina de Salazar, Camilo A. Rodriguez, Eduardo Sprinz, Jose Cerbino-Neto, Kleber Giovanni Luz, Alexandre Vargas Schwarzbold, Maria Sanali Paiva, Josefina Carlos, May Emmeline B. Montellano, Mari Rose A. de Los Reyes, Charles Y. Yu, Edison R. Alberto, Mario M. Panaligan, Milagros Saivani-Bautista, Erik Buntinx, Maya Hites, Jean-Benoit Martinot, Qasim E. Bhorat, Aysha Badat, Carmen Baccarini, Branda Hu, Jaco Jurgens, Jan Engelbrecht, Donna Ambrosino, Peter Richmond, George Siber, Joshua Liang, Ralf Clemens
Summary: The SCB-2019 vaccine, supplemented with CpG and alum, provides significant protection against COVID-19 caused by different SAR-CoV-2 viruses, including the dominant Delta variant.
Article
Medicine, General & Internal
Sube Banerjee, Juliet High, Susan Stirling, Lee Shepstone, Ann Marie Swart, Tanya Telling, Catherine Henderson, Clive Ballard, Peter Bentham, Alistair Burns, Nicolas Farina, Chris Fox, Paul Francis, Robert Howard, Martin Knapp, Iracema Leroi, Gill Livingston, Ramin Nilforooshan, Shirley Nurock, John O'Brien, Annabel Price, Alan J. Thomas, Naji Tabet
Summary: This study evaluated the efficacy and safety of mirtazapine, an antidepressant, for treating agitation in patients with dementia. The findings showed that mirtazapine did not reduce agitation symptoms compared to placebo, and there was a potentially higher mortality rate associated with mirtazapine use.