Article
Psychology, Clinical
Rei Monden, Judith G. M. Rosmalen, Klaas J. Wardenaar, Francis Creed
Summary: This prospective population-based study assessed the predictors of new onsets of irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), and fibromyalgia (FM). The study found that syndrome-specific predictors were more common than shared ones. The study also revealed a close relationship between IBS and FM, which requires further research.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Immunology
Anna-Karin Norlin, Susanna Walter, Adriane Icenhour, Asa Keita, Sigrid Elsenbruch, Olga Bednarska, Michael P. Jones, Rozalyn Simon, Maria Engstrom
Summary: This study indicates that the vulnerability to fatigue in IBS is associated with connectivity within a mesocorticolimbic network as well as immune activation. Further investigations are needed to explore peripheral immune activation and potentially central immune activation measurements.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Zahid Ijaz Tarar, Umer Farooq, Ahmad Nawaz, Mustafa Gandhi, Yezaz A. Ghouri, Asmeen Bhatt, Brooks D. Cash
Summary: The study found a significant correlation between IBS and fibromyalgia and chronic fatigue syndrome (CFS), with higher prevalence rates in IBS patients compared to the general adult population without IBS. Different subtypes of IBS, age, gender, and race were identified as predictors for increased odds of fibromyalgia and CFS.
Article
Gastroenterology & Hepatology
Magdy El-Salhy, Tarek Mazzawi, Trygve Hausken, Jan Gunnar Hatlebakk
Summary: This study investigated the factors affecting the response to fecal microbiota transplantation (FMT) in irritable bowel syndrome (IBS) patients. The results showed that male patients and those with low fecal Alistipes levels are most likely to not respond to FMT treatment.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Bridgette Wilson, Tokuwa Kanno, Rachael Slater, Megan Rossi, Peter M. Irving, Miranda C. Lomer, Chris Probert, A. James Mason, Kevin Whelan
Summary: Baseline faecal and urine metabolites can predict response to the low FODMAP diet in patients with irritable bowel syndrome.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Adrijana DSilva, Deborah A. A. Marshall, Jeff K. K. Vallance, Yasmin Nasser, Vidya Rajagopalan, Jessie H. H. Szostakiwskyj, Maitreyi Raman
Summary: Delivering yoga virtually is an effective and safe method for managing irritable bowel syndrome (IBS) symptoms. However, the evidence for its efficacy, feasibility, and safety in patients with IBS has not been determined.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Magdy El-Salhy, Renate Winkel, Christina Casen, Trygve Hausken, Odd Helge Gilja, Jan Gunnar Hatlebakk
Summary: According to this study, FMT performed according to the protocol resulted in high treatment response rates and long-term effects, with only a few mild self-limited adverse events.
Article
Integrative & Complementary Medicine
Mingming Li, Jiawei Zhu, Xuan Liu, Zhiying Dong, Jigui Tang, Cian Zhang, Jianpeng Jiao, Jiani Chen, Fenghao Yin, Shi Qiu, Feng Zhang, Shouhong Gao, Zhipeng Wang, Xia Tao, Xiaoqiang Yue, Lianna Sun, Wansheng Chen
Summary: CGGD has been found to be more effective than Dicetel in treating patients with irritable bowel syndrome (IBS). The treatment with CGGD can improve gastrointestinal motility and suppress pain, depression, and inflammation, potentially explaining its efficacy against IBS. These findings provide insights into the underlying biomolecular mechanism of CGGD in the prevention and treatment of IBS.
Article
Gastroenterology & Hepatology
Cecilia Graciela Giadans, Daniela Alejandra Rios, Beatriz Ameigeiras, Leila Haddad, Elena Noemi De Matteo, Pamela Valva, Maria Victoria Preciado
Summary: The study reveals differences in hepatic immune components between chronic hepatitis B and C infections, with hepatitis C patients showing higher specific cell frequencies in intralobular areas and different immune dominance. Prevalence of distinct cell types varies between the two infections, highlighting unique immune responses.
JOURNAL OF VIRAL HEPATITIS
(2022)
Article
Gastroenterology & Hepatology
Irina Midenfjord, Adam Borg, Hans Tornblom, Magnus Simren
Summary: This study found that psychological alterations are common in patients with irritable bowel syndrome (IBS) and there is often overlap among various psychological factors. Five psychological factors (physical fatigue, GI-specific anxiety, perceived stress, pain catastrophizing, and trait anxiety) were significantly associated with the severity of GI symptoms. An increasing number of these psychological alterations also led to a gradual increase in the overall severity of GI symptoms.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Brian E. Lacy, Mark Pimentel, Darren M. Brenner, William D. Chey, Laurie A. Keefer, Millie D. Long, Baha Moshiree
Summary: Irritable bowel syndrome (IBS) is a chronic disorder that significantly impacts patients' quality of life. The American College of Gastroenterology has developed a clinical guideline using GRADE methodology for the management of IBS, recommending a positive diagnostic approach, specific tests, treatments, and gut-directed psychotherapy to improve symptoms for patients with IBS.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Psychology, Clinical
Jeffrey M. Lackner, Gregory D. Gudleski, Christopher D. Radziwon, Susan S. Krasner, Rebecca S. Firth, Bruce D. Naliboff, Alison M. Vargovich, Ashlye B. Borden, Emeran A. Mayer
Summary: This study found that CBT-treated IBS patients who learned to self-manage painful GI symptoms by targeting rigid cognitive style showed improvement in cognitive flexibility, GI symptoms, and quality of life.
BEHAVIOUR RESEARCH AND THERAPY
(2022)
Article
Health Care Sciences & Services
Tingting Zhao, Yiming Zhang, Joochul Lee, Angela R. Starkweather, Erin E. Young, Xiaomei Cong
Summary: This study found that certain genetic polymorphisms are associated with the risk and symptoms of irritable bowel syndrome, including abdominal pain, sleep disturbance, and fatigue. These findings contribute to the understanding of how genetic variations influence the development and changes of IBS symptoms over time.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Immunology
Shuqin Gu, Xin Fu, Guofu Ye, Chengcong Chen, Xiaoyi Li, Shihong Zhong, Libo Tang, Haitao Chen, Deke Jiang, Jinlin Hou, Yongyin Li
Summary: Persistent exposure to antigens during chronic hepatitis B infection leads to exhausted immune responses, hindering viral control. L-carnitine was found to modulate immune cells in chronic HBV infection by altering transcriptional profiles and suppressing T cell proliferation and function while enhancing other immune responses. The study suggests that manipulation of L-carnitine levels may influence the prognosis of patients with HBV infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Gregory S. Sayuk, Scott A. Waldman, Darren M. Brenner
Summary: This article summarizes the mechanisms of action of commonly used therapies for chronic idiopathic constipation and irritable bowel syndrome with constipation, explaining how these mechanisms contribute to the effectiveness and safety of each treatment option.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Surgery
Antonio Iannelli, Julie Bulsei, Tarek Debs, Albert Tran, Andrea Lazzati, Jean Gugenheim, Rodolphe Anty, Niccolo Petrucciani, Eric Fontas
Summary: The study found no significant differences between patients with a history of bariatric surgery and obese patients without history of bariatric surgery undergoing liver transplantation in terms of mortality rates, re-transplantation rates, re-hospitalization rates, and costs of hospitalization and re-hospitalizations.
Article
Gastroenterology & Hepatology
Carmelo Luci, Elodie Vieira, Manon Bourinet, Deborah Rousseau, Stephanie Bonnafous, Stephanie Patouraux, Lauren Lefevre, Frederic Larbret, Virginie Prod'homme, Antonio Iannelli, Albert Tran, Rodolphe Anty, Beatrice Bailly-Maitre, Marcel Deckert, Philippe Gual
Summary: The SYK-3BP2 pathway plays an important role in the pathogenesis of chronic liver inflammatory diseases. Targeting the SYK-3BP2 pathway in myeloid cells and hepatocytes can effectively control liver inflammation and fibrosis, which may be a potential strategy for treating metabolic steatohepatitis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Osman Oecal, Regina Schinner, Kerstin Schuette, Enrico N. de Toni, Christian Loewe, Otto van Delden, Vincent Vandecaveye, Bernhard Gebauer, Christoph J. Zech, Christian Sengel, Irene Bargellini, Antonio Gasbarrini, Bruno Sangro, Maciej Pech, Peter Malfertheiner, Jens Ricke, Max Seidensticker
Summary: The study aimed to explore the relationship between follow-up imaging characteristics and overall survival in advanced HCC patients under sorafenib treatment. Objective response and early tumor shrinkage were found to be independent prognostic factors for OS in patients with HCC.
Article
Medicine, General & Internal
Wladimir Mauhin, Abdellah Tebani, Damien Amelin, Lenaig Abily-Donval, Foudil Lamari, Jonathan London, Claire Douillard, Bertrand Dussol, Vanessa Leguy-Seguin, Esther Noel, Agathe Masseau, Didier Lacombe, Helene Maillard, Soumeya Bekri, Olivier Lidove, Olivier Benveniste
Summary: The study found that there are differences in S1P levels between the classic and non-classic phenotypes of Fabry disease. Non-classic phenotype patients have higher S1P levels, while classic phenotype patients have higher lysoGb3 concentrations. S1P levels are correlated with interventricular septum thickness, but age is the key factor influencing the risk of HCM.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Ivana Dabaj, Adnan Hassani, Lydie Burglen, Leila Qebibo, Anne-Marie Guerrot, Stephane Marret, Abdellah Tebani, Soumeya Bekri
Summary: Pontocerebellar hypoplasia (PCH) is a neurodegenerative disorder that leads to severe neurodevelopmental disabilities. This study reports a case of PCH1D in an infant with two variants in the EXOSC9 gene and highlights the crucial role of the exosome in cellular homeostasis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Audrey Laurain, Isabelle Rubera, Micheline Razzouk-Cadet, Stephanie Bonnafous, Miguel Albuquerque, Valerie Paradis, Stephanie Patouraux, Christophe Duranton, Olivier Lesaux, Georges Leftheriotis, Albert Tran, Rodolphe Anty, Philippe Gual, Antonio Iannelli, Guillaume Favre
Summary: Liver fibrosis is associated with arterial calcification. Plasma inorganic pyrophosphate (PPi) levels are correlated with liver fibrosis, liver function, and arterial calcification. Liver transplantation can restore serum albumin levels and PPi levels.
Article
Biochemistry & Molecular Biology
Stephen J. J. Staklinski, Sarah Snanoudj, Anne-Marie Guerrot, Catherine Vanhulle, Francois Lecoquierre, Soumeya Bekri, Michael S. S. Kilberg
Summary: Asparagine Synthetase Deficiency (ASNSD) is caused by mutations in the ASNS gene and leads to microcephaly, seizures, brain atrophy, and developmental delays. A 9-year-old child with ASNSD was found to have compound heterozygous mutations and reduced proliferation in cells lacking asparagine. Enzymatic activity and protein expression studies in ASNS-null cells further elucidate the biological impact of ASNS mutations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Lucy Meunier, Mohamed Belkacemi, George Philippe Pageaux, Sylvie Radenne, Anais Vallet-Pichard, Pauline Houssel-Debry, Christophe Duvoux, Danielle Botta-Fridlund, Victor de Ledinghen, Filomena Conti, Rodolphe Anty, Vincent Di Martino, Marilyne Debette-Gratien, Vincent Leroy, Theophile Gerster, Pascal Lebray, Laurent Alric, Armand Abergel, Jerome Dumortier, Camille Besch, Helene Montialoux, Didier Samuel, Jean-Charles Duclos-Vallee, Audrey Coilly
Summary: This study examined the clinical outcomes of patients with cirrhosis or hepatocellular carcinoma who were treated with direct-acting antiviral agents while awaiting liver transplantation. The results showed that these drugs are safe and effective in achieving viral eradication and improving the clinical condition of patients.
Review
Biochemistry & Molecular Biology
Marwin A. Farrugia, Sebastien Le Garf, Andrea Chierici, Thierry Piche, Philippe Gual, Antonio Iannelli, Rodolphe Anty
Summary: In recent years, physical exercise interventions have been developed to reduce comorbidity and morbidity rates among patients with chronic diseases. Regular exercise has shown benefits for patients with type 2 diabetes and can potentially improve liver health in patients with cirrhosis. A systematic review of studies on personalized exercise programs suggests improvements in physical performance measures and liver function in cirrhotic patients. However, further research is needed to evaluate the long-term benefits of exercise programs in this population.
Review
Medicine, General & Internal
Thomas Levi-Strauss, Bettina Tortorici, Olivier Lopez, Philippe Viau, Dann J. Ouizeman, Baptiste Schall, Xavier Adhoute, Olivier Humbert, Patrick Chevallier, Philippe Gual, Lionel Fillatre, Rodolphe Anty
Summary: Radiomics, a combination of radiology and artificial intelligence, utilizes quantitative and high-throughput analysis of medical images to provide relevant information for diagnosis and treatment guidance. It has the potential to be a new biomarker in precision medicine, especially in oncology, where it can analyze the entire tumor and understand its heterogeneity and prognosis. However, current results sometimes lack accuracy and require additional non-radiomics data for a performing model.
Article
Biochemistry & Molecular Biology
Marwin A. Farrugia, Maena Le Corvec, Christophe Renou, Jean-Baptiste J. Nousbaum, Dann J. Ouizeman, Olivier Sire, Olivier Loreal, Hugues Tariel, Jerome Bernard, Thierry Piche, Albert Tran, Hafid Ait-Oufella, Luce Landraud, Philippe Gual, Rodolphe Anty
Summary: This study aimed to evaluate the diagnostic value of a rapid and easy-to-use mid-infrared fiber evanescent wave spectroscopy (MIR-FEWS) method for ruling out spontaneous bacterial peritonitis (SBP). The results showed that MIR-FEWS is a highly sensitive diagnostic method for ruling out SBP.
Article
Gastroenterology & Hepatology
Philippe Onana Ndong, Hanae Boutallaka, Eugenia Marine-Barjoan, Dann Ouizeman, Raja Mroue, Rodolphe Anty, Geoffroy Vanbiervliet, Thierry Piche
Summary: The study aimed to determine the prevalence of small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome (IBS) and examine the correlation between methane and hydrogen levels and IBS severity. The results showed a high prevalence of SIBO in IBS, but it did not increase the severity of the condition. Individual sensitivity to pain may have a greater impact on the severity of IBS.
Article
Medical Laboratory Technology
Abdellah Tebani, Frederic Barbey, Olivier Dormond, Franklin Ducatez, Stephane Marret, Albina Nowak, Soumeya Bekri
Summary: Fabry disease is an X-linked lysosomal rare disease caused by a deficiency of α-galactosidase A activity. The accumulation of glycosphingolipids affects the kidney, heart, and central nervous system, reducing life expectancy. A deep plasma proteomic profiling identified proteomic profiles that could distinguish FD patients from controls, highlighting the involvement of pro-inflammatory cytokines and extracellular matrix remodeling in FD pathogenesis. These findings will contribute to better understanding of the molecular mechanisms in FD and future diagnostic and therapeutic advancements.
TRANSLATIONAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Pierre Nahon, Marie Najean, Richard Layese, Kevin Zarca, Laeticia Blampain Segar, Carole Cagnot, Nathalie Ganne-Carrie, Gisele N'Kontchou, Stanislas Pol, Cendrine Chaffaut, Fabrice Carrat, Maxime Ronot, Etienne Audureau, Isabelle Durand-Zaleski
Summary: This study aimed to evaluate the cost-effectiveness of using magnetic resonance imaging (MRI) for the detection of very early hepatocellular carcinoma (HCC) in French patients with an annual HCC risk >3%. The results showed that MRI was cost-effective in this population and could favor early HCC detection.
Article
Pharmacology & Pharmacy
Tangui Barre, Stanislas Pol, Clemence Ramier, Vincent Di Beo, Fabrice Carrat, Morgane Bureau, Marc Bourliere, Celine Dorival, Lawrence Serfaty, Tarik Asselah, Jerome Boursier, Fabienne Marcellin, Patrizia Carrieri, Helene Fontaine, Camelia Protopopescu
Summary: The study found that cannabis use was associated with lower risks of overweight and obesity in patients with HBV chronic infection. Further research is needed to explore whether these benefits of cannabis and cannabinoid use can lead to reduced liver disease progression in this high-risk population.
CANNABIS AND CANNABINOID RESEARCH
(2022)
