Article
Nutrition & Dietetics
Bojung Seo, Keming Yang, Ka Kahe, Abrar A. Qureshi, Andrew T. Chan, Immaculata De Vivo, Eunyoung Cho, Edward L. Giovannucci, Hongmei Nan
Summary: This study suggests that higher intakes of DHA and consumption of canned tuna are associated with longer leukocyte telomere length (LTL) in US males.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Environmental Sciences
Priyanshi Sikka, Tapan Behl, Sanchay Sharma, Aayush Sehgal, Saurabh Bhatia, Ahmed Al-Harrasi, Sukhbir Singh, Neelam Sharma, Lotfi Aleya
Summary: Ω-3 fatty acids are recognized for their benefits on physical and mental health, primarily obtained from fish and fish products. Adequate intake of Ω-3 fatty acids can improve brain function and neuronal function, reduce depressive symptoms, and have fewer side effects compared to antidepressants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Richard L. Weinberg, Robert D. Brook, Melvyn Rubenfire, Kim A. Eagle
Summary: Omega-3 polyunsaturated fatty acids play a key role in heart-healthy diet, and can be obtained through fatty fish consumption or fish oil supplementation. They not only treat hypertriglyceridemia, but also prevent cardiovascular events, with additional benefits such as reducing inflammation and improving plaque stability.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Nutrition & Dietetics
Peder L. Myhre, Trygve Berge, Are A. Kalstad, Sjur H. Tveit, Kristian Laake, Erik B. Schmidt, Svein Solheim, Harald Arnesen, Ingebjorg Selje, Arnljot Tveit
Summary: Recent clinical trials have raised concerns about the potential adverse effects of n-3 polyunsaturated fatty acid supplementation on atrial fibrillation (AF) risk. This study aimed to assess the risk and potential mediators of AF and 'micro-AF' from n-3 PUFA in post-MI patients. The results showed that supplementation of n-3 PUFA increased the risk of 'micro-AF' and AF, and changes in EPA seemed to play an important role in mediating this effect. Rating: 8 out of 10.
CLINICAL NUTRITION
(2023)
Article
Agriculture, Multidisciplinary
Xiao-Yu Cui, Shan Jiang, Cheng-Cheng Wang, Jin-Yue Yang, Ying-Cai Zhao, Chang-Hu Xue, Yu-Ming Wang, Tian-Tian Zhang
Summary: The study demonstrated that EPA-PC, EPA-LPC, and DHA-LPC have different effects on DHA or EPA recovery and supplementation efficiency in different tissues, providing important references for understanding the time course of DHA or EPA recovery in phospholipid molecular species in different tissues.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Maria Dolores Mesa, Fernando Gil, Pablo Olmedo, Angel Gil
Summary: This study aims to estimate the amount of n-3 LC-PUFA provided by commonly consumed fishes, shrimps, and mollusks, to conduct a risk-benefit analysis of fish consumption. Consuming 2-3 servings of a variety of fishery products per week can help meet recommended n-3 LC-PUFA levels while maintaining a balance to avoid potential risks from contaminants.
Article
Fisheries
David Huyben, Teresa Grobler, Chessor Matthew, Marta Bou, Bente Ruyter, Brett Glencross
Summary: The requirement for omega-3 long-chain polyunsaturated fatty acids for Atlantic salmon is relative to the dietary lipid level, with high n-3 diets contributing to increased body weight and weight gain.
Article
Biochemistry & Molecular Biology
Ines Drenjancevic, Jan Pitha
Summary: In addition to proven medications, omega-3 polyunsaturated fatty acids (n-3 PUFAs) are considered to have additive effects on cardiovascular health. They influence the cardiovascular system through various mechanisms, including effects on metabolism, inflammation, thrombosis, and direct effects on cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Stephen W. Farrell, Laura F. DeFina, Nathan L. Tintle, David Leonard, Kenneth H. Cooper, Carolyn E. Barlow, William L. Haskell, Andjelka Pavlovic, William S. Harris
Summary: Both this study and a meta-analysis of similar studies found no evidence to suggest that consuming n-3 PUFA-rich fish or using fish oil supplements affects the risk of prostate cancer.
Review
Nutrition & Dietetics
Clemens von Schacky
Summary: The structure and function of the brain rely on a sufficient supply of EPA and DHA through the bloodstream. Lower Omega-3 Index levels are associated with increased risks, highlighting the importance of adequate intake of these essential fatty acids for optimal brain health.
Review
Medicine, General & Internal
Safi U. Khan, Ahmad N. Lone, Muhammad Shahzeb Khan, Salim S. Virani, Roger S. Blumenthal, Khurram Nasir, Michael Miller, Erin D. Michos, Christie M. Ballantyne, William E. Boden, Deepak L. Bhatt
Summary: Omega-3 fatty acids reduce cardiovascular mortality and improve cardiovascular outcomes, with higher efficacy observed with EPA monotherapy compared to EPA+DHA combination therapy.
Article
Sport Sciences
Jon-Kyle Davis, Eric C. Freese, Anthony S. Wolfe, Steven A. Basham, Kimberly M. W. Stein
Summary: The study evaluated the omega-3 PUFA blood concentrations, dietary, and supplement intake of 119 professional basketball players, with many players having insufficient fish consumption per week and only a few players supplementing with omega-3 PUFA.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Article
Nutrition & Dietetics
Annette L. West, Elizabeth A. Miles, Lihua Han, Karen A. Lillycrop, Johnathan A. Napier, Philip C. Calder, Graham C. Burdge
Summary: The study showed that transgenic Camelina sativa seed oil and fish oil are both effective in increasing the levels of eicosapentaenoic acid and docosahexaenoic acid in white blood cells. The alteration of T cell transcriptome induced by mitogens varied between the two oils, with changes related to cell proliferation and immune function. The incorporation of these fatty acids into immune cells was comparable between the two oils, suggesting potential benefits for immune function.
Article
Biochemistry & Molecular Biology
Juan Li, Meiru Mao, Jiacheng Li, Ziteng Chen, Ying Ji, Jianglong Kong, Zhijie Wang, Jiaxin Zhang, Yujiao Wang, Wei Liang, Haojun Liang, Linwen Lv, Qiuyang Liu, Ruyu Yan, Hui Yuan, Kui Chen, Yanan Chang, Guogang Chen, Gengmei Xing
Summary: This study assessed the effects of omega-3 fatty acids on alleviating inflammation and lung injury induced by PM2.5 inhalation exposure. It was found that oral administration of DHA and EPA effectively restored normal inflammatory cytokine levels and reduced lung parenchymal lesions in mice exposed to PM2.5.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Karan Kapoor, Abdulhamied Alfaddagh, Mahmoud Al Rifai, Deepak L. Bhatt, Matthew J. Budoff, Khurram Nasir, Michael Miller, Francine K. Welty, J. William McEvoy, Zeina Dardari, Michael D. Shapiro, Roger S. Blumenthal, Michael Y. Tsai, Michael J. Blaha
Summary: Analysis of the MESA cohort study found that higher baseline levels of EPA and EPA+DHA were significantly associated with lower rates of bleeding, while higher levels of DHA were significantly associated with lower rates of AF, in both unadjusted and adjusted models.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Oncology
Danielle S. Meyer, Amy E. Millen, Jing Nie, Maurizio Trevisan, Jo L. Freudenheim
Summary: No significant association was found between prediagnostic dietary fat intake and breast cancer mortality in a population-based cohort of breast cancer survivors.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Clinical Neurology
Reemal Zaheer, Roma Amin, LaTasha Riddick, Shuvro Roy, Sujin Wolff, Amy Nathanson, Scott Newsome
Summary: This study found that the prescribing patterns and therapy modifications of disease modifying therapies (DMTs) for multiple sclerosis (MS) patients were influenced by COVID-19, with a decrease in infusion therapies and delays in infusion therapies. However, prescribing patterns of oral therapies remained stable. These findings provide background and references for future studies on MS treatment.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Microbiology
Peter G. G. Shields, Kevin L. L. Ying, Theodore M. M. Brasky, Jo L. L. Freudenheim, Zihai Li, Joseph P. P. McElroy, Sarah A. A. Reisinger, Min-Ae Song, Daniel Y. Y. Weng, Mark D. D. Wewers, Noah B. B. Whiteman, Yiping Yang, Ewy A. A. Mathe
Summary: Smokers and electronic cigarette users have increased lung immune cell counts and inflammatory gene expression compared to never-smokers. This study aimed to further assess associations between lung microbiomes, immune cell subtypes, and inflammatory gene expression in smokers and electronic cigarette users. The results showed a two-fold increase in undifferentiated macrophages (M0) and a decrease in anti-inflammatory macrophages (M2) in smokers and electronic cigarette users. There were significantly differentially expressed inflammatory genes between smokers/never-smokers, smokers/electronic cigarette users, and electronic cigarette users/never-smokers, with CSF-1 and GATA3 expression correlating with M0 and M2 macrophages, respectively. Distinct lung profiles were observed for each participant group, and correlations were found between bacterial genera-DEG as well as bacterial genera-macrophage subtypes. This pilot study suggests that both smoking and electronic cigarette use have toxic effects on the lungs, but these effects may not be mediated through changes in the microbiome.
Article
Environmental Sciences
Adana A. M. Llanos, Amber Rockson, Kylie Getz, Patricia Greenberg, Eva Portillo, Jasmine A. McDonald, Dede K. Teteh, Justin Villasenor, Carolina Lozada, Jamirra Franklin, Vaishnavi More, Zorimar Rivera-Nunez, Carolyn W. Kinkade, Emily S. Barrett
Summary: Evidence shows that certain groups, such as femme-identifying individuals and racial and ethnic minorities, bear unequal burdens of chemical exposures from personal care products (PCPs). This study used an online questionnaire to assess PCP purchasing and usage behaviors and perceptions among a sample of US adults. The findings indicate that females use more PCPs than males, and there are variations in usage patterns among different racial and ethnic groups. Study participants generally expressed moderate concern about exposures and health effects from using PCPs, with minimal differences by gender, race, and ethnicity.
ENVIRONMENTAL RESEARCH
(2023)
Article
Oncology
Irina B. Grafova, Sharon L. Manne, Shawna V. Hudson, Jennifer Elliott, Adana A. M. Llanos, Biren Saraiya, Paul R. Duberstein
Summary: This study examines the associations between functional limitations and medical and credit card debt among cancer survivor families and finds sex differences. The results show that credit card debt is more common than medical debt, and families of male cancer survivors are more likely to have medical debt and less likely to have credit card debt compared to families of female cancer survivors.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Nutrition & Dietetics
Zeinab Farhat, Tyler Scheving, Diana S. Aga, Pamela A. Hershberger, Jo L. Freudenheim, Rachael Hageman Blair, Manoj J. Mammen, Lina Mu
Summary: This study aimed to compare the antioxidant and antiproliferative activity of different forms of garlic. The results showed that Garlicin (R) supplement had high antioxidant activity and strong inhibitory effect on the proliferation of lung cancer cells. Other forms of garlic, such as garlic powder and black garlic, had lower antioxidant and antiproliferative activity.
Article
Multidisciplinary Sciences
Alexandra Ioana Moatar, Aimee Rodica Chis, Mirabela Romanescu, Paula-Diana Ciordas, Diana Nitusca, Catalin Marian, Cristian Oancea, Ioan-Ovidiu Sirbu
Summary: This study evaluated the early level of circulating miR-195 in Covid-19 patients and found it to be a potential biomarker of disease severity. miR-195 is associated with several clinical and paraclinical parameters and can effectively discriminate between severe and mild forms of the disease. The study also suggests a possible role of miR-195 in long Covid and chronic fatigue syndrome.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Ana-Maria Marin, Dan-Cornel Popovici, Gheorghe Darabus, Catalin Marian, Diana Nitusca, Narcisa Mederle
Summary: This study confirms the presence of Trichinella britovi in raccoon dogs for the first time by detecting the parasite larvae in muscle samples from Romania.
Article
Biochemistry & Molecular Biology
Amarnath Singh, Garrett Kinnebrew, Ping-Ching Hsu, Daniel Y. Weng, Min-Ae Song, Sarah A. Reisinger, Joseph P. Mcelroy, Brittney Keller-Hamilton, Amy K. Ferketich, Jo L. Freudenheim, Peter G. Shields
Summary: Obesity in children and adolescents has become a global issue with long-term adverse health outcomes. Using untargeted metabolomics, this study identified metabolic features associated with BMI in male adolescents, suggesting potential biomarkers for investigating the underlying pathological mechanisms of obesity.
Article
Biochemistry & Molecular Biology
Liana Maries, Alexandra Ioana Moatar, Maria Sala-Cirtog, Laurentiu Sima, Andrei Anghel, Catalin Marian, Aimee Rodica Chis, Ioan-Ovidiu Sirbu
Summary: Left ventricle remodeling after acute myocardial infarction is a significant contributor to heart failure, but predicting it remains challenging. This study found that certain circulant microRNAs may not be effective in distinguishing patients with left ventricle remodeling from those without.
Article
Biochemistry & Molecular Biology
Liana Maries, Alexandra Ioana Moatar, Aimee Rodica Chis, Catalin Marian, Constantin Tudor Luca, Ioan-Ovidiu Sirbu, Dan Gaita
Summary: Left ventricle remodeling after acute myocardial infarction leads to heart failure, but predicting this remodeling is challenging. This study found that the microRNA miR-22 can accurately distinguish between patients with and without left ventricle remodeling. The predictive power of miR-22 is even better when combined with other clinical variables. miR-22 may be a useful predictor of ventricular function recovery in STEMI patients.
Article
Biochemistry & Molecular Biology
Diana Nitusca, Carmen Socaciu, Andreea Iulia Socaciu, Ioan Ovidiu Sirbu, Razvan Bardan, Alin Adrian Cumpanas, Edward Seclaman, Catalin Marian
Summary: Prostate cancer is a leading cause of cancer mortality in men worldwide, with a lack of specific early detection and staging biomarkers. This study identified five potential biomarkers for prostate cancer using metabolomics, with all the molecules displaying decreased levels in prostate cancer plasma samples. The high diagnostic accuracy of these metabolites suggests their potential as non-invasive biomarkers for prostate cancer detection.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Medicine, General & Internal
Simona-Alina Abu-Awwad, Marius Craina, Adrian Gluhovschi, Paula Diana Ciordas, Catalin Marian, Lioara Boscu, Elena Bernad, Mircea Iurciuc, Ahmed Abu-Awwad, Stela Iurciuc, Anca Laura Maghiari
Summary: This study investigated whether pregnant women with cardiovascular risk have shorter telomeres compared to those without cardiovascular risk. The results showed that pregnant women with cardiovascular risk had significantly shorter telomeres, which may have implications for the long-term health of both the mother and the child.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Ionut Dragos Capraru, Dan Dumitru Vulcanescu, Iulia Cristina Bagiu, Florin George Horhat, Irina Maria Popescu, Luminita Mirela Baditoiu, Delia Muntean, Monica Licker, Matilda Radulescu, Ion Cristian Mot, Mircea Mihai Diaconu, Catalin Marian
Summary: This study aimed to investigate the associations between biomarkers CRP, LDH, CK, 25-OHD, ferritin, HDL cholesterol, and clinical severity in COVID-19 patients in Romania, and their potential use in predicting ICU admission and death. The results showed that CRP, LDH, 25-OHD, ferritin, and HDL are important biomarkers for COVID-19 positive patients, especially in the pediatric population, while CK was mostly within normal ranges.
MEDICINA-LITHUANIA
(2023)
Article
Pharmacology & Pharmacy
Iosif Ilia, Doina Chioran, Daniela Radu, Raul Chioiba, Ioana Ionita, Catalin Marian, Alexandra Semenescu, Robert Cosmin Racea, Ramona Popovici, Stefania Dinu, Mircea Rivis, Andrada Iftode
Summary: Hyaluronic acid has the potential to be an effective candidate for the treatment of osteosarcoma, as it can induce cell apoptosis and alter gene expression. However, further research is needed to elucidate the molecular mechanisms involved.