Review
Medicine, General & Internal
Lumir Kunovsky, Petr Dite, Petr Jabandziev, Michal Eid, Karolina Poredska, Jitka Vaculova, Dana Sochorova, Pavel Janecek, Pavla Tesarikova, Martin Blaho, Jan Trna, Jan Hlavsa, Zdenek Kala
Summary: Exocrine pancreatic insufficiency (EPI) is caused by primary pancreatic disease or impaired exocrine pancreatic function, with chronic pancreatitis being the most common cause. Other causes include pancreatic tumors, pancreatic surgery, and cystic fibrosis. Pancreatic enzyme replacement therapy is recommended for clinically evident steatorrhea, weight loss, or symptoms of maldigestion and malabsorption associated with EPI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Andrew Cannon, Christopher Michael Thompson, Rakesh Bhatia, Katharine Anne Armstrong, Joyce Christopher Solheim, Sushil Kumar, Surinder Kumar Batra
Summary: This review discusses the key signaling events that drive pancreatic myofibroblast activation, as well as their crosstalk with the tumor microenvironment. The association of lifestyle factors with pancreatic pathologies is also explored, providing insight into potential therapeutic targets.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Tobias Schlosser, Daniel Fischer, Sandra Buettner, Valentin Blank, Albrecht Hoffmeister
Summary: In this study, CFTR dysfunction was found to be an etiological factor of chronic pancreatitis through measurement of nasal potential difference. Smoking might impair CFTR function and therefore could be a preventable cause of chronic pancreatitis.
Article
Pharmacology & Pharmacy
Bitna Kweon, Dong-Uk Kim, Jin-Young Oh, Hyuncheol Oh, Youn-Chul Kim, Yeun-Ja Mun, Gi-Sang Bae, Sung-Joo Park
Summary: Arecae pericarpium (ARP) exhibits anti-fibrotic effects in cerulein-induced chronic pancreatitis (CP), improving glandular atrophy, inflammation, and repressing collagen deposition in the pancreas.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Man Chang, Wenjuan Chen, Ruting Xia, Yangyue Peng, Pandi Niu, Hui Fan
Summary: This article reviews the interaction between chronic pancreatitis and pancreatic fibrosis, summarizes the activation mechanisms of pancreatic stellate cells, and investigates potential therapeutic strategies targeting these cells, including anti-fibrosis therapy, antioxidant therapy, and gene therapy.
Article
Pharmacology & Pharmacy
Jianwei Fan, Lifang Duan, Nan Wu, Xiaofan Xu, Jiaqi Xin, Shengnan Jiang, Cheng Zhang, Hong Zhang
Summary: Baicalin has been shown to inhibit the activation of pancreatic stellate cells (PSCs), reduce pancreatic inflammation and fibrosis, and decrease the levels of various markers associated with fibrosis in the pancreas. It inhibits the TGF-beta 1/TGF-beta R1/TAK1/NF-kappa B signaling pathway, leading to decreased MCP-1 secretion and reduced infiltration of macrophages and inflammation cells in the pancreas. This study provides a basis for the potential use of baicalin in the prevention and treatment of chronic pancreatitis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Decai Wang, Shengbo Han, Guozheng Lv, Yuhang Hu, Wenfeng Zhuo, Zhu Zeng, Jiang Tang, Yan Huang, Fan Wang, Jie Wang, Yong Zhao, Gang Zhao
Summary: In chronic pancreatitis (CP), injured pancreatic acinar cells (iPACs) induce autophagy and activation of activated pancreatic stellate cells (PSCs) through the sphingosine kinase 1 (SPHK1)/sphingosine 1-phosphate (S1P) pathway, promoting pancreatic fibrogenesis.
Review
Pharmacology & Pharmacy
Yang Wu, Chun Zhang, Mei Guo, Weikang Hu, Yangling Qiu, Mengran Li, Dong Xu, Pengfei Wu, Jing Sun, Run Shi, Zili Zhang, Kuirong Jiang
Summary: Chronic pancreatitis (CP) is a precancerous illness associated with pancreatic ductal adenocarcinoma (PDAC), but the mechanism of evolution is uncertain. CP is characterized by severe fibrosis caused by the activation of pancreatic stellate cells (PSCs). The current clinical therapeutic protocol lacks specific medicines for preventing and suppressing inflammation and fibrosis in CP. Research on targeting PSCs could lead to the development of novel therapies for pancreatic fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Dora Angyal, Marcel J. C. Bijvelds, Marco J. Bruno, Maikel P. Peppelenbosch, Hugo R. de Jonge
Summary: This review examines the role of CFTR in driving chloride, bicarbonate, and fluid secretion in the pancreatic duct, focusing on its involvement in genetic and acquired forms of pancreatitis. The potential of CFTR modulator therapy and the use of pancreatic organoids to study CFTR function are also discussed.
Article
Cell Biology
Yinjie Zhang, Baibing Yang, Joy M. Davis, Madeline M. Drake, Mamoun Younes, Qiang Shen, Zhongming Zhao, Yanna Cao, Tien C. Ko
Summary: We identified a distinct set of differentially expressed genes (DEGs) associated with extracellular matrix and cancer cell activities during the transition from chronic pancreatitis (CP) to recovery. DEGs relevant to DNA methylation and specific signaling pathways were induced during ongoing CP recovery. These shared and specific DEGs may serve as unique transcriptomic signatures and biomarkers for determining CP recovery and monitoring therapeutic responses.
MEDIATORS OF INFLAMMATION
(2021)
Article
Nutrition & Dietetics
Mette F. Olsen, Maria S. Kjoller-Svarre, Grith Moller, Terese L. Katzenstein, Bibi U. Nielsen, Tacjana Pressler, Jack Lewis, Inger H. Mathiesen, Christian Molgaard, Daniel Faurholt-Jepsen
Summary: This study describes the use of pancreatic enzyme replacement therapy (PERT) in adult patients with cystic fibrosis and assesses the factors associated with PERT dosage. The study found that PERT dosage is correlated with patients' sex, age, weight, frequency of constipation, and lung transplantation.
Article
Immunology
Xiao-Fan Xu, Jian-Wei Fan, Jia-Qi Xin, Nan Wu, He Gao, Li-Fang Duan, Wen-Bin Zou, Hong Zhang, Zhao-Shen Li
Summary: This study found that aspirin treatment can improve chronic pancreatitis by inhibiting pancreatic inflammation and fibrosis, which may be a promising option for clinical treatment.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Respiratory System
Ido Sadras, Malena Cohen-Cymberknoh, Eitan Kerem, Benjamin Z. Koplewitz, Natalia Simanovsky, Michael Wilschanski, Liron Birimberg-Schwartz, Oded Breuer
Summary: Cystic fibrosis transmembrane conductance regulator modulator therapy has been shown to have significant clinical benefits in patients with cystic fibrosis (CF), but its impact on the pancreas is still being investigated. Two cases presented acute pancreatitis after initiating elexacaftor/tezacaftor/ivacaftor modulator therapy, suggesting that modulator combination therapy may restore pancreatic acinar activity and lead to acute pancreatitis before ductal flow is improved.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Review
Nutrition & Dietetics
Peter N. Freswick, Elizabeth K. Reid, Maria R. Mascarenhas
Summary: Cystic fibrosis patients experience significant nutritional complications and comorbidities, especially those with pancreatic insufficiency. Prompt initiation of pancreatic enzymatic replacement therapy (PERT) is crucial and involves considerations such as administration methods, therapy failures, and complications.
Article
Nutrition & Dietetics
Tara L. Barto, Clarissa F. Morency, Nicoline Schaap, Ami B. Patel, Daniel J. Monticello
Summary: This study evaluated the serum triglyceride levels and tolerability in cystic fibrosis patients with exocrine pancreatic insufficiency (EPI) following the consumption of an enzyme-modified oil oral nutritional supplement (EMO-ONS) and a standard triacylglycerol-based ONS product (TAG-ONS) used concomitantly with pancreatic enzyme replacement therapy (PERT). The results showed similar effects on serum triglyceride levels and gastrointestinal tolerance between the two approaches. Therefore, EMO-based products may provide an alternative to traditional ONS products for cystic fibrosis patients without the need for PERT.
Editorial Material
Medicine, General & Internal
Gary James Connett, Lucy Anne Connett, Mike Thomas
BMJ-BRITISH MEDICAL JOURNAL
(2019)
Article
Infectious Diseases
Odel Soren, Ardeshir Rineh, Diogo G. Silva, Yuming Cai, Robert P. Howlin, Raymond N. Allan, Martin Feelisch, Jane C. Davies, Gary J. Connett, Saul N. Faust, Michael J. Kelso, Jeremy S. Webb
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2020)
Article
Respiratory System
Adam J. Causer, Janis K. Shute, Michael H. Cummings, Anthony Shepherd, Samuel R. Wallbanks, Mark Allenby, Irantzu Arregui-Fresneda, Victoria Bright, Mary P. Carroll, Gary Connett, Thomas Daniels, Tom Meredith, Zoe L. Saynor
JOURNAL OF CYSTIC FIBROSIS
(2020)
Letter
Respiratory System
Charlotta Pisinger, Jorgen Vestbo
EUROPEAN RESPIRATORY JOURNAL
(2020)
Editorial Material
Critical Care Medicine
Andy Bush, Jayesh M. Bhatt, Gary J. Connett, Iolo Doull, Francis J. Gilchrist, Jonathan Grigg, Simon C. Langton Hewer, Julian Legg, Warren Lenney, Ian P. Sinha
LANCET RESPIRATORY MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Adam J. Causer, Janis K. Shute, Michael H. Cummings, Anthony Shepherd, Mathieu Gruet, Joseph T. Costello, Stephen Bailey, Martin Lindley, Clare Pearson, Gary Connett, Mark Allenby, Mary P. Carroll, Thomas Daniels, Zoe L. Saynor
Article
Respiratory System
Sneha Varkki, Antony Terance Benjamin, Rekha Athiyarath, Sumita Danda, Ravikumar Sowmya, Gary Connett
JOURNAL OF CYSTIC FIBROSIS
(2021)
Article
Nutrition & Dietetics
Raquel Revuelta Iniesta, Adam J. Causer, Irantzu Arregui-Fresneda, Gary Connett, Mark I. Allenby, Thomas Daniels, Mary P. Carroll, Don S. Urquhart, Zoe L. Saynor
Summary: The study found that 25OHD is associated with improved lung function and aerobic fitness in children and adolescents with CF. However, in all pwCF, the relationship between 25OHD and FEV1% predicted or VO2 peak was not significant.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Respiratory System
Ruth H. Keogh, Rebecca Cosgriff, Eleni-Rosalina Andrinopoulou, Keith G. Brownlee, Siobhan B. Carr, Karla Diaz-Ordaz, Emily Granger, Nicholas P. Jewell, Alex Lewin, Clemence Leyrat, Daniela K. Schluter, Maarten van Smeden, Rhonda D. Szczesniak, Gary J. Connett
Summary: This study projects the population-level impact of the new CF drug ELEX/TEZ/IVA on IV antibiotic treatment days by combining observational UK CF Registry data with RCT results. The results indicate significant reductions in IV antibiotic requirements at the population level with the use of ELEX/TEZ/IVA.
Article
Pediatrics
Adam J. Causer, Janis K. Shute, Michael H. Cummings, Anthony Shepherd, Samuel R. Wallbanks, Richard M. Pulsford, Victoria Bright, Gary Connett, Zoe L. Saynor
Summary: This study found that treatment with Elexacaftor/Tezacaftor/Ivacaftor for 6 weeks improved exercise capacity in three adolescents with cystic fibrosis, especially in those with more severe lung disease and lower aerobic fitness at baseline. However, the mechanisms behind these improvements require further investigation in larger trials.
PEDIATRIC PULMONOLOGY
(2022)
Article
Pediatrics
Gary Connett, Stephanie Harper, Bhagarv Raut, David James
Summary: This study introduces a new management approach for acute wheezing in children, which is to use bronchodilators as needed. By comparing with previous years, it is found that this approach can safely and effectively reduce the dosage of salbutamol.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Review
Pediatrics
Gary James Connett
Summary: This review explores the possible role of abnormal triggering of the autonomic diving reflex in paediatric asthma. It suggests that stress during pregnancy could affect the developing nervous system, leading to increased parasympathetic responsiveness and excessive triggering of the diving reflex. Misfiring of this reflex could result in the pathological airway narrowing that occurs in asthma. The hypothesis also proposes that classically conditioned reflex responses become ongoing triggers of recurrent wheeze, regardless of allergen exposure.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Entomology
G. D. Bell, N. Corps, D. Mortimer, S. Gretton, N. Bury, G. J. Connett
Summary: X-ray micro-CT was used to study the tracheal system of Pre and Post hibernation Queen wasps and their workers. The findings showed that the tracheal system is more complex than previously thought, and one wasp had a previously undescribed tracheal system. Comparison was made with a study from the American Museum of Natural History, and recommendations for future studies were given.
JOURNAL OF INSECT PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Matthew J. Harmer, Lucy H. Everitt, Lillie Parker, Nikki Davis, Gary Connett, Arvind Nagra
Summary: This study aimed to assess the effectiveness of a structured transition tool for young people with type 1 diabetes transitioning between pediatric and adult diabetic services. The study found that participation in the 'Ready Steady Go' transition program was associated with improved glycemic control, lower rates of non-elective hospital admissions, and lower non-high density lipoprotein cholesterol concentrations.
PRACTICAL DIABETES
(2022)
Letter
Pediatrics
Hasitha Gajaweera, Damilola Oladele, Gary Connett
ARCHIVES OF DISEASE IN CHILDHOOD
(2021)