Article
Medicine, General & Internal
James O'Hara, Deborah D. Stocken, Gillian C. Watson, Tony Fouweather, Julian McGlashan, Kenneth MacKenzie, Paul Carding, Yakubu Karagama, Ruth Wood, Janet A. Wilson
Summary: This study aimed to assess the use of proton pump inhibitors (PPIs) in treating persistent throat symptoms. The results showed no significant difference between the lansoprazole treatment group and the placebo group at 16 weeks and 12 months.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Juan P. Frias, Srikanth Deenadayalan, Lars Erichsen, Filip K. Knop, Ildiko Lingvay, Stanislava Macura, Chantal Mathieu, Sue Pedersen, Melanie Davies
Summary: This study assessed the efficacy and safety of co-administered semaglutide with cagrilintide in participants with type 2 diabetes. The results showed that the combination treatment resulted in clinically relevant improvements in glycemic control and weight loss compared to cagrilintide alone, and it was well tolerated.
Article
Medicine, General & Internal
Vanita R. Aroda, Jens Aberle, Lars Bardtrum, Erik Christiansen, Filip K. Knop, Sanaz Gabery, Sue Pedersen, John B. Buse
Summary: This study investigated the efficacy of oral semaglutide at higher doses in patients with inadequately controlled type 2 diabetes and found that the doses of 25 mg and 50 mg were superior to the approved dose of 14 mg in reducing HbA1c and bodyweight. No new safety concerns were identified in the study.
Article
Biochemistry & Molecular Biology
Peter Kamstrup, Ema Rastoder, Pernille Hogh Hellmann, Pradeesh Sivapalan, Emil List Larsen, Jorgen Vestbo, Charlotte Suppli Ulrik, Jens P. Goetze, Filip Krag Knop, Jens Ulrik Staehr Jensen
Summary: Synthetic corticosteroids are commonly used for their anti-inflammatory and immunosuppressant effects, although their association with venous thromboembolism remains unclear. A trial was conducted to investigate the effects of prednisolone on haemostasis in healthy men. The results showed that prednisolone did not affect clot formation but influenced certain prothrombotic markers and antithrombotic markers.
Article
Gastroenterology & Hepatology
Seung Han Kim, Kwang Bum Cho, Hoon Jai Chun, Sang Woo Lee, Joong Goo Kwon, Dong Ho Lee, Sang Gyun Kim, Hwoon-Yong Jung, Ji Won Kim, Joon Seong Lee, Hyojin Park, Suck Chei Choi, Sam Ryong Jee, Hyun-Soo Kim, Kwang Hyun Ko, Seun Ja Park, Yong Chan Lee, Soo Heon Park, Ah Rong Kim, Eun Ji Kim, Hyun Wook Park, Bong Tae Kim, Geun Seog Song
Summary: Tegoprazan showed superior therapeutic efficacy compared with the placebo in Korean patients with NERD, especially in complete resolution of major symptoms, with a favorable safety profile and tolerability.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Stephen A. Harrison, Juan P. Frias, Guy Neff, Gary A. Abrams, K. Jean Lucas, William Sanchez, Sudhanshu Gogia, Muhammed Y. Sheikh, Cynthia Behling, Pierre Bedossa, Lan Shao, Doreen Chan, Erica Fong, Brittany de Temple, Reshma Shringarpure, Erik J. Tillman, Timothy Rolph, Andrew Cheng, Kitty Yale
Summary: The study evaluated the efficacy and safety of the bivalent Fc-FGF21 analogue Efruxifermin in patients with NASH and moderate or severe fibrosis. The results showed that Efruxifermin improved liver fibrosis and resolved NASH over 24 weeks with acceptable tolerability, supporting further assessment in phase 3 trials.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, General & Internal
W. Timothy Garvey, Juan P. Frias, Ania M. Jastreboff, Carel W. le Roux, Naveed Sattar, Diego Aizenberg, Huzhang Mao, Shuyu Zhang, Nadia N. Ahmad, Mathijs C. Bunck, Imane Benabbad, Xiaotian M. Zhang
Summary: This study assessed the efficacy and safety of tirzepatide, a glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, for weight management in individuals with obesity and type 2 diabetes. The results showed that once-weekly tirzepatide treatment significantly reduced bodyweight and achieved clinically meaningful weight loss, with a safety profile comparable to other weight management therapies.
Article
Medicine, General & Internal
Filip K. Knop, Vanita R. Aroda, Ruben D. do Vale, Thomas Holst-Hansen, Peter N. Laursen, Julio Rosenstock, Domenica M. Rubino, W. Timothy Garvey
Summary: This study assessed the efficacy and safety of oral semaglutide in overweight or obese adults without type 2 diabetes. The findings showed that oral semaglutide 50 mg once per day led to a significantly greater reduction in bodyweight compared to placebo. Gastrointestinal adverse events were the most common side effects. Oral semaglutide could be an effective option for weight management.
Article
Infectious Diseases
Yao-Chun Hsu, Chi-Yi Chen, I-Wei Chang, Chi-Yang Chang, Chun-Ying Wu, Teng-Yu Lee, Ming-Shiang Wu, Ming-Jong Bair, Jyh-Jou Chen, Chieh-Chang Chen, Cheng-Hao Tseng, Chi-Ming Tai, Yen-Tsung Huang, Wen-Hui Ku, Lein-Ray Mo, Jaw-Town Lin
Summary: The study investigated the efficacy and safety of tenofovir disoproxil fumarate in reducing disease progression in patients with non-cirrhotic chronic hepatitis B and minimally raised ALT. The results showed that tenofovir disoproxil fumarate can reduce the risk of liver fibrosis progression, but its effect on necroinflammation is not significant.
LANCET INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
David C. W. Lau, Lars Erichsen, Ann Marie Francisco, Altynai Satylganova, Carel W. le Roux, Barbara McGowan, Sue D. Pedersen, Kirsi H. Pietilainen, Domenica Rubino, Rachel L. Batterham
Summary: The study evaluated the dose-response relationship of cagrilintide in weight management, showing significant reductions in body weight in overweight and obese individuals with good tolerability.
Article
Medicine, General & Internal
Linda C. Giudice, Sawsan As-Sanie, Juan C. Arjona Ferreira, Christian M. Becker, Mauricio S. Abrao, Bruce A. Lessey, Eric Brown, Krzysztof Dynowski, Krzysztof Wilk, Yulan Li, Vandana Mathur, Qurratul Ann Warsi, Rachel B. Wagman, Neil P. Johnson
Summary: The effectiveness and safety of relugolix combination therapy for treating endometriosis-associated pain were evaluated in this study. The results showed that the combination therapy significantly improved symptoms and was well tolerated.
Article
Medicine, General & Internal
Brad H. Rovin, Y. K. Onno Teng, Ellen M. Ginzler, Cristina Arriens, Dawn J. Caster, Juanita Romero-Diaz, Keisha Gibson, Joshua Kaplan, Laura Lisk, Sandra Navarra, Samir V. Parikh, Simrat Randhawa, Neil Solomons, Robert B. Huizinga
Summary: This study evaluated the efficacy and safety of voclosporin for the treatment of lupus nephritis, showing a superior complete renal response rate with voclosporin in combination with MMF and low-dose steroids compared to MMF and low-dose steroids alone. The safety profile was comparable between the two groups. This finding represents an important advancement in the treatment of patients with active lupus nephritis.
Article
Rheumatology
Pascal Richette, Augustin Latourte, Jeremie Sellam, Daniel Wendling, Muriel Piperno, Philippe Goupille, Yves-Marie Pers, Florent Eymard, Sebastien Ottaviani, Paul Ornetti, Rene-Marc Flipo, Bruno Fautrel, Olivier Peyr, Jean Pierre Bertola, Eric Vicaut, Xavier Chevalier
Summary: The study found that tocilizumab was not more effective than placebo in relieving pain in patients with hand osteoarthritis. Apart from the primary endpoint, there were no significant differences in secondary outcomes between the tocilizumab group and the placebo group.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Gastroenterology & Hepatology
Jeroen M. Schuitenmaker, Froukje B. van Hoeij, Marlies P. Schijven, Jan Tack, Jose M. Conchillo, Eric J. Hazebroek, Andre J. P. M. Smout, Albert J. Bredenoord
Summary: The study results indicate that pneumatic dilation with a 35 mm balloon is not superior to sham dilation for the treatment of persistent dysphagia after fundoplication.
Article
Gastroenterology & Hepatology
Mazen Noureddin, Shaharyar Khan, Francisco Portell, Diane Jorkasky, Jameel Dennis, Omer Khan, Lars Johansson, Edvin Johansson, Arun J. Sanyal
Summary: This study aimed to evaluate the safety and efficacy of HU6 in individuals with non-alcoholic fatty liver disease (NAFLD) and high BMI. The results showed that HU6 treatment resulted in a greater relative change in liver fat content compared to the placebo group, suggesting that HU6 could be a promising pharmacological agent for treating obesity and NAFLD and its metabolic complications.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)