Article
Immunology
Yuan-Pin Hung, Jen-Chieh Lee, Bo-Yang Tsai, Jia-Ling Wu, Hsiao-Chieh Liu, Hsiu-Chuan Liu, Hsiao-Ju Lin, Pei-Jane Tsai, Wen-Chien Ko
Summary: The risk factors of Clostridium difficile-associated diarrhea (CDAD) vary among hospitalized patients with different lengths of hospital stay. Malignancy, prior cephalosporin, and proton pump inhibitor therapy are independent risk factors for CDAD. Intervention strategies for preventing CDAD may need to be tailored based on the duration of hospital stay.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Tadakuni Monma, Junichi Iwamoto, Akira Honda, Hajime Ueda, Fumio Kakizaki, Shoichiro Yara, Teruo Miyazaki, Tadashi Ikegami
Summary: The ratio of secondary bile acids in serum can serve as a biomarker for predicting susceptibility to Clostridium difficile infection, with levels below a certain threshold indicating a higher risk of CDI.
Article
Immunology
Malin Inghammar, Henrik Svanstrom, Marianne Voldstedlund, Mads Melbye, Anders Hviid, Kare Molbak, Bjorn Pasternak
Summary: In a nationwide study among adults in Denmark, it was found that the use of PPIs is associated with a moderately increased risk of community-associated Clostridium difficile infection. The elevated risk remained up to 1 year after the end of PPI treatment.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Vanessa Lang, Katrin Gunka, Jan Rudolf Ortlepp, Ortrud Zimmermann, Uwe Gross
Summary: Nosocomial infections with Clostridioides difficile have emerged as a serious health threat. This study aimed to identify risk factors for C. difficile infection beyond the well-known factors. It found that regular consumption of proton pump inhibitors, low vegetable intake, and the use of the diuretic agent torasemid were additional risk factors for CDI.
FRONTIERS IN MICROBIOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Eun Jeong Gong, Hye-Kyung Jung
Summary: This article is related to the papers by Gong et al. To access these articles, visit and.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Peter Malfertheiner, Christian Schulz, Colin W. Howden
Summary: This article is related to Gong et al papers. To view these articles, visit the website.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Elizabeth T. Jensen, Joe Yi, Wesley Jackson, Rachana Singh, Robert M. Joseph, Karl C. K. Kuban, Michael E. Msall, Lisa Washburn, Rebecca Fry, Andrew M. South, T. Michael O'Shea
Summary: Early acid suppressant use in extremely preterm infants may be associated with poorer neurodevelopmental outcomes, including decreased IQ scores, autism spectrum disorder, and epilepsy.
Article
Gastroenterology & Hepatology
Eunice Odiase, Xi Zhang, Yan Chang, Melissa Nelson, Uthra Balaji, Jinghua Gu, Qiuyang Zhang, Zui Pan, Stuart Jon Spechler, Rhonda F. Souza
Summary: In this study, it was discovered that EoE cells express ngH(+),K(+)ATPase, and IL-4 induces eotaxin-3 secretion through pathways involving ethylene glycol-bis(beta-aminoethyl)-N,N,N',N'-tetraacetoxymethyl ester, 2-aminoethoxydiphenyl borate, verapamil, and diltiazem. Potential role of L-type calcium channel inhibitors in EoE treatment was suggested.
Review
Infectious Diseases
Kristin M. D'Silva, Raaj Mehta, Michael Mitchell, Todd C. Lee, Vibha Singhal, Marnie Goodwin Wilson, Emily G. McDonald
Summary: This study found significantly higher odds of recurrent CDI among users of PPIs, which were supported by multiple sensitivity analyses. Therefore, stronger recommendations for PPI stewardship at CDI diagnosis were concluded.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Public, Environmental & Occupational Health
Johnmary T. Arinze, Maria A. J. de Ridder, Dina Vojinovic, Hanne van Ballegooijen, Emanuil Markov, Talita Duarte-Salles, Peter Rijnbeek, Katia M. C. Verhamme
Summary: This study aimed to investigate the impact of regulatory intervention on the use patterns of ranitidine-containing medicines and their therapeutic alternatives, and to report discernible trends in treatment discontinuation and switching to alternative medications.
Editorial Material
Oncology
Courtney M. Richman, David A. Leiman
Summary: Proton pump inhibitors (PPIs) are commonly used for digestive diseases, but there is conflicting data on the association between PPI use and gastric cancer risk. A pooled case-control study found that short-term PPI use was associated with increased risk of gastric cancer, but long-term use did not show this association. This study provides reassurance to patients and clinicians that long-term PPI use does not significantly increase gastric cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Medicine, General & Internal
Giuseppe Losurdo, Natale Lino Bruno Caccavo, Giuseppe Indellicati, Francesca Celiberto, Enzo Ierardi, Michele Barone, Alfredo Di Leo
Summary: Long-term use of proton pump inhibitors (PPIs) may affect the absorption of micronutrients, particularly vitamin B12, calcium, and vitamin D. A study found that long-term use of pantoprazole, a PPI, was associated with lower red blood cell count but similar hemoglobin levels. There were no significant differences in blood iron, ferritin, vitamin B12, and folate levels; however, vitamin D deficiency was more common in PPI users, with lower blood levels of vitamin D. Furthermore, PPI users had lower phosphate levels and a non-significant trend for zinc deficiency.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
M. Del Re, C. Omariniy, L. Diodati, M. Palleschi, I. Meattini, S. Crucitta, G. Lorenzini, C. Isca, A. Fontana, L. Livi, F. Piacentini, S. Fogli, U. De Giorgi, R. Danesi
Summary: The study investigated the impact of co-administration of PPIs and palbociclib on progression-free survival in breast cancer patients, revealing that patients taking PPIs had a shorter PFS and suggesting caution in prescribing PPIs in this population.
Letter
Medicine, General & Internal
Ahhyung Choi, Yunha Noh, So-Hee Park, Seung-Ah Choe, Ju-Young Shin
Summary: This cohort study aims to investigate whether the use of proton pump inhibitors during pregnancy is associated with the incidence of preeclampsia.
Review
Biochemistry & Molecular Biology
Catia Santos-Pereira, Maria T. Andres, Jose F. Fierro, Ligia R. Rodrigues, Manuela Cote-Real
Summary: Lactoferrin, a versatile natural milk-derived protein, has been found to affect proton pumping ATPases and may exhibit proton pump inhibitor-like activity. Understanding the mechanisms and outcomes of this activity is important for developing improved applications of lactoferrin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)