Article
Multidisciplinary Sciences
Monika Rau, Peter Buggisch, Stefan Mauss, Klaus H. W. Boeker, Hartwig Klinker, Tobias Mueller, Albrecht Stoehr, Jorn M. Schattenberg, Andreas Geier
Summary: Liver steatosis in chronic HCV infection does not appear to contribute significantly to fibrosis progression in this unique cohort.
Article
Multidisciplinary Sciences
Julie M. Steinbrink, Cameron Miller, Rachel A. Myers, Scott Sanoff, Anna Mazur, Thomas W. Burke, Jennifer Byrns, Annette M. Jackson, Xunrong Luo, Micah T. McClain
Summary: Renal transplantation from HCV NAAT-positive donors to uninfected recipients increases the organ donation pool but may cause adverse outcomes due to dysregulated immunologic activation. In this study, gene expression patterns in circulating leukocytes were evaluated to understand the immune dysregulation and predict clinical outcomes. HCV infection incited a marked transcriptomic response in renal transplant recipients, reflecting antiviral immune pathways, which resolved after sustained viral response. Differential gene expression was noted in patients with CMV DNAemia or allograft rejection, although accurate predictive classifiers were not developed. Acute HCV infection induces immune activation in the presence of immunosuppression, which resolves after antiviral therapy. Changes in gene expression patterns are associated with clinical outcomes, but larger studies are needed for accurate predictions.
Article
Medicine, Research & Experimental
Anja Pfau, Karen I. Lopez-Cayuqueo, Nora Scherer, Matthias Wuttke, Annekatrin Wernstedt, Daniela Gonzalez Fassrainer, Desiree E. C. Smith, Jiddeke M. van de Kamp, Katharina Ziegeler, Kai-Uwe Eckardt, Friedrich C. Luft, Peter S. Aronson, Anna Koettgen, Thomas J. Jentsch, Felix Knauf
Summary: Sulfate is important for various physiological processes in the human body. The transporter SLC26A1 plays a crucial role in sulfate reabsorption in the kidney. Through genetic analysis and functional experiments, it is confirmed that SLC26A1 is a sulfate transporter in humans. Rare SLC26A1 variants are associated with lower plasma sulfate levels at the population level.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Public, Environmental & Occupational Health
Brittney L. Dickey, Anna E. Coghill, Julie A. Rathwell, Richard R. Reich, Susan T. Vadaparampil, Shannon M. Christy, Richard Roetzheim, Elizabeth Shenkman, Anna R. Giuliano
Summary: Chronic hepatitis C virus infection is a major cause of hepatocellular carcinoma in the U.S. Screening for HCV is recommended for baby boomers, and this recommendation has expanded to all adults due to increasing rates of HCV infection in younger adults. This study assesses the burden of HCV infection across demographics and supports the shift from age and risk-based screening guidelines to universal adult screening.
PREVENTIVE MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Shi, Ya-fei Qi, Gong-yu Lan, Qijun Wu, Bing Ma, Xian-yi Zhang, Ruo-yun Ji, Yu-jia Ma, Yang Hong
Summary: The study evaluated the value of multiparametric three-dimensional MR elastography in chronic hepatitis B and C, showing its potential in detecting early necroinflammation, distinguishing necroinflammation from liver fibrosis, and correlating with hepatic venous pressure gradient.
Article
Gastroenterology & Hepatology
Kazumasa Sakamoto, Kiyoaki Ito, Hiroshi Yotsuyanagi, Hiroshi Yatsuhashi, Yasuhito Tanaka, Shuhei Hige, Yasuhiro Takikawa, Yoshiyuki Ueno, Kazuhide Yamamoto, Fumio Imazeki, Jun Inoue, Masayuki Kurosaki, Takeji Umemura, Hidenori Toyoda, Eiji Mita, Kojiro Michitaka, Tatsuji Maeshiro, Norie Yamada, Atsushi Suetsugu, Miwa Kawanaka, Yuya Seko, Kentaro Matsuura, Akinori Okumura, Yoshitaka Fukuzawa, Masaya Sugiyama, Masashi Mizokami, Masashi Yoneda
Summary: This study found that the distribution of HBV genotypes among CHB patients in Japan has changed over time, with an increase in genotype A among young adults and a shift of genotypes B and C towards older age groups. This data provides important baseline information for comparative studies on the impact of universal HBV vaccination.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Endocrinology & Metabolism
Chun-Han Cheng, Chia-Ying Chu, Huan-Lin Chen, I-Tsung Lin, Chia-Hsien Wu, Yuan-Kai Lee, Ming-Jong Bair
Summary: This study analyzed the factors associated with insulin resistance (IR) in chronic HCV-infected patients and evaluated the changes in glucose homeostasis after treatment with direct-acting antiviral agents (DAAs). The results showed that obesity, treatment experience, high serum ALT and triglyceride levels, as well as advanced hepatic fibrosis were independently associated with IR in these patients. After viral elimination with DAA therapy, there was a significant reduction in mean HOMA-IR in patients with baseline high IR, HCV genotype 1, and treatment experience.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Virology
Mayu Higuchi, Nobuharu Tamaki, Masayuki Kurosaki, Kento Inada, Sakura Kirino, Koji Yamashita, Yuka Hayakawa, Shuhei Sekiguchi, Leona Osawa, Kenta Takaura, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Nobuyuki Enomoto, Namiki Izumi
Summary: Most patients achieved sustained virological response (SVR) with direct-acting antivirals (DAA) therapy, but some patients, especially those with advanced fibrosis, did not show improvement in liver stiffness after achieving SVR. Despite obtaining SVR, improvement in liver stiffness could not be obtained in some cases.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Duygu Demirtas, Emre Unal, Ilkay S. Idilman, Zuhal Akcoren, Mehmet Akif Goktas, Meryem Seda Boyraz, Sevilay Karahan, Diclehan Orhan, Mithat Haliloglu, Musturay Karcaaltincaba, Hasan Ozen
Summary: Magnetic resonance elastography (MRE) shows good agreement with the Ishak scoring system in evaluating liver fibrosis in children. MRE-LS values differ significantly among different Ishak fibrosis stages. MRE has high sensitivity and specificity for assessing liver fibrosis in pediatric patients.
INSIGHTS INTO IMAGING
(2023)
Article
Acoustics
Sheng-Hung Chen, Hsueh-Chou Lai, Wen-Pang Su, Jung-Ta Kao, Po-Heng Chuang, Wei-Fan Hsu, Hung-Wei Wang, Tsung-Yu Tsai, Hung-Yao Chen, Cheng-Yuan Peng
Summary: The study found that in patients receiving direct-acting antiviral therapy, liver stiffness showed a biphasic decline with treatment duration, while spleen stiffness started to decline after treatment. This trend is consistent with the resolution of hepatic necroinflammation and regression of liver fibrosis.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Medicine, General & Internal
Jian Wang, Weimao Ding, Jiacheng Liu, Yong Liu, Xiaomin Yan, Juan Xia, Weihua Wu, Bei Jia, Yuxin Chen, Dongmei Gao, Shuqin Hong, Xiaohong Wang, Li Wang, Xin Tong, Shengxia Yin, Zhaoping Zhang, Jie Li, Rui Huang, Chao Wu
Summary: The coexistence of HBsAg and anti-HBs is associated with severe liver fibrosis and cirrhosis in patients with chronic hepatitis B, especially among those who are HBeAg negative.
Article
Gastroenterology & Hepatology
Mi Na Kim, Kyungdo Han, Juhwan Yoo, Seong Gyu Hwang, Sang Hoon Ahn
Summary: This study found that patients with chronic viral hepatitis and concurrent fatty liver have a higher risk of developing hepatocellular carcinoma and mortality, highlighting the importance of managing fatty liver in reducing these risks for patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Infectious Diseases
Bibigul S. Ilyassova, Balzhan Abzhaparova, Dariga S. Smailova, Aidos Bolatov, Bolatbek Baymakhanov, Vyacheslav Beloussov, Maxim Solomadin, Kunsulu Shamsivaliyeva, Gulnara Alpysbayava, Gaukhar Issakova, Joanna Granica, Dina Mukushkina, Inkar Y. Sagatov, Shokan Kaniyev
Summary: This study investigated the molecular epidemiology of HBV and HDV in Kazakhstan for the first time. The results showed that HBV is mainly represented by genotype D, followed by genotypes A and C, while all HDV samples belonged to genotype 1. These findings contribute to the understanding of global viral epidemiology and have potential implications for public health policy and clinical research on chronic hepatitis in Kazakhstan.
BMC INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Yejin Kim, Yoosoo Chang, Min-Jung Kwon, Yun Soo Hong, Mi Kyung Kim, Won Sohn, Yong Kyun Cho, Hocheol Shin, Sarah H. Wild, Christopher D. Byrne, Seungho Ryu
Summary: The study found that fasting ketonuria was associated with a decreased risk of incident NAFLD in healthy individuals. Those with persistent ketonuria had the greatest decrease in risk for developing NAFLD. Further exploration is needed to understand the role of hyperketonemia in preventing NAFLD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Na Liu, Nan Yang, Wenqi Ma, Shujuan Yang, Chunhua Hu, Juan Li, Yingren Zhao, Guanghua Xu, Yingli He
Summary: This study suggests that antiviral treatment should be considered for CHB patients with high viral load regardless of the disease activity phase to minimize further hepatocyte damage.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Grazia Pennisi, Marco Enea, Manuel Romero-Gomez, Mauro Vigano, Elisabetta Bugianesi, Vincent W. -s Wong, Anna Ludovica Fracanzani, Giada Sebastiani, Jerome Boursier, Annalisa Berzigotti, Mohammed Eslam, Javier Ampuero, Amine Benmassaoud, Claudia La Mantia, Yuly P. Mendoza, Jacob George, Antonio Craxi, Calogero Camma', Victor de Ledinghen, Salvatore Petta
Summary: The occurrence of extrahepatic events (EHE) in patients with non-alcoholic fatty liver disease (NAFLD) is relevant and increases according to the severity of liver fibrosis, while the risk of liver-related events (LRE) is low in patients with mild fibrosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Grazia Pennisi, Rosaria Maria Pipitone, Daniela Cabibi, Marco Enea, Manuel Romero-Gomez, Mauro Vigano, Elisabetta Bugianesi, Vincent Wai-Sun Wong, Anna Ludovica Fracanzani, Giada Sebastiani, Annalisa Berzigotti, Francesca Di Salvo, Antonino Giulio Giannone, Claudia La Mantia, Giulia Lupo, Rossana Porcasi, Federica Vernuccio, Rossella Zito, Vito Di Marco, Calogero Camma, Antonio Craxi, Victor de Ledinghen, Stefania Grimaudo, Salvatore Petta
Summary: The presence of a cholestatic pattern in patients with NAFLD predicts a higher risk of major liver-related outcomes independently from other features of liver disease.
LIVER INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Roberto Cannella, Carla Camma, Francesco Matteini, Ciro Celsa, Paolo Giuffrida, Marco Enea, Albert Comelli, Alessandro Stefano, Calogero Camma, Massimo Midiri, Roberto Lagalla, Giuseppe Brancatelli, Federica Vernuccio
Summary: This study explored the potential of radiomics on gadoxetate disodium-enhanced MRI for predicting hepatocellular carcinoma (HCC) response after transarterial embolization (TAE). The results showed that radiomics models based on gadoxetate disodium-enhanced MRI can achieve good performance in predicting the response of HCCs treated with TAE.
Article
Gastroenterology & Hepatology
Grazia Pennisi, Marco Enea, Alessandra Pandolfo, Ciro Celsa, Michela Antonucci, Carlo Ciccioli, Giuseppe Infantino, Claudia La Mantia, Stefanie Parisi, Adele Tulone, Vito Di Marco, Antonio Craxi, Calogero Camma, Salvatore Petta
Summary: This study aimed to assess the accuracy of AGILE 3+, a score based on various factors, for the diagnosis of advanced fibrosis and the prediction of liver-related events in patients with NAFLD. The results showed that AGILE 3+ had higher diagnostic performance compared to FIB-4 and LSM.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Francesco Vizzutti, Ciro Celsa, Vincenza Calvaruso, Marco Enea, Salvatore Battaglia, Laura Turco, Marco Senzolo, Silvia Nardelli, Roberto Miraglia, Davide Roccarina, Claudia Campani, Dario Saltini, Cristian Caporali, Federica Indulti, Stefano Gitto, Alberto Zanetto, Gabriele Di Maria, Marcello Bianchini, Maddalena Pecchini, Silvia Aspite, Chiara Di Bonaventura, Michele Citone, Tomas Guasconi, Fabrizio Di Benedetto, Umberto Arena, Fabrizio Fanelli, Luigi Maruzzelli, Oliviero Riggio, Patrizia Burra, Antonio Colecchia, Erica Villa, Fabio Marra, Calogero Camma, Filippo Schepis
Summary: The aim of this study was to develop and validate a multivariable model for an accurate prediction of mortality in older adults. The results showed that creatinine and sodium levels are useful predictors for decision making in older adults. Further efforts to update the prediction model with larger sample size are warranted.
Review
Cardiac & Cardiovascular Systems
Grazia Pennisi, Ciro Celsa, Marco Enea, Marco Vaccaro, Vito Di Marco, Carlo Ciccioli, Giuseppe Infantino, Claudia La Mantia, Stefanie Parisi, Federica Vernuccio, Antonio Craxi, Calogero Camma, Salvatore Petta
Summary: This study aimed to quantify histological improvement and its risk factors in NASH patients enrolled in the placebo arms of RCTs, and to compare the effect of investigational drugs for NASH on histological outcomes. The meta-analysis on placebo arms showed NASH resolution without worsening of fibrosis in 17% of patients and at least 1 stage improvement of fibrosis without worsening of NASH in 21% of patients. Phase 3 RCTs, older age, and higher AST levels were associated with progression of liver disease. Network meta-analysis suggested that Semaglutide, Pioglitazone alone or in combination with Vitamin E, Aldafermin, Lanifibranor, and Obeticholic acid were the most effective interventions for NASH improvement and fibrosis reduction.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Editorial Material
Oncology
Fabrizio Bronte, Sandro Sferrazza, Francesco Giuseppe Carbone
FRONTIERS IN ONCOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Francesco Vizzutti, Ciro Celsa, Salvatore Battaglia, Roberto Miraglia, Marco Enea, Fabio Marra, Cristian Caporali, Calogero Camma, Filippo Schepis
Letter
Gastroenterology & Hepatology
Francesco Vizzutti, Ciro Celsa, Salvatore Battaglia, Roberto Miraglia, Marco Enea, Fabio Marra, Antonio Colecchia, Calogero Camma, Filippo Schepis
Review
Oncology
Anju Jose, Maria Grazia Bavetta, Erika Martinelli, Fabrizio Bronte, Emilio Francesco Giunta, Kanjoormana Aryan Manu
Summary: Hepatocellular carcinoma is the most common primary liver cancer in patients with liver cirrhosis. Recent advances in understanding its molecular mechanisms and staging have led to the development of new therapies, including targeted therapy and immunotherapy, which have shown promising results, particularly in advanced cases.
JOURNAL OF ONCOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Loreta A. Kondili, Maria Grazia Rumi, Antonio Craxi
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Nicola Pugliese, Vincenza Calvaruso, Mario Masarone, Roberta D'Ambrosio, Sara Battistella, Anna Licata, Marcello Persico, Maria Paola Anolli, Marco Distefano, Salvatore Petta, Francesco Paolo Russo, Vito Di Marco, Alessio Aghemo
Summary: This retrospective study found that G/P treatment achieved high SVR rates of 97.9% in Caucasian patients aged 75 years and older with chronic HCV infection. The study included 570 patients who received G/P treatment at five referral centers in Italy between October 2017 and January 2022.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Daniela Cabibi, Antonino Giulio Giannone, Sandro Bellavia, Roberta Lo Coco, Anna Lo Bianco, Eleonora Formisano, Gregorio Scerrino, Giuseppa Graceffa
Summary: This study found a correlation between serum anti-thyroglobulin-antibodies (TgAb) and papillary thyroid carcinoma, as well as pre-neoplastic histological changes such as papillary-like nuclear features (PLNF) and lymphocytic infiltrate (LI). TgAb positivity can predict the presence of PLNF and LI. The expression of HBME1 in papillary thyroid carcinoma may indicate the presence of altered thyroglobulin triggering TgAb and LI.
Article
Gastroenterology & Hepatology
Giuseppe Miceli, Vincenza Calvaruso, Alessandra Casuccio, Grazia Pennisi, Massimo Licata, Chiara Pintus, Maria G. Basso, Mariachiara Velardo, Mario Daidone, Emanuele Amodio, Salvatore Petta, Fabio Simone, Giuseppe Cabibbo, Domenico Di Raimondo, Antonio Craxi, Antonio Pinto, Antonino Tuttolomondo
Summary: This study investigated the correlation between HRV parameters and the degree of portal hypertension in patients with cirrhosis. The results showed that liver dysfunction was positively correlated with HRV parameters, while the presence of ascites was negatively correlated. Drug treatment also had an impact on HRV parameters. These findings suggest a role of the autonomic nervous system in hepatic decompensation.
HEPATOLOGY COMMUNICATIONS
(2023)