Article
Pharmacology & Pharmacy
Gokcen Birlik Demirel, Seyma Bayrak
Summary: We have developed a triple pH/redox/ultrasound-triggered hybrid nanocarrier system for controlled drug delivery. This system consists of a mesoporous silica coated magnetic core and a pH/redox-responsive polymer layer. The results showed that the hybrid nanoparticles exhibited efficient drug release in cellular pH environment and in the presence of specific conditions (10 mM GSH, pH = 5.5, 37 degrees C). Ultrasound-triggered release was also effective in controlling drug release. In vitro cytotoxicity tests demonstrated that the hybrid nanoparticles had strong cell-killing effects on MCF-7 cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Article
Biochemistry & Molecular Biology
Aziz Ullah, Gyu-Jin Lee, Hyunji Kim, Hyuk Taek Kwon, Sung In Lim
Summary: The gravity of threats posed by microplastic pollution to the environment cannot be overestimated. Microplastics reach humans causing various hazardous effects through the food chain. This study presents a hydrogel-encapsulated, bioinspired colonic delivery system for PETase. The system exhibits high encapsulation efficiency, pH-dependent PETase release, and potential application for colonic delivery of PETase.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Werner Tegge, Giulia Guerra, Alexander Hoeltke, Lauritz Schiller, Ulrike Beutling, Kirsten Harmrolfs, Lothar Groebe, Hannah Wullenkord, Chunfa Xu, Herbert Weich, Mark Broenstrup
Summary: A novel conjugation strategy was explored to make potent antibiotics more selective by accumulating the drug and releasing it triggered by infection. Bacterial targeting was achieved using a modified fragment of a human antimicrobial peptide, and the release of the drug was limited to infection-related situations through a linker cleaved by neutrophil elastase. The antibacterial efficacy of the conjugates was successfully demonstrated in co-cultures of human neutrophils and Escherichia coli.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Maximilian Regenold, Kan Kaneko, Xuehan Wang, H. Benson Peng, James C. Evans, Pauric Bannigan, Christine Allen
Summary: Triggered drug delivery strategies, such as thermosensitive liposomes, have shown improved targetability for chemotherapeutics. However, most studies have focused on doxorubicin encapsulation, while other drugs could also benefit from this targeted delivery approach.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Tao Sun, Chen Jiang
Summary: Drug delivery systems (DDS) triggered by local microenvironment represent the state-of-art of nanomedicine design, aiming to precisely recognize diseased sites, reduce side effects, and expand the therapeutic window. However, the design of DDS functioning at microcosmic levels is still challenging and underexploited.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Polymer Science
Rachel Yie Hang Tan, Choy Sin Lee, Mallikarjuna Rao Pichika, Sit Foon Cheng, Ki Yan Lam
Summary: This review summarizes the applications of pH-responsive polyurethane in the biomedical and drug delivery fields in recent years, including controlled drug delivery systems for oral administration, intravaginal administration, and targeted drug delivery systems for chemotherapy treatment. Additionally, it discusses other applications such as surface biomaterials, sensors, and optical imaging probes.
Article
Polymer Science
Yanggui Wu, Huiying Wang, Qianqian Liu, Frederic Lortie, Julien Bernard, Wolfgang H. Binder, Senbin Chen, Jintao Zhu
Summary: This study successfully constructs polymer micelles loaded with chemotherapy drugs and photothermal agents for combined chemo-photothermal therapies, by integrating biomedical applications with supramolecular chemistry.
Article
Engineering, Chemical
Dan-Na Hu, Xiao-Jie Ju, Xing-Qun Pu, Rui Xie, Wei Wang, Zhuang Liu, Liang-Yin Chu
Summary: The copolymer Alg-g-PNA shows temperature and glucose responsiveness, with the ability to transition between sol and gel states for insulin delivery based on environmental conditions. Additionally, the hydrogels demonstrate good biocompatibility and reversible sol-gel transitions in response to changes in blood glucose levels, making them a promising option for self-regulating insulin delivery in diabetes therapy.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Li Wang, Lanlan Wang, Peilan Xu, Cong Liu, Shengyu Wang, Xian Luo, Mengqi Li, Jiajing Liu, Zhiyu Zhao, Weisong Lai, Fanghong Luo, Jianghua Yan
Summary: This study presents a novel tumor embolic agent called tTF-EG3287@Liposomes, which shows prolonged retention, enhanced accumulation in tumor, and superior antitumor effect compared to tTF-EG3287. The pH-responsive liposomes have potential application in the treatment of solid tumors.
MOLECULAR PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Haitao Ding, Ping Tan, Shiqin Fu, Xiaohe Tian, Hu Zhang, Xuelei Ma, Zhongwei Gu, Kui Luo
Summary: Microenvironment-responsive drug delivery systems (DDSs) achieve targeted drug delivery and improve drug efficacy by responding to specific pH conditions in diseased tissues. Various synthetic approaches have been developed to prepare pH-sensitive DDSs, including the introduction of pH-sensitive chemical bonds or groups. Different nano DDSs, such as liposomes, micelles, hydrogels, dendritic macromolecules, and organic-inorganic hybrid nanoparticles, can respond to pH variations. These pH-sensitive DDSs have been applied in research on anticancer therapy and the diagnosis of cancer, inflammation, antibacterial infection, and neurological diseases.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Lu Fan, Xiaoxuan Zhang, Min Nie, Ye Xu, Yuetong Wang, Luoran Shang, Yongxiang Zhao, Yuanjin Zhao
Summary: This study proposes a new strategy for designing controllably separable microneedle patches by integrating photothermal responsive phase-changing microspheres into conical hydrogel microneedles. These patches can intelligently control the detachment of microneedles and sustainably release drugs, demonstrating practical values for versatile drug delivery and clinical applications.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Chaolei Hu, Yimeng Sun, Gil van Wissen, Yitong Peng, Andrij Pich
Summary: In this study, visible light- and temperature-responsive poly(N-vinylcaprolactam) microgels decorated by donor-acceptor Stenhouse adducts (DASAs) were synthesized for the first time using a robust and straightforward post-modification synthesis route. The microgels exhibited homogeneous distributions and temperature responsiveness in aqueous solutions. The photoswitching behaviors of the microgels in different solvents were systematically investigated, and their size in aqueous solutions could be modulated by visible light irradiation. Moreover, the microgels showed potential application in the photostimulated delivery of hydrophobic drugs.
CHEMISTRY OF MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Baoyin Yuan, Yanan Xi, Cuihua Qi, Mingzhu Zhao, Xiaoyan Zhu, Jinlu Tang
Summary: A smart dual-targeted DNA nanocapsule was designed with a sequentially triggered strategy based on double targeting elements, providing precise and selective delivery of chemotherapeutics to tumor cells while inhibiting migration and invasion.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Biomaterials
Quan-Bing Chen, Mei-Hua Shen, Xiao-He Ren, Shuai Zhu, Jin-Ting Shang, Wei Liu, Zhao-Wei Zhang, Zhi-Jun Dong, Hua-Zhi Gu, Xian-Zheng Zhang, Qiong Yuan, Tao Zou
Summary: This study utilizes tumor-triggered targeting ammonium bicarbonate liposomes for fluorescence and photothermal imaging-guided chemo/photothermal/photodynamic multimodal therapy, which effectively treats tumors without significant side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Pharmacology & Pharmacy
Francesca K. H. Gavins, Zihao Fu, Moe Elbadawi, Abdul W. Basit, Miguel R. D. Rodrigues, Mine Orlu
Summary: Food-mediated changes to drug absorption are difficult to predict. Machine learning techniques show promise in predicting the food effect and can reduce animal studies and accelerate oral drug development.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Editorial Material
Pharmacology & Pharmacy
Juergen Siepmann, Abdul Basit, Thomas Rades
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Editorial Material
Pharmacology & Pharmacy
Eneko Larraneta, Juan Dominguez-Robles, Andriana Margariti, Abdul W. Basit, Alvaro Goyanes
THERAPEUTIC DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Yang Mai, Christine M. Madla, Haibin Shao, Yujia Qin, Hamid A. Merchant, Sudaxshina Murdan, Abdul W. Basit
Summary: This study demonstrates that excipients have sex-specific effects on drug bioavailability and intestinal efflux transporters. Understanding the mechanisms behind these effects can lead to more effective pharmaceutical design and personalized formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Youssef Abdalla, Moe Elbadawi, Mengxuan Ji, Manal Alkahtani, Atheer Awad, Mine Orlu, Simon Gaisford, Abdul W. Basit
Summary: Three-dimensional (3D) printing in medicine is changing the way medicine is produced, offering precise digital fabrication and personalized designs. Selective laser sintering (SLS), an emerging 3D printing technology, is gaining attention for its high precision and ability to work with a wide range of pharmaceutical materials. However, fully realizing the potential of SLS for medicine requires expertise and extensive trial-and-error research. This study used machine learning (ML) to predict the printability of SLS formulations, achieving high accuracy by combining formulation composition data with various characterization techniques.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Laura E. McCoubrey, Alessia Favaron, Atheer Awad, Mine Orlu, Simon Gaisford, Abdul W. Basit
Summary: Colonic drug delivery allows access to specific therapeutic targets, improving drug bioavailability and minimizing off-target effects. However, successful design and development of colon-targeted medicines require careful consideration of the colon's distinct physiological environment. This review discusses the important parameters for effective design and formulation strategies for colon-targeted drugs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Lucia Rodriguez-Pombo, Laura Martinez-Castro, Xiaoyan Xu, Jun Jie Ong, Carlos Rial, Daniel Nieto Garcia, Alejandro Gonzalez-Santos, Julian Flores-Gonzalez, Carmen Alvarez-Lorenzo, Abdul W. Basit, Alvaro Goyanes
Summary: 3D printing is revolutionizing patient care by providing personalized treatments. To meet the demands of fast-paced clinical environments, 3D printing technologies must be able to produce objects quickly. Rotary volumetric printing, an emerging technology, was used for the first time to simultaneously print two paracetamol-loaded 3D printed tablets. This study demonstrates the potential of rotary volumetric printing for efficient manufacturing of personalized medicines.
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
(2023)
Article
Pharmacology & Pharmacy
Atheer Awad, Eleanor Hollis, Alvaro Goyanes, Mine Orlu, Simon Gaisford, Abdul W. Basit
Summary: Acute severe ulcerative colitis (ASUC) is a growing health burden that often requires multiple therapeutic agents. This study demonstrates the feasibility of using 3D printing to create suppositories containing two anti-inflammatory drugs, budesonide and tofacitinib citrate, for the treatment of ASUC. The suppositories were successfully fabricated using semi-solid extrusion (SSE) 3D printing and showed consistent dissolution and disintegration behaviors regardless of their drug content, indicating the flexibility of the technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
(2023)
Article
Medicine, Research & Experimental
Francesca K. H. Gavins, Liu Dou, Yujia Qin, Christine M. Madla, Sudaxshina Murdan, Abdul W. Basit, Yang Mai, Mine Orlu
Summary: The study examined the effects of food intake and sex on the expression of P-gp, BCRP, and MRP2 transporters in the intestines of rats. The results showed that food intake and sex influenced the expression of P-gp and BCRP, while different strains of rats exhibited variation in the expression of P-gp, BCRP, and MRP2. ELISA was found to be a more useful method than PCR for quantifying protein expression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Fanjin Wang, Nannapat Sangfuang, Laura E. McCoubrey, Vipul Yadav, Moe Elbadawi, Mine Orlu, Simon Gaisford, Abdul W. Basit
Summary: This study presents a method to predict the gastrointestinal (GI) stability of peptide therapeutics based solely on the amino acid sequence. Using machine learning techniques, classification models were trained on 109 peptides, demonstrating the key determinants of stability to be lipophilicity, rigidity, and size. These models provide valuable tools for the development of oral peptide therapeutics.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
Shazia Bashir, Nguyen Ngoc N. Phuoc, Tharangani Herath, Abdul Basit, Ruth Zadoks, Sudaxshina Murdan
Summary: Intensive tilapia farming has led to the emergence of novel pathogens, including Streptococcus agalactiae (GBS) which caused the first outbreak of foodborne GBS illness in humans. A proof-of-concept study developed an oral vaccine that provided significant protection from GBS in tilapia, showing promise for future use against other bacterial pathogens and fish species.
Article
Pharmacology & Pharmacy
Farhan Taherali, Nerisha Chouhan, Fanjin Wang, Sebastien Lavielle, Maryana Baran, Laura E. McCoubrey, Abdul W. Basit, Vipul Yadav
Summary: Most marketed peptide drugs are administered parenterally due to their instability in the gastrointestinal tract. This study investigates the potential of cyclisation and D-amino acid substitution to improve stability and permeability of oxytocin-based peptides in the colon. Results show that disulfide bond cyclisation provides improved stability, while certain D-AA substitutions enhance both stability and permeability. The findings highlight the potential of strategic peptide design for oral delivery to the colon.
Article
Pharmacology & Pharmacy
Thomas D. Pollard, Iria Seoane-Viano, Jun Jie Ong, Patricija Januskaite, Sahar Awwad, Mine Orlu, Manuel F. Bande, Abdul W. Basit, Alvaro Goyanes
Summary: Inkjet printing is used to print drugs on contact lenses for localized delivery and personalized dosing, while NIR spectroscopy is used as a quality control method for drug quantification but has not been demonstrated with contact lenses. In this study, a glaucoma therapy drug was successfully printed onto contact lenses using a modified commercial inkjet printer. The drug-loaded ink was designed to match commercial ink properties while maximizing drug loading and avoiding inflammation. Multiple passes of printing demonstrated personalized drug dosing and NIR was used for accurate quantification. This combination represents a novel method for personalization and quantification of drug-loaded contact lenses.
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
(2023)
Article
Pharmacology & Pharmacy
Sarah J. Trenfield, Xiaoyan Xu, Alvaro Goyanes, Martin Rowland, David Wilsdon, Simon Gaisford, Abdul W. Basit
Summary: Selective laser sintering (SLS) 3D printing is capable of creating drug products with varied release profiles by changing the laser scanning speed. Reflectance Fourier Transform - Near Infrared (FT-NIR) spectroscopy was evaluated as a non-destructive approach to predicting 3D printed tablet density and drug release. The developed univariate models demonstrated high linearity and accuracy in predicting density and drug release. The feasibility of SLS 3D printing to produce drug products containing a narrow therapeutic index drug and the potential of FT-NIR spectroscopy as a non-destructive quality control method were demonstrated.
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
(2023)
Article
Pharmacology & Pharmacy
Siyuan Sun, Manal E. Alkahtani, Simon Gaisford, Abdul W. Basit, Moe Elbadawi, Mine Orlu
Summary: This study presents an alternative approach to train models for classifying the quality of 3D-printed dosage forms using synthetic images. By using machine vision techniques, high classification accuracies were achieved, and the models were subjected to rigorous stress tests. The results demonstrate the great potential of virtual images for accelerated, reliable, and sustainable AI model development to enhance the quality control of 3D-printed medicines.
