Review
Neurosciences
Aleksi Kokkonen, Emma A. Honkanen, Daniel T. Corp, Juho Joutsa
Summary: Deep brain stimulation (DBS) is an effective treatment for various brain disorders, but its mechanisms of action and detailed molecular effects still need further investigation.
Review
Immunology
Wenxia Dong, Ning Wang, Zhe Qi
Summary: The prevalence of brain cancer is increasing and brings significant healthcare challenges. Immunotherapies present diagnostic imaging challenges for brain tumors. Effective neuroimaging techniques are necessary for diagnosing and monitoring brain tumors, but differentiating between tumors and necrotic lesions or inflamed tissues remains a challenge. This review summarizes recent advances in neuroimaging methods for enhancing brain tumor diagnosis and evaluating inflamed lesions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Benjamin Haenisch, Justine Y. Hansen, Boris C. Bernhardt, Simon B. Eickhoff, Juergen Dukart, Bratislav Misic, Sofie Louise Valk
Summary: This study investigates the role of neurotransmitter transporter and receptor molecules in the structure-function relationships in the human brain. Using positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors, the researchers discovered three main spatial gradients of chemoarchitectural similarity in the cortical and subcortical regions of the brain. The findings show that the organization of the receptome shares similarities with functional and structural brain anatomy.
Editorial Material
Oncology
Hannah M. Linden, David A. Mankoff
Summary: [F-18]fluoroestradiol (FES) PET is an FDA-approved imaging biomarker that predicts clinical benefit of endocrine therapy and measures target activity in drug development. A recent study showed that tumor heterogeneity of expression predicts clinical benefit, and serial FES monitoring can assess estrogen receptor blockade and posttreatment release.
CLINICAL CANCER RESEARCH
(2023)
Review
Medicine, General & Internal
Alan Miranda, Daniele Bertoglio, Sigrid Stroobants, Steven Staelens, Jeroen Verhaeghe
Summary: Anesthesia is a major limitation in translating preclinical brain PET scans to clinical settings, as it can affect the accuracy of tracer results. Despite advances in motion correction methods, wider adoption of this technique in brain research is needed.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Christophe van de Wiele, Sezgin Ustmert, Bart De Spiegeleer, Pieter-Jan De Jonghe, Mike Sathekge, Maes Alex
Summary: Various potential PET-apoptosis imaging radiopharmaceuticals have been developed to assess the response to cancer treatment. Some of these radiopharmaceuticals showed enhanced uptake in xenografted tumors in mice, but to varying degrees. Two validated radioligands showed favorable characteristics in healthy individuals, but did not significantly affect bone marrow. Further research is needed to evaluate the clinical value of these radiopharmaceuticals for apoptosis imaging in cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Teng Zhang, Shuang Wu, Xiaohui Zhang, Yiwu Dai, Anxin Wang, Hong Zhang, Mei Tian
Summary: Quantification approaches of PET imaging in living brains have been recommended for clinical diagnosis of neurological disorders. This review compared PET template-based and MRI-aided spatial normalization approaches. The study also discussed ROI-based and voxel-wise quantitative methods, as well as the concerns and clinical applications of these approaches. A recipe for PET spatial normalization and quantification was concluded to improve diagnosis accuracy in clinical practice.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Martin Kocher, Christiane Jockwitz, Philipp Lohmann, Gabriele Stoffels, Christian Filss, Felix M. Mottaghy, Maximilian I. Ruge, Carolin Weiss Lucas, Roland Goldbrunner, Nadim J. Shah, Gereon R. Fink, Norbert Galldiks, Karl-Josef Langen, Svenja Caspers
Summary: This study used structural MRI and amino acid PET in conjunction with brain atlases and elastic registration techniques to investigate the impact of treatment-related brain damage on cognitive functioning in well-functioning WHO Grade III/IV glioma patients. The results showed that T2/FLAIR hyperintensities caused by radiation therapy significantly impaired cognitive performance, especially affecting the left hemisphere functional nodes and fiber tracts, which were highly correlated with verbal episodic memory dysfunction.
Article
Chemistry, Analytical
Siyang Liu, Ye Liu, Zhe Zhang, Xiaodong Wang, Yicheng Yang, Kai Sun, Jiangbo Yu, Daniel T. Chiu, Changfeng Wu
Summary: This study developed a near-infrared optical transducer to monitor glucose variations in cerebrospinal fluid, and observed abnormal glucose uptake in transgenic mice with brain tumors.
ANALYTICAL CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivan Ho Shon, Thomas Hennessy, Jennifer Guille, Michael P. Gotsbacher, Angelina J. Lay, Bruce McBride, Rachel Codd, Philip J. Hogg
Summary: This study evaluates the biodistribution, radiation dosimetry, safety, and tumor uptake of the novel radiopharmaceutical GA-68 ([GA-68] GA-CDI) for imaging multiple forms of cell death. The results demonstrate that GA-68 ([GA-68] GA-CDI) is safe, has low radiation dosimetry, and excellent biodistribution and imaging characteristics. It shows potential advantages over previous radiopharmaceuticals for imaging cell death and has progressed to a proof-of-concept trial.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei Tian, Chuantao Zuo, A. Cahid Civelek, Ignasi Carrio, Yasuyoshi Watanabe, Keon Wook Kang, Koji Murakami, John O. Prior, Yan Zhong, Xiaofeng Dou, Congcong Yu, Chentao Jin, Rui Zhou, Fengtao Liu, Xinyi Li, Jiaying Lu, Hong Zhang, Jian Wang
Summary: This article introduces the international consensus and practice guideline, aiming to promote the standardized use of presynaptic dopaminergic PET imaging in parkinsonism.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Chemistry, Multidisciplinary
Ya-Qiong Yan, Hao Wang, Yuliang Zhao
Summary: Radionuclide imaging is a premier imaging method in clinical practice, utilizing PET and SPECT to detect anatomical abnormalities. Peptides as targeting vectors for contrast agents offer high specificity and low toxicity. Radiolabeled peptide probes have become essential tools for clinical radionuclide diagnosis.
CHINESE CHEMICAL LETTERS
(2022)
Article
Pharmacology & Pharmacy
Gaelle Hugon, Sebastien Goutal, Ambre Dauba, Louise Breuil, Benoit Larrat, Alexandra Winkeler, Anthony Novell, Nicolas Tournier
Summary: Focused ultrasound in combination with microbubbles enhances therapeutics delivery to the brain by increasing blood-brain barrier permeability. PET imaging using [F-18]FDS is evaluated as a marker for BBB integrity, showing significantly increased distribution in the brain after FUS. These findings demonstrate the potential of [F-18]FDS PET as a sensitive and reproducible marker for noninvasive monitoring of BBB disruption induced by FUS in vivo.
Article
Endocrinology & Metabolism
Ayla Mansur, Eugenii A. Rabiner, Hideo Tsukada, Robert A. Comley, Yvonne Lewis, Mickael Huiban, Jan Passchier, Roger N. Gunn
Summary: The study evaluates the test-retest reproducibility of F-18-BCPP-EF in humans, showing its suitability for quantifying MC-I in clinical studies. Results indicate that both DVR-1 and SUVR-1 have improved test-retest variability, with SUVR-1 highly correlated with DVR-1.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Pierre Cheung, Olof Eriksson
Summary: Diabetes is a chronic metabolic disease that affects over 400 million people globally, with traditional diagnostic methods having limitations in accurately reflecting disease progression. Studying beta-cell mass is crucial for understanding disease processes, but invasive procedures are required. Nuclear medical imaging techniques offer a non-invasive approach for studying beta-cell mass, potentially leading to breakthroughs in diabetes research and therapies.
Article
Clinical Neurology
Yuen-Siang Ang, Cristina Cusin, Yoann Petibon, Daniel G. Dillon, Micah Breiger, Emily L. Belleau, Marc Normandin, Hans Schroder, Sean Boyden, Emma Hayden, M. Taylor Levine, Aava Jahan, Ashley K. Meyer, Min Su Kang, Devon Brunner, Steven E. Gelda, Jacob Hooker, Georges El Fakhri, Maurizio Fava, Diego A. Pizzagalli
Summary: This study investigated option generation in major depressive disorder and how dopamine might modulate this process, as well as the effects of modafinil on option generation in healthy individuals. The findings showed that patients with major depressive disorder generated fewer but more unique options, and dopamine activity in the putamen played a key role in option generation. Modafinil was also found to reduce the creativity of options produced by healthy individuals.
Article
Ophthalmology
Yi Zhou, James Murrough, Yinxi Yu, Neeta Roy, Rony Sayegh, Penny Asbell, Maureen G. Maguire, Gui-Shuang Ying
Summary: Depression is associated with more severe symptoms and signs of dry eye disease, suggesting that depression should be considered as a comorbidity in the management of patients with dry eye disease.
JAMA OPHTHALMOLOGY
(2022)
Article
Psychiatry
Yael Jacob, Laurel S. Morris, Gaurav Verma, Sarah B. Rutter, Priti Balchandani, James W. Murrough
Summary: The hippocampus and amygdala limbic structures play a critical role in the development of major depressive disorder (MDD). This study explores the role of their subregions in the whole brain network to uncover patterns related to the disorder. The results suggest that alterations in the connectivity and clustering of these subregions are associated with the diagnosis and severity of depression.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Adam Bayes, Brooke Short, Carlos A. Zarate, Lawrence Park, James W. Murrough, Declan M. McLoughlin, Patricio Riva-Posse, Robert Schoevers, Jolien Veraart, Sagar Parikh, Paul Glue, Johnson Fam, Rupert McShane, Veronica Galvez, Donel Martin, Phern-Chern Tor, Andre R. Brunoni, Colleen K. Loo
Summary: The safety monitoring of ketamine and esketamine presents knowledge gaps, with no standard monitoring for off-label generic ketamine and varying regulations for intranasal esketamine. The Ketamine Side Effect Tool (KSET) is recommended for comprehensive safety monitoring of acute and longer term side effects.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Lorig Kachadourian, James Murrough, Carly Kaplan, Sabrina Kaplan, Jordyn Feingold, Adriana Feder, Dennis Charney, Steven Southwick, Lauren Peccoralo, Jonathan DePierro, Jonathan Ripp, Robert Pietrzak
Summary: This study examined the association between acute COVID-19-related PTSD, MDD, and GAD symptoms and burnout and functional difficulties in frontline healthcare workers. The results suggest that early interventions targeting transdiagnostic symptoms of MDD, PTSD, and GAD may help mitigate the risk of burnout and functional difficulties in this population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yentl Y. van der Zee, Lars M. T. Eijssen, Philipp Mews, Aarthi Ramakrishnan, Kelvin Alvarez, Casey K. Lardner, Hannah M. Cates, Deena M. Walker, Angelica Torres-Berrio, Caleb J. Browne, Ashley Cunningham, Flurin Cathomas, Hope Kronman, Eric M. Parise, Laurence de Nijs, Li Shen, James W. Murrough, Bart P. F. Rutten, Eric J. Nestler, Orna Issler
Summary: This study explored the potential use of miRNAs as biomarkers for MDD and its treatment. The findings showed that there were significant differences in blood miRNA signatures between stress-resilient and stress-susceptible mice after an incubation period. Additionally, ketamine treatment was more effective than imipramine at re-establishing baseline miRNA expression levels in mice that responded behaviorally to the drug. The study also identified miR-144-3p as a candidate biomarker for depression diagnosis and predicting ketamine treatment response.
MOLECULAR PSYCHIATRY
(2022)
Article
Behavioral Sciences
Daniel L. Ranti, Andrew J. Warburton, John W. Rutland, Jonathan T. Dullea, Matthew Markowitz, Derek A. Smith, Sophie Z. Karwoska Kligler, Sarah Rutter, Mackenzie Langan, Annie Arrighi-Allisan, Ilena George, Gaurav Verma, James W. Murrough, Bradley N. Delman, Priti Balchandani, Laurel S. Morris
Summary: Emerging evidence suggests a relationship between blood-brain barrier breakdown and elevated inflammatory cytokines in depression. This study used ultra-high field MRI to explore the link between glymphatic system dysfunction and psychological trauma in patients with major depressive disorder (MDD) and healthy controls. The results showed that trauma experience was positively correlated with glymphatic neuroanatomy in MDD patients and the overall population. Age also correlated positively with glymphatic parameters in all participants. These findings suggest a potential role of glymphatic impairment in trauma-related symptomatology.
BRAIN AND BEHAVIOR
(2022)
Article
Psychiatry
Judy Alper, Rui Feng, Gaurav Verma, Sarah Rutter, Kuang-han Huang, Long Xie, Paul Yushkevich, Yael Jacob, Stephanie Brown, Marin Kautz, Molly Schneider, Hung-Mo Lin, Lazar Fleysher, Bradley N. Delman, Patrick R. Hof, James W. Murrough, Priti Balchandani
Summary: This study aimed to assess volumetric differences in hippocampal subfields between patients with major depressive disorder (MDD), treatment-resistant depression (TRD) and healthy controls (HC) using high-resolution MRI data. The results showed that MDD and TRD patients had reduced volume in the right-hemisphere CA2/3 subfield compared to HC. Negative correlations between subfield volumes and life-stressor checklist scores were also found. This study provides valuable insights into the pathophysiology of depression.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Sara Costi, Audrey Evers, Manish K. Jha, Matthew Klein, Jessica R. Overbey, Ki A. Goosens, JoColl Burgess, Kelvin Alvarez, Adriana Feder, Dennis S. Charney, James W. Murrough
Summary: Stress exposure is a key risk factor for the development of major depressive disorder and posttraumatic stress disorder. Enhancing stress resilience in at-risk populations could potentially protect against stress-induced disorders. The administration of ketamine one week prior to an acute stressor prevents the development of stress-induced depressive-like behavior in rodents. This study aimed to test if the prophylactic effect of ketamine against stress also applies to humans.
NEUROBIOLOGY OF STRESS
(2023)
Meeting Abstract
Neurosciences
Orna Issler, Yentl Y. van der Zee, Chunfeng Tan, Junshi Wang, Aarthi Ramakrishnan, Benoit Labonte, Carol A. Tamminga, Yan Dong, James W. Murrough, Li Shen, Eric J. Nestler
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Letter
Psychiatry
Audrey Evers, Matthew Klein, Amy Aloysi, James Murrough, Manish K. Jha
ANNALS OF CLINICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Benedetta Bigio, Olivia Barnhill, Josh Dobbin, Paolo de Angelis, Marin Kautz, Francis Lee, James Murrough, Natalie Rasgon, Carla Nasca
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Yael Jacob, Gaurav Verma, Sarah Rutter, Laurel Morris, Priti Balchandani, James Murrough
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Laurel Morris, Marishka Mehta, Christopher Ahn, Morgan Corniquel, Gaurav Verma, Yael Jacob, Priti Balchandani, James Murrough
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
James Murrough, Sarah Boukezzi, Sara Costi, Flurin Cathomas, Lisa Shin, Scott Russo, Laurel Morris
BIOLOGICAL PSYCHIATRY
(2022)