Article
Immunology
Darshika J. Udawatte, Diane M. M. Lang, Jeffrey R. Currier, Carey L. Medin, Alan L. Rothman
Summary: Dengue virus, a prevalent arthropod-borne virus, targets the human protein RIPK1 to evade the innate immune response. This interaction inhibits the activation of NF-kappa B, a key player in inflammation and cell death. The NS3 protein of DENV is responsible for this suppression, independent of its protease activity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biophysics
Ru Cheng, Fu Zhu, Min Huang, Qiang Zhang, Hui Hong Yan, Xiao Hui Zhao, Fu Kang Luo, Chun Mei Li, Hui Liu, Gao Lin Liang, Cheng Zhi Huang, Jian Wang
Summary: In this study, a new biosensor named hepatitis virus indicator was developed for the simultaneous detection of HBV and HCV. The biosensor utilized Exo III assisted signal amplification strategy and particle counting technology with a dark-field microscopy, enabling sensitive and selective detection.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Microbiology
Tsai-Ling Liao, Yi-Ming Chen, Shie-Liang Hsieh, Kuo-Tung Tang, Der-Yuan Chen, Ying-Ying Yang, Hung-Jen Liu, Sheng-Shun Yang
Summary: This study investigates the roles of BAFF and exosomal miRNAs in the extrahepatic manifestations of HCV infection, revealing an association between HCV-infected hepatocyte-derived miRNAs and host TLR7 genetic background with BAFF expression. The findings suggest a potential mechanism for HCV infection-related autoimmunity and provide insights into the development of extrahepatic diseases, offering a possible target for treatment.
Review
Virology
Hui-Chun Li, Chee-Hing Yang, Shih-Yen Lo
Summary: The life cycle of the hepatitis C virus can be divided into several stages, including viral entry, protein translation, RNA replication, viral assembly, and release. The replication of HCV genomic RNA is regulated by various factors and has led to the development of direct-acting antivirals targeting the replication complex.
Article
Gastroenterology & Hepatology
Po-Yao Hsu, Yu-Ju Wei, Po-Cheng Liang, Jia-Jung Lee, Sheng-Wen Niu, Jiun-Chi Huang, Cheng-Ting Hsu, Tyng-Yuan Jang, Ching- Huang, Yi-Hung Lin, Ming-Yen Hsieh, Meng-Hsuan Hsieh, Szu-Chia Chen, Chia-Yen Dai, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Jer-Ming Chang, Ming-Lun Yeh, Chung-Feng Huang, Yi-Wen Chiu, Shang-Jyh Hwang, Wan-Long Chuang, Ming-Lung Yu
Summary: Hemodialysis patients are at increased risk of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. This study found that hemodialysis patients with HCV exhibited a higher burden of comorbidities, especially in ischemic heart diseases, respiratory disorders, and mental/behavioral disorders, compared to patients with HBV and those without viral hepatitis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Baoyu Mai, Ling Han, Jiarui Zhong, Jingqi Shu, Zelin Cao, Jiaqi Fang, Xiaoying Zhang, Zelin Gao, Fengxia Xiao
Summary: This study indicates that ROF is the active component within the total flavonoids, which may alleviate ETH-induced liver injury by inhibiting NF-κB phosphorylation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sakshi Kamboj, Akanksha Rajput, Amber Rastogi, Anamika Thakur, Manoj Kumar
Summary: This study developed the Anti-HCV platform using machine learning and QSAR approaches to predict repurposed drugs targeting HCV non-structural proteins. Different machine learning techniques were used to develop predictive models, which were validated through molecular docking. Promising repurposed drugs were identified, which may be useful in antiviral drug development against HCV.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biophysics
Suchanat Boonkaew, Abdulhadee Yakoh, Nattaya Chuaypen, Pisit Tangkijvanich, Sirirat Rengpipat, Weena Siangproh, Orawon Chailapakul
Summary: Electrochemical paper-based analytical devices (ePADs) are simple, portable, and low-cost analytical devices for point-of-care testing of clinical biomarkers. A sequential ePAD has been developed for simultaneous detection of hepatitis B surface antigen and hepatitis C core antigen by integrating dual flow behaviors, avoiding the need for complex multi-step reagent manipulation by the user. The proposed ePAD shows high promise as an easy-to-use, portable, and extendable sensor for other multiplex biological assays.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Public, Environmental & Occupational Health
S. Mehmandoost, M. Khezri, G. Mousavian, F. Tavakoli, F. Mehrabi, H. Sharifi, K. Dolan, M. Shokoohi
Summary: This study systematically summarized the prevalence of HIV, HBV, and HCV infections among incarcerated people in Iran. The results showed that the prevalences of these infections are relatively high in this population. Meta-analysis and regression analysis found a decrease in HIV and HCV infections over time.
Editorial Material
Virology
Syeda Kanza Kazmi, Fatima Muhammad Asad Khan, Valentino Natoli, Reem Hunain, Zarmina Islam, Ana Carla dos Santos Costa, Shoaib Ahmad, Mohammad Yasir Essar
Summary: Hepatitis is a significant cause of mortality worldwide, with around 1.34 million deaths annually. Africa is not immune to this issue, with an estimated 100 million individuals infected with Hepatitis B or C. The continent, already fragile, is further burdened by the onset of the COVID-19 pandemic, which could potentially worsen the threat from viral diseases like Hepatitis. Strengthening prevention policies is essential for Africa to build resilience against such threats.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Oncology
Yung-Rung Lai, Ya-Lan Chang, Chiu-Hsiang Lee, Tung-Han Tsai, Kuang-Hua Huang, Chien-Ying Lee
Summary: The study found that patients with HBV and HCV have a higher incidence of NHL, indicating a significant correlation.
Review
Immunology
Wen Hou, Xiaoli Wu
Summary: This study investigates the roles of gamma delta T cells in HBV and HCV infections, discussing the different roles they play in the progression of liver diseases at various stages.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xinyu Lu, Qianhui Chen, Hongyan Liu, Xiaoyong Zhang
Summary: The non-canonical NF-kappa B signaling pathway is crucial in HBV infection, influencing host immune responses, viral replication, and liver damage. Understanding the interaction between HBV and this pathway may lead to the discovery of potential therapeutic targets and drugs for treating HBV infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Wanting Shi, Kang Li, Yonghong Zhang
Summary: Viral hepatitis, primarily caused by HBV and HCV, is a global health concern. Delayed diagnosis and treatment can lead to liver damage and the development of cirrhosis. Traditional methods have limitations in detecting viral presence, while the use of nanomaterials has advanced virus detection technologies.
Article
Oncology
Shih-Han Hung, Tzong-Hann Yang, Yen-Fu Cheng, Chin-Shyan Chen, Herng-Ching Lin
Summary: This case-control study investigates the associations between head and neck cancer (HNC), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection, and suggests a potential association between HBV and HCV infections and the risk of HNC.
Article
Biochemical Research Methods
Xiaojun Yan, Jingyu Wang, Lu Zhu, Jonathan Joseph Lowrey, Yuanyuan Zhang, Wei Hou, Jiahong Dong, Yanan Du
Article
Engineering, Biomedical
Jingyu Wang, Fengling Chen, Longwei Liu, Chunxiao Qi, Bingjie Wang, Xiaojun Yan, Chenyu Huang, Wei Hou, Michael Q. Zhang, Yang Chen, Yanan Du
Article
Chemistry, Physical
Longwei Liu, Zhifeng You, Hongsheng Yu, Lyu Zhou, Hui Zhao, Xiaojun Yan, Dulei Li, Bingjie Wang, Lu Zhu, Yuzhou Xu, Tie Xia, Yan Shi, Chenyu Huang, Wei Hou, Yanan Du
Article
Gastroenterology & Hepatology
Terence N. Bukong, Wei Hou, Karen Kodys, Gyongyi Szabo
Letter
Infectious Diseases
Wei Hou, Congdoanh Trieu, Yanan Du, Cindy Wang, Wing-Kin Syn
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2018)
Article
Biochemical Research Methods
Lijuan Yu, Chie Aoki, Yohko Shimizu, Kazufumi Shimizu, Wei Hou, Fumihiro Yagyu, Xianzi Wen, Masamichi Oshima, Aikichi Iwamoto, Bin Gao, Wenjun Liu, George Fu Gao, Yoshihiro Kitamura
JOURNAL OF VIROLOGICAL METHODS
(2010)
Article
Multidisciplinary Sciences
Liping Xie, Tongzhou Wang, Tianqi Huang, Wei Hou, Guoliang Huang, Yanan Du
SCIENTIFIC REPORTS
(2014)
Article
Gastroenterology & Hepatology
Wei Hou, Zhixiao Huo, Yanan Du, Cindy Wang, Wing-Kin Syn
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2020)
Letter
Medical Laboratory Technology
Wei Hou
CLINICAL LABORATORY
(2019)
Letter
Medical Laboratory Technology
Wei Hou
CLINICAL LABORATORY
(2019)
Letter
Medical Laboratory Technology
Wei Hou
CLINICAL LABORATORY
(2019)
Letter
Medical Laboratory Technology
Wei Hou
CLINICAL LABORATORY
(2019)
Review
Cell Biology
Wei Hou, Wing-Kin Syn
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2018)