Review
Medicine, General & Internal
Elizabeth E. Powell, Vincent Wai-Sun Wong, Mary Rinella
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common global health issue with significant associations with metabolic syndrome and type 2 diabetes, leading to serious complications like cirrhosis and hepatocellular carcinoma. While cardiovascular disease and extrahepatic malignancy are the main causes of death in NAFLD patients, advanced liver fibrosis is a key prognostic marker for liver-related outcomes and overall mortality.
Review
Biochemistry & Molecular Biology
Tieshan Teng, Shuai Qiu, Yiming Zhao, Siyuan Zhao, Dequan Sun, Lingzhu Hou, Yihang Li, Ke Zhou, Xixi Yu, Changyong Yang, Yanzhang Li
Summary: Non-alcoholic fatty liver disease (NAFLD) is strongly correlated with obesity, insulin resistance, metabolic syndrome, and genetic components. The disease progression includes non-alcoholic fatty liver, non-alcoholic steatohepatitis, and liver cirrhosis, with different clinical phenotypes. There is currently no FDA-approved medication specifically for treating NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Enis Kostallari, Shantha Valainathan, Louise Biquard, Vijay H. Shah, Pierre-Emmanuel Rautou
Summary: Chronic liver disease affects over 800 million people worldwide with a high mortality rate. Understanding the role of extracellular vesicles in liver diseases can lead to the development of more effective therapies.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Gastroenterology & Hepatology
Joseph A. Akambase, Jhon E. Prieto, Angelo Z. Z. Mattos, Angelo A. A. Mattos, Enrique Carrera, Javier Diaz-Ferrer, Patricia Gallardo, Andrea Curia, Esteban G. Ballerga, Cristiane V. Tovo, Domingo Balderramo, Jose D. Debes
Summary: This study investigated the associations between clinical characteristics and histopathological features of non-alcoholic fatty liver disease (NAFLD) in South America. The results showed that metabolic syndrome, hypertension, and type 2 diabetes mellitus (T2DM) were significantly associated with significant fibrosis, severe steatosis, and liver inflammation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Medicine, General & Internal
Manuel Romero-Gomez
Summary: Non-alcoholic steatohepatitis is a part of the spectrum of metabolic-associated fatty liver diseases, which is characterized by fatty degeneration linked to obesity, diabetes, metabolic syndrome, dyslipidemia, and immune-mediated disorders. This disease has high prevalence, heterogeneity, complexity, and dynamic nature, with pruritus and asthenia as the main clinical manifestations. Diagnosis can be aided by biochemical or imaging-based non-invasive tests, although liver biopsy remains the gold standard. Lifestyle changes and drug therapy are the main treatment options.
Review
Pharmacology & Pharmacy
Xiangyun Tan, Xinyu Huang, Zhuhang Lu, Liang Chen, Junjie Hu, Xianxiang Tian, Zhenpeng Qiu
Summary: Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive liver disease with increasing prevalence. Abnormal regulation of lipophagy in NAFLD patients indicates the potential role of mTORC1 in restoring failed autophagy. Targeting mTORC1 to promote lipophagy has the potential to become an effective therapeutic strategy for NAFLD. This article provides an overview of the main pathways through which mTORC1 participates in lipophagy formation and the intervention effect of mTORC1-regulated lipophagy in NAFLD, offering new therapeutic strategies for the prevention and treatment of NAFLD in the future.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Atsushi Nakamura, Tsubasa Yoshimura, Hitoshi Asakura
Summary: This study investigated the relationship between hepatic fat loss and malnutrition in chronic liver disease using magnetic resonance imaging. The results showed that decreased body fat mass and triglycerides, as well as increased nutritional assessment score, were associated with hepatic fat loss. Furthermore, hepatic fat loss and Child-Pugh score were identified as independent prognostic factors for patients with cirrhosis. These findings emphasize the importance of preserving liver fat content in nutritional therapy for cirrhotic patients.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Medicine, General & Internal
Rafael Paternostro, Michael Trauner
Summary: Non-alcoholic fatty liver disease (NAFLD) is a liver disease with various pathologies. In addition to lifestyle changes and a few specific medications, there are new treatment options being studied. Treating complications of end-stage liver disease caused by non-alcoholic steatohepatitis (NASH) is important for the treatment of the complete clinical spectrum of NAFLD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Abraham S. Meijnikman, Dimitra Lappa, Hilde Herrema, Omrum Aydin, Kimberly A. Krautkramer, Valentina Tremaroli, Louise E. Olofsson, Annika Lundqvist, Sjoerd Bruin, Yair Acherman, Joanne Verheij, Siv Hjorth, Victor E. A. Gerdes, Thue W. Schwartz, Albert K. Groen, Fredrik Backhed, Jens Nielsen, Max Nieuwdorp
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, with increased risk of mortality driven by extrahepatic cancers and liver and cardiovascular disease. Women with NAFLD have a higher risk of disease progression and worse outcome. Therefore, understanding the pathophysiology of NAFLD in women is critical. This study used a systems biology approach to analyze different organs and revealed differences in metabolites, gene expression, and gut microbial features between patients with and without NAFLD. These findings provide novel strategies for studying the pathophysiology of NAFLD in humans.
Article
Gastroenterology & Hepatology
Hannes Hagstrom, Tracey G. Simon, Bjorn Roelstraete, Olof Stephansson, Jonas Soderling, Jonas F. Ludvigsson
Summary: This study revealed a strong association between maternal obesity and future NAFLD in offspring among young individuals in Sweden. Adjustment for socio-economic and metabolic factors did not change this finding, suggesting maternal obesity as an independent risk factor for NAFLD in offspring.
JOURNAL OF HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hossein Rafiei, Michelle Yeung, Sara Kowalski, Gerald Krystal, Ingrid Elisia
Summary: Non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH) and hepatocarcinoma is a serious and growing problem. The development of new therapies is hindered by a lack of high-throughput assays for drug testing. This study describes the development of a simple transwell assay using a combination of HepG2 hepatocytes, hepatic LX-2 stellate cells, and differentiated THP-1 cells to recapitulate the main features of NAFLD/NASH.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Yamei Duan, Xiongfeng Pan, Jiayou Luo, Xiang Xiao, Jingya Li, Prince L. Bestman, Miyang Luo
Summary: This study found a significant association between inflammatory cytokines and non-alcoholic fatty liver disease (NAFLD). Increased concentrations of C-reactive protein (CRP), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and intercellular adhesion molecule-1 (ICAM-1) were significantly associated with increased risks of NAFLD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Arun J. Sanyal, Stephen A. Williams, Joel E. Lavine, Brent A. Neuschwander-Tetri, Leigh Alexander, Rachel Ostroff, Hannah Biegel, Kris V. Kowdley, Naga Chalasani, Srinivasan Dasarathy, Anna Mae Diehl, Rohit Loomba, Bilal Hameed, Cynthia Behling, David E. Kleiner, Saul J. Karpen, Jessica Williams, Yi Jia, Katherine P. Yates, James Tonascia
Summary: Using modified-aptamer proteomics, researchers identified diagnostic signatures for key histological features of NAFLD in 636 patients. The protein models accurately diagnosed various severities of NAFLD and were able to monitor treatment effectiveness.
JOURNAL OF HEPATOLOGY
(2023)
Review
Oncology
James A. Thomas, Bradley J. Kendall, Christine Dalais, Graeme A. Macdonald, Aaron P. Thrift
Summary: Non-alcoholic fatty liver disease (NAFLD) is associated with hepatocellular carcinoma (HCC) and extrahepatic cancer. The incidence rate of HCC is higher in patients with advanced liver fibrosis or cirrhosis, while the incidence rate of extrahepatic cancers is even higher. These findings emphasize the importance of prevention and early detection of cancer in adults with NAFLD.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Guanlin Li, Huapeng Lin, Pimsiri Sripongpun, Lilian Y. Liang, Xinrong Zhang, Vincent W. S. Wong, Grace L. H. Wong, W. Ray Kim, Terry C. F. Yip
Summary: The study compared the SAFE score with other non-invasive tests in diagnosing liver fibrosis and predicting liver-related events in Asian patients with NAFLD. The results showed that transient elastography had the highest AUROC for detecting significant fibrosis, followed by the SAFE score. The SAFE score also outperformed other blood-based algorithms in predicting liver-related events.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Christoph Grander, Timon E. Adolph, Verena Wieser, Patrick Lowe, Laura Wrzosek, Benedek Gyongyosi, Doyle V. Ward, Felix Grabherr, Romana R. Gerner, Alexandra Pfister, Barbara Enrich, Dragos Ciocan, Sophie Macheiner, Lisa Mayr, Matthias Drach, Patrizia Moser, Alexander R. Moschen, Gabriel Perlemuter, Gyongyi Szabo, Anne Marie Cassard, Herbert Tilg
Meeting Abstract
Gastroenterology & Hepatology
C. Grander, F. Grabherr, T. E. Adolph, G. Perlemuter, G. Szabo, A. M. Cassard, H. Tilg
JOURNAL OF HEPATOLOGY
(2017)
Article
Multidisciplinary Sciences
Laura Wrzosek, Dragos Ciocan, Patrick Borentain, Madeleine Spatz, Virginie Puchois, Cindy Hogot, Gladys Ferrere, Camille Mayeur, Gabriel Perlemuter, Anne-Marie Cassard
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Dragos Ciocan, Vinciane Rebours, Cosmin Sebastian Voican, Laura Wrzosek, Virginie Puchois, Anne-Marie Cassard, Gabriel Perlemuter
SCIENTIFIC REPORTS
(2018)
Article
Gastroenterology & Hepatology
Dragos Ciocan, Cosmin Sebastian Voican, Laura Wrzosek, Cindy Hugot, Dominique Rainteau, Lydie Humbert, Anne-Marie Cassard, Gabriel Perlemuter
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2018)
Article
Neurosciences
Dragos Ciocan, Anne-Marie Cassard, Laurent Becquemont, Celine Verstuyft, Cosmin Sebastian Voican, Khalil El Asmar, Romain Colle, Denis David, Severine Trabado, Bruno Feve, Philippe Chanson, Gabriel Perlemuter, Emmanuelle Corruble
Summary: Patients with major depressive episodes exhibit distinct blood microbiome and metabolomic signatures, which change after treatment. Dysbiosis in the blood may serve as a new therapeutic target and prognostic tool for the treatment of major depressive episodes.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Camille Houron, Dragos Ciocan, Nicolas Trainel, Francoise Mercier-Nome, Cindy Hugot, Madeleine Spatz, Gabriel Perlemuter, Anne-Marie Cassard
Summary: The study suggests that pectin plays a positive role in non-alcoholic fatty liver disease (NAFLD) by affecting gut bacteria, with preventive and curative fecal microbiota transfer (FMT) having different mechanisms of action on NAFLD.
Article
Cell Biology
Dragos Ciocan, Madeleine Spatz, Nicolas Trainel, Kevin Hardonniere, Severine Domenichini, Francoise Mercier-Nome, Aurore Desmons, Lydie Humbert, Sylvere Durand, Guido Kroemer, Antonin Lamaziere, Cindy Hugot, Gabriel Perlemuter, Anne-Marie Cassard
Summary: Pectin improves alcohol-induced liver disease in mice by modifying the bile acid cycle through effects on the intestinal microbiota and enhanced bile acid excretion.
Article
Gastroenterology & Hepatology
Natalia Nunez, Aurelie Derre-Bobillot, Nicolas Trainel, Goran Lakisic, Alexandre Lecomte, Francoise Mercier-Nome, Anne-Marie Cassard, Helene Bierne, Pascale Serror, Cristel Archambaud
Summary: This study reveals the ability of Enterococcus faecalis to survive and proliferate in hepatocytes and exhibit similar behaviors in kidney cells. This finding is of great significance for understanding pathobiont-driven diseases.
Article
Biochemistry & Molecular Biology
Tom Hutteau-Hamel, Amine Mellouk, Nicolas Trainel, Anne-Marie Cassard, Pierre Bobe
Summary: This study reveals the relationship between membrane cholesterol content and ATP-induced cellular responses in T cells. In CD4(+) T cells, cholesterol content is positively correlated with CD62L shedding, pore formation, phosphatidylserine externalization, and cell death. In CD8(+) T cells, cholesterol, GM1, and P2X7 levels are negatively correlated with these cellular responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Medicine, General & Internal
Dragos Ciocan, Anne-Marie Cassard
Review
Nutrition & Dietetics
Wanchao Hu, Anne-Marie Cassard, Dragos Ciocan
Summary: Alterations in the gut microbiota composition play a role in the development and severity of NAFLD and ALD. Interventions such as fecal microbiota transfer and probiotics have shown potential in reducing liver damage progression. This review focuses on the impact of pectin, a soluble fiber, on gut bacteria in reducing liver injury in NAFLD and ALD.
Article
Biochemical Research Methods
S. Servain-Viel, M. -L. Aknin, S. Domenichini, G. Perlemuter, A. -M. Cassard, G. Schlecht-Louf, V. Lievin-Le Moal
Summary: Flow cytometry protocol for measuring bacterial viability under safer conditions was developed to minimize the risks of biological and chemical exposure. The protocol involves a viability labeling step before bacteria fixation and reduced use of harmful reagents, achieving reliable results in different conditions.
Review
Gastroenterology & Hepatology
Anne-Marie Cassard, Dragos Ciocan
CLINICAL AND MOLECULAR HEPATOLOGY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
Dragos M. Ciocan, Vinciane Rebours, Anne-Marie Cassard-Doulcier, Cosmin Sebastian Voican, Laura Wrzosek, Virginie Puchois, Gabriel Perlemuter