Review
Biochemistry & Molecular Biology
Rebecca J. Howard
Summary: The superfamily of pentameric ligand-gated ion channels plays crucial roles in electrochemical signal transduction across evolution, with increasing structural studies focusing on three model subfamilies. Common themes include gating mechanisms and diversity beyond the protein level.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Food Science & Technology
Lee Jones, Callum Waite, Edgar Neri-Castro, Bryan G. Fry
Summary: The distribution and potency of post-synaptic neurotoxic activity in Crotalinae venoms, particularly within the Atropoides, Metlapilcoatlus, Cerrophidion, and Porthidium clade, were investigated. The study revealed potent binding activity in venoms from certain snake species, indicating the presence of toxins that bind to post-synaptic receptors. This finding highlights the need for further research on the neurotoxic activity in these poorly studied snakes.
Article
Engineering, Environmental
Stephen Short, Alex Robinson, Elma Lahive, Amaia Green Etxabe, Szabolcs Hernadi, M. Gloria Pereira, Peter Kille, David J. Spurgeon
Summary: Neonicotinoids, widely used in 120 countries, require accurate prediction of nontarget species sensitivity. Combining toxicology with toxicogenomics can improve predictions and identify susceptible species. Variations in AChBP expression can explain differential species sensitivity to neonicotinoids.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Takehito Terajima, Tomonori Suzuki, Ryo Horikoshi, Shohei Doi, Mizuki Nakamura, Fumika Kobayashi, Kathleen A. Durkin, Kenji Shimomura, Satoshi Nakamura, Kazumi Yamamoto, Motohiro Tomizawa
Summary: This study investigates the binding mechanism of a novel insecticide FLP with insect nAChR, finding that FLP primarily binds to the beta subunit of nAChR; the results suggest that the interaction between FLP and T77R, T77K, T77N, or T77Q nAChR enhances the drug's binding potency.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Changliang Liu, Xintong Cai, Andreas Ritzau-Jost, Paul F. Kramer, Yulong Li, Zayd M. Khaliq, Stefan Hallermann, Pascal S. Kaeser
Summary: Information flow in neurons involves integration of inputs in dendrites, generation of action potentials near the soma, and release of neurotransmitters from nerve terminals in the axon. A study found that acetylcholine-releasing neurons in the striatum can induce action potential firing in distal dopamine axons. This mechanism segregates the control of dopamine signaling between axons and somata.
Review
Chemistry, Medicinal
Edouard Montigne, David Balayssac
Summary: This scoping review provides an overview of studies on peripheral neuropathic pain (PNP) in rodent models, exploring compounds targeting cholinergic neurotransmission. The results highlight the potential of cholinergic compounds for the management of neuropathic pain, emphasizing the need for clinical trials.
Article
Neurosciences
Melissa A. Tapia, Xiao-Tao Jin, Brenton R. Tucker, Leanne N. Thomas, Noah B. Walker, Veronica J. Kim, Steven E. Albertson, Naresh Damuka, Ivan Krizan, Seby Edassery, Jeffrey N. Savas, Kiran Kumar Solingapuram Sai, Sara R. Jones, Ryan M. Drenan
Summary: This study investigated the behavior and neurobiological effects of intermittent nicotine intake in rats. The results suggest that intermittent nicotine intake may lead to increased craving and enhanced response to nicotine-associated cues. Additionally, intermittent nicotine intake also caused increased nicotine binding in the brain and specific changes in the proteome of certain neural structures.
Article
Neurosciences
Xiao-Tao Jin, Ryan M. Drenan
Summary: The interpeduncular nucleus (IPN) is involved in nicotine dependence and regulation of fear responses, affective states, and novelty processing. Neurons in the IPN express nicotinic acetylcholine receptors (nAChR) and receive cholinergic innervation. Studies have shown that IPL neurons express Chrna7 (alpha 7 nAChR subunit) and are sensitive to acetylcholine (ACh) stimulation. These findings contribute to a better understanding of cholinergic modulation in the IPN.
Article
Biochemistry & Molecular Biology
Yoshihisa Ozoe, Yoshiki Matsubara, Yuji Tanaka, Yasuhide Yoshioka, Fumiyo Ozoe, Takahiro Shiotsuki, Kazuki Nomura, Toshifumi Nakao, Shinichi Banba
Summary: Dinotefuran is a unique insecticide that acts on specific nicotinic acetylcholine receptor (nAChR) subtypes, leading to differences in its insecticidal activity compared to imidacloprid.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Food Science & Technology
Uthpala Chandrasekara, Richard J. Harris, Bryan G. Fry
Summary: This study reveals the specific amino acid positions in King Cobra venom that selectively bind to their prey's physiological pathways. The findings show that three negatively charged amino acids in the venom strongly bind to neurotoxins, shedding light on the evolution of lineage-selective toxins driven by specialist prey.
Article
Agronomy
Joseph Nguyen, Razi Ghazali, Philip Batterham, Trent Perry
Summary: Exposure to spinosad leads to degradation of the alpha 6-like target protein, potentially contributing to the toxicity of spinosyns towards insects.
PEST MANAGEMENT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Lauren Wills, Paul J. Kenny
Summary: Nicotine acts on neuronal nicotinic acetylcholine receptors (nAChRs) in the central nervous system to modulate reward and aversion circuits, ultimately influencing the development of addiction to nicotine-containing tobacco products.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Immunology
Alice Courties, Juliette Petit, Ariane Do, Manon Legris, Ines Kouki, Audrey Pigenet, Pradeep K. Sacitharan, Francois-Paul Ehkirch, Francis Berenbaum, Jeremie Sellam
Summary: This study investigated the role of non-neuronal cholinergic system in osteoarthritis (OA). The results showed that the cholinergic system, through alpha 7nAchR, can counteract the effects of inflammation on osteoblasts. Deletion of alpha 7nAchR may limit cartilage degradation in age-related OA. Therefore, enhancing the cholinergic system could be a potential therapeutic target, although it may depend on CHRFAM7A expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Han-Shen Tae, David J. Adams
Summary: Pentameric nicotinic acetylcholine receptors (nAChRs) are found in muscle or neuronal cells, and have also been observed in non-neuronal cells. They play a crucial role in various physiological and pathological processes, including synaptic transmission, modulation of transmitter release, neuropathic pain, inflammation, and cancer. There are 17 different subunits of nAChRs that produce subtypes with diverse pharmacological properties. Knock-out models have been used to study the expression and function of some nAChR subtypes extensively. Alpha-conotoxins, small peptides derived from cone snail venom, selectively target many nAChR subtypes expressed in heterologous systems, and have potential pharmaceutical value.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Ari Dienel, Remya A. Veettil, Kanako Matsumura, Jude P. J. Savarraj, H. Alex Choi, Peeyush T. Kumar, Jaroslaw Aronowski, Pramod Dash, Spiros L. Blackburn, Devin W. McBride
Summary: The study demonstrates that stimulating nicotinic acetylcholine alpha(7) receptors (α(7)-AChR) can reduce inflammation and improve outcomes in aneurysmal subarachnoid hemorrhage. Animal experiments and analysis of patient plasma samples support α(7)-AChR as a potential target for treating SAH.
Article
Biochemistry & Molecular Biology
Valentina Licheri, Daniel Eckernas, Filip Bergquist, Mia Ericson, Louise Adermark
Article
Biochemistry & Molecular Biology
Bo Soderpalm, Klara Danielsson, Andrea de Bejczy, Louise Adermark, Mia Ericson
Article
Biochemistry & Molecular Biology
Anna Loften, Louise Adermark, Mia Ericson, Bo Soderpalm
Summary: Alcohol use disorder is a chronic brain disorder with significant morbidity and mortality. This study investigated the role of cholinergic interneurons in regulating dopamine levels in the nucleus accumbens, finding that extracellular dopamine levels are not tonically controlled by acetylcholine but are involved in ethanol-induced dopamine release.
Article
Clinical Neurology
Yasmin Olsson, Helga Hoifodt Lido, Klara Danielsson, Mia Ericson, Bo Soderpalm
Summary: Approved medications for alcohol use disorder have modest effects, but targeting the glycinergic system to elevate central glycine levels may reduce ethanol intake in rats.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Article
Neurosciences
Klara Danielsson, Oona Lagstrom, Mia Ericson, Bo Soderpalm, Louise Adermark
Summary: The study suggests that repeated amphetamine exposure leads to selective effects on dopamine signaling in striatal subregions, explaining why tolerance develops towards the drug's rewarding effects but not its psychosis inducing properties.
Article
Psychiatry
Klara Danielsson, Rosita Stomberg, Louise Adermark, Mia Ericson, Bo Soderpalm
Summary: Schizophrenia is characterized by positive, negative, and cognitive symptoms, with positive symptoms showing a better response to antipsychotic treatment. Drug abuse is prevalent in schizophrenia, with some drugs potentially alleviating negative symptoms and others exacerbating symptoms. The study found that substances inducing psychosis affect dopamine release in the striatum differently from substances that do not induce psychosis.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Marta Lantero Rodriguez, Maaike Schilperoort, Inger Johansson, Elin Svedlund Eriksson, Vilborg Palsdottir, Jan Kroon, Marcus Henricsson, Sander Kooijman, Mia Ericson, Jan Boren, Claes OhIsson, John-Olov Jansson, Malin C. Levin, Patrick C. N. Rensen, Asa Tivesten
Summary: Testosterone acts as a negative regulator of metabolic BAT activity in male mice, modulating BAT activity through an indirect pathway. Castration promotes the expression of thermogenic markers, decreases lipid content, and increases fatty acid uptake in BAT. BAT-specific AR deficiency and AR agonist treatment do not affect BAT activity, indicating that androgens do not directly modulate BAT activity via the AR pathway.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Neurosciences
Louise Adermark, Oona Lagstrom, Anna Loften, Valentina Licheri, Amy Havenang, Eleonora Anna Loi, Rosita Stomberg, Bo Soderpalm, Ana Domi, Mia Ericson
Summary: Astrocytes in the striatum modulate neurotransmission by impacting neuronal excitability, with the involvement of dopamine. This modulation is demonstrated through metabolic uncoupling, chemogenetic inhibition, and inhibition of glial glutamate transporters, ultimately leading to a reduction in transmitter release probability and synaptic depression.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Yasmin Olsson, Helga Lido, Mia Ericson, Bo Soderpalm
Summary: Interventions that increase glycine levels and target GlyR can reduce ethanol intake in rats. However, peripheral injection of glycine-containing dipeptides is inefficient in elevating central glycine levels, but can raise accumbal dopamine levels, especially in rats with a lower endogenous dopamine tone.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Article
Neurosciences
Edvin Vestin, Oona Lagstrom, Ana Domi, Mia Ericson, Bo Soderpalm, Louise Adermark
Summary: Amphetamine addiction is associated with neuroadaptations in the amygdala, which may contribute to compulsive drug taking and increase the risk for relapse. This study found that brief exposure to amphetamine induced long-lasting synaptic changes in different subregions of the amygdala, highlighting their relevance to relapse risk.
Article
Biology
Marica Andersson, Jonathan A. C. Roques, Geoffrey Mukisa Aliti, Karin Ademar, Henrik Sundh, Kristina Sundell, Mia Ericson, Petronella Kettunen
Summary: The housing density of zebrafish affects their welfare, with a density of 1 fish/L leading to higher stress levels and aggressive behavior. However, densities between 4 and 16 fish/L do not compromise the welfare of zebrafish.
Article
Biochemistry & Molecular Biology
Karin Ademar, Louise Adermark, Bo Soderpalm, Mia Ericson
Summary: This study demonstrates that both N-acetylhomotaurine and the calcium moiety of acamprosate can increase dopamine levels in the nucleus accumbens, and the combination of these two components has a better effect.
Article
Behavioral Sciences
Amir Lotfi, Valentina Licheri, Johanna Andersson, Bo Soderpalm, Mia Ericson, Louise Adermark
Summary: Repeated exposure to amphetamine induces behavioral sensitization and long-lasting neuroadaptations in the dorsal striatal subregions, but these transformations are not driven by changes in GABAergic neurotransmission.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Clinical Neurology
J. Titulaer, O. Radhe, K. Danielsson, S. Dutheil, M. M. Marcus, K. Jardemark, T. H. Svensson, G. L. Snyder, M. Ericson, R. E. Davis, A. Konradsson-Geuken
Summary: Lumateperone is a novel drug approved for the treatment of schizophrenia and depressive episodes associated with bipolar depression. It simultaneously modulates key neurotransmitters and improves symptoms while enhancing prosocial behavior. The drug affects dopamine and glutamate signaling, potentially contributing to its effectiveness in improving mood-related symptoms.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna Loften, Louise Adermark, Mia Ericson, Bo Soderpalm
Summary: This study suggests that the rewarding effects of ethanol may be associated with ethanol-induced dopamine release in the nucleus accumbens, which involves glycine receptors. However, ethanol reward does not seem to be regulated by basal dopamine output.