期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 79, 期 -, 页码 95-102出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2015.03.003
关键词
Biodegradable polysaccharides; Multilayer; Chitosan; Alginate; Functional compounds
资金
- Fundacao para a Ciencia e Tecnologia [SFRH/BD/73178/2010, SFRH/BPD/72753/2010]
- POPH-QREN
- FSE (Portugal)
- FCT [PEst-OE/EQB/LA0023/2013]
- Project BioInd - Biotechnology and Bioengineering for improved Industrial and Agro-Food processes [NORTE-07-0124-FEDER-000028]
- Programa Operacional Regional do Norte (ON.2 - O Novo Norte), QREN, FEDER
This work aimed at the development of biodegradable nanocapsules as carriers of two bioactive compounds, 5-aminosalycilic acid and glycomacropeptide. Nanocapsules were produced through layer-by-layer (LbL) deposition of chitosan (CH) and alginate (ALG) layers on polystyrene nanoparticles. The bioactive compounds were incorporated on the third layer of the nanocapsules being its encapsulation efficiency and release behaviour evaluated. The LbL deposition process, stability, morphology and size of the multilayer nanocapsules were monitored by means of zeta potential and transmission electron microscopy (TEM). The bioactive compounds release from the CH/ALG nanocapsules was successfully described by a mathematical model (linear superimposition model - LSM), which allowed concluding that bioactive compounds release is due to both Brownian motion and the polymer relaxation of the CH/ALG layers. Final results demonstrated that the synthesized LbL hollow nanocapsules presented spherical morphology and a good capacity to encapsulate different bioactive compounds, being the best results obtained for the system containing 5-aminosalycilic acid (with an encapsulation efficiency of approximately 70%). CH/ALG multilayer nanocapsules could be a promising carrier of bioactive compounds for applications in food and pharmaceutical industries. (C) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据