Article
Clinical Neurology
Karen Kelley, Maggie Walgren, Hilary L. DeShong
Summary: This study found that anger rumination is the strongest predictor of both antisocial and borderline symptoms, while worry negatively predicts antisocial symptoms. Rumination and worry explain far more variance in borderline symptoms compared to antisocial symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Ignazio S. Piras, Giulia Braccagni, Matthew J. Huentelman, Marco Bortolato
Summary: This study is the first to use RNA sequencing to examine the molecular mechanisms underlying antisocial personality disorder (ASPD) and conduct disorder (CD). The results suggest that these disorders are associated with alterations in the orbitofrontal cortex, including downregulation of excitatory neuron transcripts and upregulation of astrocyte transcripts, as well as modifications in synaptic regulation and glutamatergic neurotransmission pathways.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Editorial Material
Psychology, Clinical
Jean-Paul Selten
Summary: This paper examines the validity of the hubris syndrome, including clinical description, laboratory study, and excluding other disorders. The research suggests that the hubris syndrome may be a non-organic personality change that occurs after individuals gain substantial power or achieve overwhelming success.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Gulay Tasci, Suheda Kaya, Mehmet Kalayci, Murad Atmaca
Summary: This study compared the levels of acyl ghrelin (AG), des-acyl ghrelin (DAG), and leptin in patients with antisocial personality disorder (ASPD) and healthy controls. The results showed that AG and DAG levels were significantly higher in patients, while leptin levels were significantly lower. There was also a positive correlation between AG and DAG levels and impulsivity and aggression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Brenda De Wit-De Visser, Madeleine Rijckmans, Jeroen K. Vermunt, Arno van Dam
Summary: ASPD and ASB have significant impacts on individuals, their environment, and society, with no evidence-based treatments currently available. Contradictory research findings on therapy effectiveness and underlying factors of ASB further fuel the debate on the accuracy of the conceptualization of ASPD and the homogeneity of this population.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Behavioral Sciences
Wolfgang Retz, Ylva Ginsberg, Daniel Turner, Steffen Barra, Petra Retz-Junginger, Henrik Larsson, Phil Asherson
Summary: ADHD is closely linked to the development of conduct problems during socialization in early life and to an increased risk for antisocial activities and delinquency over the lifespan. The interaction between ADHD and common comorbid disorders like substance use disorders as well as changing environmental conditions could mediate the course of antisocial and delinquent behavior with increasing age. However, this complex interaction is only partially understood so far.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Medicine, General & Internal
Ana De la Rosa-Caceres, Marta Narvaez-Camargo, Andrea Blanc-Molina, Nehemias Romero-Perez, Daniel Dacosta-Sanchez, Bella Maria Gonzalez-Ponce, Alberto Parrado-Gonzalez, Lidia Torres-Rosado, Cinta Mancheno-Velasco, Oscar Martin Lozano-Rojas
Summary: This study analyzed the association between personality facets in the Alternative Model of Personality Disorder (AMPD) of DSM-5 and the diagnostic criteria of alcohol-use disorder (AUD). The results showed that risk taking, callousness, and irresponsibility facets had the strongest association with AUD criteria, bridging externalizing personality traits with AUD criteria.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Carlotta Lunghi, Lionel Cailhol, Victoria Massamba, Elhadji A. Laouan Sidi, Caroline Sirois, Elham Rahme, Louis Rochette, Suzane Renaud, Evens Villeneuve, Marion Koch, Robert Biskin, Cathy Martineau, Philippe Vincent, Pierre David, Alain Lesage
Summary: Psychotropic medication use is common among individuals with Cluster B personality disorders, with an increase in usage observed after diagnosis, especially for antipsychotics, antidepressants, and mood stabilizers.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Social
Fabiano Koich Miguel, Gisele Magarotto Machado, Giselle Pianowski, Lucas de Francisco Carvalho
Summary: The study found that antisocial traits, especially lower levels of empathy and higher levels of callousness, deceitfulness, and risk-taking, are directly associated with lower compliance with COVID-19 containment measures.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2021)
Review
Psychology, Biological
Mario F. Mendez
Summary: This literature review explores the neurobiology of psychopathic traits compared to behavioral variant frontotemporal dementia (bvFTD), showing similarities in impairment of socioemotional perception, empathy, impulsivity, and altered moral judgment. While changes in psychopathy primarily occur in the amygdala and to a lesser extent, the anterior insula, neuropathology in bvFTD involves a wider paralimbic region. Relatively intact medial prefrontal and anterior cingulate cortices in psychopathy facilitate theory of mind and psychopathic traits such as deceitfulness, manipulation, bold fearlessness, and risk-taking behavior. Dysfunctional connectivity in psychopathy and direct involvement in bvFTD potentially explain the similarities and differences between these two conditions.
BIOLOGICAL PSYCHOLOGY
(2022)
Review
Psychology, Multidisciplinary
Julian Koenig, Julian F. Thayer, Michael Kaess
Summary: Psychophysiological research methods provide important insights into the normal and pathological functioning of the human organism. Existing studies on the psychophysiological concomitants of personality pathology are mixed, with a focus on borderline personality disorder. Findings suggest robust alterations in ANS function related to severe early maltreatment and trauma, as well as symptoms of dissociation, although lifestyle and secondary health factors are often overlooked.
CURRENT OPINION IN PSYCHOLOGY
(2021)
Article
Psychology, Clinical
Allison M. Daurio, Jeanette Taylor
Summary: This study explores how the triarchic model is related to Cluster B personality traits, finding that disinhibition positively predicts all Cluster B PDs, meanness positively predicts ASPD, NPD, and BPD, but negatively predicts HPD, and boldness positively predicts ASPD, NPD, and HPD while negatively predicting BPD.
PERSONALITY DISORDERS-THEORY RESEARCH AND TREATMENT
(2022)
Article
Psychiatry
Cindy L. Ehlers, Marc A. Schuckit, Victor Hesselbrock, David A. Gilder, Derek Wills, Kathleen Bucholz
Summary: This study describes the clinical course and symptom profile of DSM-IV Antisocial Personality Disorder (ASPD) and Adult Antisocial Behavior Syndrome (AABS). The results show that although the clinical course of antisocial behaviors does not differ based on race or sex, there are significant differences in symptom counts and age of onsets across groups. Women report fewer symptoms and at an older age compared to men, and those with ASPD have more symptoms overall. AA and AI participants and those with ASPD are more likely to be suspended/expelled from school and arrested at a younger age than EA.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Psychiatry
Khrystyna Stetsiv, Ian A. McNamara, Melissa Nance, Ryan W. Carpenter
Summary: Despite being underrecognized, the co-occurrence of personality disorders and substance use disorders is generally high. The prevalence varies depending on the type of PD and SUD, the population assessed, and the sampling methods used. Theoretical explanations include shared etiology and predisposition models, emphasizing the importance of transactional processes. Potential mechanisms include personality traits and transdiagnostic characteristics.
CURRENT PSYCHIATRY REPORTS
(2023)
Article
Law
Alexandra Junewicz, Stephen Bates Billick
Summary: Genetic factors play a significant role in the etiology of antisocial behavior and psychopathic traits, and gene-environment interactions are crucial for interventions and preventive efforts. Utilizing research findings to promote rehabilitative and developmentally appropriate policies can benefit youth in the juvenile justice and social welfare systems.
JOURNAL OF THE AMERICAN ACADEMY OF PSYCHIATRY AND THE LAW
(2021)
Article
Cell Biology
Patrick Szu-Ying Yen, Yen-Chin Liu, Chun-Hsien Chu, Shiou-Lan Chen
Summary: Chronic hypertension may lead to abnormal neuronal function and an increase in the expression of glutamatergic receptors, affecting the locomotor activity of rodents.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Psychology, Clinical
Ying-Chih Cheng, Po-Hsiu Kuo, Min- Su, Wei-Lieh Huang
Summary: The effects of non-invasive, non-convulsive electrical neuromodulation (NINCEN) on depression, anxiety, and sleep disturbance vary in different studies. This meta-analysis found that transcranial direct current stimulation (tDCS) has significant effects on both depression and anxiety, and these effects are robust across different populations and treatment parameters. Cerebral electrotherapy stimulation (CES) is also effective for depression and anxiety, especially in patients with low severity.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Jia-Chi Shan, I-Ming Chen, Po-Hsien Lin, Wei J. Chen, Shih-Cheng Liao, Ming-Been Lee, Po-Hsiu Kuo
Summary: This study examined the associations between prior lifetime mental disorders and subsequent suicidal behaviors in Taiwan. The findings suggest that mood disorders, anxiety disorders, and substance use disorders play significant roles in suicidal ideation and attempts. The study highlights the importance of considering anxiety and substance use disorders in population-based suicide prevention strategies.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Cell Biology
Mei-Chuan Chou, Hsiang-Chun Lee, Yen-Chin Liu, Patrick Szu-Ying Yen, Ching-Kuan Liu, Chu-Huang Chen, Tzu-Han Hsieh, Shiou-Lan Chen
Summary: This study found that long-term consumption of a high-fat diet may cause lipid metabolism overload in the brain and damage to glial cells. This may affect the protection of the brain and the survival of specific neurons.
Article
Biochemistry & Molecular Biology
Hsing-Chun Kuo, Kam-Fai Lee, Shiou-Lan Chen, Shu-Chen Chiu, Li-Ya Lee, Wan-Ping Chen, Chin-Chu Chen, Chun-Hsien Chu
Summary: This study investigated the regulatory mechanisms of PGE(2) tolerance in microglia. The presence of neurons was found to be necessary for PGE(2) tolerance, while neural contact was sufficient for the development of microglial PGE(2) tolerance. Furthermore, TLR4 signal and de novo protein synthesis were shown to be necessary for microglia to develop PGE(2) tolerance.
Article
Psychiatry
Micah Cearns, Azmeraw T. Amare, Klaus Oliver Schubert, Anbupalam Thalamuthu, Joseph Frank, Fabian Streit, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Franziska Degenhardt, Maria Del Zompo, J. Raymond De Paulo, Bruno Etain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Yi Hsiang Hsu, Stephane Jamain, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara Konig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nothen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Vincent Millischer, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fasil Tekola-Ayele, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Stephanie H. Witt, Gloria Roberts, Peter P. Zandi, Martin Alda, Michael Bauer, Francis J. McMahon, Philip B. Mitchell, Thomas G. Schulze, Marcella Rietschel, Scott R. Clark, Bernhard T. Baune
Summary: This study utilized a combination of genetic and clinical factors to predict lithium response in patients with bipolar disorder. By stratifying patients genetically and training machine-learning models with clinical predictors, significant improvements in lithium response prediction were achieved.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Genetics & Heredity
Chien-Chang Lee, Meng-tse Gabriel Lee, I-Hsuan Huang, Jasmine Tan, Zachary R. McCaw, Ke-Ying Su, Tzu-Chun Hsu, Ruby Y. J. Huang, Po-Hsiu Kuo, Shyr-Chyr Chen
Summary: Using the Taiwan Biobank, this study identified associations between NGF, IL1A, IL1B genes and primary dysmenorrhea in Han Chinese women in Taiwan.
JOURNAL OF HUMAN GENETICS
(2022)
Article
Psychology, Clinical
Chiao-Erh Chang, Jui Wang, Yi-Ting Lin, Chih-Chiang Chiu, Ming-Hsien Hsieh, Ming-Chyi Huang, Mong-Liang Lu, Hsi-Chung Chen, Wei J. Chen, Po-Hsiu Kuo
Summary: This study compared the clinical features, psychosocial characteristics, and comorbidity patterns between the unipolar mania (UM) and depressive-manic (D-M) subgroups. The results showed that compared to the D-M group, the UM group had more psychotic symptoms, a higher proportion of morningness chronotype, better sleep quality, higher extraversion, lower neuroticism, and less harm avoidance personality traits. Additionally, different lifetime comorbidity patterns were observed between the two groups.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Yi-Hsuan Lin, Chi-Shin Wu, Chen-Chung Liu, Po-Hsiu Kuo, Hung-Yu Chan, Wei J. Chen
Summary: The study retrospectively reviewed first-admission schizophrenia patients in Taiwan and found that patients using long-acting injectable antipsychotics had the lowest risk of readmission, with a risk reduction of 15-20% compared to oral risperidone. However, the prescription prevalence of LAIs remained low (<10%) during the follow-up period.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Yun-Ling Chen, Po-Hsiu Kuo
Summary: Objective depression and perceived stress are important risk factors for adolescent suicidal behaviors. This study examined the joint effects of parenting styles on suicidal ideation (SI) and attempt (SA) in early adolescents, while considering individual factors, and evaluated the role of social support in mitigating the risk. The results showed that depression, father's low care and high authoritarian parenting styles, and low acceptance and high authoritarian parenting styles were strong risk factors, while overall social support was a protective factor for SI and SA in early adolescents. Perceived stress and mother's low care and high authoritarian parenting style were also identified as risk factors for SI. Overall, family and social factors should be considered in suicidal prevention and interventions for early adolescents.
ARCHIVES OF SUICIDE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yen-Feng Lin, Wen-Hai Chou, Tung-Hsia Liu, Chiu-Ping Fang, Hsiang-Wei Kuo, Po-Hsiu Kuo, Shih-Jen Tsai, Sheng-Chang Wang, Ren-Hua Chung, Hsiao-Hui Tsou, Andrew C. H. Chen, Yu-Li Liu
Summary: The study found that the gene encoding the GABRD subunit of the GABA-A receptor is associated with amphetamine use in heroin dependent patients under MMT in Taiwan. Two genetic variants in the GABRD, rs2889475 and rs2376805, were found to be associated with the positive urine amphetamine test. The CC genotype carriers of rs2889475 showed a four times higher risk of amphetamine use than those with TT genotype, while the GG genotype carriers of rs2376805 showed a three times higher risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ran Zhou, Shih-Heng Chen, Zhan Zhao, Dezhen Tu, Sheng Song, Yubao Wang, Qingshan Wang, Jing Feng, Jau-Shyong Hong
Summary: Recent studies have found increased expression of complements in neurodegenerative diseases like Alzheimer's and Parkinson's diseases. However, the mechanism and role of complements in neurodegeneration are unclear. This study showed that acute neuroinflammation increased the expression of complement C3, and sustained expression during chronic neuroinflammation required the release of damage-associated molecule patterns (DAMPs). The activation of microglial NADPH oxidase (NOX2) was found to be involved in the sustained expression of C3. The findings suggest a role of C3 in regulating chronic neuroinflammation and driving progressive neurodegeneration.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Kaoru Inoue, Hamed Bostan, MaKenna R. Browne, Owen F. Bevis, Carl D. Bortner, Steven A. Moore, Aaron A. Stence, Negin P. Martin, Shih-Heng Chen, Adam B. Burkholder, Jian-Liang Li, Natalie D. Shaw
Summary: SMCHD1 mutations cause congenital arhinia and FSHD2. Loss of SMCHD1 activity leads to DUX4 expression and cell death in placode cells derived from hESCs and iPSCs. Herpesvirus infection may amplify DUX4 expression in SMCHD1 KO cells, indicating an environmental disease modifier.
Article
Biochemistry & Molecular Biology
Wei-Chen Chien, Chung-Wei Lin, Ching-Kuan Liu, Shiou-Lan Chen, Mei-Chuan Chou, Chung-Yao Hsu
Summary: Obstructive sleep apnea (OSA) is associated with cognitive decline, especially memory impairment, in the elderly. This study aimed to identify the PSG parameters that can predict memory impairment in OSA patients aged 50 and above.
Article
Psychiatry
Shiau-Shian Huang, Yu-Hsiang Yu, His-Han Chen, Chia-Chun Hung, Yao-Ting Wang, Chieh Hsin Chang, Syu-Jyun Peng, Po-Hsiu Kuo
Summary: This study found that the functional connectivity (FC) of major depressive disorder (MDD) patients was worse than that of controls at baseline, but improved after treatment. Responders showed better FC in the high-frequency bands than non-responders, both before and after treatment.
