Article
Hematology
Emma G. Bouck, Frederik Denorme, Lori A. Holle, Elizabeth A. Middelton, Antoinette M. Blair, Bas de Laat, Joshua D. Schiffman, Christian Con Yost, Matthew T. Rondina, Alisa S. Wolberg, Robert A. Campbell
Summary: COVID-19 and sepsis both involve activation of endogenous coagulation and fibrinolysis, but impact plasma procoagulant and fibrinolytic potential differently. Dysregulation of procoagulant and fibrinolytic pathways may uniquely contribute to the pathophysiology of COVID-19 and sepsis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Adel Hinsenkamp, Kiara Kun, Fatime Gajnut, Aliz Majer, Zsombor Lacza, Istvan Hornyak
Summary: Fibrin membranes are widely used in regenerative medicine due to their biocompatibility, biodegradability, high growth factor content, and cell attachment support. Cryoprecipitate isolation can increase fibrinogen and platelet concentration in plasma, affecting membrane thickness and growth factor content. However, membrane thickness does not significantly influence cell attachment, as demonstrated by live-dead staining and XTT measurements.
Article
Biophysics
Xiao Ma, Caihong Yang, Ruirui Zhang, Jie Yang, Yan Zu, Xin Shou, Yongxiang Zhao
Summary: A novel natural biomass-based hydrogel microparticle was developed using microfluidic electrospray technology. The microparticles showed enhanced chemotherapy effect, inhibited tumor growth, and exhibited good biocompatibility and sustained drug release.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Nurul H. Sulimai, Jason Brown, David Lominadze
Summary: This review discusses the role of fibrinogen and its derivatives in inflammatory diseases and their effects on immunomodulation.
Review
Biochemistry & Molecular Biology
Ilker S. Bayer
Summary: This article presents recent advances in the understanding and application of fibrin and fibrin-fiber-incorporated biomedical materials for wound healing and tissue repair. It discusses the key roles of fibrinogen and fibrin fibers in tissue regeneration and their functions in wound healing stages. Additionally, it explores the modification of fibrin with next-generation materials to enhance stability and medical efficacy, along with an examination of the mechanical properties of fibrin-based materials.
Article
Polymer Science
Ritika Singh Petersen, Anja Boisen, Stephan Sylvest Keller
Summary: The study introduces a high-throughput technique - Micromechanical Punching (MMP) for fabrication of non-spherical microparticles. It allows production of microparticles from prepatterned, porous, and fibrous films, constituting thermoplastics and thermosetting polymers. This method shows potential to make micro/nanofabrication more accessible to research and industrial communities for engineered particles applications.
Review
Hematology
Leonid Medved, John W. Weisel
Summary: This review summarizes the current understanding of the structure and interactions of fibrinogen's alpha C regions. The alpha C-domain and alpha C-connector play important roles in fibrinogen conversion and clot mechanics, as well as interaction with other proteins during hemostasis and wound healing.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Pharmacology & Pharmacy
Marcus Wanselius, Yassir Al-Tikriti, Per Hansson
Summary: Drug-eluting beads made of responsive polyelectrolyte networks are used in the treatment of liver cancer. Recent research has shown that the release and swelling rates of these beads are controlled by the formation of a depletion layer in the microgel. By controlling the stability of drug aggregates and the swelling properties of the network, it is possible to control the release profile of other drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Richard J. Fish, Cristina Freire, Corinne Di Sanza, Marguerite Neerman-Arbez
Summary: Thrombosis assays in larval zebrafish can distinguish between quantitative and qualitative fibrinogen disorder models, providing insights into the thrombotic phenotype of novel fibrinogen mutations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
S. R. Aravind, S. Lakshmi, S. Ranjith, Lissy K. Krishnan
Summary: Clinical-grade curcumin-incorporated fibrin matrix, in either lyophilized wafer or injectable hydrogel forms, has shown advantages as a local delivery system for sustained release of active curcumin in controlling cancer cell growth. In vitro and in vivo studies demonstrated the apoptotic function of curcumin on cancer cells, as well as its immuno-modulation effects and nontoxic response when released from the fibrin matrix. The potential of curcumin in preventing tumor growth and metastasis through sustained delivery from the fibrin matrix was highlighted.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Shiyu Wu, Zhengjie Shan, Lv Xie, Mengxi Su, Peisheng Zeng, Peina Huang, Lingchan Zeng, Xinyue Sheng, Zhipeng Li, Gucheng Zeng, Zhuofan Chen, Zetao Chen
Summary: Research has shown that clot-immune responses can be regulated by tuning the mesoporous pore sizes, which in turn reduces inflammation of macrophages.
Review
Pharmacology & Pharmacy
Petronille Roy, Nathalie Mignet, Marc Pocard, Vincent Boudy
Summary: Peritoneum is a common site of metastasis for digestive and ovarian primary cancers, but traditional treatments such as systemic chemotherapy have limited effectiveness. Recent therapeutic advances have introduced an aggressive strategy combining cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. However, a study showed that this combination did not improve overall survival and relapse-free survival.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Mahnaz Amiri, Payam Khazaeli, Ali Salehabadi, Masoud Salavati-Niasari
Summary: Hydrogels are widely used in drug delivery due to their biocompatibility and related properties. Continuous drug release to target areas can be achieved by activating/modifying hydrogels with magnetic or fluorescent materials. Developing new crosslinked polymers with biocompatibility and biodegradability is essential for novel drug delivery platforms.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Review
Polymer Science
Se Min Kim, Madhumita Patel, Rajkumar Patel
Summary: Core-shell particles are well known for their unique structure and promising biomedical applications. PLGA, an FDA-approved polymer, is recognized as a vehicle material for drug delivery systems based on these particles. These systems are utilized for cancer therapy and tissue regeneration, particularly bone, cartilage, and periodontal regeneration.
Article
Engineering, Multidisciplinary
Sung Jun Min, Jae Seo Lee, Haram Nah, Ho-Jin Moon, Sang Jin Lee, Hyeon Jeong Kang, Yu-Shik Hwang, Il Keun Kwon, Dong Nyoung Heo
Summary: Biodegradable hydrogels have great potential as biomaterials for controlled-release systems in skin tissue regeneration. In this study, keratin-based hydrogels were synthesized and their properties were investigated for controllable protein delivery. The results showed that these hydrogels exhibited promising biological performance and could serve as suitable carriers for controlled protein delivery.
JOURNAL OF BIONIC ENGINEERING
(2023)
Article
Oncology
Jyoti Gupta, Haaris Ahsan Safdari, Mehboob Hoque
Summary: Nanoparticles play a crucial role in enhancing the efficacy of traditional cancer vaccines and modulating the tumor microenvironment (TME) efficiently, showing great potential for clinical formulations in cancer immunotherapy in the near future.
SEMINARS IN CANCER BIOLOGY
(2021)
Correction
Microbiology
Nida Mubin, Mohd. Saad Umar, Swaleha Zubair, Mohammad Owais
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Applied
Mohammad Shahwaz Ahmad, Mohd Khalid, Mohammad Shahnawaz Khan, Mohammad Shahid, Musheer Ahmad, Haris Saeed, Mohammad Owais, Mo Ashafaq
Summary: By designing two dinuclear Cu (II) complexes with different substituents, the study investigated their biological activities. The results showed that one of the complexes exhibited enhanced catecholase activity and antibacterial properties.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Adel M. Abuzenadah, Fatin Al-Sayes, Syed Sahajada Mahafujul Alam, Mehboob Hoque, Sajjad Karim, Ibtessam M. R. Hussain, Shams Tabrez
Summary: Angiogenesis is crucial for tumor development, and targeting VEGFR-2 signaling is a promising strategy for cancer treatment. This study identified bioactive compounds from Rauwolfia serpentina that effectively bind with VEGFR-2. Molecular docking results showed strong interactions between these compounds and VEGFR-2, and they possess favorable drug-like properties without significant toxicity. These findings suggest the potential of these compounds for antiangiogenic drug development.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Munazza Tamkeen Fatima, Zeyaul Islam, Ejaj Ahmad, Mehboob Hoque, Marriam Yamin
Summary: The research explored the potential of fibrin-based plasma beads and liposome-PB systems as delivery systems for combating fungal infections. These systems exhibited the ability to sustain the release of antifungal compounds in the bloodstream and gradually accumulate in vital organs, offering safe and effective alternatives for drug delivery.
Article
Chemistry, Physical
Hina Qamar, Adil Saeed, Mohammad Owais, Touseef Hussain, Kashif Hussain, Aziz Ur Rahman, Sarfraz Ahmed, Sachin Kumar, Zulfiqar Ahmad Khan
Summary: A simple and environmentally friendly one-pot synthesis method was proposed in this study to design stable, novel nanocomposites to combat bacterial resistance to beta-lactam antibiotics. Through various characterization techniques, the stability and antibacterial activity of the composite material were confirmed, indicating potential application in drug delivery for bactericidal therapeutic purposes.
Review
Neurosciences
Asim Azhar, Mohammad Akram Wali, Qudsia Rashid, Wajihul Hasan Khan, Khaled Al-hosaini, Mohammad Owais, Mohammad Amjad Kamal
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has become a global concern since March 2020. Initially thought to be limited to the respiratory system, the virus has been found to affect other organs, including the nervous system. Reports indicate that SARS-CoV-2 can penetrate the central nervous system (CNS) and cause neurological symptoms. This comprehensive review examines the entry routes of SARS-CoV-2 into the CNS, the molecular mechanisms involved, clinical symptoms, and associated nervous system diseases.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Shams Tabrez, Torki A. Zughaibi, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Azhar U. Khan
Summary: In this study, 12 potent compounds were identified from a traditional Chinese medicine database as potential GLS inhibitors. Among them, ZINC03978829 and ZINC32296657 exhibited higher binding energy values with GLS. Molecular dynamics simulations confirmed that these compounds form stable complexes with GLS, suggesting their potential as therapeutic agents against cancer. Further laboratory testing is required to optimize these compounds as GLS inhibitors.
Article
Cell Biology
Zarnain Jamil, Arif Uddin, Syed Sahajada Mahafujul Alam, Arijit Samanta, Nojood Altwaijry, Mohd Ahmar Rauf, Safdar Ali, Mohd Shahnawaz Khan, Muhammad Nadeem Asghar, Mehboob Hoque
Summary: Autophagy is involved in various human pathologies and is regulated by a set of autophagy-related genes. This study analyzed the nucleotide composition and codon usage pattern of human autophagy genes, revealing an overall low codon usage bias. Both nucleotide composition and evolutionary forces influence the codon usage pattern of these genes.
Article
Genetics & Heredity
Arijit Samanta, Syed Sahajada Mahafujul Alam, Safdar Ali, Mehboob Hoque
Summary: The newly emerged Omicron (B.1.1.529) variant of the SARS-CoV-2 virus shows higher infectivity in humans, raising concerns about possible transmission via intermediate hosts. Through protein-protein interaction analysis, it was found that Omicron interacts with the ACE2 receptor of 122 mammalian hosts with different amino acid residues. This indicates a greater potential for new host transmission and infection.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Correction
Biochemistry & Molecular Biology
Shams Tabrez, Torki A. A. Zughaibi, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Azhar U. U. Khan
Article
Biochemistry & Molecular Biology
Iftikhar Ahmad, Mehboob Hoque, Syed Sahajada Mahafujul Alam, Torki A. Zughaibi, Shams Tabrez
Summary: Cancer development is associated with deregulation of cell signaling pathways caused by genetic and epigenetic alterations. The PI3K/Akt/mTOR pathway is a major deregulated pathway in cancer, and several drug candidates are being investigated to target this pathway. Curcumin and plumbagin are potential anticancer compounds that individually target the PI3K/Akt/mTOR pathway. This study investigates their synergistic effect by employing molecular docking and molecular dynamics analysis. The results show increased binding affinity and decreased inhibition constant when curcumin and plumbagin are sequentially docked against PI3K, Akt, and mTOR. MD simulations and MM-GBSA analyses validate the more stable conformation of target proteins when interacting with the combination of curcumin and plumbagin, indicating their synergistic role against cancer cells. The findings pave the way for further investigation of their combinatorial effect in vitro and in vivo models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Syed Sahajada Mahafujul Alam, Arijit Samanta, Faizan Uddin, Safdar Ali, Mehboob Hoque
Summary: Natural compound Tan IIA derived from the roots of Traditional Chinese Medicine herb Salvia miltiorrhiza exhibits remarkable anticancer properties against various types of cancer by modulating multiple signaling pathways. It inhibits tumor cell growth and proliferation, metastasis, invasion, and angiogenesis, while inducing apoptosis and autophagy. This review focuses on the role of Tan IIA in cancer treatment and its underlying molecular mechanisms.
PHARMACOLOGICAL REPORTS
(2023)
Review
Oncology
Farheen Badrealam Khan, Parul Singh, Yahya F. Jamous, Syed Azmal Ali, Abdullah, Shahab Uddin, Qamar Zia, Manoj Kumar Jena, Mohsina Khan, Mohammad Owais, Chih Yang Huang, Venkatesh Chanukuppa, Chrismawan Ardianto, Long Chiau Ming, Waqas Alam, Haroon Khan, Mohammad Akli Ayoub
Summary: This article reviews the use of proteomics to study the molecular details of phytochemicals such as curcumin, genistein, and tanshinone IIA. These phytochemicals have various pharmacological properties that are extensively studied to understand their mechanisms of action. Proteomics technology has proved to be a reliable approach to unravel the molecular intricacies of phytochemicals.
Article
Chemistry, Multidisciplinary
Shams Tabrez, Azhar U. Khan, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Torki A. Zughaibi
Summary: This study biosynthesized ZnO NPs from pumpkin seed extract and demonstrated their anticancer potential in breast cancer cells, showing promise for future applications in cancer treatment.
NANOTECHNOLOGY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)