Article
Psychology, Clinical
Damian Czarnecki, Marcin Ziolkowski, Jan Chodkiewicz, Marta Gorzkiewicz, Napoleon Waszkiewicz, Anna Dlugosz, Jacek Budzynski, Anna Junkiert-Czarnecka, Agnieszka Kulak-Bejda
Summary: This study aimed to assess changes in the severity of alcohol craving according to allelic variants of the 5-HTTLPR gene polymorphism during hospitalisation and their association with selected clinical variables in alcohol-dependent patients. The results showed that there was a decrease in the severity of alcohol craving at the 6th week of the follow-up in subjects with the short/short allele and long/short allele of the 5-HTTLPR gene.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2023)
Article
Pharmacology & Pharmacy
Ming-Fen Ho, Cheng Zhang, Irene Moon, Brandon J. J. Coombes, Joanna Biernacka, Michelle Skime, Doo-Sup Choi, Paul E. E. Croarkin, Mark A. A. Frye, Quyen Ngo, Cedric Skillon, Tyler S. S. Oesterle, Victor M. M. Karpyak, Hu Li, Richard M. M. Weinshilboum
Summary: This study aimed to identify biomarkers associated with acamprosate treatment response in patients with alcohol use disorder (AUD) using proteomics and RNA sequencing. The findings suggest that baseline plasma TNFSF10 concentration is associated with alcohol craving intensity and acamprosate treatment outcomes. In addition, inflammation-related pathways are highly associated with relapse during acamprosate treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Ran Zhu, Zhaojun Ni, Ran Tao, Jun Cheng, Liangjun Pang, Shun Zhang, Yang Zhang, Yanxue Xue, Yundong Ma, Wei Sun, Lin Lu, Jiahui Deng, Hongqiang Sun
Summary: Repeated exposure to olfactory stimulus during non-rapid eye movement sleep did not significantly affect cue reactivity and craving in patients with alcohol dependence.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Clinical
Warren Logge, Andrew Baillie, Paul Haber, Ellen Towers, Benjamin C. Riordan, Kirsten Morley
Summary: This study aimed to evaluate the role of sex in the relationship between daily alcohol consumption, stress, and craving in response to baclofen treatment. The results showed that baclofen abolished the association between stress and drinking in females, but this was not observed in males.
ADDICTIVE BEHAVIORS
(2023)
Review
Emergency Medicine
Kiran Punia, William Scott, Kriti Manuja, Monica Sabbineni, Kaitryn Campbell, Iris M. Balodis, James Mackillop
Summary: This systematic review evaluates the efficacy of anti-craving medications for the treatment of alcohol use disorder (AUD) in the emergency department (ED). The existing evidence is limited, but supports the use of naltrexone pharmacotherapy, particularly extended-release injections. More randomized controlled trials are needed for substantive direct evidence.
ACADEMIC EMERGENCY MEDICINE
(2023)
Article
Medicine, Research & Experimental
Doaa Fathi, Ahmed I. Abulsoud, Muhammed A. Saad, Noha N. Nassar, Mina M. Maksimos, Sherine M. Rizk, Mahmoud A. Senousy
Summary: Agomelatine treatment in a rat model of alcoholism led to a significant decrease in alcohol consumption and positive effects on behavior and biochemical markers. Agomelatine reversed alcohol cravings and withdrawal symptoms associated with alcohol dependence by modulating the Notch1 signaling pathway.
Article
Substance Abuse
Nozomu Hashimoto, Hiroshi Habu, Soshi Takao, Shinji Sakamoto, Yuko Okahisa, Keitaro Matsuo, Manabu Takaki, Yoshiki Kishi, Norihito Yamada
Summary: This study identified clinical moderators that affect treatment response to nalmefene in alcohol-dependent patients. Age, family history of problem drinking, age at onset of problem drinking, and smoking status were found to be possible positive moderators. Patients with favorable prognostic factors such as non-smoking status, no family history of problem drinking, and a late-onset of problem drinking selectively benefit from nalmefene. Further research is needed to validate these exploratory results.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Chemistry, Medicinal
Hongsong Feng, Rui Wang, Chang-Guo Zhan, Guo-Wei Wei
Summary: In this study, a deep generative model combining a stochastic differential equation (SDE)-based diffusion model with a pretrained autoencoder is proposed. The model efficiently generates molecules targeting multiple opioid receptors and evaluates their ADMET properties. Molecular optimization is performed to enhance the pharmacokinetic properties of lead compounds. Advanced binding affinity predictors are built using molecular fingerprints, providing a valuable tool for evaluating the pharmacological effects of the generated molecules.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Eric C. Anderson, Julie A. Cantelon, Amanda Holmes, Grace E. Giles, Tad T. Brunye, Robin Kanarek
Summary: The ability to regulate the intake of unhealthy foods is crucial in today's food environments. Increasing activity in the dorsolateral prefrontal cortex (DLPFC) may enhance cognitive control and emotional regulation, leading to better resistance against consuming unhealthy but palatable foods. Anodal transcranial direct current stimulation (tDCS) targeting the right DLPFC was found to decrease the perception of pleasantness but not the urge to consume highly palatable foods.
Article
Food Science & Technology
Gabriele Kavaliauskaite, Margaret Thibodeau, Rebecca Ford, Qian Yang
Summary: Distinct hedonic patterns of sweet taste liking have been recognized for more than half a century. However, current classification methods for Sweet Liking Status (SLS) lack consistency. This study used a large dataset and applied Agglomerative Hierarchical Clustering (AHC) and correlation matrices to classify SLS. Three distinct consumer clusters were identified: High Sweet Likers (HSL), Medium Sweet Likers (MSL), and Low Sweet Likers (LSL). A rapid three-solution method was also explored as a simplified and efficient way of classifying participants for SLS.
FOOD QUALITY AND PREFERENCE
(2023)
Review
Neurosciences
Matheus Cheibub David Marin, Maria Olivia Pozzolo Pedro, Giuliana Perrotte, Anderson S. Martins-da-Silva, Dangela L. S. Lassi, Israel Kanaan Blaas, Fernando Ikeda Castaldelli, Maria Beatriz Brisola dos Santos, Guilherme Trevizan Kortas, Marcela Waisman Campos, Julio Torales, Antonio Ventriglio, Cintia de Azevedo-Marques Perico, Andre B. Negrao, Kae Leopoldo, Arthur Guerra de Andrade, Andre Malbergier, Joao Mauricio Castaldelli-Maia
Summary: The treatment of substance addiction has been a persistent challenge with limited therapeutic options. Although there are recommendations for specific treatments for Alcohol Use Disorder (AUD), there is a lack of specific medication for alcohol cravings. Effective drugs for promoting abstinence and relieving cravings include Naltrexone, Acamprosate, Baclofen, Gabapentin, and Topiramate.
Article
Neurosciences
Joanna M. Biernacka, Brandon J. Coombes, Anthony Batzler, Ada Man-Choi Ho, Jennifer R. Geske, Josef Frank, Colin Hodgkinson, Michelle Skime, Colin Colby, Lea Zillich, Sofia Pozsonyiova, Ming-Fen Ho, Falk Kiefer, Marcella Rietschel, Richard Weinshilboum, Stephanie S. O'Malley, Karl Mann, Ray Anton, David Goldman, Victor M. Karpyak
Summary: The study demonstrates the impact of genetic polymorphism on AUD treatment response and identifies genetic variants associated with potentially medication-specific effects on AUD treatment response.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Patrick Bach, Rilana Schuster, Anne Koopmann, Sabine Vollstaedt-Klein, Rainer Spanagel, Falk Kiefer
Summary: Recent studies have found a negative correlation between plasma calcium concentrations and alcohol craving, as well as a predictive link between higher calcium levels and increased alcohol cue-induced brain response in frontal areas. Functional brain activation in these regions is negatively correlated with craving for alcohol, suggesting a potential modulatory effect of plasma calcium concentrations on craving inhibition during early abstinence.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Substance Abuse
Jack T. Waddell, William R. Corbin, David P. MacKinnon, Robert F. Leeman, Kelly S. DeMartini, Lisa M. Fucito, Henry R. Kranzler, Stephanie S. O'Malley
Summary: Objective Naltrexone is effective in treating heavy drinking among young adults. However, few studies have examined its effects on subjective response and craving in natural drinking environments. This study used daily diary data to analyze the effects of treatment condition (naltrexone vs. placebo) and medication dosage on subjective response and craving. The results show that naltrexone reduces intense subjective effects and craving, with medication dosage affecting within-person effects. The study suggests that future research can confirm and expand these findings using momentary assessments.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ming-Fen Ho, Cheng Zhang, Lixuan Wei, Lingxin Zhang, Irene Moon, Jennifer R. Geske, Michelle K. Skime, Doo-Sup Choi, Joanna M. Biernacka, Tyler S. Oesterle, Mark A. Frye, Marvin D. Seppala, Victor M. Karpyak, Hu Li, Richard M. Weinshilboum
Summary: This study investigates the differences in metabolomic profiles between patients who achieved sobriety and those who relapsed during acamprosate treatment. The results show that certain plasma components are associated with treatment outcomes and craving intensity, and identify a series of genes that are ethanol responsive. Additionally, several genetic variations associated with treatment outcomes were identified.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)