Article
Neurosciences
Stina Lundberg, Erika Roman, Richard L. Bell
Summary: This study aimed to examine the behavioral profiles of rats selectively bred for high or low alcohol consumption during adolescence. The results showed that there was no common behavioral profile for either high or low alcohol-consuming rat lines, and the effect of sex was minimal. The high alcohol-consuming rats displayed high activity and risk-associated behaviors, while the low alcohol-consuming rats displayed low activity, high shelter-seeking behavior, and open area avoidance.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Simon N. Katner, Alena M. Sentir, Kevin B. Steagall, Zheng-Ming Ding, Leah Wetherill, Frederic W. Hopf, Eric A. Engleman
Summary: Understanding risk factors that increase the development of addiction is crucial, and studying genetically-selected EtOH-preferring rodents can provide insights into mechanisms underlying compulsive drinking and lead to new treatments for AUDs.
Article
Medicine, Research & Experimental
Joanna Kuczynska, Barbara Nieradko-Iwanicka
Summary: Ketoprofen is a commonly used NSAID with side effects mainly occurring in the gastrointestinal tract, and it does not have a gastroprotective effect on the stomach mucosa after ethanol-induced injury.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Substance Abuse
Fiona R. Beyer, Ryan P. W. Kenny, Eugenie Johnson, Deborah M. Caldwell, Claire Garnett, Stephen Rice, Julija Simpson, Colin Angus, Dawn Craig, Matt Hickman, Susan Michie, Eileen F. S. Kaner
Summary: This study compares the effectiveness of practitioner versus digitally delivered interventions for reducing hazardous and harmful alcohol consumption. The findings suggest that practitioner delivered interventions are more effective in reducing consumption up to 6 months, but there is no evidence of a difference at 12 months.
Article
Neurosciences
M. Adrienne McGinn, Brendan J. Tunstall, Joel E. Schlosburg, Adriana Gregory-Flores, Olivier George, Giordano de Guglielmo, Barbara J. Mason, Hazel J. Hunt, George F. Koob, Leandro F. Vendruscolo
Summary: The study demonstrated the potential of GR modulators in reducing alcohol consumption, with different effects observed in different circumstances. These findings provide insights for the development of treatments for AUD.
Article
Environmental Sciences
Akram Hernandez-Vasquez, Horacio Chacon-Torrico, Rodrigo Vargas-Fernandez, Leandro Nicolas Grendas, Guido Bendezu-Quispe
Summary: Alcohol consumption is a public health problem in Peru, with higher binge drinking rates observed among men. Factors associated with binge drinking vary by gender and include age, education level, marital status, and ethnic self-identification.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Tala Al-Rousan, Alison A. Moore, Benjamin H. Han, Roxanne Ko, Joseph J. Palamar
Summary: Binge drinking has increased among older men in the United States while it has remained stable among older women. Although tobacco and cannabis use is associated with an increased risk of binge drinking among both older men and women, demographic correlates tend to differ by sex.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Behavioral Sciences
Ida Fredriksson, Nitya Jayaram-Lindstrom, Peter W. Kalivas, Philippe A. Melas, Pia Steensland
Summary: The study found that N-acetylcysteine (NAC) can reduce relapse-like drinking and improve impulse control in long-term alcohol drinking rats, but has no effect on levels of alcohol drinking or motivation to drink alcohol. These findings support the use of NAC as an adjuvant treatment for alcohol use disorder (AUD) and warrant further investigation in substance use settings.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
C. Leonardo Jimenez Chavez, Camron D. Bryant, Melissa A. Munn-Chernoff, Karen K. Szumlinski
Summary: Selective PDE4B inhibition is an effective strategy for reducing excessive alcohol intake in murine models of binge drinking, with minimal off-target effects. While reducing sensitivity to acute alcohol intoxication, PDE4B inhibition reduces binge alcohol drinking without influencing behavioral sensitivity to alcohol in alcohol-experienced mice. Additionally, A33 is equally effective in males and females and exerts a quantitatively similar reduction in alcohol intake in mice with a genetic predisposition for high versus moderate alcohol preference. These findings further support the safety and potential clinical utility of targeting PDE4 for treating AUD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Silvia Baldari, Isabella Manni, Giuliana Di Rocco, Francesca Paolini, Belinda Palermo, Giulia Piaggio, Gabriele Toietta
Summary: The study observed a decrease in bone marrow progenitor cell proliferation rate in response to toxic effects of aldehydes generated by alcohol oxidation, as reflected by bioluminescent alteration in a mouse model. Boosting acetaldehyde catabolism or antioxidant administration partially restored physiological proliferation of bone marrow cells.
Article
Substance Abuse
Ian A. McNamara, Scott E. King, William R. Corbin, Kim Fromme
Summary: This study shows that college athletes are more likely to binge drink both before and during college, even when considering several known risk factors related to athletic populations. Factors such as drinking norms and personality traits were found to predict binge drinking. Sports participation before college entry was associated with binge drinking at matriculation, and continued participation in sports was associated with increased risk throughout the college years.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2022)
Article
Psychology, Multidisciplinary
Judith Andre, Momar Diouf, Margaret P. Martinetti, Olivia Ortelli, Fabien Gierski, Frederic Furst, Olivier Pierrefiche, Mickael Naassila
Summary: This study aims to identify homogeneous drinking groups and develop a new tool to assess the severity of binge drinking regardless of gender. Through clustering analysis and a partial proportional odds model, key factors of drinking and behavior were identified, and homogeneous drinking groups were created. The results show a progressive severity in the drinking pattern, and frequency of drinking behavior and drunkenness are central features of binge drinking.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Public, Environmental & Occupational Health
M. Arantxa Colchero, Tonatiuh Barrientos-Gutierrez, Carlos M. Guerrero-Lopez, Sergio Bautista-Arredondo
Summary: Studies in Mexico found that binge drinking is associated with the density of alcohol-selling outlets and alcohol prices, with living in areas with more outlets associated with higher binge drinking risk, and living in states with lower prices associated with more frequent binge drinking. Implementing spatial restrictions to alcohol-selling outlets could help reduce binge drinking along with strong fiscal policies.
PREVENTIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hwa-Young Lee, Geum-Hwa Lee, The-Hiep Hoang, Seung Wook Kim, Choon Gil Kang, Jae Hyeok Jo, Myoung Ja Chung, Kyunghyun Min, Han -Jung Chae
Summary: This study found that turmeric extract can enhance the activity of alcohol-metabolizing enzymes in the liver, regulate oxidative stress and inflammation, and increase the activity of antioxidant enzymes. These results suggest a potential beneficial effect of turmeric extract against acute liver toxicity.
Letter
Medicine, General & Internal
Jeffrey T. Howard, Jessica K. Perrotte, Kassandra Flores, Caleb Leong, Joseph David Nocito, Krista J. Howard
Summary: This cross-sectional study examines the prevalence trends of binge drinking and heavy alcohol consumption among pregnant women and nonpregnant women from 2011 to 2020.
Article
Substance Abuse
Jamie E. Toalston, Gerald A. Deehan, Sheketha R. Hauser, Eric A. Engleman, Richard L. Bell, James M. Murphy, William J. McBride, Zachary A. Rodd
Article
Clinical Neurology
Zheng-Ming Ding, Cynthia M. Ingraham, Zachary A. Rodd, William J. McBride
JOURNAL OF PSYCHOPHARMACOLOGY
(2015)
Article
Neurosciences
S. R. Hauser, G. A. Deehan, R. Dhaher, C. P. Knight, J. A. Wilden, W. J. Mcbride, Z. A. Rodd
Article
Neurosciences
Laura B. Zahodne, Nicole Schupf, Adam M. Brickman, Richard Mayeux, Melanie M. Wall, Yaakov Stern, Jennifer J. Manly
JOURNAL OF ALZHEIMERS DISEASE
(2016)
Article
Biochemistry & Molecular Biology
Sheketha R. Hauser, Amy L. Bracken, Gerald A. Deehan, Jamie E. Toalston, Zheng-Ming Ding, William A. Truitt, Richard L. Bell, William J. McBride, Zachary A. Rodd
Article
Biochemistry & Molecular Biology
Zheng-Ming Ding, Cynthia M. Ingraham, Zachary A. Rodd, William J. McBride
Article
Neurosciences
William A. Truitt, Sheketha R. Hauser, Gerald A. Deehan, Jamie E. Toalston, Jessica A. Wilden, Richard L. Bell, William J. McBride, Zachary A. Rodd
PSYCHOPHARMACOLOGY
(2015)
Article
Neurosciences
Sheketha R. Hauser, Gerald A. Deehan, Jamie E. Toalston, Richard L. Bell, William J. McBride, Zachary A. Rodd
PSYCHOPHARMACOLOGY
(2014)
Article
Neurosciences
Simon N. Katner, Jamie E. Toalston, Michael P. Smoker, Zachary A. Rodd, William J. McBride, Eric A. Engleman
PSYCHOPHARMACOLOGY
(2015)
Article
Neurosciences
Robert A. Waeiss, Christopher P. Knight, Sheketha R. Hauser, Lauren A. Pratt, William J. McBride, Zachary A. Rodd
PSYCHOPHARMACOLOGY
(2019)
Review
Substance Abuse
Fulton T. Crews, Donita L. Robinson, L. Judson Chandler, Cindy L. Ehlers, Patrick J. Mulholland, Subhash C. Pandey, Zachary A. Rodd, Linda P. Spear, H. Scott Swartzwelder, Ryan P. Vetreno
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Substance Abuse
Sheketha R. Hauser, Christopher P. Knight, William A. Truitt, Robert Aaron Waeiss, Ian S. Holt, Gustavo B. Carvajal, Richard L. Bell, Zachary A. Rodd
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Neurosciences
Zachary A. Rodd, Sheketha R. Hauser, H. Scott Swartzwelder, R. Aaron Waeiss, Debomoy K. Lahiri, Richard L. Bell
PSYCHOPHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sheketha R. Hauser, Patrick J. Mulholland, William A. Truitt, R. Aaron Waeiss, Eric A. Engleman, Richard L. Bell, Zachary A. Rodd
Summary: The study suggests that binge-like alcohol exposure during adolescence leads to a persistent hyperdopaminergic state in adulthood, influencing the adult neurochemical response to alcohol. Alcohol exposure affects gene expression, dendritic spine morphology, and dopamine levels in the nucleus accumbens shell.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Serhii O. Soloviov, Tetiana S. Todosiichuk, Olena Kovaliuk, Gabriel M. Filippelli, Olena P. Trokhymenko, Iryna Dziublyk, Zachary A. Rodd
Summary: This study examined the rates of rotavirus and norovirus infections throughout Ukraine and found that childhood diarrhea impacts Ukraine significantly.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Substance Abuse
Atefeh Bakhtazad, Afsaneh Asgari Taei, Fatemeh Parvizi, Mehdi Kadivar, Maryam Farahmandfar
Summary: This study found that repeated morphine pretreatment can reverse the impairment of spatial learning and memory caused by ethanol, and this effect may be explained by the modulation of CaMKII and BDNF expressions in the hippocampus and amygdala.
