Review
Oncology
Zili Zhai, Takeshi Yamauchi, Sarah Shangraw, Vincent Hou, Akiko Matsumoto, Mayumi Fujita
Summary: Acetaldehyde (AcAH), a carcinogenic byproduct of ethanol metabolism, has been linked to the development of malignancies in the upper gastrointestinal tract as well as cutaneous melanoma. This review examines the sources of ethanol and AcAH in the skin, their metabolic pathways, and the role of dysfunctional ethanol and AcAH metabolizing enzymes in melanoma development and progression. Data analysis also shows reduced activity of alcohol and AcAH metabolizing enzymes in melanoma tissues.
Article
Food Science & Technology
Naila Boby, Eon-Bee Lee, Muhammad Aleem Abbas, Na-Hye Park, Sam-Pin Lee, Md. Sekendar Ali, Seung-Jin Lee, Seung-Chun Park
Summary: FSC pretreatment reduces blood alcohol and acetaldehyde concentrations, modulates liver enzyme activities, increases antioxidant enzyme expression, and decreases inflammatory cytokine gene expression in the liver. Additionally, it shows no acute oral toxicity in female rats and may be beneficial for reducing alcohol-induced damage.
Article
Endocrinology & Metabolism
Shiyun Jin, Qi Cao, Fanghan Yang, Hongying Zhu, Su Xu, Qi Chen, Ziyi Wang, Yuhong Lin, Resat Cinar, Robert J. Pawlosky, Ye Zhang, Wei Xiong, Bin Gao, George F. Koob, David M. Lovinger, Li Zhang
Summary: The study demonstrates that astrocytic ALDH2 metabolizes ethanol in the brain, affecting the behavioral effects of alcohol. It shows that astrocytic ALDH2 controls the production and behavioral effects of alcohol metabolites in different brain regions.
Article
Food Science & Technology
Sisi Chen, Shimin Jia, Keke Suo, Qiaozhen Kang, Limin Hao, Laizheng Lu, Xin Liu, Jinyong Huang, Jike Lu
Summary: Exposure to environmental stresses enhances the adaptability of bacteria and up-regulates the expression of oxidative stress-related genes and antioxidant enzymes. This study evaluated the effects of untreated and ethanol-induced Lactococcus lactis intracellular extracts on alcohol metabolism in mice. The results showed that ethanol-induced intracellular extracts enhanced alcohol metabolism in mice and had potential benefits on liver health.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Review
Oncology
Takeshi Yamauchi, Sarah Shangraw, Zili Zhai, Dinoop Ravindran Menon, Nisha Batta, Robert P. Dellavalle, Mayumi Fujita
Summary: Studying social-environmental risk factors associated with melanoma is crucial for improving public health initiatives and patient outreach and education methods.
Article
Food Science & Technology
Hua Cao, Tuoyu Zhou, Haibo Tang, Pengya Feng, Gohar Ali, Pu Liu, Xiangkai Li
Summary: The genetically modified EcN has shown effectiveness in detoxifying ethanol metabolites in liver disease models, restoring liver function, inhibiting oxidative stress, lipid peroxidation, and inflammation, as well as promoting the recovery of gut microbiota homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biotechnology & Applied Microbiology
Shin-Ichi Hachisuka, Jia Fong Chong, Tsuyoshi Fujiwara, Akiyo Takayama, Yumiko Kawakami, Shosuke Yoshida
Summary: The bacterium Ideonella sakaiensis, which degrades poly(ethylene terephthalate) (PET), has been found to produce enzymes that convert PET into its monomeric compounds. This study identified the enzymes involved in the metabolism of ethylene glycol (EG) in I. sakaiensis and demonstrated the unique alcohol oxidation pathway of the bacterium. Understanding these metabolic pathways is important for the potential engineering of I. sakaiensis for bioremediation and biorecycling purposes.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Avital Granit Mizrahi, Ahinoam Gugenheim, Haneen Hamad, Roa'a Hamed, Nino Tetro, Ofra Maimon, Salome Khutsurauli, Hovav Nechushtan, Benjamin Nisman, Deborah Duran, Widad Samman, Liron Birimberg-Schwartz, Myriam Grunewald, Sara Eyal, Tamar Peretz
Summary: This study found that histone deacetylase inhibitor valproic acid (VPA) can alter glucose metabolism in triple-negative breast cancer (TNBC) cells and is correlated with cisplatin sensitivity. Overexpression of ALDH may be one mechanism of cellular resistance to VPA, and its inhibition can enhance the therapeutic efficacy of VPA-chemotherapeutic drug combinations.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Behavioral Sciences
Otto T. Holbrook, Brandon Molligoda, Kristen N. Bushell, Kyle L. Gobrogge
Summary: Previous research on Alcohol Use Disorder (AUD) has mainly focused on the behavioral or chemical consequences following ethanol intake, but these areas have rarely been studied together. Unlike other abused drugs, ethanol has a unique metabolic pathway that produces downstream metabolites, which can form biologically active products. These metabolites can affect various behavioral responses associated with AUD. This review examines preclinical and chemical research on these downstream products and proposes a chemobehavioral model of AUD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Microbiology
Vijay Shankar Singh, Basant Kumar Dubey, Parul Pandey, Sushant Rai, Anil Kumar Tripathi
Summary: Azospirillum brasilense has the ability to cometabolize ethanol in medium containing fructose or glycerol as a carbon source, leading to enhanced production of alcohol dehydrogenase and aldehyde dehydrogenase. In glycerol-supplemented medium, a new paralog of alcohol dehydrogenase (ExaA1) is synthesized to facilitate the utilization of ethanol by A. brasilense. The expression of exaA1 is induced by glycerol and negatively regulated by the RpoH2 sigma factor.
JOURNAL OF BACTERIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Satoshi Yano, Jinyun Wang, Shigeru Kabayama, Taichi Hara
Summary: Excessive alcohol consumption can lead to multi-systemic diseases, with alcoholic liver disease being the most common and severe one. Electrolytic hydrogen water (EHW) has been shown to inhibit ethanol-induced hepatocellular damage by regulating the metabolism of ethanol and acetaldehyde in liver cells. This suggests that EHW may be beneficial in the prevention of alcoholic liver disease.
Article
Biochemistry & Molecular Biology
Natalie Payne, Arlette Kpebe, Chloe Guendon, Carole Baffert, Julien Ros, Regine Lebrun, Yann Denis, Laetitia Shintu, Myriam Brugna
Summary: Through studying Desulfovibrio fructosovorans, we discovered that Hnd is involved in ethanol metabolism and oxidizes H-2 via its electron bifurcation mechanism, producing NADH and reduced ferredoxin.
MOLECULAR MICROBIOLOGY
(2022)
Article
Food Science & Technology
Sulhee Lee, Young-Seo Park
Summary: This study found that administration of water-soluble propolis can significantly reduce ethanol content in rat serum after ethanol feeding, mainly through the increase of ADH and ALDH activities rather than the increase in the expression of ADH or ALDH genes.
FOOD SCIENCE AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Evangelia Eirini Tsermpini, Anja Plemenitas Iljes, Vita Dolzan
Summary: Alcohol use disorder (AUD) is a prevalent and disabling disorder with various comorbidities. The relationship between alcohol metabolism and oxidative stress is not fully understood. Studies have shown that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration.
Article
Medical Laboratory Technology
Maryam Razzaghy-Azar, Mitra Nourbakhsh, Mehdi Vafadar, Mona Nourbakhsh, Saeed Talebi, Ali Sharifi-Zarchi, Elham Salehi Siavashani, Masoud Garshasbi
Summary: A novel inborn error of methanol metabolism due to a mutation in the ADH1C gene was discovered in an 11.58-year-old boy, leading to periods of coma, euphoria, and ataxia. Zinc supplementation dramatically reduced methanol levels and alleviated symptoms, highlighting a potential treatment for this condition.
CLINICAL BIOCHEMISTRY
(2021)
Article
Substance Abuse
Atefeh Bakhtazad, Afsaneh Asgari Taei, Fatemeh Parvizi, Mehdi Kadivar, Maryam Farahmandfar
Summary: This study found that repeated morphine pretreatment can reverse the impairment of spatial learning and memory caused by ethanol, and this effect may be explained by the modulation of CaMKII and BDNF expressions in the hippocampus and amygdala.