Review
Neurosciences
Ana Vazquez-agredos, Fernando Gamiz, Milagros Gallo
Summary: Adolescence is a crucial developmental period marked by brain network reorganization and epigenetic mechanisms. Behaviors like alcohol and drug abuse are common during adolescence and are associated with increased susceptibility to stress. Exposure to stress, alcohol, or drugs disrupts the epigenetic mechanisms mediated by miRNAs, which modify gene expression involved in neurodevelopmental processes. The expression patterns of miRNAs in the adolescent rodent brain are influenced by stress and drug abuse, indicating their significant role in regulating brain development during adolescence.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Hamed Salmanzadeh, S. Mohammad Ahmadi-Soleimani, Maryam Azadi, Robert F. Halliwell, Hossein Azizi
Summary: Adolescence is a critical transitional period in brain development, associated with increased risk-taking behaviors. Substance abuse during this time may cause long-term neurobiological changes, highlighting the importance of further research in understanding the effects of drugs on human brain development.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Neurosciences
Vanessa Lozano Wun, Lara C. Foland-Ross, Booil Jo, Tamar Green, David Hong, Judith L. Ross, Allan L. Reiss
Summary: Turner syndrome (TS) is a common sex chromosome abnormality in females, causing various physical, cognitive, and socio-emotional characteristics. This study investigated the effects of TS on the development of cortical gray matter volume, thickness, and surface area in the brain. The results revealed both direct and indirect effects of X-monosomy on brain development in TS, with differences observed in various brain regions. These findings provide valuable insights into the understanding of TS-associated alterations in brain structure.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
M. A. Infante, S. C. Eberson, Y. Zhang, T. Brumback, S. A. Brown, I. M. Colrain, F. C. Baker, D. B. Clark, M. D. De Bellis, D. Goldston, B. J. Nagel, K. B. Nooner, Q. Zhao, K. M. Pohl, E. Sullivan, A. Pfefferbaum, S. F. Tapert, W. K. Thompson
Summary: This study utilized longitudinal data and found that binge drinking has negative effects on adolescent brain development, especially in the frontal regions. The study also revealed a dose-response relationship between the number of binge drinking episodes and the proximity of decreased brain volume.
Article
Chemistry, Multidisciplinary
Ying-Ying Chen, Zhu Gui, Di Hu, Meng -Yuan Chen, Jin-Gang He, Yu-Qi Feng, Jie Wang, Bi-Feng Yuan
Summary: Alcohol consumption is a leading cause of death worldwide, and adolescent alcohol use can have long-term effects on RNA epigenetic modifications in the brain.
CHINESE CHEMICAL LETTERS
(2024)
Article
Multidisciplinary Sciences
Bo-Yong Park, Casey Paquola, Richard A. Bethlehem, Oualid Benkarim, Bratislav Misic, Jonathan Smallwood, Edward T. Bullmore, Boris C. Bernhardt
Summary: This study analyzed the development of structural and functional brain networks in adolescents and found that multiple corticocortical structural networks continue to differentiate in youth. Regions with more similar structural wiring were more likely to be functionally coupled. Additionally, increased structural differentiation was associated with reduced functional interactions, illustrating the interaction between brain structure and function in adolescent development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Anthony Steven Dick, Daniel A. Lopez, Ashley L. Watts, Steven Heeringa, Chase Reuter, Hauke Bartsch, Chun Chieh Fan, David N. Kennedy, Clare Palmer, Andrew Marshall, Frank Haist, Samuel Hawes, Thomas E. Nichols, Deanna M. Barch, Terry L. Jernigan, Hugh Garavan, Steven Grant, Vani Pariyadath, Elizabeth Hoffman, Michael Neale, Elizabeth A. Stuart, Martin P. Paulus, Kenneth J. Sher, Wesley K. Thompson
Summary: The ABCD Study is the largest longitudinal study in the United States focusing on neurodevelopment and children's health, with aims to explore adolescent brain cognitive development through assessments covering various aspects like mental health, substance use, culture, environment, neurocognition, and genetics. Recruiting approximately 11,880 children aged 9-10 and their parents/guardians, the study will involve annual in-person visits for at least 10 years. The data collected will be utilized for meaningful associations, population inferences, hypothesis testing, power and precision evaluations, and best practices in reproducible research and reporting results.
Article
Psychology, Clinical
Jeremy Harper, Stephen M. Malone, William G. Iacono
Summary: The study showed that deviations in parietal P3 and midfrontal theta prospectively predict the emergence of normative/non-pathological drinking in adolescents, providing significant explanatory variance beyond prominent self-report and familial risk measures.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Neurosciences
Rachel M. Brouwer, Jelle Schutte, Ronald Janssen, Dorret Boomsma, Hilleke E. Hulshoff Pol, Hugo G. Schnack
Summary: Children and adolescents exhibit high variability in brain development, with females generally passing through developmental stages earlier than males by up to 1 year. The difference between brain age and chronological age is heritable, as is the change in this difference over time. Reliable brain age predictors can help detect early signs of abnormal brain development and potential risk for neurodevelopmental disorders.
Article
Neurosciences
Preeti Kar, Jess E. Reynolds, William Ben Gibbard, Carly McMorris, Christina Tortorelli, Catherine Lebel
Summary: Prenatal alcohol exposure is associated with alterations in brain white matter microstructure. Children with prenatal alcohol exposure show slower white matter development in certain brain regions, which may have implications for cognitive and behavioral learning.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Daniel A. Lopez, Zachary P. Christensen, John J. Foxe, Laura R. Ziemer, Paige R. Nicklas, Edward G. Freedman
Summary: The study found that children who experienced possible mTBI or mTBI are at a higher risk of emotional or behavioral problems. However, brain metrics did not clearly mediate the relationship between mTBI and mental health outcomes.
Article
Endocrinology & Metabolism
Cecilia Rapp, John Hamilton, Kaleigh Richer, Munawwar Sajjad, Rutao Yao, Panayotis K. Thanos
Summary: Alcohol misuse, particularly during adolescence, presents a serious health concern, as it is associated with negative effects on brain glucose metabolism (BGluM). This study utilized a binge drinking model in adolescent rats and found that all doses of ethanol led to decreased BGluM in multiple brain regions involved in sensory, motor, and cognitive processes. These findings highlight the detrimental effects of acute binge drinking on brain function and emphasize the need for further research on the long-term consequences and recovery after cessation of alcohol binge drinking.
METABOLIC BRAIN DISEASE
(2022)
Article
Clinical Neurology
Santosh Thapa, Jessica C. Sheu, Alamelu Venkatachalam, Jessica K. Runge, Ruth Ann Luna, Chadi A. Calarge
Summary: In this study, no significant association was found between major depressive disorder (MDD) or selective serotonin reuptake inhibitor (SSRI) use and gut microbiome in older adolescents. This suggests that the bidirectional interaction between gut bacteria and the brain may be more nuanced in this age group, requiring further investigation.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neuroimaging
Yiman Li, Zheyi Zhou, Yuqi Zhang, Hui Ai, Mingfang Liu, Jing Liu, Li Wang, Jiang Qiu, Zhuo Rachel Han, Zhanjun Zhang, Yue-Jia Luo, Pengfei Xu
Summary: Adolescence is the peak period for the onset of generalized anxiety disorder (GAD). Reasonable parental monitoring plays a crucial role in the delayed development of specific brain networks associated with GAD in adolescents.
NEUROIMAGE-CLINICAL
(2023)
Article
Pharmacology & Pharmacy
Wen Liu, Aaron R. Rohlman, Ryan Vetreno, Fulton T. Crews
Summary: The study found that adolescent binge drinking affects adult OL markers in PFC regions, while also impacting OPC marker expression; furthermore, these effects could lead to lasting changes in PFC function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Substance Abuse
Atefeh Bakhtazad, Afsaneh Asgari Taei, Fatemeh Parvizi, Mehdi Kadivar, Maryam Farahmandfar
Summary: This study found that repeated morphine pretreatment can reverse the impairment of spatial learning and memory caused by ethanol, and this effect may be explained by the modulation of CaMKII and BDNF expressions in the hippocampus and amygdala.