期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 72, 期 -, 页码 502-509出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2014.08.041
关键词
Phosphorylated soybean protein isolate/poly(L-lactic acid)/zirconium dioxide nanofibrous membranes; Electrospinning technique; Antimicrobial activity and release behavior
资金
- National Natural Science Foundation of China [31171788, 31371859]
Electrospinning technique was used to fabricate the model drug Nisin loaded phosphorylated soybean protein isolate/poly(L-lactic acid)/zirconium dioxide (Nisin-PSPI/PLLA/ZrO2) nanofibrous membranes. The average diameter of drug carrier PSPI/PLLA/ZrO2 nanofibers increased with the increase of content PSPI and some spindle-shape beads appeared when PSPI content reached 25 wt%. The loading dosage of Nisin caused no significant changes in the size and morphology of nanofibers when Nisin content was below 9 wt%. There existed hydrogen and Zr-O-C bonds among PSPI, PLLA and ZrO2 units, and the crystalline of PLLA matrix decreased owning to the introducing of PSPI and ZrO2 units. Moreover, the water absorption capability and degradation rate of PSPI/PLLA/ZrO2 nanofibrous membranes increased with increasing PSPI content. The antimicrobial activity and release experimental results showed that Nisin-PSPI/PLLA/ZrO2 nanofibrous membranes displayed well controlled release and better antimicrobial activity against Staphylococcus aureus (S. aureus), and the Nisin release from the medicated nanofibers could be described by Fickian diffusion model. The Nisin-PSPI/PLLA/ZrO2 nanofibrous membranes may have potential as a new nanofibrous membrane in drug delivery, food active packaging and wound dressing. (C) 2014 Elsevier B.V. All rights reserved.
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