Article
Horticulture
Ying Xiang, Xiao- Yu Huang, Yu -Wen Zhao, Chu-Kun Wang, Quan Sun, Da -Gang Hu
Summary: In this study, a tonoplast ATP-binding cassette transporter, MdABCI17, was found to be involved in the regulation of anthocyanin accumulation during apple fruit ripening. Up-regulation of MdABCI17 expression significantly increased anthocyanin content and promoted the expression of other anthocyanin biosynthesize genes.
SCIENTIA HORTICULTURAE
(2024)
Article
Nutrition & Dietetics
Michinori Matsuo, Yutaka Ogata, Yoshihide Yamanashi, Tappei Takada
Summary: ATP-binding cassette protein G5 (ABCG5)/ABCG8 heterodimer exports cholesterol from cells, while Niemann-Pick C1-like 1 (NPC1L1) imports cholesterol and vitamin K. This study found that ABCG5/ABCG8 transports vitamin K-3 out of cells, and this transport is competitively inhibited by vitamin K-1. The findings suggest that ABCG5 and ABCG8 are involved in the transport of sterols and vitamin K, and ABCG5/ABCG8 and NPC1L1 might play important roles in the regulation of vitamin K absorption and excretion.
Article
Entomology
Janin Roesner, Hans Merzendorfer
Summary: ABC transporters are suggested to play a role in insecticide detoxification, with specific TcABCA-C genes being upregulated in response to insecticide exposure. Inhibition of ABC transporters enhances the toxicity of certain insecticides, while silencing of specific TcABCC genes increases susceptibility to particular insecticides. These findings highlight the potential involvement of ABC transporters in detoxification processes in insects.
Article
Plant Sciences
Cheng Song, Xiaoli Li, Bin Jia, Li Liu, Peipei Wei, Muhammad Aamir Manzoor, Fang Wang, Biqi Yao Li, Guanglin Wang, Cunwu Chen, Bangxing Han
Summary: Peucedanum praeruptorum Dunn is a traditional Chinese medicine rich in coumarins. This study analyzed the variations in coumarin components and the gene expression of P. praeruptorum at the bolting stage. The results showed that the content of coumarins decreased after bolting, and several genes involved in coumarin biosynthesis were downregulated. Further investigation is needed to fully understand the indirect effect of bolting on coumarin formation.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Medicine, General & Internal
Damian Malinowski, Pawel Grzegolkowski, Katarzyna Piotrowska, Marcin Slojewski, Marek Drozdzik
Summary: This study aimed to characterize the expression and localization of membrane transporters and carriers in the seminal vesicles. The results confirm the secretory and barrier functions of the seminal vesicle epithelium.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Narakorn Khunweeraphong, Karl Kuchler
Summary: Multidrug resistance can be a major issue in cancer treatment and microbial infections, with dysregulated overexpression of ATP-binding cassette transporter members being linked to this phenomenon. High-resolution atomic structures from X-ray crystallography or cryo-EM are helping to improve understanding of the mechanisms and dynamics driving these transporters, offering new perspectives for therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Michele Galluccio, Lara Console, Lorena Pochini, Mariafrancesca Scalise, Nicola Giangregorio, Cesare Indiveri
Summary: Membrane transport systems play a crucial role in maintaining cell homeostasis and drug interactions. E. coli is a preferred host for expressing human membrane proteins, but their hydrophobicity and structural differences pose challenges. This review summarizes various strategies for expressing human transport systems in bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Ying Huang, Chenyang Xue, Liangdong Wang, Ruiqian Bu, Jianqiang Mu, Yong Wang, Zhongmin Liu
Summary: This study uses cryo-EM to resolve the structures of hMRP4 in different states, including apo inward-open, ATP-bound outward-open, PGE1 substrate-bound, and sulindac inhibitor-bound states. The findings reveal the competition between substrate and inhibitor for the same binding pocket and provide insights into the transport and inhibition mechanism of hMRP4, which have implications for drug development.
COMMUNICATIONS BIOLOGY
(2023)
Review
Biology
Lara Console, Mariafrancesca Scalise
Summary: Extracellular vesicles, including exosomes, play a crucial role in promoting chemoresistance in cancer cells through various mechanisms.
Article
Microbiology
Christopher J. Winski, Yuanyuan Qian, Shahriar Mobashery, Felipe H. Santiago-Tirado
Summary: This study demonstrates a novel dual role for PDR transporters in C. neoformans, which could represent a potential target for antifungal therapeutics. Furthermore, the atypical half-size transporter encoded by PDR6 is conserved in many fungal pathogens, but absent in model nonpathogenic fungi. This study provides insights into the function of this unique group of fungal half-size PDR transporters that, although conserved, remain largely understudied.
Article
Medicine, Research & Experimental
Lara Garcia-Varela, Manuel Rodriguez-Perez, Antia Custodia, Rodrigo Moraga-Amaro, Nicola A. Colabufo, Pablo Aguiar, Tomas Sobrino, Rudi A. J. O. Dierckx, Aren van Waarde, Philip H. Elsinga, Gert Luurtsema
Summary: P-glycoprotein (P-gp) inducer MC111 increases P-gp functionality in the whole brain of rats, potentially offering a treatment option for neurodegenerative diseases.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Takashi Kuromori, Eriko Sugimoto, Kazuo Shinozaki
Summary: ABA, a stress hormone in plants, has potential as a mobile molecule. A homolog of AtABCG25, named BdABCG25, was identified in Brachypodium distachyon and found to be a putative functional homolog of AtABCG25. Regulating intercellular ABA transport may be a novel strategy for breeding stress-tolerant monocot crops.
Article
Physiology
Riccardo F. Romersi, Sascha C. T. Nicklisch
Summary: An organism's diet plays a crucial role in its exposure to beneficial nutrients and harmful environmental chemicals. Transporters in the intestine prevent the uptake of xenobiotics from dietary sources. While some chemicals induce the expression of defense transporters in fish and aquatic invertebrates, others can bind to and inhibit certain transporters, leading to toxic accumulations. The molecular interactions between xenobiotics and transporters are poorly understood in aquatic organisms, highlighting the need for further research.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Adriana Maria Diaz-Anaya, Louise Gerard, Martine Albert, Jean-Francois Gaussin, Marielle Boonen, Jean-Pierre Gillet
Summary: ABCB5 beta is a marker protein associated with melanoma stem cells and skin progenitor cells. The study reveals that ABCB5 beta is predominantly localized to the endoplasmic reticulum and is degraded by the proteasome system. Treatment with SAHA, a molecule promoting chaperone-assisted folding, increases the expression of ABCB5 beta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Lara Garcia-Varela, David Vallez Garcia, Takeharu Kakiuchi, Hiroyuki Ohba, Shingo Nishiyama, Tetsuro Tago, Philip H. Elsinga, Hideo Tsukada, Nicola A. Colabufo, Rudi A. J. O. Dierckx, Aren van Waarde, Jun Toyohara, Ronald Boellaard, Gert Luurtsema
Summary: This study aimed to evaluate the pharmacokinetics of (R)-[C-11]verapamil in nonhuman primates and establish it as a reference tracer for P-gp in comparison with other PET tracers. The results suggest that using the 1-tissue compartment model and shorter PET scan durations can be suitable for measuring P-gp function at the blood-brain barrier in nonhuman primates.
MOLECULAR PHARMACEUTICS
(2021)
Article
Microbiology
Laurence Bousquet, Alain Pruvost, Anne-Cecile Guyot, Robert Farinotti, Aloise Mabondzo
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2009)
Article
Pharmacology & Pharmacy
Laurence Bousquet, Alain Pruvost, Nathalie Didier, Robert Farinotti, Aloise Mabondzo
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2008)
Article
Gastroenterology & Hepatology
Etienne Patin, Zoltan Kutalik, Julien Guergnon, Stephanie Bibert, Bertrand Nalpas, Emmanuelle Jouanguy, Mona Munteanu, Laurence Bousquet, Laurent Argiro, Philippe Halfon, Anne Boland, Beat Muellhaupt, David Semela, Jean-Francois Dufour, Markus H. Heim, Darius Moradpour, Andreas Cerny, Raffaele Malinverni, Hans Hirsch, Gladys Martinetti, Vijayaprakash Suppiah, Graeme Stewart, David R. Booth, Jacob George, Jean-Laurent Casanova, Christian Brechot, Charles M. Rice, Andrew H. Talal, Ira M. Jacobson, Marc Bourliere, Ioannis Theodorou, Thierry Poynard, Francesco Negro, Stanislas Pol, Pierre-Yves Bochud, Laurent Abel