期刊
AIDS
卷 25, 期 10, 页码 1329-1331出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0b013e3283478575
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资金
- MRC [G0500384] Funding Source: UKRI
- Medical Research Council [G0500384] Funding Source: researchfish
HIV-specific Elispot responses were investigated in 57 antiretroviral therapy-naive children, of median age 9.9 years. CD8(+) T-cell responses were detected in 96% children; Nef was the immunodominant protein. Responses broadened over time, but there was no association between magnitude, breadth or specificity of response and viraemia. Gag-specific CD4(+) T-cell responses, detectable in 26% children, correlated inversely with viraemia (R=-0.43, P<0.001), suggesting that preservation of this cell population may be an important goal of therapeutic/vaccine strategies.
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