期刊
AIDS
卷 24, 期 11, 页码 1625-1631出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0b013e32833a8e6d
关键词
disease progression; HIV-1; polymorphism; survival rate; TIM1
资金
- Department of Medical Sciences, Ministry of Public Health, Thailand
- Japanese Foundation for AIDS prevention
- Ministry of Health, Labor and Welfare, Japan
- Japan Health Science Foundation
- program of Founding Research Centers for Emerging and Reemerging Infection Disease
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan
- Heiwa Nakajima Foundation, Japan
Objective: To investigate association of TIM1 sequence variations with HIV/AIDS progression. Introduction: HIV-1 infected individuals have wide variations in disease progression including AIDS. T cell immunoglobulin and mucin 1 (TIM1) is a cell surface protein involved in the regulation of Th1/Th2 immune response. Materials and methods: We sequenced the highly polymorphic exon 4 of TIM1 from 246 individuals of HIV-1 infected Thai female cohort to determine their TIM1 haplo-types. Associations of TIM1 haplotypes with baseline clinical data (sero-status, plasma viral load, CD4 cell count, and symptomatic AIDS) and survival status during 3 years of follow-up were evaluated. Results: Seven TIM1 haplotypes, D3-A, D4, D3-C, D1, W-A, W-C, and D3-C*, were found in the cohort. Patients possessing the D3-A haplotype showed trends towards higher CD4(+) cell count (P=0.06) and lower proportion of AIDS-related symptoms (P=0.022) than the other patients at the baseline. Kaplan-Meier analysis demonstrated that patients carrying the D3-A haplotype had a better survival rates (P=0.019) than the others. D3-A haplotypes was tightly linked to the lower expression levels of TIM1. Conclusion: TIM1 D3-A haplotype is associated with the delay of disease progression to AIDS in the HIV-1 infected Thai females. (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
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