期刊
AIDS
卷 24, 期 13, 页码 2075-2080出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0b013e32833c3298
关键词
BAFF; CXCL12; CXCR4; interleukin-7; pediatric AIDS
资金
- Swedish MRC
- Swedish International Development Agency (SIDA-SAREC)
- EU Europrise network of excellence
- EU [Health-F3-2007-201433]
- Regione Autonoma della Sardegna, Cagliari, Italy
- Ministero della Salute, Rome, Italy
- Stockholm County Council
- Karolinska Institutet
Objective: To characterize the level of immature-transitional B-cells in blood during pediatric HIV-1 infection in relation to active or suppressed viremia. We also aimed at characterizing the level of expression of CXCR4, CXCR5 and CCR7 on immature-transitional B-cells, as these receptors are important mediators for homing of B-cells. Design: Forty-eight HIV-1 vertically infected children (33 viral controllers and 15 viremic patients) and 33 age-matched healthy controls were enrolled in a cross-sectional study. Methods: We measured the levels of peripheral immature-transitional B-cells in all groups in relation to switched memory B-cells by flow cytometry. In parallel we evaluated CXCR4, CXCR5 and CCR7 expression on immature-transitional B-cells and measured plasma levels of CXCL12, BAFF and interleukin-7 by ELISA. Results: We observed a lack of physiological age-related decline of immature-transitional B-cells in viremic children in parallel to a decreased level of switched memory B-cells. Interestingly, immature-transitional B-cells from viremic children presented with high levels of CXCR4. On the contrary, the level of CXCL12, the natural ligand for CXCR4, was lowest in the HIV-1 infected group, as compared with controls. Conclusion: Control of HIV-1 viremia through antiretroviral treatment appears to be crucial in decreasing the expansion and alteration of immature-transitional B-cells. (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
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