Review
Oncology
Nicla Porciello, Ornella Franzese, Lorenzo D'Ambrosio, Belinda Palermo, Paola Nistico
Summary: Profiling the T-cell receptor repertoire allows for the investigation of antitumor immune response. By tracking the spatiotemporal variation of T-cell populations, the key cells responsible for tumor eradication can be identified. Furthermore, improvements in T-cell sequencing provide new opportunities and challenges for research.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Takayuki Chikata, Hiroyuki Gatanaga, Hung The Nguyen, Daisuke Mizushima, Yu Zhang, Nozomi Kuse, Shinichi Oka, Masafumi Takiguchi
Summary: This study investigated HIV-1-specific CD8(+) T cell responses in 200 Japanese HIV-1-exposed seronegative (HESN) men who have sex with men (MSM). The results showed the presence of HLA-B*51:01-restricted Pol TI8- specific and HLA-A*02:06-restricted Pol SV9-specific CD8+ T cells in two and one individuals, respectively. These HIV-1-specific T cells may contribute to suppressing HIV-1 replication in HESN-MSM individuals.
Review
Medical Laboratory Technology
Jielite Huang, Jinlin Chen, Yafeng Xie, Zhuoran Liu
Summary: This article provides a comprehensive overview of immune evasion strategies in spirochetes infection, including antigenic variation, overcoming the attack of the complement system, interfering with immune cells, and persistent infection.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Cell Biology
Haiyu Li, Yongyao Tang, Yujing Wang, Yue Li, Yi Yang, Kui Liao, Fangzhou Song, Shixiong Deng, Yaokai Chen
Summary: Immune non-responder after highly active antiretroviral therapy (HAART) is a major problem in AIDS patients, leading to opportunistic infections and high mortality. The underlying mechanism of this immune reconstitution failure is poorly understood. In this study, single-cell sequencing and chromatin accessibility analysis were performed on peripheral blood mononuclear cells (PBMCs) from immune non-responders (INR) and responders (IR) with HIV-1 infection. The results showed that INRs had low expression of mucosal-associated invariant T (MAIT) cells, which were associated with impaired mitochondrial function and apoptosis signaling. Restoring mitochondrial function could potentially improve the immune dysfunction in MAIT cells against bacterial co-infections in INR subjects.
CELL DEATH & DISEASE
(2022)
Review
Immunology
Meifang Liu, Shujuan Liang, Cai Zhang
Summary: Autoimmune diseases result from the loss of self-tolerance and can be categorized into organ-specific and systemic types. Genetic and environmental factors play a role in autoimmunity development, while innate immunity has been shown to contribute to the onset of autoimmune diseases. NK cells have dual roles in autoimmunity, and their varied effects in different disease contexts suggest their potential as therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Virology
Kwang Il Jung, Savannah McKenna, Vijayamahantesh Vijayamahantesh, Ying He, Bumsuk Hahm
Summary: This article summarizes the role and response of type I interferons after virus infections, emphasizing their protective immune responses and potential negative effects such as inflammation and immune suppression.
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Ana C. Ossa-Giraldo, Yurany Blanquiceth, Lizdany Florez-Alvarez, Katherin Contreras-Ramirez, Mauricio Rojas, Juan C. Hernandez, Wildeman Zapata
Summary: This study compares the immunological profile of Colombian seronegative MSM with different risk sexual behaviors. The results show that high-risk MSM have higher numbers of sexual partners and engage in unprotected anal intercourse, as well as exhibit a quiescent profile of T cells and NK cells and increased expression of Serpin A1.
Article
Cell Biology
Phillip Pymm, Stefan Tenzer, Edmund Wee, Mirjana Weimershaus, Anne Burgevin, Simon Kollnberger, Jan Gerstoft, Tracy M. Josephs, Kristin Ladell, James E. McLaren, Victor Appay, David A. Price, Lars Fugger, John I. Bell, Hansjoerg Schild, Peter van Endert, Maria Harkiolaki, Astrid K. N. Iversen
Summary: This study discovers that the cytotoxic T lymphocyte (CTL) and natural killer (NK) cell responses to a specific epitope in the human immunodeficiency virus are associated with enhanced immune control. The length and mutations of the epitope influence the CTL and NK cell responses, leading to viral escape.
Article
Medicine, Research & Experimental
Xiaoxia Hou, Fangming Zhu, Yingmeng Ni, Tiantian Chen, Juan Du, Xinnan Liu, Yichao Han, Yahui Liu, Wei Du, Yangyang Li, Xiaoxia Wang, Dan Li, Rui Liang, Bin Li, Guochao Shi
Summary: The study showed that USP4 deficiency can alleviate airway inflammation and hyperresponsiveness in asthma, and treatment with Vialinin A may serve as a promising therapeutic target.
Article
Materials Science, Multidisciplinary
M. A. Alshaikh, N. H. AlShamrani, A. M. Elaiw
Summary: This paper presents two HIV/HTLV co-infection models with antibody immune response, investigating the properties and global stability of the solutions. The stability results are based on constructing Lyapunov functions and using LaSalle's invariance principle. Numerical simulations are conducted to support the theoretical findings.
RESULTS IN PHYSICS
(2021)
Review
Immunology
Alessandra Aiello, Saeid Najafi-Fard, Delia Goletti
Summary: Tuberculosis (TB) and Coronavirus disease-2019 (COVID-19) are the deadliest infectious diseases in humans, causing over 11 million deaths worldwide in the past 3 years. While they share similarities such as transmission, primary target, symptoms, and diagnostic tools, they differ in aspects such as incubation period, involvement of immune cells, persistence, and immunopathological response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Veronica Ayechu-Muruzabal, Bente Poelmann, Alinda J. Berends, Nienke Kettelarij, Johan Garssen, Belinda van't Land, Linette E. M. Willemsen
Summary: This study explores the protective capacity of bioactive components in human milk against viral infections in early life, specifically in the prevention of enteric viral infections. The effects of 2'FL, abundantly present in human milk, on intestinal epithelial cells (IEC) and innate immune cells were studied, shedding light on mucosal host-defense mechanisms upon viral triggers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Maxine A. Hoeft, Wendy A. Burgers, Catherine Riou
Summary: This review examines the intersection of the HIV and SARS-CoV-2 pandemics. While COVID-19 in those with well-controlled HIV infection poses no greater risk, people with advanced HIV disease are more vulnerable to poor COVID-19 outcomes. COVID-19 vaccines are effective in the majority of PWH, but reduced efficacy, breakthrough infections, and faster waning of effectiveness have been observed. People with advanced HIV may also experience prolonged infection that may give rise to new variants.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Rachel A. Bender Ignacio, Sayan Dasgupta, Rogelio Valdez, Urvashi Pandey, Siavash Pasalar, Ricardo Alfaro, Florian Hladik, German Gornalusse, Javier R. Lama, Ann Duerr
Summary: Previous studies on linking immune activation biomarkers with HIV risk often relied on cross-sectional samples, but this study showed that dynamic changes in certain biomarkers, in addition to traditional risk factors, could jointly predict HIV risk and modify the association between sociobehavioral risk factors and HIV acquisition.
Article
Immunology
Samuel E. Norton, Kirsten A. Ward-Hartstonge, John L. McCall, Julia K. H. Leman, Edward S. Taylor, Fran Munro, Michael A. Black, Barbara Fazekas de St Groth, Helen M. McGuire, Roslyn A. Kemp
JOURNAL OF IMMUNOLOGY
(2019)
Article
Immunology
Marc A. Russo, Nathan T. Fiore, Caryn van Vreden, Dominic Bailey, Danielle M. Santarelli, Helen M. McGuire, Barbara Fazekas de St Groth, Paul J. Austin
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Cell Biology
Phillip D. Fromm, Pablo A. Silveira, Jennifer L. Hsu, Michael S. Papadimitrious, Tsun-Ho Lo, Xinsheng Ju, Fiona Kupresanin, Adelina Romano, Wei-Hsun Hsu, Christian E. Bryant, Benjamin Kong, Edward Abadir, Ahmed Mekkawy, Helen M. McGuire, Barbara Fazekas de St Groth, Ilona Cunningham, Elizabeth Newman, John Gibson, P. Mark Hogarth, Derek N. J. Hart, Georgina J. Clark
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Immunology
John Zaunders, C. Mee Ling Munier, Helen M. McGuire, Hannah Law, Annett Howe, Yin Xu, Barbara Fazekas de St Groth, Peter Schofield, Daniel Christ, Brad Milner, Solange Obeid, Wayne B. Dyer, Nitin K. Saksena, Anthony D. Kelleher
Article
Biochemical Research Methods
Samuel E. Norton, Julia K. H. Leman, Tiffany Khong, Andrew Spencer, Barbara de St Groth, Helen M. McGuire, Roslyn A. Kemp
BMC BIOINFORMATICS
(2020)
Article
Physiology
Brianna Larsen, Amanda Cox, Candice Colbey, Michael Drew, Helen McGuire, Barbara Fazekas de St Groth, David Hughes, Nicole Vlahovich, Gordon Waddington, Louise Burke, Bronwen Lundy, Nicholas West, Clare Minahan
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Immunology
Mehdi R. Pirozyan, Helen M. McGuire, Abdullah Al Emran, Hsin-Yi Tseng, Jessamy C. Tiffen, Jenny H. Lee, Matteo S. Carlino, Alexander M. Menzies, Georgina Long, Richard A. Scolyer, Barbara Fazekas de St Groth, Peter Hersey
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Blair Z. Johnson, Sonia McAlister, Helen M. McGuire, Vetrichevvel Palanivelu, Andrew Stevenson, Peter Richmond, Debra J. Palmer, Jessica Metcalfe, Susan L. Prescott, Fiona M. Wood, Barbara Fazekas de St Groth, Matthew D. Linden, Mark W. Fear, Vanessa S. Fear
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Hematology
Gloria Castellano-Gonzalez, Helen M. McGuire, Fabio Luciani, Leighton E. Clancy, Ziduo Li, Selmir Avdic, Brendan Hughes, Mandeep Singh, Barbara Fazekas de St Groth, Giorgia Renga, Marilena Pariano, Marina M. Bellet, Luigina Romani, David J. Gottlieb
Article
Hematology
Slavica Vuckovic, Christian E. Bryant, Ka Hei Aleks Lau, Shihong Yang, James Favaloro, Helen M. McGuire, Georgina Clark, Barbara Fazekas de St Groth, Felix Marsh-Wakefield, Najah Nassif, Edward Abadir, Vinay Vanguru, Derek McCulloch, Christina Brown, Stephen Larsen, Scott Dunkley, Liane Khoo, John Gibson, Richard Boyle, Douglas Joshua, P. Joy Ho
Article
Biochemistry & Molecular Biology
Nabila Seddiki, John Zaunders, Chan Phetsouphanh, Vedran Brezar, Yin Xu, Helen M. McGuire, Michelle Bailey, Kristin McBride, Will Hey-Cunningham, Cynthia Mee Ling Munier, Laura Cook, Stephen Kent, Andrew Lloyd, Barbara Cameron, Barbara Fazekas de St Groth, Kersten Koelsch, Mark Danta, Hakim Hocini, Yves Levy, Anthony D. Kelleher
Summary: CD73+ memory CD4+ T cells are reduced early in HIV-1 infection and not restored in chronic infection, being infected with HIV-1 DNA and potentially contributing to the long-lived HIV reservoir in treated individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Katharine A. Kott, Stephen T. Vernon, Thomas Hansen, Macha de Dreu, Souvik K. Das, Joseph Powell, Barbara Fazekas de St Groth, Belinda A. Di Bartolo, Helen M. McGuire, Gemma A. Figtree
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Multidisciplinary Sciences
Lauren Stern, Helen M. McGuire, Selmir Avdic, Barbara Fazekas de St Groth, David Gottlieb, Allison Abendroth, Emily Blyth, Barry Slobedman
Summary: This study assessed the immune cell compartments of haematopoietic stem cell recipients in the early post-transplantation period and identified key features of effector memory CD4(+) T cells and mucosal associated invariant T cells during human cytomegalovirus infection and reactivation.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Jayden A. O'Brien, Helen M. Mcguire, Diana Shinko, Barbara Fazekas de St Groth, Marc A. Russo, Dominic Bailey, Danielle M. Santarelli, Katie Wynne, Paul J. Austin
Summary: Using high-dimensional suspension mass cytometry, this study identified distinct immunological signatures associated with painful neuropathy in type 1 diabetes patients. The findings suggest potential mechanisms by which pain in type 1 diabetes is initiated and maintained, paving the way for targeted treatments.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2021)
Article
Immunology
Helen M. McGuire, Simone Rizzetto, Barbara P. Withers, Leighton E. Clancy, Selmir Avdic, Lauren Stern, Ellis Patrick, Barbara Fazekas de St Groth, Barry Slobedman, David J. Gottlieb, Fabio Luciani, Emily Blyth
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2020)
