Article
Engineering, Biomedical
Nooshin Zandi, Banafsheh Dolatyar, Roya Lotfi, Yousef Shallageh, Mohammad Ali Shokrgozar, Elnaz Tamjid, Nasim Annabi, Abdolreza Simchi
Summary: The engineered bilayer scaffolds, composed of gelatin nanofibers and composite hydrogels, show promising potential in accelerating wound healing process. The controlled delivery of growth factors on the bilayer scaffolds enhances wound closure and tissue regeneration. The unique structure of the scaffolds mimics the extracellular matrix, providing a platform for tailored growth factor release and improved adhesion to native tissue.
ACTA BIOMATERIALIA
(2021)
Article
Thermodynamics
Caifeng Meng, Yunpeng Liu, Zhiheng Xu, Hongyu Wang, Xiaobin Tang
Summary: In this study, a core-shell nanosphere structured selective emitter was designed and optimized for thermophotovoltaic (TPV) systems, leading to improved efficiency and higher output power density and system efficiency. The mechanism of selective emission characteristics was elucidated, and the simulation results showed insensitivity to polarization and incident angle. The research paves the way for a more efficient design of TPV systems.
Article
Genetics & Heredity
Bach Quang Le, Tuan Chun Tan, Seong-Baek Lee, Ju Woong Jang, Young Sik Kim, Jung Soo Lee, Jae Won Choi, Padmapriya Sathiyanathan, Victor Nurcombe, Simon M. Cool
Summary: A novel biomaterial scaffold has been developed in this study, which can effectively release bone morphogenetic protein 2 (BMP2) to promote bone regeneration. The scaffold, composed of bovine collagen type I, bone granules, and heparan sulfate with increased affinity for BMP2, retained 58% of the initial BMP2 amount over 27 days and demonstrated bioactivity.
Article
Cell Biology
Runfeng Cao, Anqi Zhan, Zheng Ci, Cheng Wang, Yunlang She, Yong Xu, Kaiyan Xiao, Huitang Xia, Li Shen, Depeng Meng, Chang Chen
Summary: The study developed a biomimetic biphasic scaffold for osteochondral defect repair, controlling the composition, stiffness, and pore size to promote adhesion, proliferation, chondrogenic, and osteogenic differentiation of bone marrow stem cells. In vitro and in vivo results showed that the biphasic scaffold significantly enhanced concomitant repair of superficial cartilage and subchondral bone, demonstrating its promising osteochondral repair effect.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luciana Sartore, Chiara Pasini, Stefano Pandini, Kamol Dey, Marco Ferrari, Stefano Taboni, Harley H. L. Chan, Jason Townson, Sowmya Viswanathan, Smitha Mathews, Ralph W. Gilbert, Jonathan C. Irish, Federica Re, Piero Nicolai, Domenico Russo
Summary: This paper introduces a novel process to develop composite scaffolds with a core-shell structure for bone tissue regeneration. The core provides temporary mechanical support, while the shell enhances biocompatibility and provides bioactive properties. The hybrid polymer devices closely mimic the morphology and stiffness of bones, and can efficiently support the growth and differentiation of human mesenchymal stromal cells towards the osteogenic phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Tengjisi, Yue Hui, Guangze Yang, Changkui Fu, Yun Liu, Chun-Xia Zhao
Summary: Biomimetic core-shell nanoparticles - silica nanocapsules were recently developed using a designer dual-functional peptide SurSi under environmentally friendly conditions, allowing precise control of peptide-induced biosilicification for the formation of oil-core silica-shell nanocapsules with uniform size and monodispersity. The fundamental mechanism of silica formation through peptide catalyzed biosilicification was systematically investigated to optimize the formation of biomimetic silica nanocapsules, providing valuable insights for making core-shell nanoparticles via controlling nucleation and reaction at interfaces.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Engineering, Biomedical
Deborah L. Dorcemus, Hyun S. Kim, Syam P. Nukavarapu
Summary: The development of a biodegradable matrix with uniquely arranged bone and cartilage supporting phases, by incorporating hydroxyapatite into a PLGA template and loading different growth factors onto different parts of the scaffold, facilitated spatial distribution of chondrogenesis and osteogenesis. Experimental results showed that this inverse gradient matrix can promote spatial differentiation of human mesenchymal stem cells into cartilage and bone cells within the scaffold.
BIOMEDICAL MATERIALS
(2021)
Article
Polymer Science
Tianqi Liu, Bo Yang, Wenqing Tian, Xianglin Zhang, Bin Wu
Summary: In this study, a coaxial cryogenic printing technique was developed to fabricate 3D scaffolds with a PCL/SA shell/core structure, which broadens the material range of coaxial printing and shows promising potential in drug release applications.
Article
Biotechnology & Applied Microbiology
Matilde Tschon, Silvia Brogini, Annapaola Parrilli, Serena Bertoldi, Antonietta Silini, Ornella Parolini, Silvia Fare, Lucia Martini, Francesca Veronesi, Milena Fini, Gianluca Giavaresi
Summary: Chondral and osteochondral lesions are challenging problems in orthopedics, causing disability and impacting healthcare systems. This in vivo study developed a tissue engineering approach using a hybrid scaffold made of porous polyurethane foam coated with calcium phosphates. The scaffold allowed tissue growth and penetration, showing promising results for bone regeneration.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Multidisciplinary Sciences
Qiubo Zhang, Xinxing Peng, Yifan Nie, Qi Zheng, Junyi Shangguan, Chao Zhu, Karen C. Bustillo, Peter Ercius, Linwang Wang, David T. Limmer, Haimei Zheng
Summary: The atomic ripening pathway for Cd-CdCl2 core-shell nanoparticles is mediated by crack defects, as revealed by liquid cell transmission electron microscopy.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Xiao Zhang, Yang Liu, Qiang Zuo, Qingyun Wang, Zuxi Li, Kai Yan, Tao Yuan, Yi Zhang, Kai Shen, Rui Xie, Weimin Fan
Summary: The newly developed bioink and silk fibroin-based bilayered scaffold have shown promising results in mimicking osteochondral tissue, with the ability to control mechanical properties, composition, and growth factor release in each layer. In vitro and in vivo experiments demonstrated the scaffold's effectiveness in promoting osteochondral regeneration and repair.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Article
Chemistry, Physical
Haomin Guo, Qi Hu, Chengyun Zhang, Haiwen Liu, Runmin Wu, Shusheng Pan
Summary: In this paper, the generation of hot electrons in plasmon metal nanocavities is enhanced by surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR). A Si@Pd core-omega shell nanocavity is formed by sputtering Pd nanomembrane (NMB) on the surface of Si nanosphere (NS) on a glass substrate. The coupling of plasmon and Mie resonance induces a plasmon-Mie resonance in the nanocavity, controlling the optical property of Si NS. When excited by near-infrared-1 (NIR-1, 650 nm-900 nm) femtosecond (fs) laser, the luminescence intensity of Si NS is significantly enhanced due to the synergistic interaction of plasmon and Mie resonance. The resonance coupling regulates the resonant mode of the nanocavity, enabling multi-dimensional nonlinear optical response, which can be applied in the fields of biological imaging and nanoscale light source.
Article
Biotechnology & Applied Microbiology
Chen-Hung Lee, Dong-Yi Chen, Ming-Jer Hsieh, Kuo-Chun Hung, Shu-Chun Huang, Chia-Jung Cho, Shih-Jung Liu
Summary: This study developed an advanced and encouraging vehicle to improve clinically applicable diabetic wound care. Nanofibrous insulin/vildagliptin core-shell biodegradable (PLGA) scaffolds were prepared to deliver vildagliptin and insulin for the repair of diabetic wounds. The core-shell nanofibrous scaffolds released vildagliptin and insulin effectively and accelerated wound healing. The insulin/vildagliptin-loaded core-shell nanofibers extended drug delivery and enhanced wound repair associated with diabetes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Miaomiao Shang, Bingjie Ma, Xueyan Hu, Ling Liu, Jin Wang, Xuan Zhang
Summary: Rapid and portable water purification technologies are increasingly important for travelers in the wild. This study presents a biomimetic nanofiber membrane with dual functions, capable of efficiently removing soluble and insoluble contaminants. The membrane shows excellent purification performance in both laboratory and field tests.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Mehdi Shahedi Asl, Behzad Nayebi, Mohammad Farvizi, Reza Alaghmandfard, Mohammadreza Shokouhimehr, G. D. Janaki Ram, Mohsen Mohammadi
Summary: Several core-shell nanosphere chains were observed in the electron beam melted Ti-48Al-2Cr-2Nb samples. The formation mechanism of such core-shell nanospheres, induced by Al vaporization during the electron beam melting of gamma-TiAl, was investigated using various analytical techniques. The core and shell of the nanospheres were characterized as porous Al and alpha-Al2O3, respectively.
Article
Acoustics
Amit Katiyar, Jenna Osborn, Malaya DasBanerjee, Lijie Grace Zhang, Kausik Sarkar, Krishna Pada Sarker
JOURNAL OF ULTRASOUND IN MEDICINE
(2020)
Article
Nanoscience & Nanotechnology
Xuan Zhou, Sara Tenaglio, Timothy Esworthy, Sung Yun Hann, Haitao Cui, Thomas J. Webster, Hicham Fenniri, Lijie Grace Zhang
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Materials Science, Biomaterials
Se-jun Lee, Dayun Yan, Xuan Zhou, Haitao Cui, Timothy Esworthy, Sung Yun Hann, Michael Keidar, Lijie Grace Zhang
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Multidisciplinary Sciences
Haitao Cui, Chengyu Liu, Timothy Esworthy, Yimin Huang, Zu-xi Yu, Xuan Zhou, Hong San, Se-jun Lee, Sung Yun Hann, Manfred Boehm, Muhammad Mohiuddin, John P. Fisher, Lijie Grace Zhang
Article
Nanoscience & Nanotechnology
Xuan Zhou, Margaret Nowicki, Hao Sun, Sung Yun Hann, Haitao Cui, Timothy Esworthy, James D. Lee, Michael Plesniak, Lijie Grace Zhang
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Nanoscience & Nanotechnology
Yue Wang, Haitao Cui, Yancheng Wang, Chengyao Xu, Timothy J. Esworthy, Sung Yun Hann, Manfred Boehm, Yin-Lin Shen, Deqing Mei, Lijie Grace Zhang
Summary: 4D printing enables the creation of pre-designed structures with time-dependent, dynamic shape changes to promote uniform cellular growth and distribution. The development of near-infrared light-sensitive cardiac constructs allows on-demand shape changes to mimic the curved topology of myocardial tissue.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Sung Yun Hann, Haitao Cui, Timothy Esworthy, Xuan Zhou, Se-jun Lee, Michael W. Plesniak, Lijie Grace Zhang
Summary: The development of vascular networks is crucial for tissue fabrication in regenerative medicine. 3D printing vascularized bone has gained attention due to bone disorders, but challenges persist due to the need for nanoscale precision. A novel 3D printing approach was combined with biocompatible materials to enhance vascular growth and tissue bioactivity.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Biomaterials
Alejandro Herreros-Pomares, Xuan Zhou, Silvia Calabuig-Farinas, Se-Jun Lee, Susana Torres, Timothy Esworthy, Sung Yun Hann, Eloisa Jantus-Lewintre, Carlos Camps, Lijie Grace Zhang
Summary: Traditional two-dimensional (2D) in vitro cell cultures and animal models are limited in simulating the native environment for cancer stem cell (CSC) studies, but novel three-dimensional (3D) cell cultures show promise in enriching CSCs from lung cancer patients. Different 3D printing platforms were used to produce rigid and hydrogel-based scaffolds, with gene expression analysis confirming overexpression of stemness and invasion promoters in cells grown on hydrogel scaffolds and tumor spheres. The 3D printed models, especially those using GelMA-PEGDA hydrogels, outperform 2D culture models in mimicking tumor complexity and regulating cancer cell behavior.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Materials Science, Biomaterials
Tarun Agarwal, Dishary Banerjee, Rocktotpal Konwarh, Timothy Esworthy, Jyoti Kumari, Valentina Onesto, Prativa Das, Bae Hoon Lee, Frank A. D. T. G. Wagener, Pooyan Makvandi, Virgilio Mattoli, Sudip Kumar Ghosh, Tapas Kumar Maiti, Lijie Grace Zhang, Ibrahim T. Ozbolat
Summary: This review focuses on the significance of using 3D bioprinting technology in liver tissue engineering, as well as the opportunities for stem cells and differentiation strategies for different types of liver cells.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Materials Science, Biomaterials
Tarun Agarwal, Gabriele Maria Fortunato, Sung Yun Hann, Bugra Ayan, Kiran Yellappa Vajanthri, Dario Presutti, Haitao Cui, Alex H. P. Chan, Marco Costantini, Valentina Onesto, Concetta Di Natale, Ngan F. Huang, Pooyan Makvandi, Majid Shabani, Tapas Kumar Maiti, Lijie Grace Zhang, Carmelo De Maria
Summary: Bioprinting technologies have made significant advancements in the fabrication of engineered cardiac tissue, offering possibilities for functional cardiac tissue models for regenerative and diagnostic applications, while also discussing the related challenges and prospects.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Biotechnology & Applied Microbiology
Nathan J. Castro, Greta Babakhanova, Jerry Hu, K. A. Athanasiou
Summary: Traditional destructive tests are limited in their applicability to biomanufacturing, making nondestructive testing methods, such as photo- and acoustic-based techniques, more important. These methods allow for quantitative measurements of structural, compositional, and functional variances in soft tissues.
TRENDS IN BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Yue Wang, Haitao Cui, Timothy Esworthy, Deqing Mei, Yancheng Wang, Lijie Grace Zhang
Summary: The rapid development of 3D printing has had a significant impact on the field of biomedical engineering, particularly 4D printing. While there has been progress made in the development of 4D printing for tissue scaffolds and medical devices, there are limitations in printable smart materials and achievable responses with current stimulation sources. This review highlights recent progress in 4D printing, focusing on printing mechanisms, smart ink mechanisms, structural design, and printing technologies. It also summarizes recent studies on tissue/organ regeneration and medical device applications, and discusses current challenges and future perspectives of 4D printing.
ADVANCED MATERIALS
(2022)
Article
Acoustics
Jenna Osborn, Megan S. Anderson, Morgan Beddingfield, Lijie Grace Zhang, Kausik Sarkar
Summary: Scientists are facing challenges in creating effective biomimetic constructs in tissue engineering with sustained and controlled delivery of growth factors. They have explored acoustic droplet vaporization (ADV) in GelMA hydrogels and discovered the performance of different perfluorocarbon droplets. The results provide a potential application of ADV in hydrogel scaffolds for tissue engineering.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Sung Yun Hann, Haitao Cui, Timothy Esworthy, Lijie Grace Zhang
Summary: In this study, a two-in-one 4D smart cardiac construct that integrates the functions of minimally invasive cell vehicles and in situ tissue patches was developed for repairing damaged myocardial tissue.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Materials Science, Biomaterials
Tarun Agarwal, Sung Yun Hann, Irene Chiesa, Haitao Cui, Nehar Celikkin, Simone Micalizzi, Andrea Barbetta, Marco Costantini, Timothy Esworthy, Lijie Grace Zhang, Carmelo De Maria, Tapas Kumar Maiti
Summary: The article discusses the combination of 3D printing technology and smart materials in additive manufacturing to create biomimetic structures that can dynamically reshape in response to external stimuli. This approach shows promise in various biomedical areas.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
