Article
Agriculture, Dairy & Animal Science
Ana Lourdes Zamora-Perez, Jaime Luna-Aguirre, Guillermo Moises Zuniga-Gonzalez, Olivia Torres-Bugarin, Blanca Miriam Torres-Mendoza, Martha Patricia Gallegos-Arreola, Ramon Guillermo Ortiz-Garcia, Juan Ernesto Gutierrez-Sevilla, Belinda Claudia Gomez-Meda
Summary: Crocodiles are territorial reptiles that can be quickly assessed for exposure to toxic agents by analyzing abnormal structures in their blood. The presence of nuclear buds in blood cells may be a more sensitive biomarker for genotoxic damage compared to micronuclei, and could be used as a bioindicator to assess the health status of these reptiles and monitor genotoxic pollutants in their habitats.
Article
Engineering, Environmental
Hang Yu, Meiqi Song, Keqi Hu, Yujian Wang, Ruifang Fan, Zongying Yang, Hansruedi Glatt, Albert Braeuning, Yungang Liu
Summary: Bisphenol compounds may increase the genotoxic effects of metabolically activated carcinogens by modulating the expression of nuclear receptors and xenobiotic-metabolizing enzymes in human liver cancer cells, potentially aggravating chromosome damage caused by impactful carcinogens in human cells.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Milad Darboui, Reza Askari Moghadam, Rasoul Parichehr
Summary: In this paper, a microfluidic chip inspired by fish gills was designed and fabricated to separate blood cells from serum. The chip utilizes a reservoir with parallel rows of filter columns to filter the blood, similar to the filtering action of fish gills. Simulation results show that the microchip is able to completely separate cells from serum at a blood flow rate of 134 μl/s.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Biochemistry & Molecular Biology
Florence Isabella Ogili, Daoud Ali, Gerald N. Attamah, Uduak Aletan, Henrietta Ijeoma Kelle, Maureen N. Chukwu, Christopher D. Nwani
Summary: The study investigated the effects of tramadol on C. gariepinus juveniles, finding that exposure led to abnormal behavior, increased mortality, changes in hematological parameters and oxidative stress responses. The results suggest that tramadol is toxic to fish and its use in aquatic environments should be monitored.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Patricia Molz, Diene da Silva Schlickmann, Juliana Priebe Steffens, Eduarda da Silva Limberger Castilhos, Hildegard Hedwig Pohl, Michael Fenech, Silvia Isabel Rech Franke
Summary: This study investigated the potential association between the use of muscle-building supplements and DNA damage. The results showed that individuals who used supplements had higher DNA damage indexes and frequency compared to those who did not use supplements. However, there was no significant difference in the micronuclei and nuclear buds between the groups.
Article
Multidisciplinary Sciences
Zubair Ahmad Sheikh, Imtiaz Ahmed, Kousar Jan, Naveed Nabi, Francesco Fazio
Summary: This research investigates the effects of sex on haematological, biochemical, and blood cell morphology in cultured brown trout. The study finds significant differences in Hb content, RBC count, and Hct content between male and female fish. However, there were no significant differences in most of the other parameters analyzed. These findings suggest the potential use of the data to evaluate fish health and improve overall fish population production.
Article
Biochemistry & Molecular Biology
Adrianna W. Bara-Halama, Dominika Idziak-Helmcke, Jolanta Kwasniewska
Summary: This study demonstrates for the first time the presence of DNA methylation in micronuclei induced by the mutagenic treatment MH, providing insights into the mechanisms of gene expression regulation in plant mutagenesis. The use of advanced techniques allows the in situ analysis of DNA methylation in specific DNA sequence sites, revealing the importance of this phenomenon in altering gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Bing Wu, Yingli Qu, Yifu Lu, Saisai Ji, Liang Ding, Zheng Li, Miao Zhang, Heng Gu, Qi Sun, Bo Ying, Feng Zhao, Xulin Zheng, Yidan Qiu, Zheng Zhang, Ying Zhu, Zhaojin Cao, Yuebin Lv, Xiaoming Shi
Summary: This study aimed to explore the effect of blood mercury (BHg) on the relationship between sea fish consumption frequency and tri-glyceride (TG) levels in Chinese adults. The results showed that sea fish consumption frequency was negatively associated with TG levels, while BHg levels were positively associated with TG levels. BHg levels mediated the association between sea fish consumption frequency and TG levels. These findings suggest that BHg may reduce the beneficial effect of sea fish consumption on TG levels.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Xiaoteng Fan, Tao Yan, Tingting Hou, Xiaofan Xiong, Leilei Feng, Shiyi Li, Zaizhao Wang
Summary: This study investigated the changes in fish mitochondria upon serum deprivation using zebrafish embryonic fibroblast cells. The results showed that mitochondrial content and membrane potential were reduced, and intracellular ROS levels were increased in serum deprivation treated fish cells. The impaired mitochondria had rough and fracted outer membranes, and fused mitochondria were frequently observed. The mRNA expressions of mitochondrial fusion genes (mfn1b, mfn2, and opa1) were upregulated. The mtDNA copy numbers of mtatp6, mtcox1, mtcytb, mtnd4, and mtnd6 were significantly reduced, but the mRNA expressions of these genes increased, indicating compensatory effects in mitochondria. Moreover, the methylation of whole mtDNA was found to be increased, reflecting the instability of fish mtDNA with mitochondrial dysfunction under nutrient fluctuations. Overall, these findings suggest that fish health may be significantly affected during aquaculture processes due to profound and long-lasting deficits in mitochondrial response to external variables.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Fisheries
Burak Evren Inanan, Umit Acar, Tulden Inanan
Summary: This study evaluated the effects of Ferula elaeochytris root powder on adult male goldfish, with findings showing that 1% of FRP in the diet can have beneficial effects on certain blood parameters, while also negatively impacting spermatozoa parameters and inducing oxidative stress conditions in tissues. It was concluded that the concentration and key compounds of medicinal herbs used as supplements in fish diets should be carefully considered for optimal results.
Article
Biochemistry & Molecular Biology
Molly Guscott, Akash Saha, Jovanna Maharaj, Sarah E. McClelland
Summary: Within tumour types, cancerous cells often have an incorrect chromosome number or structure, leading to chromosomal instability and micronucleus formation. These micronuclei can undergo structural changes and membrane rupturing, contributing to metastasis, immune cell activation, and overall tumour progression.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Review
Cell Biology
Juli Bai, Feng Liu
Summary: cGAS plays a crucial role as a DNA sensor in the cytosol and nucleus, with potential additional functions beyond DNA sensing in the nucleus that are still poorly understood.
Editorial Material
Pharmacology & Pharmacy
Elizabeth R. Smith, Jing-Quan Wang, Dong-Hua Yang, Xiang Xi Xu
Summary: Taxanes are a group of successful drugs commonly used in chemotherapy to treat malignant tumors. However, drug resistance to taxanes is a common issue in subsequent treatments. In this review, the focus is on experimental findings and ideas related to the mechanism of taxane resistance involving the cancer nuclear envelope, aiming to provide new insights for overcoming taxane resistance.
DRUG RESISTANCE UPDATES
(2022)
Article
Clinical Neurology
Aster V. E. Harder, Lisanne S. Vijfhuizen, Peter Henneman, Ko Willems van Dijk, Cornelia M. van Duijn, Gisela M. Terwindt, Arn M. J. M. van den Maagdenberg
Summary: Using H-1-NMR spectroscopy, this study identified metabolites in serum that can distinguish between lifetime and active migraine patients and controls. Metabolites involved in lipid, glucose, and amino acid metabolism were found to be associated with active migraine status, suggesting potential diagnostic biomarkers for this common brain disorder.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Biotechnology & Applied Microbiology
Layon Zafra-Lemos, Luis Fernando Cusioli, Rosangela Bergamasco, Luciana Andreia Borin-Carvalho, Ana Luiza de Brito Portela-Castro
Summary: The study demonstrated the genotoxic and cytotoxic effects of 2,4-dichlorophenoxyacetic acid (2,4-D) on Astyanax lacustris, while suggesting the potential application of an activated carbon filter made from coconut husks for the effective removal of 2,4-D from water and reduction of its toxic effects on fish.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2021)
Article
Toxicology
Riaz Hussain, Abdul Ghaffar, Ghulam Abbas, Ghazala Jabeen, Iahtasham Khan, Rao Zahid Abbas, Sobia Noreen, Zahid Iqbal, Iqra Rasheed Chaudhary, Hafiz Muhammad Ishaq, Muhammad Taslim Ghori, Ahrar Khan
Summary: This study evaluated the effects of sublethal concentrations of thiamethoxam on freshwater fish. The results showed that thiamethoxam exposure caused alterations in blood biochemistry, genotoxicity, and histopathology in the exposed fish.
Article
Toxicology
Shfaia Tehseen Gul, Rabia Liaquat Khan, M. Kashif Saleemi, Maqbool Ahmad, Riaz Hussain, Ahrar Khan
Summary: This study investigated the extent to which selenium and vitamin E ameliorate the toxic effects of thiamethoxam in broiler birds. The results showed that the combination of selenium and vitamin E partially improved the hematological and biochemical parameters.
Article
Toxicology
Sheraz Ahmed Bhatti, Muhammad Zargham Khan, Muhammad Kashif Saleemi, Zahoor Ul Hassan, Ahrar Khan
Summary: The present study found that adding activated charcoal can partially reduce the toxic effects caused by ochratoxin A in broiler feed, particularly at lower doses. However, at higher doses, activated charcoal is ineffective and may have toxicological effects on broiler chickens.
Article
Mathematical & Computational Biology
Muhammad Umar Farooq, Rukhshanda Anjum, Abdul Gaffar, Huma Bashir, Naziha Al-Aidroos, Ahmed Alsanad
Summary: Neutrosophic set (NS) is a framework for describing the imprecision and uncertainty of events, focusing on association, neutrality, and nonassociation degrees. Neutrosophic graphs (NGs) and single-valued NGs (SVNGs) are used for events with abundant information. The manuscript develops various forms of SVNGs and demonstrates their applications with mathematical proofs and examples.
COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE
(2022)
Article
Mathematics, Applied
Maliha Rashid, Amna Kalsoom, Abdul Ghaffar, Mustafa Inc, Ndolane Sene
Summary: This manuscript aims to prove a multiple fixed point result for partially ordered s-distance spaces under a specific weak contractive condition. The result generalizes well-known results in literature and includes an application for the existence of solutions in a system of integral equations.
JOURNAL OF FUNCTION SPACES
(2022)
Article
Veterinary Sciences
Riaz Hussain, Zhang Guangbin, Rao Zahid Abbas, Abu Baker Siddique, Mudassar Mohiuddin, Iahtasham Khan, Tauseef Ur Rehman, Ahrar Khan
Summary: This study analyzed the occurrence and toxinotypes of enterotoxemia in small ruminants in the desert area of Bahawalpur, Pakistan. The results showed significant differences in mortality rates caused by Clostridium perfringens type A and type D. It is important to follow a proper vaccination schedule to protect the health of small ruminants.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cell Biology
Xuwen Li, Sumaira Naseem, Riaz Hussain, Abdul Ghaffar, Kun Li, Ahrar Khan
Summary: The study reveals that the synthetic insecticide PPF has adverse toxic impacts on multiple tissues of Labeo rohita fish, including increased DNA damage, elevated oxidative stress markers, and reduced antioxidant enzyme concentrations.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biotechnology & Applied Microbiology
Riaz Hussain, Iahtasham Khan, Adil Jamal, Bahaeldeen Babiker Mohamed, Ahrar Khan
Summary: This study investigated the prevalence of brucellosis and its effects on hematological, oxidative stress, and antioxidant enzymes in cattle breeds reared in tropical-desert conditions in Pakistan for the first time. The results showed a relatively high prevalence of brucellosis and significant changes in hematological parameters and antioxidant enzymes in infected cattle.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Veterinary Sciences
Iqra Zaheer, Wei Chen, Ahrar Khan, Abdelmotaleb Elokil, Muhammad Kashif Saleemi, Tean Zaheer, Muhammad Zargham Khan
Summary: This study compares the immunopathological effects of in ovo vaccination and post-hatch vaccination against IBD in White Leghorn chicks. The results show that in ovo vaccinated groups have higher antibody titers and long-term protective immunity against IBD.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Abdul Hannan, Bushra Akhtar, Ali Sharif, Fozia Anjum, Imran Pasha, Ahrar Khan, Muhammad Furqan Akhtar, Ammara Saleem
Summary: This study prepared quercetin-loaded chitosan nanoparticles and validated their anti-rheumatic effects in a Freund's complete adjuvant-induced arthritic rat model. The high-dose Q-NPs were found to reduce ankle diameter and levels of inflammatory cytokines, as well as showing significant effects on biochemical tests and oxidative stress parameters. The study concludes that Q-NPs administration may be used for the treatment of rheumatoid arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Mathematics, Interdisciplinary Applications
Shao-wen Yao, Pakeeza Ashraf, Abdul Ghaffar, Misbah Kousar, Mustafa Inc, Niat Nigar
Summary: The main objective of this research is to analyze the geometrical properties of a quaternary four-point interpolatory subdivision scheme with a shape parameter, and determine the precise range of the shape parameter to generate fractal and convex limit curves. By varying the tension parameters, the curve maintains its characteristics and geometrical configuration. These techniques provide an easily performable method for geometric modeling and offer an alternative strong strategy for complex figure modeling.
FRACTALS-COMPLEX GEOMETRY PATTERNS AND SCALING IN NATURE AND SOCIETY
(2023)
Article
Mathematics, Applied
Nargis Khan, Muhammad Sadiq Hashmi, Abdul Ghaffar, Hameed Ullah, Mustafa Inc
Summary: The main purpose of this paper is to study the effects of velocity slip on the magneto hydrodynamics (MHD) axi-symmetric viscous fluid flow between two disks with different stretching ratios. The study considers temperature and concentration jumps. MHD flows are important in industrial and engineering sectors, as well as in biological fields, and the resulting system of PDE's is solved using the HAM method. The behavior of velocity, temperature, and concentration profiles are observed graphically.
ZAMM-ZEITSCHRIFT FUR ANGEWANDTE MATHEMATIK UND MECHANIK
(2023)
Article
Physics, Multidisciplinary
M. Arfan, A. Ghaffar, F. K. Alsaif, Y. Khan, I. Shakir
Summary: Scattering of a Gaussian beam by a perfect electromagnetic conductor (PEMC) sphere was investigated using the framework of generalized Lorenz-Mie theory (GLMT). The influence of parameters such as sphere size, beam waist radius, and beam center position on scattering and extinction efficiencies, normalized energy flow, and scattering asymmetry factor was numerically analyzed. The amplitude of efficiency factors is significantly modified by varying these parameters. Increasing the waist radius leads to an increase in the normalized energy flow for the PEMC sphere. The study of scattering characteristics for PEMC sphere illuminated by a Gaussian beam can also be extended to investigate metamaterial structures.
INDIAN JOURNAL OF PHYSICS
(2023)
Article
Veterinary Sciences
Sumaira Naseem, Abdul Ghaffar, Riaz Hussain, Ahrar Khan
Summary: This study investigated the toxico-pathologic effects of Pyriproxyfen (PPF) in fish. The results showed various clinical ailments and significant differences in the weight of specific visceral organs in the treated fish. Blood markers and pathological changes in visceral organs confirmed the potential risks of PPF in freshwater fish.
PAKISTAN VETERINARY JOURNAL
(2022)
Article
Thermodynamics
Majid Hussain, Akhtar Ali, Abdul Ghaffar, Mustafa Inc
Summary: This research utilizes the Homotopy analysis method to study the thermal boundary layer flow over an extending wedge, non-dimensionalizing the problem with similarity variables and demonstrating the accuracy of the method and relevant parameters through figures. A comparison with existing results in a limiting case reveals reliable outcomes.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
