Article
Biotechnology & Applied Microbiology
Chang Liu, Linshuang Li, Bo Yang, Yiqing Zhao, Xiyuan Dong, Lixia Zhu, Xinling Ren, Bo Huang, Jing Yue, Lei Jin, Hanwang Zhang, Lan Wang
Summary: This study examined the role of N6-methyladenine (m(6)A) methylation in aging-related ovarian reserve decline. The researchers performed a transcriptome-wide profiling of m(6)A methylation in the ovarian granulosa cells of younger and older women. They found that m(6)A methylation was highly conserved and enriched in specific regions of the mRNA. The older group had a higher number of m(6)A methylated genes. Further analysis revealed the enrichment of these methylated genes in various signaling pathways. Additionally, several genes were found to be differently expressed and modified by m(6)A in the aging ovary.
Article
Chemistry, Multidisciplinary
Chuanchuan Zhou, Qi Guo, Jiayu Lin, Meng Wang, Zhi Zeng, Yujie Li, Xiaolan Li, Yuting Xiang, Qiqi Liang, Jiawen Liu, Taibao Wu, Yanyan Zeng, Shanyang He, Sanfeng Wang, Haitao Zeng, Xiaoyan Liang
Summary: The activation of pyroptotic macrophages in human ovaries increases with age, leading to changes in the ovarian immune microenvironment and accelerated reproductive decline. This discovery provides important insights into the aging process of the ovaries and offers potential strategies for delaying senescence and promoting reproductive health.
Article
Biochemistry & Molecular Biology
Xueying Fan, Ioannis Moustakas, Monika Bialecka, Julieta S. del Valle, Arend W. Overeem, Leoni A. Louwe, Gonneke S. K. Pilgram, Lucette A. J. van der Westerlaken, Hailiang Mei, Susana M. Chuva de Sousa Lopes
Summary: This study examines the transcriptional signatures of human oocytes and granulosa cells from small antral follicles, revealing the diversity of follicle types and contributing to the understanding of human folliculogenesis and oogenesis at the molecular level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mengnan Ma, Huiming Wang, Yi Zhang, Jinbi Zhang, Jingge Liu, Zengxiang Pan
Summary: The study identified that ssc-circINHA-001 plays a role in resisting GC apoptosis by enhancing INHBA expression through adsorbing miR-214-5p, miR-7144-3p, and miR-9830-5p. Low expression of ssc-circINHA-001 increases free miRNAs, inhibits INHBA expression, and leads to GC apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Pavine L. C. Lefevre, Thomas C. Nardelli, Weon-Young Son, Amy R. Sadler, Dorothea F. K. Rawn, Cindy Goodyer, Bernard Robaire, Barbara F. Hales
Summary: Overall, exposure to PBDEs was found to be associated with dysregulation of gene expression pathways essential for ovulation. Mural granulosa cells were more sensitive to PBDE exposure compared to cumulus cells, and exposure to different PBDE congeners resulted in distinct gene expression changes related to innate immunity and inflammation pathways.
Article
Cell Biology
Hongcai Cai, Tianli Chang, Yamin Li, Yinzhao Jia, Huiying Li, Mengdi Zhang, Ping Su, Ling Zhang, Wenpei Xiang
Summary: The study found that circDDX10 levels in GCs decrease with age and are positively correlated with AMH and AFC. circDDX10 is also related to the number of obtained oocytes and rates of good quality embryos.
Article
Biochemistry & Molecular Biology
Kamiya Bridges, Humphrey H-C Yao, Barbara Nicol
Summary: This study reveals the significance of the Runx1 gene in mouse ovarian development. Loss of Runx1 leads to an increased prevalence of ovarian tumors and also affects normal granulosa cell differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Mengyu Liu, Wenzhu Li, Xiaowei Zhou, Mingjuan Zhou, Wenjie Zhang, Qiang Liu, Aijun Zhang, Bufang Xu
Summary: This study found that cell-free fat extract (CEFFE) can rescue the decline in ovarian function and improve fertility in naturally aging mice. CEFFE was found to increase sex hormone levels, angiogenesis, and the number of growth follicles. It also improved granulosa cell function by promoting proliferation, alleviating senescence, and repairing DNA damage.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Yong Du, Yi Ding, Tianyun Shi, Wei He, Zhoufang Mei, Xintong Feng, Xiaohua Zhang, Zhijun Jie
Summary: This study reveals that circXPO1 plays a role in the pathogenesis of COPD by modulating TAB3 through sponging miR-23b-3p. Suppression of circXPO1 can inhibit cigarette smoke-induced inflammatory cytokine production and cellular senescence. CircXPO1 knockdown has a potential therapeutic effect on attenuating CS-induced inflammation and senescence in the mouse lungs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biology
Min Chen, Fangfang Dong, Min Chen, Zhiming Shen, Haowei Wu, Changhuo Cen, Xiuhong Cui, Shilai Bao, Fei Gao
Summary: PRMT5 plays a crucial role in follicle development by regulating WT1 expression and facilitating the translation of Wt1 mRNA through methylation of HnRNPA1. It is essential for granulosa cell lineage maintenance, follicle structure, and steroidogenesis-related gene expression.
Review
Biochemistry & Molecular Biology
Stephanie Chauvin, Joelle Cohen-Tannoudji, Celine J. Guigon
Summary: This review provides a comprehensive overview of the role of E2 in female folliculogenesis and the various effects of ERβ splice isoforms. It also discusses how deregulation of E2 signaling can lead to two ovarian pathologies and emphasizes the need for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Riva Shmulevich, Valery Krizhanovsky
Summary: Senescence is a crucial biological process that can block tumorigenesis and limit tissue damage, but accumulation of senescent cells can promote age-related diseases. Recent advances have shown the significant role of cellular metabolism in regulating cell senescence, and future research should focus on elucidating metabolic mechanisms to develop new therapeutic strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Pharmacology & Pharmacy
Xin-Xin Zhang, Shi-Hao He, Xu Liang, Wei Li, Tian-Fang Li, Dai-Feng Li
Summary: Osteoarthritis is a chronic joint disease characterized by cartilage destruction, with aging playing a key role. Current treatments are palliative, and there is a need for disease-modifying drugs. Cellular senescence, synovial inflammation, and epigenetic changes may contribute to its pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cristina Mas-Bargues
Summary: Aging is a complex biological process characterized by the decline in cellular and tissue function. Stem cells and mitochondria play important roles in this process, influencing tissue function and aging. This review discusses the mechanisms through which mitochondria impact stem cell fate decisions and explores potential anti-aging therapies targeting mitochondrial health.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Rodrigo D. Carrasco, Kylie M. Hutt, Christina P. McKenzie, Gregg P. Adams
Summary: This case report describes a llama with a granulosa cell tumor, which is hormonally active in camelids and presents with clinical features similar to other large animal species.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Oncology
Yifan Meng, Wanrong Lu, Ensong Guo, Jia Liu, Bin Yang, Ping Wu, Shitong Lin, Ting Peng, Yu Fu, Fuxia Li, Zizhuo Wang, Yuan Li, Rourou Xiao, Chen Liu, Yuhan Huang, Funian Lu, Xue Wu, Lixin You, Ding Ma, Chaoyang Sun, Peng Wu, Gang Chen
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Yuan Li, Jiaqi Li, Ensong Guo, Jia Huang, Guangguang Fang, Shaohua Chen, Bin Yang, Yu Fu, Fuxia Li, Zizhuo Wang, Rourou Xiao, Chen Liu, Yuhan Huang, Xue Wu, Funian Lu, Lixin You, Ling Feng, Ling Xi, Peng Wu, Ding Ma, Chaoyang Sun, Beibei Wang, Gang Chen
CELL AND BIOSCIENCE
(2020)
Article
Oncology
Chen Liu, Yuhan Huang, Tianyu Qin, Ensong Guo, Peng Wu, Chaoyang Sun, Gang Chen
FRONTIERS IN ONCOLOGY
(2020)
Article
Medicine, General & Internal
Yu Fu, Yongsheng Li, Ensong Guo, Liang He, Jia Liu, Bin Yang, Fuxia Li, Zizhuo Wang, Yuan Li, Rourou Xiao, Chen Liu, Yuhan Huang, Xue Wu, Funian Lu, Lixin You, Tianyu Qin, Chaolong Wang, Kezhen Li, Peng Wu, Ding Ma, Chaoyang Sun, Gang Chen
Summary: The study found that among patients with laboratory-confirmed COVID-19, the viral PCR positivity rate peaked within the first 3 days, while the seroconversion rate peaked within 4 to 5 weeks. Critically ill patients had a longer duration of viral positivity, and low IgM titers were identified as an independent risk factor for persistent viral positivity.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Oncology
Bin Yang, Xi Li, Yu Fu, Ensong Guo, Youqiong Ye, Fuxia Li, Si Liu, Rourou Xiao, Chen Liu, Funian Lu, Jia Huang, Tianyu Qin, Leng Han, Guang Peng, Gordon B. Mills, Chaoyang Sun, Gang Chen
Summary: This study demonstrates that the combination of MEK inhibitors with PARP inhibitors and anti-PD-L1 can significantly inhibit tumor growth in mutant KRAS tumors by triggering DNA damage, activating immune responses, and reducing myeloid-derived suppressor cell infiltration.
Article
Public, Environmental & Occupational Health
Jean Bosco Munyemana, Esperance Mukanoheli, Theoneste Nsabimana, Jean Damascene Niringiyumukiza
Summary: The study in Rwanda assessed the prevalence of HCV infection and comorbidities among HIV patients, finding that those with HIV/HCV coinfection had a higher rate of comorbidities compared to those with HIV mono-infection, indicating the need for more interventions in this group.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Chemistry, Multidisciplinary
Xun Tian, Xin Wang, Zifeng Cui, Jia Liu, Xiaoyuan Huang, Caixia Shi, Min Zhang, Ting Liu, Xiaofang Du, Rui Li, Lei Huang, Danni Gong, Rui Tian, Chen Cao, Ping Jin, Zhen Zeng, Guangxin Pan, Meng Xia, Hongfeng Zhang, Bo Luo, Yonghui Xie, Xiaoming Li, Tianye Li, Jun Wu, Qinghua Zhang, Gang Chen, Zheng Hu
Summary: A 15-gene classifier has been developed to accurately predict the clinical response to neoadjuvant chemotherapy in cervical cancer patients, offering a promising approach for guiding the selection of appropriate treatment strategies.
Article
Oncology
Zhenkun Wang, Ensong Guo, Bin Yang, Rourou Xiao, Funian Lu, Lixin You, Gang Chen
Summary: This study assessed the long-term trends of mortality from the three major gynecologic cancers in China from 1990 to 2019, identifying age, period, and cohort effects. While cervical cancer remained the most common cause of death among Chinese women, ovarian cancer replaced uterine cancer as the second leading cause of death in gynecologic cancers after 2005. The mortality trends of all three major gynecologic cancers showed significant age, cohort, and period effects.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Ecology
Zizhuo Wang, Rourou Xiao, Jia Huang, Xu Qin, Dianxing Hu, Ensong Guo, Chen Liu, Funian Lu, Lixin You, Chaoyang Sun, Gang Chen
Summary: The study revealed a close relationship between the vaginal microbiota of cervical cancer patients and their responsiveness to platinum-based chemotherapy, with higher alpha diversity in nonresponders compared to responders and the enrichment of the Bacteroides genus in nonresponders.
Article
Multidisciplinary Sciences
Peng Wu, Dongsheng Chen, Wencheng Ding, Ping Wu, Hongyan Hou, Yong Bai, Yuwen Zhou, Kezhen Li, Shunian Xiang, Panhong Liu, Jia Ju, Ensong Guo, Jia Liu, Bin Yang, Junpeng Fan, Liang He, Ziyong Sun, Ling Feng, Jian Wang, Tangchun Wu, Hao Wang, Jin Cheng, Hui Xing, Yifan Meng, Yongsheng Li, Yuanliang Zhang, Hongbo Luo, Gang Xie, Xianmei Lan, Ye Tao, Jiafeng Li, Hao Yuan, Kang Huang, Wan Sun, Xiaobo Qian, Zhichao Li, Mingxi Huang, Peiwen Ding, Haoyu Wang, Jiaying Qiu, Feiyue Wang, Shiyou Wang, Jiacheng Zhu, Xiangning Ding, Chaochao Chai, Langchao Liang, Xiaoling Wang, Lihua Luo, Yuzhe Sun, Ying Yang, Zhenkun Zhuang, Tao Li, Lei Tian, Shaoqiao Zhang, Linnan Zhu, Ashley Chang, Lei Chen, Yiquan Wu, Xiaoyan Ma, Fang Chen, Yan Ren, Xun Xu, Siqi Liu, Huanming Yang, Lin Wang, Chaoyang Sun, Ding Ma, Xin Jin, Gang Chen
Summary: The authors conducted blood sampling and multi-omics analysis on COVID-19 patients of various disease severities, reporting a trans-omics landscape of COVID-19. The study found differences in characteristics between patients with different disease severities, suggesting potential clues for pathophysiology and therapeutic strategies of COVID-19.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Ensong Guo, Rourou Xiao, Yifan Wu, Funian Lu, Chen Liu, Bin Yang, Xi Li, Yu Fu, Zizhuo Wang, Yuan Li, Yuhan Huang, Fuxia Li, Xue Wu, Lixin You, Tianyu Qin, Yiling Lu, Xiaoyuan Huang, Ding Ma, Gordon B. Mills, Chaoyang Sun, Gang Chen
Summary: Inhibition of WEE1 enhances the efficacy of cancer immunotherapy by regulating dsRNA and interferon responses, leading to increased recruitment of anti-tumor T cells and elevated PD-L1 levels. This study demonstrates the potential of combining WEE1 inhibitors with anti-PD-L1 therapies to improve patient outcomes and overcome resistance.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Medicine, General & Internal
Wenting Li, Jie Jiang, Yu Fu, Yuanming Shen, Chuyao Zhang, Shuzhong Yao, Congjian Xu, Min Xia, Ge Lou, Jihong Liu, Bei Lin, Jianliu Wang, Weidong Zhao, Jieqing Zhang, Wenjun Cheng, Hongyan Guo, Ruixia Guo, Fengxia Xue, Xipeng Wang, Lili Han, Xia Zhao, Xiaomao Li, Ping Zhang, Jianguo Zhao, Jiezhi Ma, Qin Yao, Xiaohang Yang, Yingyu Dou, Zizhuo Wang, Jingbo Liu, Yong Fang, Kezhen Li, Beibei Wang, Gang Chen, Xiaodong Cheng, Chaoyang Sun, Beihua Kong
Summary: A systematic evaluation was conducted on 4001 patients with endometrial cancer who underwent complete surgical staging, revealing over one-fourth of patients had PLN-PAN+ lymph node metastasis pattern. PLN-PAN+ showed comparable survival outcomes with other metastatic patterns, and no effective clinical methods were achieved for predicting PAN+.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Chen Liu, Yuhan Huang, Tianyu Qin, Lixin You, Funian Lu, Dianxing Hu, Rourou Xiao, Xu Qin, Ensong Guo, Bin Yang, Xi Li, Junpeng Fan, Xiong Li, Yu Fu, Si Liu, Zhuozi Wang, Yingyu Dou, Wei Wang, Wenting Li, Xiaohang Yang, Jingbo Liu, Wenju Peng, Li Zhang, Yaoyuan Cui, Chaoyang Sun, Gang Chen
Summary: This study found that CDK4/6 inhibitor palbociclib faced resistance in multiple ovarian cancer models, but adding BRD4 inhibitor AZD5153 could overcome this issue, and the combination of the two demonstrated synergistic effects in inducing cell cycle arrest and increasing apoptosis.
Article
Cell Biology
Jia Huang, Wanying Shan, Fuxia Li, Zizhuo Wang, Jing Chen, Funian Lu, Ensong Guo, Rajluxmee Beejadhursing, Rourou Xiao, Chen Liu, Bin Yang, Xi Li, Yu Fu, Ling Xi, Shixuan Wang, Ding Ma, Gang Chen, Chaoyang Sun
Summary: Research suggests that ovarian activity has an influence on gut microbiota and vaginal health. Transferring fecal microbiota from ovary-intact mice can alleviate vaginal atrophy in ovariectomized mice. This association between gut microbiota and vaginal health may offer alternative treatment options for VVA patients who are hesitant towards hormone therapy.
Article
Oncology
Fuxia Li, Ensong Guo, Jia Huang, Funian Lu, Bin Yang, Rourou Xiao, Chen Liu, Xue Wu, Yu Fu, Zizhuo Wang, Shaohua Peng, Yu Lei, Zhongzhen Guo, Lei Li, Ling Xi, Chaoyang Sun, Si Liu, Gang Chen
AMERICAN JOURNAL OF CANCER RESEARCH
(2020)