Article
Endocrinology & Metabolism
Sarah Charlier, Janina Vavanikunnel, Claudia Becker, Susan S. Jick, Christian Meier, Christoph R. Meier
Summary: The study found that patients with good glycemic control who were treated with metformin monotherapy had a lower risk of fractures, while glycemic control in patients receiving other antidiabetic medications was not associated with fracture risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Gebrehiwot Lema Legese, Getahun Asres, Shitaye Alemu, Tesfaye Yesuf, Yeabsira Aklilu Tesfaye, Tsegaw Amare
Summary: This study aims to identify determinants of poor glycemic control among type 2 diabetes mellitus patients at a diabetes mellitus clinic in University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. A hospital-based case-control study was conducted, and a total of 90 cases and 90 controls with type 2 diabetes were recruited. The results showed that age less than 65 years, inadequate physical exercise, presence of comorbidities, non-adherence to anti-diabetes medications, persistent proteinuria, and high-density lipoprotein less than 40 mg/dl were the determinants of poor glycemic control. Therefore, targeted educational and behavioral modification programs should be practiced to improve glycemic control.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Norazida Ab Rahman, Ming Tsuey Lim, Shantini Thevendran, Najwa Ahmad Hamdi, Sheamini Sivasampu
Summary: This study assessed medication burden, regimen complexity, and adherence among T2DM patients and found that high medication count and regimen complexity were associated with poor glycemic control, while adherence was inversely associated with HbA1c level. These parameters can be used to identify patients with complex pharmacotherapy regimens for targeted interventions to achieve optimum outcomes and ease of self-care.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Kim Sui Wan, Feisul Mustapha, Arunah Chandran, Shubash Shander Ganapathy, Nurhaliza Zakariah, Sivarajan Ramasamy, Gunenthira Rao Subbarao, Muhammad Fadhli Mohd Yusoff
Summary: Diabetes is a growing global health emergency. This study focuses on a 10-year retrospective cohort of type 2 diabetes patients in Malaysia, revealing suboptimal control of blood glucose, blood pressure, and lipid levels.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Emil F. Coccaro, Sophie Lazarus, Joshua Joseph, Kathline Wyne, Tina Drossos, Louis Phillipson, Mary de Groot
Summary: The study found that negative emotional experience is positively related to diabetes-related distress, while the skill at regulating these emotions is negatively related to diabetes-related distress, with a medium-size relationship between these emotional regulation variables and diabetes-related distress. The data suggest that diabetes-related distress in adults with diabetes is meaningfully linked to negative emotionality and skill at regulating such emotions, with a stronger relationship than perceived psychological stress or diabetes self-care.
Article
Nutrition & Dietetics
Wei-Lun Wen, Hui-Chun Huang, Hsiu-Chu Lin, Wan-Ching Lo, Szu-Chia Chen, Mei-Yueh Lee
Summary: In patients newly diagnosed with T2DM, glycemic durability is negatively associated with higher glycemic burden.
Review
Endocrinology & Metabolism
Andressa Karoline Pinto de Lima Ribeiro, Josilayne Patricia Ramos Carvalho, Natali Valim Oliver Bento-Torres
Summary: This study conducted a systematic review to analyze the relationship between physical training variables and glycemic control in individuals with T2DM. The results showed that aerobic, resistance, and combined training interventions were associated with reductions in HbA1c and fasting glucose. However, the diversity of the physical exercise intervention protocols investigated in the studies limited the generalizability of the evidence.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Shylaja Srinivasan, Ling Chen, Miriam Udler, Jennifer Todd, Megan M. Kelsey, Morey W. Haymond, Silva Arslanian, Philip Zeitler, Rose Gubitosi-Klug, Kristen J. Nadeau, Katherine Kutney, Neil H. White, Josephine H. Li, James A. Perry, Varinderpal Kaur, Laura Brenner, Josep M. Mercader, Adem Dawed, Ewan R. Pearson, Sook-Wah Yee, Kathleen M. Giacomini, Toni Pollin, Jose C. Florez
Summary: In this study, a genome-wide approach was used to identify common variants associated with metformin response in youth with type 2 diabetes. Although several variants reached a suggestive threshold, none of the previously published adult variants reached genome-wide significance. Replication studies confirmed that the ATRNL1 variant rs76195229 was associated with worse metformin response. Additionally, a higher beta-cell polygenic score was associated with reduced beta-cell function over time.
PEDIATRIC DIABETES
(2023)
Review
Psychology, Multidisciplinary
Esperanza Varela-Moreno, Monica Carreira Soler, Jose Guzman-Parra, Francisco Jodar-Sanchez, Fermin Mayoral-Cleries, Maria Teresa Anarte-Ortiz
Summary: This systematic review examines the efficacy of psychological interventions delivered through information and communication technologies (ICTs) for improving depressive symptomatology in patients with diabetes. The results show that these interventions have beneficial effects on depressive symptoms at the end of treatment and in the short and long term. However, they do not appear to significantly improve glycemic control.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Nutrition & Dietetics
Thanitsara Rittiphairoj, Krit Pongpirul, Kantima Janchot, Noel T. Mueller, Tianjing Li
Summary: This systematic review found that probiotics may have a glucose-lowering effect in participants with type 2 diabetes mellitus, especially in those with poorly controlled diabetes and those not receiving insulin therapy.
ADVANCES IN NUTRITION
(2021)
Article
Health Care Sciences & Services
Yi-Ling Cheng, Ying-Ru Wu, Kun-Der Lin, Chun-Hung Richard Lin, I-Mei Lin
Summary: This study used machine learning methods to explore the relationships between various risk factors and glycemic control in patients with type 2 diabetes mellitus. The results revealed that high depression scores may be a risk factor in one subgroup but not in others.
Article
Chemistry, Medicinal
Wajiha Mahjabeen, Dilshad Ahmed Khan, Shakeel Ahmed Mirza, Muhammad Amjad Pervez
Summary: This study found that delta-tocotrienol supplementation in addition to oral hypoglycemic agents can improve glycemic control, inflammation, oxidative stress, and miRNA expression in patients with type 2 diabetes mellitus without any adverse effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Jeanie B. Tryggestad, Megan M. Kelsey, Kimberly L. Drews, Steven D. Chernausek, Elia N. Escaname, Elvira Isganaitis, Sarah Macleish, Siripoom Mckay, Jennifer Sprague, Steve Willi
Summary: This study assessed pregnancy outcomes in young women with youth-onset type 2 diabetes and found a high rate of maternal complications related to significant socioeconomic disadvantage. Improving contraception rates and reproductive planning could potentially prevent these serious complications in young mothers and infants.
Review
Medicine, Research & Experimental
Simeon I. Taylor, Zhinous Shahidzadeh Yazdi, Amber L. Beitelshees
Summary: Diabetes mellitus is a significant public health issue, with pharmacotherapy aiming to prevent complications. Clinical trials have shown that intensive glycemic control can slow the progression of complications, with some drugs also demonstrating cardiovascular benefits and slowed progression of diabetic kidney disease.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Endocrinology & Metabolism
Mulualem Tesfaye Birhan, Teklie Mengie Ayele, Fikire Wondimu Abebe, Fiseha Nigussie Dgnew
Summary: This article summarizes the effect of bromocriptine in the management of type 2 diabetes (T2DM). The analysis of 8 studies shows that patients who took bromocriptine treatment had significantly reduced blood glucose and BMI, which reduces cardiovascular risk in T2DM patients.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Meeting Abstract
Endocrinology & Metabolism
Monia Garofolo, Daniela Lucchesi, Elisa Gualdani, Pierpaolo Falcetta, Massimo Giambalvo, Paolo Francesconi, Stefano Del Prato, Giuseppe Penno
Article
Endocrinology & Metabolism
Cristina Bianchi, Francesco Raggi, Chiara Rossi, Simona Frontoni, Riccardo C. Bonadonna, Stefano Del Prato, Anna Solini
Summary: The study reveals that MG53 is associated with glucose tolerance, and higher levels of MG53 are related to worsened glucose regulation and impaired beta-cell function. Among individuals at high risk of T2DM, those with higher baseline MG53 levels are more likely to progress to T2DM.
DIABETES & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Rumyana Dimova, Nevena Chakarova, Giuseppe Daniele, Cristina Bianchi, Angela Dardano, Stefano Del Prato, Tsvetalina Tankova
Summary: This study aimed to assess the relationship between insulin secretion and sensitivity, and daily glucose variability (GV) in the early stages of dysglycemia. The results showed that impairment of glucose tolerance was associated with worsening GV, and the increase in GV was inversely related to insulin secretion and action.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Endocrinology & Metabolism
Monia Garofolo, Vinicio Napoli, Daniela Lucchesi, Sandra Accogli, Maria Letizia Mazzeo, Piercarlo Rossi, Emanuele Neri, Stefano Del Prato, Giuseppe Penno
Summary: The study explores the role of kidney ultrasonography in differentiating diabetic kidney disease (DKD) phenotypes in type 2 diabetes patients, showing that there are differences in morphological and vascular properties among different DKD phenotypes. The findings suggest the potential of imaging techniques in better characterizing DKD phenotypes in clinical practice.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Letter
Endocrinology & Metabolism
Chantal Mathieu, Stefano Del Prato
Editorial Material
Endocrinology & Metabolism
Chantal Mathieu, Jeannette Soderberg, Stefano Del Prato, Anne-Marie Felton, Xavier Cos, Carine de Beaufort, Jean-Francois Gautier, Bastian Hauck, Angus Forbes, Robert Heine, Peter Schwarz, Bart Torbeyns
Article
Neurosciences
Silvia Animali, Cecilia Steinwurzel, Angela Dardano, Veronica Sancho-Bornez, Stefano Del Prato, Maria Concetta Morrone, Giuseppe Daniele, Paola Binda
Summary: Brain function is affected by metabolic changes and obesity, but little is known about the impact of transient metabolic changes on brain plasticity. In this study, researchers investigated the effect of fasting and fed states on ocular dominance plasticity following short-term monocular deprivation. They also examined the correlation between plasticity changes and variations in glucose metabolism, leptin signaling, and fatty acid metabolism. The results showed that fasting reduced the manifestation of short-term plasticity compared to the fed state, and GLP-1 infusion did not have reliable effects. The reduction in plasticity during fasting was associated with an increase in plasma beta-hydroxybutyrate levels, suggesting a link between neural function and alternative energy substrates. These findings reveal a previously unexplored connection between homeostatic brain plasticity and the physiological changes associated with the daily fast-fed cycle.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Review
Endocrinology & Metabolism
Tadej Battelino, Charles M. Alexander, Stephanie A. Amiel, Guillermo Arreaza-Rubin, Roy W. Beck, Richard M. Bergenstal, Bruce A. Buckingham, James Carroll, Antonio Ceriello, Elaine Chow, Pratik Choudhary, Kelly Close, Thomas Danne, Sanjoy Dutta, Robert Gabbay, Satish Garg, Julie Heverly, Irl B. Hirsch, Tina Kader, Julia Kenney, Boris Kovatchev, Lori Laffel, David Maahs, Chantal Mathieu, Didac Mauricio, Revital Nimri, Rimei Nishimura, Mauro Scharf, Stefano Del Prato, Eric Renard, Julio Rosenstock, Banshi Saboo, Kohjiro Ueki, Guillermo E. Umpierrez, Stuart A. Weinzimer, Moshe Phillip
Summary: Randomised controlled trials and other prospective clinical studies have traditionally used HbA1c as a measure of average blood glucose levels, but with the increasing use of continuous glucose monitoring (CGM), CGM-derived metrics are being considered for use in these studies. This consensus statement recommends the use of CGM data in clinical studies to provide additional clinical information beyond HbA1c. Standardizing the collection and reporting of CGM data in clinical trials can enhance the interpretability of the data and inform therapeutic decisions related to hypoglycaemia, postprandial hyperglycaemia, and glucose variability.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hertzel C. Gerstein, Zhuoru Li, Chinthanie Ramasundarahettige, Seungjae Baek, Kelley R. H. Branch, Stefano Del Prato, Carolyn S. P. Lam, Renato D. Lopes, Richard Pratley, Julio Rosenstock, Naveed Sattar
Summary: In the AMPLITUDE-O trial, adding either 4 mg or 6 mg weekly of efpeglenatide reduced major adverse cardiovascular events in people with type 2 diabetes. The benefits of efpeglenatide appear to be dose-related.
Article
Endocrinology & Metabolism
Cristina Bianchi, Alex Brocchi, Walter Baronti, Francesca Nicoli, Fabrizia Citro, Michele Aragona, Vito Cela, Stefano Del Prato, Alessandra Bertolotto
Summary: This study aimed to evaluate the impact of assisted reproductive technology (ART) on the risk of gestational diabetes mellitus (GDM) in single pregnancies. The study found that ART women had a significantly higher prevalence of GDM compared to women with spontaneous conception, and ART women above the age of 40 were more likely to develop GDM. Additionally, ART treatment appeared to be associated with an increased rate of preterm delivery, lower neonatal birth weight, and Apgar score, especially in women with GDM.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Anna Solini, Domenico Trico, Stefano Del Prato
Summary: Major cardiovascular outcome trials and real-life observations have shown that GLP-1 receptor agonists (GLP-1RAs) provide clinically relevant cardiovascular protection regardless of GLP-1 homology. GLP-1RAs offer cardioprotective benefits through various mechanisms, including improved insulin secretion and action, weight loss, reduced blood pressure, improved lipid profile, as well as direct effects on the heart and vasculature. The available evidence has led professional and medical societies to recommend GLP-1RAs for reducing cardiovascular risk in people with type 2 diabetes.
Article
Endocrinology & Metabolism
Pierpaolo Falcetta, Francesca Nicoli, Fabrizia Citro, Annamaria Ciccarone, Monia Garofolo, Stefano Del Prato, Cristina Bianchi
Summary: The study aimed to evaluate the impact of adding a GLP-1 RA in individuals with T2D on a BB insulin regimen. The results showed that HbA1c and body weight significantly decreased at 6 months after starting GLP-1 RA therapy and remained stable up to 24 months. In addition, at 24 months, a large percentage of subjects discontinued prandial and basal insulin. The findings suggest that replacing prandial insulin with GLP-1 RA is a valuable strategy to simplify the BB insulin regimen, improve glycemic control, and promote weight loss in people with T2D.
ACTA DIABETOLOGICA
(2023)
Meeting Abstract
Endocrinology & Metabolism
F. Citro, F. Nicoli, M. Aragona, L. Battini, C. Bianchi, S. Del Prato, A. Bertolotto
Meeting Abstract
Endocrinology & Metabolism
P. Falcetta, M. Garofolo, D. Lucchesi, E. Gualdani, M. Giambalvo, P. Francesconi, S. Del Prato, G. Penno
Meeting Abstract
Endocrinology & Metabolism
M. Garofolo, V. Napoli, D. Lucchesi, S. Accogli, M. Mazzeo, P. Rossi, P. Falcetta, M. Giambalvo, E. Neri, G. Penno, S. Del Prato
