Article
Cell Biology
Andre N. Alves, Carla M. Sgro, Matthew D. W. Piper, Christen K. Mirth
Summary: Nutrition has a significant impact on animal fitness and female fecundity. This study found that different essential amino acids have varying effects on egg production in Drosophila melanogaster, with methionine and histidine depletion resulting in a slower decline. TOR signaling was identified as a key regulator of this difference, highlighting the importance of amino acid sensitivity and signaling pathways in determining reproductive outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Eric Le Bourg
Summary: By selecting and imposing restrictions on fruit flies, it was found that adult flies had longer lifespans when their viability was lower, indicating selection for the fittest individuals. However, observing a wild-type strain under different conditions showed that increasing viability did not significantly increase lifespan, suggesting a lack of clear correlation between development and lifespan.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Plant Sciences
Yifan Xu, Xingyou Liu, Hao Tang, Lichao Zhong, Xiang Zhu, Jie Shen
Summary: Trehalose is widely used as a food additive, but recent studies have found harmful effects. Using Drosophila melanogaster as a model organism, it was found that high concentrations of trehalose can significantly shorten the lifespan of female flies by 12.5% when compared to controls.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Virginia Eickelberg, Kai Lueersen, Stefanie Staats, Gerald Rimbach
Summary: This article introduces the application of Drosophila melanogaster as a model organism in nutrition research, and provides a detailed description of the methods for phenotyping Drosophila. The practical application of fly phenotyping is demonstrated through a discussion of obese phenotypes in response to high-sugar diet and high-fat diet feeding. It is also found that the diets have impacts on the transcriptome and metabolome of Drosophila, which is important for understanding the underlying molecular mechanisms.
Article
Biochemistry & Molecular Biology
Tahlia L. Fulton, Christen K. Mirth, Matthew D. W. Piper
Summary: Restricting protein intake has been repeatedly shown to have beneficial health outcomes, including increased stress tolerance. By studying Drosophila melanogaster, researchers found that transiently restricting a single essential amino acid can protect adult flies against a lethal dose of nicotine. The protection varied depending on the specific amino acid and the duration and intensity of its restriction. By modifying the signaling of two cellular sensors of amino acids, GCN2 and mTORC1, the researchers discovered that GCN2 is necessary for the protective effects while suppressing mTORC1 is sufficient to induce nicotine resistance.
Article
Cell Biology
Minwoo Baek, Wijeong Jang, Changsoo Kim
Summary: This study identifies dual oxidase (duox) as a source of neuronal oxidative stress associated with animal lifespan. The research found that reducing oxidative stress in neurons extends the lifespan of Drosophila melanogaster, with duox playing a crucial role in this process.
Article
Biochemistry & Molecular Biology
Matthew D. W. Piper, Brooke Zanco, Carla M. Sgro, Margo Adler, Christen K. Mirth, Russell Bonduriansky
Summary: Reducing overall food intake or altering the proportion of protein relative to other macronutrients can extend lifespan in various organisms. A recent study using Drosophila melanogaster females has identified a single micronutrient that can explain the impact of dietary restriction on lifespan. This finding suggests a potential mechanism involving a trade-off between lifespan and reproduction, depending on the availability of an essential micronutrient - a sterol.
Article
Cell Biology
Cara L. Green, Michaela E. Trautman, Krittisak Chaiyakul, Raghav Jain, Yasmine H. Alam, Reji Babygirija, Heidi H. Pak, Michelle M. Sonsalla, Mariah F. Calubag, Chung-Yang Yeh, Anneliese Bleicher, Grace Novak, Teresa T. Liu, Sarah Newman, Will A. Ricke, Kristina A. Matkowskyj, Irene M. Ong, Cholsoon Jang, Judith Simcox, Dudley W. Lamming
Summary: Restriction of dietary isoleucine (IleR) improves metabolic health, promotes leanness and glycemic control in mice, and extends lifespan.
Article
Endocrinology & Metabolism
Calum Forteath, Ify Mordi, Raid Nisr, Erika J. Gutierrez-Lara, Noor Alqurashi, Iain R. Phair, Amy R. Cameron, Craig Beall, Ibrahim Bahr, Mohapradeep Mohan, Aaron K. F. Wong, Adel Dihoum, Anwar Mohammad, Colin N. A. Palmer, Douglas Lamont, Kei Sakamoto, Benoit Viollet, Marc Foretz, Chim C. Lang, Graham Rena
Summary: Using cellular approaches and proteomics, we found that metformin therapy for diabetes alters the regulation of branched chain amino acids through the suppression of the amino acid transporter SNAT2.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Nattapong Wongchum, Ananya Dechakhamphu
Summary: The study found that XN supplementation can extend the lifespan of fruit flies, increase their antioxidant enzyme activities, improve their survival rates against hydrogen peroxide and paraquat, and enhance their resistance to cold and heat shock as well as starvation stress.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Entomology
Carolyn Ma, Christen K. Mirth, Matthew D. Hall, Matthew D. W. Piper
Summary: The composition and quality of diet have significant impacts on animal wellbeing and life-history traits. This study demonstrates that dietary protein quality plays a crucial role in modifying the effects of protein quantity on female reproduction across various diets. These findings highlight the importance of considering the relative value of different nutrient sources and their potential physiological outcomes.
JOURNAL OF INSECT PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gulperi Yalcin, Juri Kim, Dongseong Seo, Cheol-Koo Lee
Summary: FK506-sensitive proline rotamase 1 protein (Fpr1p), a homologue of mammalian FKBP12, plays important roles in protein folding and preventing protein aggregation. This study shows that deletion of FPR1 reduces yeast lifespan, and rapamycin treatment does not extend lifespan in the absence of FPR1, indicating that FPR1 is essential for the lifespan extension mechanism of rapamycin in yeast. Additionally, caloric restriction has a different effect on lifespan compared to rapamycin, suggesting that rapamycin affects lifespan through a distinct pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Suhayl Mulla, Adele R. Ludlam, Aiman Elragig, Cathy Slack, Zita Balklava, Michael Stich, Alex Cheong
Summary: Ageing research aims to identify factors that affect lifespan and understand their effects. This study introduces a bilogistic model to describe the shape of lifespan curves in Caenorhabditis elegans. The model provides a better fit to experimental data than other models, and can identify and confirm biphasic lifespan data.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ekaterina Proshkina, Elena Yushkova, Liubov Koval, Nadezhda Zemskaya, Evgeniya Shchegoleva, Ilya Solovev, Daria Yakovleva, Natalya Pakshina, Natalia Ulyasheva, Mikhail Shaposhnikov, Alexey Moskalev
Summary: Small RNAs play a crucial role in coordinating various cellular processes, affecting gene expression, genomic stability, and suppressing mutagenic transposon activity, thus influencing aging, longevity, and sensitivity to stress factors. Proteins of the Argonaute family are essential for the biogenesis and activity of small RNAs, but their role in regulating lifespan and radioresistance is still not well understood. Studies on knockdown of Argonaute genes in different tissues of Drosophila melanogaster show tissue-specific effects on lifespan, survival after irradiation, and retrotransposon levels, providing insights into the associated molecular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yanyu Feng, Hanjin Lu, Jiamiao Hu, Baodong Zheng, Yi Zhang
Summary: The research showed that R-phycocyanin (R-PC) has anti-aging activity. It was also found that the effectiveness of anti-aging drugs may vary between genders. Therefore, the study aimed to investigate the differential effects and underlying molecular mechanisms of R-PC on aging in male and female drosophila melanogaster. The results showed that R-PC exerted anti-aging effects through different mechanisms in male and female drosophila melanogaster.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Cell Biology
Xiaolan Fan, Tiantian Huang, Yingdong Tong, Ziqiang Fan, Ziyue Yang, Deying Yang, Xueping Mao, Mingyao Yang
Summary: p62, also known as SQSTM1, is a crucial predictor of autophagic flux and plays a role in maintaining protein homeostasis in cells. It has the ability to resist oxidative stress, and its multiple domains allow it to interact with vital signaling pathways, influencing cell proliferation, apoptosis, and survival. Recent studies have also shown its involvement in the aging process.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Xiaolan Fan, Ziqiang Fan, Ziyue Yang, Tiantian Huang, Yingdong Tong, Deying Yang, Xueping Mao, Mingyao Yang
Summary: This review highlights the association between aging and macromolecular damage, and discusses the potential of flavonoid molecules in delaying aging and prolonging healthy lifespan. The study suggests the need for further exploration of the clinical application of flavonoids in anti-aging treatment, which could provide valuable information for drug design and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Andre N. Alves, Carla M. Sgro, Matthew D. W. Piper, Christen K. Mirth
Summary: Nutrition has a significant impact on animal fitness and female fecundity. This study found that different essential amino acids have varying effects on egg production in Drosophila melanogaster, with methionine and histidine depletion resulting in a slower decline. TOR signaling was identified as a key regulator of this difference, highlighting the importance of amino acid sensitivity and signaling pathways in determining reproductive outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Fisheries
Rongrong Yang, Jia Hu, Bo Zeng, Deying Yang, Diyan Li, Mingyao Yang, Xiaolan Fan, Xiaoyan Li, Xueping Mao, Yulei Liu, Yongqing Lyu, Yan Li
Summary: This study analyzed the genetic changes of short pentraxin genes in primates. The results revealed diversity in these genes across different species and showed that adaptive selection has caused these changes. However, there is a lack of genetic variation in these genes in the Macaca fascicularis and M. mulatta primate models.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Review
Geriatrics & Gerontology
Zhixiao Yuan, Yutian Zeng, Yao Tian, Shuai Wang, Binyan Hong, Mingyao Yang
Summary: This review summarizes the connection between SIRT6 and glycolytic metabolism, discusses its involvement in life-threatening diseases like cancer, neurodegenerative diseases, and cardiovascular disease, and explores possible treatment approaches using SIRT6.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matthew D. W. Piper, Brooke Zanco, Carla M. Sgro, Margo Adler, Christen K. Mirth, Russell Bonduriansky
Summary: Reducing overall food intake or altering the proportion of protein relative to other macronutrients can extend lifespan in various organisms. A recent study using Drosophila melanogaster females has identified a single micronutrient that can explain the impact of dietary restriction on lifespan. This finding suggests a potential mechanism involving a trade-off between lifespan and reproduction, depending on the availability of an essential micronutrient - a sterol.
Review
Biochemistry & Molecular Biology
Yao Tian, Yuanliangzi Tian, Zhixiao Yuan, Yutian Zeng, Shuai Wang, Xiaolan Fan, Deying Yang, Mingyao Yang
Summary: This review discusses the role of iron metabolism in aging and age-related neurodegenerative diseases, as well as recent developments in using iron chelators as treatment strategies. Understanding iron metabolism is crucial for filling the knowledge gap in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xingyi Cheng, Meng Xie, Lu Luo, Yao Tian, Guixiang Yu, Qi Wu, Xiaolan Fan, Deying Yang, Xueping Mao, Uma Gaur, Mingyao Yang
Summary: This research demonstrates that the AKT inhibitor GSK690693 can extend the lifespan of Drosophila by improving oxidative resistance, intestinal integrity, and increasing autophagy. It may become an effective compound for anti-aging intervention.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Correction
Biotechnology & Applied Microbiology
Feng Li, Chengdong Wang, Zhongxian Xu, Mingzhou Li, Linhua Deng, Ming Wei, Hemin Zhang, Kai Wu, Ruihong Ning, Diyan Li, Mingyao Yang, Mingwang Zhang, Qingyong Ni, Bo Zeng, Desheng Li, Ying Li
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Siqi Wang, Feng Xiao, Jiamei Li, Xiaolan Fan, Zhi He, Taiming Yan, Mingyao Yang, Deying Yang
Summary: Circular RNAs (circRNAs) are a class of covalently circular noncoding RNAs that can regulate aging and age-related diseases through various mechanisms, such as acting as miRNA sponges, and have the potential to be biomarkers for aging and age-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Helen J. Rushby, Zane B. Andrews, Matthew D. W. Piper, Christen K. Mirth
Summary: Modifying the proportions of macronutrients in the diet has significant effects on the reproduction and health of animals. In this study, using capillary feeding assays, we explored how adult fruit flies compromise their nutrient intake when limited to single diets. We found that young male and female flies compromised by consuming more food on diets with low protein to carbohydrate ratios. Additionally, female flies showed greater variations in carbohydrate intake compared to males, and mated females consumed more food than virgin females.
Article
Entomology
Brooke Zanco, Lisa Rapley, Joshua N. Johnstone, Amy Dedman, Christen K. Mirth, Carla M. Sgro, Matthew D. W. Piper
Summary: Limiting calories or specific nutrients in a diet has been shown to extend lifespan and reduce reproduction in various species. However, recent findings in fruit flies indicate that supplementing their diet with cholesterol can extend lifespan to the same extent as dietary restriction while sustaining high egg production. The study also suggests that offspring viability is not compromised by the lifespan extension caused by dietary cholesterol supplementation.
JOURNAL OF INSECT PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Sarah Mele, Felipe Martelli, Jiayi Lin, Oguz Kanca, John Christodoulou, Hugo J. Bellen, Matthew D. W. Piper, Travis K. Johnson
Summary: Amino acid disorders (AADs) are rare inherited conditions that affect one in 6500 live births, often leading to neurological decline and death in infants. Dietary modification can be an effective treatment for some AADs like phenylketonuria, but the potential for dietary therapy remains largely unexplored for most AADs. Drosophila is a suitable animal model for nutrigenomic disease modeling due to its conserved amino acid pathways, genetic tractability, and the availability of a customizable synthetic diet.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Nutrition & Dietetics
Yue Gao, Xingyi Cheng, Yao Tian, Zhixiao Yuan, Xiaolan Fan, Deying Yang, Mingyao Yang
Summary: Nutrition during developmental stages has long-term effects on adult physiology, disease, and lifespan, known as nutritional programming. This study demonstrated that developmental diets can influence the lifespan of adult Drosophila, particularly through a low-yeast diet. The activity of the Drosophila transcription factor FOXO (dFOXO) was found to be upregulated under developmental low-nutrient conditions, and its knockdown abolished the lifespan-extending effect of the larval low-yeast diet.
Article
Genetics & Heredity
Javier Gomez Ortega, David P. Raubenheimer, Sonika P. Tyagi, Christen P. Mirth, Matthew D. W. P. Piper
Summary: Dietary nutrient composition plays a crucial role in shaping vital fitness traits and behaviors. Fruit flies, like Drosophila melanogaster, experience protein limitation at the level of amino acids. Despite significant differences in gene expression between male and female flies, their amino acid utilization patterns are remarkably conserved.
