期刊
AGING-US
卷 6, 期 12, 页码 992-1009出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100710
关键词
long noncoding RNAs; senescence-associated lncRNAs; epigenetic control by lncRNAs; lncRNA regulation of post-transcriptional gene expression; lncRNA influencing aging phenotypes
资金
- National Institute on Aging-Intramural Research Program of the National Institutes of Health
During aging, progressive deleterious changes increase the risk of disease and death. Prominent molecular hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, cellular senescence, stem cell exhaustion, and altered intercellular communication. Long noncoding RNAs (lncRNAs) play important roles in a wide range of biological processes, including age-related diseases like cancer, cardiovascular pathologies, and neurodegenerative disorders. Evidence is emerging that lncRNAs influence the molecular processes that underlie age-associated phenotypes. Here, we review our current understanding of lncRNAs that control the development of aging traits.
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