期刊
AGING-US
卷 4, 期 5, 页码 350-358出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100461
关键词
aging; diabetes; retinopathy; nephropathy; diseases; anti-aging drugs; growth hormone
Calorie restriction (CR), which deactivates the nutrient-sensing mTOR pathway, slows down aging and prevents age-related diseases such as type II diabetes. Compared with CR, rapamycin more efficiently inhibits mTOR. Noteworthy, severe CR and starvation cause a reversible condition known as starvation diabetes. As was already discussed, chronic administration of rapamycin can cause a similar condition in some animal models. A recent paper published in Science reported that chronic treatment with rapamycin causes a diabetes-like condition in mice by indirectly inhibiting mTOR complex 2. Here I introduce the notion of benevolent diabetes and discuss whether starvation-like effects of chronic high dose treatment with rapamycin are an obstacle for its use as an anti-aging drug.
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