Review
Biochemistry & Molecular Biology
Sandra Diaz del Moral, Maha Benaouicha, Ramon Munoz-Chapuli, Rita Carmona
Summary: The translation introduces the importance of insulin and insulin-like growth factors during embryonic development and their role in cardiac development and cardiomyocyte proliferation. The study also discusses the clinical potential of utilizing the IGF signaling pathway for adult cardiac repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Katharina Doerr, Michael Kammer, Roman Reindl-Schwaighofer, Matthias Lorenz, Thomas Prikoszovich, Rodrig Marculescu, Dietrich Beitzke, Alice Wielandner, Reinhold G. Erben, Rainer Oberbauer
Summary: The study aimed to investigate the effect of FGF23 suppression by calcimimetic therapy on LVH progression in patients with chronic kidney disease. The results showed that etelcalcetide treatment inhibited the progression of LVH compared to alfacalcidol, potentially reducing the risk of sudden cardiac death in this population.
CIRCULATION RESEARCH
(2021)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Article
Engineering, Biomedical
Mingsheng Xie, Yiqian Zhang, Zixuan Xiong, Sophie Hines, Jiangyinzi Shang, Karen L. Clark, Susheng Tan, Peter G. Alexander, Hang Lin
Summary: In this study, hyaline cartilage-like tissues were generated from human mesenchymal stromal cells (hMSCs) and displayed robust capacity in repairing osteochondral defects in rats. The use of hMSC-generated extracellular matrix eliminated the need for exogenous scaffolds. Through optimization, it was determined that hypoxic culture and supplementation of insulin-like growth factor-1 (IGF1) in the chondrogenic medium resulted in robust cartilage formation with minimal hypertrophy. It was also demonstrated that hypoxic culture suppressed chondrogenesis and hypertrophy by modulating the Wnt/β-catenin and IGF1 pathways, respectively. This study provides a new method for generating hyaline cartilage-like tissue from hMSCs, which has potential clinical applications in cartilage tissue engineering.
ACTA BIOMATERIALIA
(2022)
Article
Cardiac & Cardiovascular Systems
Mahmoud Abdellatif, Viktoria Trummer-Herbst, Alexander Martin Heberle, Alina Humnig, Tobias Pendl, Sylvere Durand, Giulia Cerrato, Sebastian J. Hofer, Moydul Islam, Julia Voglhuber, Jose Miguel Ramos Pittol, Oliver Kepp, Gerald Hoefler, Albrecht Schmidt, Peter P. Rainer, Daniel Scherr, Dirk von Lewinski, Egbert Bisping, Julie R. McMullen, Abhinav Diwan, Tobias Eisenberg, Frank Madeo, Kathrin Thedieck, Guido Kroemer, Simon Sedej
Summary: This study suggests a biphasic relationship between insulin-like growth factor 1 receptor (IGF1R) signaling and cardiac health. Higher IGF1R signaling in young mice leads to declining cardiac function and shorter lifespan, while lower IGF1R signaling improves cardiac function and extends lifespan in aging mice.
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Article
Oncology
Lian E. M. Stadhouders, Jonathon A. B. Smith, Brendan M. Gabriel, Sander A. J. Verbrugge, Tim D. Hammersen, Detmar Kolijn, Ilse S. P. Vogel, Abdalla D. Mohamed, Gerard M. J. de Wit, Carla Offringa, Willem M. H. Hoogaars, Sebastian Gehlert, Henning Wackerhage, Richard T. Jaspers
Summary: The Warburg effect, commonly associated with cancer, was investigated in relation to muscle hypertrophy, showing that glycolysis and non-essential amino acid synthesis play important roles in the process. Inhibiting glycolysis or key enzymes in the serine biosynthesis pathway decreased myotube size, while promoting glycolytic flux increased myotube size, suggesting a reprogramming of metabolism to facilitate anabolism in hypertrophying muscle cells.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
Summary: In children with Prader-Willi syndrome receiving GH treatment, high immunoreactive IGF-I levels are often observed, while free IGF-I levels are low, indicating a significant discrepancy between the two.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Elma Zaganjor, Haejin Yoon, Jessica B. Spinelli, Elizabeth R. Nunn, Gaelle Laurent, Paulina Keskinidis, Suganja Sivaloganathan, Shakchhi Joshi, Giulia Notarangelo, Stacy Mulei, Mathew T. Chvasta, Sarah A. Tucker, Krystle Kalafut, Robert A. H. van de Ven, Clary B. Clish, Marcia C. Haigis
Summary: This study provides a temporal analysis of adipocyte differentiation, uncovering early metabolic events that stimulate transcriptional reprogramming.
Review
Environmental Sciences
Chiara Talia, Lisa Connolly, Paul A. Fowler
Summary: This review discusses the effects of endocrine disruptors on the IGF system, focusing on different categories of EDs and their potential molecular mechanisms. While there is a lack of studies linking ED exposure to changes in IGF levels for some ED classes, this remains an area of concern that requires further research to improve reproducibility and determine the degree of risk EDs pose to the IGF system.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Plant Sciences
Longwei Xu, Yuanyuan Su, Xiaolin Yang, Xueyang Bai, Yu Wang, Chengui Zhuo, Zhe Meng
Summary: This study aims to investigate the effect of Gramine on pathological cardiac hypertrophy and clarify the mechanisms behind its action. In vitro experiments showed that Gramine significantly improved Angiotensin II-induced hypertrophy of cardiomyocytes, while having minimal effects on fibroblast activation. In vivo experiments demonstrated that Gramine effectively attenuated myocardial hypertrophy, interstitial fibrosis, and cardiac dysfunction induced by transverse aortic constriction. Mechanistically, Gramine was found to alleviate pathological cardiac hypertrophy by inhibiting the interaction between TGFBR1 and Runx1.
Article
Cell Biology
Yan Zou, Le Pan, Yi Shen, Xiang Wang, Chenxing Huang, Hao Wang, Xuejuan Jin, Chao Yin, Ying Wang, Jianguo Jia, Juying Qian, Yunzeng Zou, Hui Gong, Junbo Ge
Summary: Progressive cardiac fibrosis is accelerated by elevated serum levels of Wnt5a and Wnt11 in hypertension patients, leading to diastolic dysfunction. Pressure overload increases the secretion of Wnt5a and Wnt11 from cardiomyocytes and cardiac fibroblasts, promoting cardiac fibrosis through the activation of FZD5 and EGFR crosstalk.
CELL DEATH & DISEASE
(2021)
Article
Medical Laboratory Technology
Jason K. Y. Lee, Kendall Cradic, Ravinder J. Singh, JoAnna Jones, Jieli Li
Summary: This study compared the measurement of IGF-1 on four different platforms and found significant variations between them. These variations should be considered when managing patients with pituitary disorders.
CLINICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Shiva Nasr, Athar Nakisa, Setareh Jandaghian, Monireh Kouhi, Erfan Sadeghi, Jaleh Varshosaz
Summary: This systematic review found that flavonoid supplements do not have a significant effect on IGF-1 and IGFBP-3. However, a high soy diet has beneficial effects on components of the IGF system, which may be useful in breast cancer.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Microbiology
Diana Moreira, Vasco Rodrigues, Maria Abengozar, Luis Rivas, Eduardo Rial, Mireille Laforge, Xiaoling Li, Marc Foretz, Benoit Viollet, Jerome Estaquier, Anabela Cordeiro da Silva, Ricardo Silvestre
Article
Gastroenterology & Hepatology
Alicia S. Wellman, Mallikarjuna R. Metukuri, Nevzat Kazgan, Xiaojiang Xu, Qing Xu, Natalie S. X. Ren, Agnieszka Czopik, Michael T. Shanahan, Ashley Kang, Willa Chen, M. Andrea Azcarate-Peril, Ajay S. Gulati, David C. Fargo, Leonard Guarente, Xiaoling Li
Article
Biochemistry & Molecular Biology
Sanghoon Kwon, Sunmi Seok, Peter Yau, Xiaoling Li, Byron Kemper, Jongsook Kim Kemper
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Sung E. Choi, Sanghoon Kwon, Sunmi Seok, Zhen Xiao, Kwan-Woo Lee, Yup Kang, Xiaoling Li, Kosaku Shinoda, Shingo Kajimura, Byron Kemper, Jongsook Kim Kemper
MOLECULAR AND CELLULAR BIOLOGY
(2017)
Article
Medicine, Research & Experimental
Yang Jiang, Yuan Cao, Yongbin Wang, Wei Li, Xinyi Liu, Yixuan Lv, Xiaoling Li, Jun Mi
Article
Medicine, General & Internal
Yongbin Wang, Guifang Gan, Bocheng Wang, Jinliang Wu, Yuan Cao, Dan Zhu, Yan Xu, Xiaona Wang, Hongxiu Han, Xiaoling Li, Ming Ye, Jiangmin Zhao, Jun Mi
Article
Biochemistry & Molecular Biology
He Huang, Shuang Tang, Ming Ji, Zhanyun Tang, Miho Shimada, Xiaojing Liu, Shankang Qi, Jason W. Locasale, Robert G. Roeder, Yingming Zhao, Xiaoling Li
Article
Biochemistry & Molecular Biology
M. Ming, K. Soltani, C. R. Shea, X. Li, Y. Y. He
Article
Biology
Wei Fan, Shuang Tang, Xiaojuan Fan, Yi Fang, Xiaojiang Xu, Leping Li, Jian Xu, Jian-Liang Li, Zefeng Wang, Xiaoling Li
Summary: The study reveals that sphingolipid metabolism is transcriptionally controlled by SIRT1 in mESCs, and deletion of SIRT1 leads to accumulation of sphingomyelin, affecting membrane fluidity and neural differentiation. This key regulatory mechanism may provide insights for potential treatment of human neurological diseases through pharmacological manipulation of SIRT1-mediated sphingomyelin degradation.
Review
Cell Biology
Yi Fang, Xiaoling Li
Summary: The endoderm, one of the three primary germ layers, gives rise to important organs, but growing cells/tissues from endodermal organs in vitro is challenging. Human pluripotent stem cells (hPSCs) hold great promise for generating endodermal cells for therapeutic development. Recent research has revealed the active role of metabolism and epigenetics in regulating endoderm differentiation.
TRENDS IN CELL BIOLOGY
(2022)
Article
Cell Biology
Yi Fang, Wei Fan, Xiaojiang Xu, Agnes K. Janoshazi, David C. Fargo, Xiaoling Li
Summary: This study demonstrates the crucial role of SIRT1 in regulating cardiomyocyte alignment during development, with SIRT1 deficiency leading to misalignment of cardiomyocytes and abnormal beating patterns.
JOURNAL OF CELL SCIENCE
(2022)
Article
Developmental Biology
Magdalina J. Cummings, Hongyao Yu, Sudikshya Paudel, Guang Hu, Xiaoling Li, Myriam Hemberger, Xiaoqiu Wang
Summary: A distinct age-related alteration in the uterine environment has been identified as a prevalent cause of reproductive decline in older female mice. Sirtuin 1 (SIRT1), a multifunctional enzyme involved in regulating cell viability, senescence, and inflammation during aging, is reduced in aged decidua. Uterine-specific ablation of Sirt1 gene accelerates premature uterine aging and impairs invasion and spacing of blastocysts, as well as decidualization of stromal cells.
MOLECULAR HUMAN REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Shuang Tang, Yi Fang, Gang Huang, Xiaojiang Xu, Elizabeth Padilla-Banks, Wei Fan, Qing Xu, Sydney M. Sanderson, Julie F. Foley, Scotty Dowdy, Michael W. McBurney, David C. Fargo, Carmen J. Williams, Jason W. Locasale, Ziqiang Guan, Xiaoling Li
Article
Biochemistry & Molecular Biology
Jing Lu, Qing Xu, Ming Ji, Xiumei Guo, Xiaojiang Xu, David C. Fargo, Xiaoling Li
Article
Biochemistry & Molecular Biology
Natalie S. X. Ren, Ming Ji, Erik J. Tokar, Evan L. Busch, Xiaojiang Xu, DeAsia Lewis, Xiangchun Li, Aiwen Jin, Yanping Zhang, William K. K. Wu, Weichun Huang, Leping Li, David C. Fargo, Temitope O. Keku, Robert S. Sandler, Xiaoling Li
