Review
Biochemistry & Molecular Biology
Emanuela Alessandra Greco, Cristina Antinozzi, Luigi Di Luigi, Antonio Aversa, Paolo Sgro
Summary: This review summarizes the basic research and translational results applicable to the use of tadalafil in the treatment of obesity, bone loss, and prostate cancer. Tadalafil may have a regulatory effect on various diseases and pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Lei Zhang, JinFeng Wu, QiuMei Wu, XiangJuan Zhang, ShuaiCai Lin, WanLi Ran, Li Zhu, ChengYan Tang, Xing Wang
Summary: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. The mechanisms behind male propensity in HCC incidence, prognosis, and treatment responses are complex and inconclusive. This review integrates current knowledge on how hormones regulate HCC development in a sexually dimorphic manner. Understanding the role of sex hormones in HCC may lead to personalized therapeutic strategies in high-risk populations.
Article
Endocrinology & Metabolism
Hannah Collden, Maria E. Nilsson, Anna-Karin Norlen, Andreas Landin, Sara H. Windahl, Jianyao Wu, Karin L. Gustafsson, Matti Poutanen, Henrik Ryberg, Liesbeth Vandenput, Claes Ohlsson
Summary: This study established a comprehensive atlas of sex hormone concentrations in tissues and serum of male mice, revealing the distribution characteristics of sex hormones. Brain sex hormone levels are well correlated with serum levels, and white adipose tissue serves as a major reservoir of sex hormones in mice. Progesterone is the most abundant sex hormone in castrated mice.
Review
Cell Biology
Wenjiao Liu, Ting Gong, Fangxiong Shi, Houqiang Xu, Xiang Chen
Summary: This article explores the signaling mechanisms through which taste receptor factors influence testosterone synthesis in male reproduction and discusses their potential role in regulating male fertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Ram B. Jain, Alan Ducatman
Summary: Sex hormones influence excretion of PFAS in rodents, but their influence in humans is unclear. This study analyzed data from NHANES and found that in US females aged ≥20 years, those who took hormonal replacement therapy had higher serum PFAS concentrations compared to nonusers, regardless of hysterectomy or natural menopause status. The results suggest that estrogen hormones may be associated with higher serum PFAS in postmenopausal women.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Medicine, General & Internal
Le-Tian Huang, Jia-He Wang
Summary: Sarcopenia is characterized by excessive loss of skeletal muscle mass, strength, and function, associated with overall poor muscle performance status in the elderly and chronic disease patients. Its causes are multifactorial, involving molecular mechanisms such as mitochondrial function, inflammatory pathways, and circulating hormones. Age-related changes in sex steroid hormone concentrations play a significant role in the pathogenesis of sarcopenia, suggesting therapeutic interventions targeting these hormones may be beneficial in combination with specific exercise and nutrition regimens.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Datu Agasi Mohd Kamal, Siti Fatimah Ibrahim, Azizah Ugusman, Mohd Helmy Mokhtar
Summary: This study found aberrant expression of sex steroid receptors in polycystic ovary syndrome and demonstrated that Kelulut honey treatment can normalize the expression of these receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Danielle F. Miyagishima, Jennifer Moliterno, Elizabeth Claus, Murat Gunel
Summary: This study reviews the relationship between hormones and meningiomas, finding that most meningiomas express progesterone and somatostatin receptors, but the conclusions regarding other receptors are still uncertain. Ongoing clinical trials using somatostatin analogs in combination with other therapies show promise. Therefore, a reevaluation of hormone-based monotherapy is needed.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Briana N. C. Chronister, Eduardo Gonzalez, Dolores Lopez-Paredes, Jose Suarez-Torres, Sheila Gahagan, Danilo Martinez, Janeth Barros, David R. Jacobs, Harvey Checkoway, Jose R. Suarez-Lopez
Summary: This study found that elevated levels of testosterone, cortisol, and estradiol in adolescents were associated with altered mood. Cortisol and testosterone were significant effect modifiers in the relationships between most hormones and depression and anxiety.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Oncology
Naoko Honma, Yoko Matsuda, Tetuo Mikami
Summary: TNBC lacks an effective treatment target and is usually associated with a poor clinical outcome due to hormone unresponsiveness. Besides ER-alpha, other sex steroid receptors like AR, ER-beta, and GPER are frequently expressed in TNBC, highlighting the importance of understanding their biological and clinical significance in TNBC. A comprehensive viewpoint on the role of sex steroid hormones in TNBC is crucial for correctly understanding the association between the carcinogenic mechanism or pathobiology of TNBC and sex steroid hormones.
Article
Multidisciplinary Sciences
Marwa M. M. Elsayed, Ghada E. E. El Refaye, Ahmed Rabiee, Sameh Abouzeid, Hany F. F. Elsisi
Summary: This study investigated the impact of aerobic exercise combined with dietary restriction on hormonal, metabolic, and psychological variables in postmenopausal women. The results showed significant changes in all measured variables in the experimental group compared to the control group.
Article
Chemistry, Medicinal
Namita Dube, Sabab Hasan Khan, Riley Sasse, C. Denise Okafor
Summary: Allosteric pathways in proteins involve networks of amino acid residues that transmit signals between distant sites. This study uses molecular dynamics simulations and suboptimal path analysis to discover new allosteric networks in steroid receptors, focusing on evolutionarily conserved pathways. The researchers identify a conserved network connecting a predicted allosteric site between helices 9 and 10 of the ligand-binding domain to the activation function surface 2 (AF-2). The study suggests the evolutionary importance of this site in steroid receptors and provides an approach to discover previously unknown allosteric sites in proteins.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Medicinal
Namita Dube, Sabab Hasan Khan, Riley Sasse, C. Denise Okafor
Summary: Allosteric pathways in proteins allow for the transmission of signals between distant sites through inter-residue interactions. This study utilizes molecular dynamics simulations and suboptimal path analysis to identify new allosteric networks in steroid receptors, focusing on evolutionarily conserved pathways. The investigation reveals a conserved network connecting a predicted allosteric site located between helices 9 and 10 of the ligand-binding domain to the activation function surface 2 (AF-2). The importance of this site is highlighted by its presence in a region characterized by conserved inter-residue contacts.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Biology
Maggie E. Amer, Azza Othman, Hajer Mohammed Abozaid, Mohamed A. El-Missiry
Summary: This study demonstrates that melatonin (MLT) mitigates radiation-induced testicular injury through its antioxidant, anti-inflammatory, anti-apoptotic, and anti-DNA damage actions.
BIOLOGICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Melissa Gonzalez De Acevedo, James Gelsleichter
Summary: This study examined the potential role of gonadal steroid hormones in regulating female sperm storage (FSS) in the bonnethead species. The findings suggest that hormones like 17 beta-estradiol, testosterone, and progesterone may play roles in regulating FSS. Immunohistochemistry also showed the presence of hormone receptors in the reproductive tract of female bonnetheads.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luca Vanella, Martina Canestraro, Craig R. Lee, Jian Cao, Darryl C. Zeldin, Michal L. Schwartzman, Nader G. Abraham
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2015)
Article
Biochemistry & Molecular Biology
Jian Cao, Peter L. Tsenovoy, Ellen A. Thompson, John R. Falck, Robert Touchon, Komal Sodhi, Rita Rezzani, Joseph I. Shapiro, Nader G. Abraham
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2015)
Article
Geriatrics & Gerontology
Huaxin Zhang, Xiuying Chen, Lin Liu, Li Fan, Jian Cao, Xiaoli Li, Guoliang Hu, Yixin Hu, Bingpo Zhu, Xianfeng Liu, Yan Gao, Cong Ma, Wenxiu Leng
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2014)
Article
Cardiac & Cardiovascular Systems
Xin Huang, Yan Yue, Yinmeng Wang, Yujiao Deng, Lu Liu, Yanqi Di, Shasha Sun, Deyou Chen, Li Fan, Jian Cao
CARDIOVASCULAR ULTRASOUND
(2018)
Article
Geriatrics & Gerontology
Li Fan, Jian Cao, Lin Liu, Xiaoli Li, Guoliang Hu, Yixin Hu, Bingpo Zhu
Article
Biochemistry & Molecular Biology
Tian-meng Chen, Jian Li, Lin Liu, Li Fan, Xiao-ying Li, Yu-tang Wang, Nader G. Abraham, Jian Cao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2013)
Article
Hematology
Wen-Xiu Leng, Jun-Wei Ren, Jian Cao, Yu-Long Cong, Hua Cui, Guo-Liang Hu, Qing-Qing Hu, Hui Niu, Li Fan
THROMBOSIS RESEARCH
(2013)
Article
Pharmacology & Pharmacy
Lu Liu, Xin Huang, Jinliao Gao, Yusong Guo, Yanqi Di, Shasha Sun, Xinli Deng, Jian Cao
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2018)
Article
Pharmacology & Pharmacy
Xiao Zou, Xin-li Deng, Yin-meng Wang, Jian-hua Li, Lin Liu, Xin Huang, Lu Liu, Jian Cao, Li Fan
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2020)
Review
Cardiac & Cardiovascular Systems
Bo Guan, Lu Liu, Xintao Li, Xin Huang, Wenyi Yang, Shasha Sun, Yufei Ma, Yan Yu, Jiakun Luo, Jian Cao
Summary: The study analyzed the association between epicardial adipose tissue (EAT) and blood pressure, finding that hypertensive patients had higher EAT thickness compared to normotensive patients, and increased EAT thickness might be associated with a high risk of non-dipper blood pressure.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Oncology
Wenyi Yang, Haiyan Shi, Xin Huang, Yufei Ma, Bo Guan, Shasha Sun, Yan Yu, Jiakun Luo, Fan Tian, Jian Cao
Summary: The study revealed a negative correlation between ideal cardiovascular health metrics and the prevalence of high epicardial adipose tissue volume (EATV), indicating the importance of EATV as a useful parameter in clinical practice.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yujiao Deng, Xin Huang, Guangyi Wang, Jian Cao, Shengshu Wang, Yue Li, Yiru Wang, Jing Ye, Peifang Zhang, Xiaotian Chen, Yukun Luo, Kunlun He
Summary: Transthoracic contrast echocardiography (TTCE) is the preferred screening test for pulmonary arteriovenous malformations (PAVMs). The pulmonary right-to-left shunt (RLS) grade on TTCE not only identifies the likelihood of PAVMs but also predicts the probability for embolization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Xin Huang, Yuan Liu, Bo Guan, Wenyi Yang, Shasha Sun, Jiakun Luo, Yukun Luo, Jian Cao, Yujiao Deng
Summary: Real-time three-dimensional echocardiography (RT-3DE) and two-dimensional speckle tracking imaging (STI) can sensitively assess the left ventricular (LV) systolic function in elderly patients with non-ST elevation myocardial infarction (NSTEMI) and ST elevation myocardial infarction (STEMI), as well as the extent of transmural damage in the myocardium.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Kailiang Li, Weihao Xu, Bo Hu, Qing Shan, Lin Liu, Jian Cao
Summary: The study constructed a modified Healthy Aging Index (mHAI) and found a significant association between mHAI and functional status as well as fall risk in older adults. This can serve as a simple assessment tool to determine mobility status and identify high-risk individuals among older people.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Xian-Feng Liu, Jian Cao, Li Fan, Lin Liu, Jian Li, Guo-Liang Hu, Yi-Xin Hu, Xiao-Li Li
JOURNAL OF GERIATRIC CARDIOLOGY
(2013)