期刊
AGING CELL
卷 13, 期 1, 页码 197-200出版社
WILEY-BLACKWELL
DOI: 10.1111/acel.12161
关键词
apoptosis; ER stress; telomerase; hTERT
资金
- National Basic Research Program of China [2012CB911203]
- National Natural Science Foundation of China [31371398, 31071200, 31171320, 31201038]
Telomerase contributes to cell proliferation and survival through both telomere-dependent and telomere-independent mechanisms. In this report, we discovered that endoplasmic reticulum (ER) stress transiently activates the catalytic components of telomerase (TERT) expression in human cancer cell lines and murine primary neural cells. Importantly, we show that depletion of hTERT sensitizes cells to undergo apoptosis under ER stress, whereas increased hTERT expression reduces ER stress-induced cell death independent of catalytically active enzyme or DNA damage signaling. Our findings establish a functional link between ER stress and telomerase, both of which have important implications in the pathologies associated with aging and cancer.
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