DGCR8-mediated disruption of miRNA biogenesis induces cellular senescence in primary fibroblasts

MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence

(2016) Bernard S. Marasa et al.   Aging-US

Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts

(2013) Ruth Greussing et al.   BMC GENOMICS

DiGeorge Syndrome Critical Region 8 (DGCR8) Protein-mediated microRNA Biogenesis Is Essential for Vascular Smooth Muscle Cell Development in Mice

(2012) Zixuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

The microcosmos of cancer

(2012) Amaia Lujambio et al.   NATURE

Senescence-associated microRNAs linked to tumorigenesis

(2011) Subramanya Srikantan et al.   CELL CYCLE

A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts

(2011) R Faraonio et al.   CELL DEATH AND DIFFERENTIATION

Differential expression of oncogenic miRNAs in proliferating and senescent human fibroblasts

(2011) Miao Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Depletion of key protein components of the RISC pathway impairs pre-ribosomal RNA processing

(2011) Xue-hai Liang et al.   NUCLEIC ACIDS RESEARCH

Identification of microprocessor-dependent cancer cells allows screening for growth-sustaining micro-RNAs

(2011) D Peric et al.   ONCOGENE

Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex

(2011) K. Fenelon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRegulators come of age in senescence

(2011) Myriam Gorospe et al.   TRENDS IN GENETICS

The tumor suppressor ING1 contributes to epigenetic control of cellular senescence

(2010) María Abad et al.   AGING CELL

A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells

(2010) Sonia A. Melo et al.   CANCER CELL

Regulation of the MicroRNA Processor DGCR8 by the Tumor Suppressor ING1

(2010) D. Gomez-Cabello et al.   CANCER RESEARCH

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21Waf1/Cip1

(2010) V Borgdorff et al.   ONCOGENE

Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region

(2010) S Wu et al.   ONCOGENE

MiRNA Profile Associated with Replicative Senescence, Extended Cell Culture, and Ectopic Telomerase Expression in Human Foreskin Fibroblasts

(2010) Laura N. Bonifacio et al.   PLoS One

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells

(2008) Rajini Mudhasani et al.   JOURNAL OF CELL BIOLOGY

MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression

(2008) I. Ivanovska et al.   MOLECULAR AND CELLULAR BIOLOGY

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

(2008) Kimberly L Stark et al.   NATURE GENETICS

Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation

(2008) Yangming Wang et al.   NATURE GENETICS

DGCR8-dependent microRNA biogenesis is essential for skin development

(2008) R. Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA