Article
Biotechnology & Applied Microbiology
Patrick Lansdon, Maci Carlson, Brian D. Ackley
Summary: The study used the soil-dwelling nematode Caenorhabditis elegans as a model to investigate immune responses against microbial pathogens. The results showed that different isolates of C. elegans exhibited varying susceptibility to different pathogenic bacteria, and their gene expression profiles were also significantly different. This study provides insights into the evolution of immune responses within organisms.
Article
Multidisciplinary Sciences
Phillip A. Frankino, Talha F. Siddiqi, Theodore Bolas, Raz Bar-Ziv, Holly K. Gildea, Hanlin Zhang, Ryo Higuchi-Sanabria, Andrew Dillin
Summary: The transcription factor SKN-1/NRF2 can sense and respond to changes in metabolic state. Knockdown of the amidohydrolase T12A2.1/amdh-1 activates a unique subset of SKN-1 regulated genes, independent of P38-MAPK signaling components. Histidine catabolism genes are required for this activation, possibly through accumulation of a specific catabolite. Activating SKN-1 results in increased oxidative stress resistance but decreased survival to heat stress.
Article
Environmental Sciences
Pei -Ling Yen, Cai-Ru Yang, Mei-Lun Huang, Ting -An Lin, Vivian Hsiu-Chuan Liao
Summary: This study aims to evaluate the effects of chronic DEHP exposure on innate immunosenescence in C. elegans. The length of the exposure period significantly impacts DEHP-induced age-related declines, which is linked to immunosenescence and oxidative stress. DEHP exposure increases the expression of riok-1, a human RIO kinase homolog, which is associated with DEHP-induced HLH-30/TFEB translocation.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Cell Biology
Yangli Liu, Jun Zhou, Ning Zhang, Xueying Wu, Qian Zhang, Wenfeng Zhang, Xinyu Li, Ye Tian
Summary: Mitochondrial perturbations in neurons can regulate organism-wide mitochondrial homeostasis and adaptability by activating the unfolded protein response in the intestine. This regulation involves the coordinated action of GPCR and its downstream signaling in sensory neurons.
DEVELOPMENTAL CELL
(2022)
Article
Developmental Biology
Chee Kiang Ewe, Geneva Alok, Joel H. Rothman
Summary: The intestine plays a crucial role in protecting the host from environmental toxins and pathogens, in addition to its functions in digestion and nutrient absorption. In C. elegans, the gene regulatory network governing embryonic development of the endoderm and intestine overlaps with stress response and homeostasis regulation. The connections between intestinal development regulation and stress response mechanisms suggest potential genetic and epigenetic variations in early embryonic regulatory events.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Siqi Jiang, Na Deng, Bisheng Zheng, Tong Li, Rui Hai Liu
Summary: Rhodiola extract was found to significantly extend the lifespan of C. elegans and enhance its stress resistance by regulating gene expression and promoting protein translocation.
Review
Microbiology
Leah J. Radeke, Michael A. Herman
Summary: Microbiomes establish close functional associations with hosts, with studies focusing on bacterial interactions with Caenorhabditis elegans and exploring the composition of the native microbiome to integrate into research on innate immunity and pathogenesis.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2021)
Article
Multidisciplinary Sciences
Hillary A. Miller, Shijiao Huang, Elizabeth S. Dean, Megan L. Schaller, Angela M. Tuckowski, Allyson S. Munneke, Safa Beydoun, Scott D. Pletcher, Scott F. Leiser
Summary: This study found that mimicking dietary restriction by blocking food odor signaling can extend lifespan. Serotonin and dopamine were identified as playing a role in limiting lifespan in response to food odor. The study revealed the involvement of a neural network in dietary perception.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Shiling Feng, Chunyan Zhang, Tao Chen, Lijun Zhou, Yan Huang, Ming Yuan, Tian Li, Chunbang Ding
Summary: The study found that OLE significantly prolongs the lifespan of Caenorhabditis elegans and increases their resistance to lethal heat shock and oxidative stress. OLE regulates stress resistance and lifespan extension in nematodes through the activation of the IIS and SKN-1/Nrf2 signaling pathways.
Article
Cell Biology
Yujin Lee, Yoonji Jung, Dae-Eun Jeong, Wooseon Hwang, Seokjin Ham, Hae-Eun H. Park, Sujeong Kwon, Jasmine M. Ashraf, Coleen T. Murphy, Seung-Jae Lee
Summary: Genetic inhibition of the DAF-2/insulin/IGF-1 receptor in Caenorhabditis elegans can enhance immunocompetence in old age by up-regulating anti-aging transcription factors and preventing immune aging. This study may lead to the development of strategies against immune aging in humans, as many functions are conserved across phyla.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Cell Biology
Jeong-Hoon Hahm, Farida S. Nirmala, Pyeong Geun Choi, Hyo-Deok Seo, Tae Youl Ha, Chang Hwa Jung, Jiyun Ahn
Summary: Dietary restriction (DR) is an effective intervention for prolonging longevity in many organisms, but the molecular mechanisms by which DR influences aging and immunity are not fully understood. Through studying Caenorhabditis elegans, researchers discovered that the F-box gene fbxc-58 mediates the beneficial effects of DR on extending the health span of the worm and preventing mitochondrial deterioration during aging.
Review
Biochemistry & Molecular Biology
Szilvia Lukacsi, Zsolt Farkas, Eva Saskoi, Zsuzsa Bajtay, Krisztina Takacs-Vellai
Summary: Endocytosis provides cellular nutrition and homeostasis, while pathogens often exploit this entry point to infect host cells. Phagocytosis plays a key role in protecting against invading microbes, with initial recognition of infection differing between mammals and C. elegans. However, molecules involved in efferocytosis are highly conserved between the two species, making C. elegans a powerful model for studying phagocytic mechanisms. Additionally, studies in both mammals and worms show that defective apoptotic cell clearance can lead to the activation of innate immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Hao Peng, Huili Bai, Yan Pan, Jun Li, Zhe Pei, Yuying Liao, Cuilan Wu, Changting Li, Li Tao, Shuhong Zhong, Chunxia Ma, Zhongwei Chen, Xiaoning Li, Yu Gong, Leping Wang, Fengsheng Li
Summary: In this study, different pathogenicity strengths of E. coli strains were observed in C. elegans, and the detection rate of virulence factors did not correspond to the pathogenicity in the nematodes. The results confirmed that C. elegans could serve as a fast and convenient detection model for evaluating the pathogenicity of pathogenic bacteria.
Review
Immunology
Debanjan Goswamy, Javier E. Irazoqui
Summary: This review discusses the induction of ROS by microbes during intestinal infection in C. elegans, highlighting the dual role of ROS as antimicrobials and signaling molecules. Failure to maintain appropriate levels of ROS can lead to oxidative stress and cellular damage. The proposed hypothesis suggests that ROS drive a collapse in proteostasis in infected C. elegans, potentially leading to death. The conserved signaling pathways discussed in this study may provide new insights into human health and disease.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Cell Biology
Qin Wang, Rong Fu, Gang Li, Shaojie Xiong, Yi Zhu, Huimin Zhang
Summary: Hedgehog signaling plays important roles in epithelial barrier tissues' development and homeostasis. The study reveals the direct regulation of innate immunity in epithelial cells by Hedgehog signaling. Loss of Patched family receptor induces up-regulation of antimicrobial peptides in epidermis through a STAT-dependent pathway. The findings demonstrate the immune-surveillance function of Hedgehog receptors and the insult-sensing and response strategy of epithelial tissues.
